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Knock in Biological News

US-Mexico border wall could threaten wildlife species

... he added, "it makes the animals more susceptible to disease, drought and other weather extremes, and predation. We've seen one or two mountain lions knock down populations of sheep once they get a taste for mutton." The scientists say the wall along the U.S.-Mexican border is not the only issue for ...

Nanotechnology holds promise for STD drug delivery

... Science . "We wanted to develop a new strategy of delivering siRNAs with a FDA-approved material." As their name suggests, siRNAs interfere and knock out the function of genes in higher organism as well as in microbes that may cause STDs. The researchers designed siRNAs to target a gene expressed ...

Straw bale house survives violent shaking at earthquake lab

... RENO, Nev. It huffed and puffed, but the 82-ton-force, earthquake-simulation shake table could not knock down the straw house designed and built by University of Nevada, Reno alumna and civil engineer Darcey Donovan. The full-scale, 14-by-14-foot ...

A natural approach for HIV vaccine

... have been based. But in high concentrations, a combination of the sets of antibodies cloned from the individual patients seemed to act as teams to knock down the virus in cell culture as well as any single antibody studied to date. These natural antibodies were also able to recognize a range of HIV ...

LSTM and UoL secure £1.4m ($2m) to develop new 'magic bullet' antimalarial drug

... they did twenty years ago. This project is seeking to develop a drug which works differently. "Our initial research indicates that if we can knock out this enzyme in the parasite we can stop the disease progressing through its usual stages within the body thereby eliminating the clinical ...

Plums poised to give blueberries run for the money

... of plums, nectarines and peaches. The first comparison was for antioxidants, molecules that sweep through a body looking for free radicals to knock out. Free radicals are atoms or molecules that lurk where diseases like cancer and heart disease are found. "If the radicals aren't taken care ...

Invasive plants challenge scientists in face of environmental change

... of weedy species to compete with native plants. Classic weed control techniques like pulling, mowing, herbicide treatments, fire and grazing that knock back invaders often leave ecological "vacuums" that can give other exotic plant species the chance for a foothold, he said. "Things are hitting ...

NYU scientists discover dangerous new method for bacterial toxin transfer

... Most phages, however, require a very specific DNA sequence for attaching this packaged genetic material to the genome of other bacteria. "If you knock out that attachment site, the phage has a very difficult time finding another one," he says. He and Dr. Chen found that the rules of the attachment ...

Chemist receives NIH funding to unravel tricks of neuronal wiring

... However, this technique cannot be used to study proteins involved in development because these proteins can have multiple functions. "If you knock out a developmental protein, there is a potential that you affect some upstream event so you never do the event you are interested in," Maurer said. ...

Brain background to body mass

... but rather the loss of a region of DNA of around 45,000 bases. The authors suggest that this lack of genome sequence near a gene called NEGR1might knock out genomic sequences that regulate activity of NEGR1. Such a variant has not been previously detected in studies of common obesity. "It may seem ...

UC Davis researchers exploring gene therapy to fight AIDS

... also found that these people are naturally resistant to HIV," said Bauer. "So, more than 10 years ago, we began our work creating a gene that would knock down expression of CCR5 and other key receptors and interfere with other routes of HIV infection." For IPS-based anti-HIV gene therapy to become ...

100-meter sprint world record could go as low as 9.48 seconds

... due to a population increase. However, Denny suspects that female sprinters have room for improvement too, and predicts that they could eventually knock more than 0.4s of the current 100m world record to cover the distance in 10.19s. Looking at marathon runners, Denny predicts that males could cut ...

Scientists present 'moving' theory behind bacterial decision-making

... is necessary to make anthrax lethal. Cavanagh and Bobay say that knowledge of AbrB's function could make it a likely target for a drug that would knock out its function. That would prevent anthrax from "going lethal." "We now know more about the protein that causes you to die from anthrax ...

New gene-silencing pathway found in plants

... if activated. Pikaard and colleagues were able to confirm that both Pol IV and Pol V are necessary for silencing by examining mutations that knock out, or disable, the different genes coding for the polymerases. 'Junk' no more This research adds to a growing body of evidence ...

Complex systems and Mars missions help understand how life began

... opposite approach from that of the genomics pioneer Craig Venter, who wants to build a minimal living cell. "Venter wants to see what is left if you knock out everything but what is needed to survive," says Von Kiedrowski. "We want to look at how you get to that from the bottom up. Darwin's tree of life ...

Sensitive laser instrument could aid search for life on Mars

... laser desorption mass spectroscopy. By focusing a laser beam on a spot less than one-hundredth the width of a pencil point, the researchers can knock microscopic fragments off the mineral. Those fragments react with organic molecules to form detectable charged particles called ions. The team can ...

Exhausted B cells fail to fight HIV

... a protein called FCRL4, which dampens B cells' ability to respond to infection. How HIV turns on FCRL4 remains to be seen. HIV is already known to knock out the defensive cells that directly attack and destroy infected cells. This new study reveals yet another way the virus dismantles the immune ...

New technique allows targeted inactivation of genes in research model

... allows us to gain novel insights into this process that are not easy to make in mouse models. However, we had not previously been able to directly knock out a gene of interest, an approach available in the mouse. The work we have done with the Wolfe lab will open up completely new avenues for our own ...

Genetic 'tag team' keeps cells on cycle

... Haase noted. Its a new way of thinking, he said. Weve spent decades on a reductionist approach to science -- in which researchers typically knock out one or two genes to see what they do. That method has been phenomenally successful. But now, with genome technologies, we have the opportunity to ...

UMass Medical School's Craig Mello elected to American Academy of Arts and Sciences

... potential for understanding and manipulating the cellular basis of human disease, and is now the state-of-the-art method by which scientists can knock down the expression of specific genes to thus define the biological functions of those genes. Just as important has been the finding that RNAi is a ...

A step forward in virology

... the cell membrane, an evagination forms, a bleb. The virus itself is the trigger for the formation of the evagination. Using a messenger substance to knock on the door, the virus triggers a signaling chain reaction inside the cell so that the bleb forms, catches the virus and smuggles it into the cell. ...

Effective cancer immune therapy through order in the blood vessels

... structure for clinical tumor therapy, says DKFZs Professor Gnter Hmmerling, one of the scientists leading the study. But we dont necessarily have to knock out Rgs5 to improve the success of immune therapies. Available therapeutics that normalize tumor vasculature should also increase the invasion of ...

E.coli a future source of energy?

... process on a massive scale. These bacteria have 5,000 genes that enable them to survive environmental changes, Wood explained. When we knock things out, the bacteria become less competitive. We havent given them an ability to do something. They dont gain anything here; they lose. The ...

Making sense of antisense microRNAs

... generates homeotic phenotypes via direct repression of Hox gene targets. The paper from Dr. Welcome Bender (Harvard Medical School) demonstrates that knock out of miR-iab-4 reveals the existence of a miRNA transcribed from the opposite strand. Furthermore, the loss of the antisense miRNA causes subtle ...

New plant study reveals a 'deeply hidden' layer of the transcriptome

... information from the genome is actually expressed, adds co-first author Brian D. Gregory, Ph.D., a postdoctoral researcher in Eckers lab. When you knock down exosome activity, you see changes in the transcriptome that are not visible under any other circumstance. Since the common notion is that the ...

Cat fleas' journey into the vacuum is a 'one-way trip'

... to kill fleas and other household pests, including studying the use of ultraviolet light. We're hoping to find that exposure to UV light could knock the flea population down even further. It appears to be a pretty powerful technology for this purpose, he said. ...

Council to honor NJIT SmartPin

... invention is flexible, reliable, and not as costly to produce because it is so small and easy to manufacture. Down the road, we should be able to knock out in production what are essentially tiny bio-hazard chips. The chips can be readily deployed in battlefields, population centers, and ...

Northwestern to expose most deadly infectious diseases in 3-D

... to do its work. "We'll see what the proteins look like and see what they need to grow so scientists can use this information to design drugs to knock them out," explained Anderson, a professor of molecular pharmacology and biological chemistry. We might look at a protein that copies a virus' or ...

Joslin researchers uncover potential role of leptin in diabetes

... insulin and leptin circulating in the bloodstream. To understand the role of leptin in the islets, researchers developed a mouse model (known as a knock out or KO mouse) genetically engineered not to produce leptin receptors in the pancreas, while maintaining the receptors in the brain and the rest of ...

American Chemical Society's Weekly PressPac -- Aug. 15, 2007

... inhibitors showing promise as a new weapon in war on cancer Chemical & Engineering News With hopes fading for development of a magic bullet to knock out cancer a single medicine targeted to the individual genetics of each patient researchers are increasingly looking toward cocktails of ...

Structure of 450 million year old protein reveals evolution's steps

... proteins function. These permissive mutations appear to pave the way for future, more significant changes. Its like they prepared for opportunity to knock in the form of a new hormone, Ortlund said. The permissive mutations bolstered the receptors structure, like contractors reinforce a historic ...

Minimal genome should be twice the size, study shows

... needed for the minimal genome. However this knock out approach wrongly removes many of the genes ... Biochemistry at the University of Bath. "This knock out approach misses the fact that there are ... of the same cellular product. "When you knock out one gene, the genome can compensate by using ...

Mutating the entire genome

... by making the genes they control malfunction. “We know how to knock out genes, and that technology is very good at changing any given gene in ... gene or other DNA sequence knocked out. So using existing technology to knock out the estimated 20,000 mouse genes would cost $200 million, and knocking ...

Successful cell engineering may lead to mad cow prevention, say researchers

... a cloned, transgenic goat fetus which exhibited a greater than 90 percent knock down of PrP. Previous studies involving mice in which the PrP gene has ... diseases from ever starting," Westhusin explains. "We were able to knock down the genes that are involved with diseases in goats. In cattle, the ...

Sugar helps control cell division

... certain proteins called cyclins, but experiments have shown that you can knock out any of these and still get perfectly normal cell division," says the ... at the hub of activity during cell division," notes Slawson. "When we knock it out or block it with a chemical, the cell cycle lengthens and cell ...

In mice, drug protects against diabetes and atherosclerosis

... mice lacking these lipid chaperones, there was no sign of heart disease. Next, the researchers turned to humans. While the scientists could not knock out the aP2 gene in humans, they could focus on subjects in the large Nurses' Health Study and the Health Professionals Follow-Up study who were ...

How plague-causing bacteria disarm host defense

... proteins are the bad guys that help bacterial pathogens do their job of infecting the host by crippling the body's immune system. In essence, they knock down the front door of resistance and disarm the cell's alarm system. Now, researchers at the University of California, San Diego (UCSD) School of ...

Genome of Clostridium botulinum reveals the background to world's deadliest toxin

... genetic system. Professor Nigel Minton, Professor of Applied Molecular Microbiology at The University of Nottingham, has developed new methods to knock out genes in clostridia. "Even after decades of research, only a handful of mutants had been made in clostridia, and none in C. botulinum," ...

Genes and biomarkers that allow doctors to choose the right therapy for the right patient

... and his colleagues performed a genome-scale scan of two cancer cell lines using high-throughput RNAi, "interfering" RNA strands that bind to and knock out one gene individually, across the genome. It is a systematic and highly efficient technique that uses high-speed mechanization to quickly ...
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