American Chemical Society weekly presspac -- June 10, 2009
Toward an "electronic nose" to sniff out kidney
disease in exhaled breath
... even when patients have lost 75 percent of their kidney
function. The most reliable test, a kidney
biopsy, is invasive and may result in infections ...
Tips from the American Journal of Pathology
... 2009, 174: 1996-1999
Novel Markers for kidney
A group led by Drs. Erwin ... of Michigan have established novel markers of kidney
disease progression. Their report can be found ... the American Journal of Pathology .
disease may affect up to 16.8% of the US ...
3-D kidney atlas created for researchers and physicians
... the development and diseases of the kidney. The kidney
Atlas was part of the European Renal Genome ... euros. At the conclusion of the project, the kidney
Atlas was presented at MDC during a two-day ... a rise in the number of renal patients. Loss of kidney
function is among the most common causes of death ...
Study finds novel genetic risk factors for kidney disease
... common mutations that are associated with altered kidney
disease risk. One of the discovered genes, the ... well understood and its relationship to chronic kidney
disease risk was not known previously. The ... million adults in the United States have chronic kidney
disease characterized by ...
UT Southwestern researchers probe kidney damage, protection in lupus
... DALLAS April 21, 2009 kidney
damage associated with the autoimmune disease ... underlie the pathology of lupus, particularly kidney
disease," said Dr. Edward Wakeland, chairman of ... action of the immune cells might be causing the kidney
The CXCR4 molecule was already known ...
CFI awards $854,098 to University of Montreal and partners
... of new chemically complex drugs."
Dr. Shao-Ling Zhang, a researcher at ... the private sector to investigate how to prevent kidney
diseases in newborns.
"While maternal ... problems later in life, such as hypertension, kidney
disease, and metabolic syndrome, a phenomenon ...
Tips from the American Journal of Pathology
... Tracking Acute kidney
Dr. Eisei Noiri and colleagues at the ... identified a novel biomarker to monitor acute kidney
injury. They present their data in the April ... The American Journal of Pathology .
injury may be reversible if treated promptly and ...
Is it really only our kidneys that control blood pressure?
... death through heart attacks, strokes and kidney
disease in a third of the UK population. For ... over its cause yet still cannot agree; is the kidney
or the brain to blame?
This month, ... that controlling blood volume is the key, as the kidney
automatically makes more urine as blood pressure ...
UAB's Lisa Guay-Woodford earns top international nephrology prize
... Advancement in the Understanding of Polycystic kidney
Disease, given by the The PKD Foundation and the ... original contributions to the field of polycystic kidney
disease (PKD) research, clinical practice and the ... the molecular genetic determinants of polycystic kidney
disease. She is trained and certified as a ...
Freezing kidney cancer: Hot treatment should be new gold standard for destroying small tumors
... SAN DIEGO, Calif. (March 9, 2009)Freezing kidney
tumorsusing a safe minimally invasive ... such an early stage is truly significant news for kidney
cancer patients," he added.
It's important ... optionsespecially since the incidence of kidney
cancer has been steadily increasing in this ...
For old or young dialysis patients, AV fistulas remain pure gold
... shows that for those individuals with chronic kidney
disease, it doesn't matter if you're young or ... in Lebanon, N.H. When kidneys failcalled chronic kidney
or end-stage renal diseasetreatment in the form ... fistulas remain the gold standard of access for kidney
dialysis patients. They last longer, need less ...
Society of Interventional Radiology hosts 34th annual scientific meeting
... and illustrations are available.
Cancer With Cold: Remarkable Results
More than 75 percent of individuals who are diagnosed with kidney
cancer have tumors that are 4 centimeters or less ... and efficacy of freezingor using cryoablationfor kidney
cancer tumors. It's important that individuals ...
Updated formula measures kidney function more accurately
... Measuring kidney
function in children can be expensive, ... to offer an accurate estimate of a child's kidney
This new estimate formula, developed ... and chemotherapy and more accurately assessing kidney
function in children battling ...
Shorter wait means longer life for kidney transplant candidates
... Fla. How long a patient survives after a kidney
transplant could depend on where he or she signs ... overall survival chances for people waiting for a kidney
transplant, rather than for people who had ... not every patient who would benefit from a kidney
transplant will ever get one in fact, most of ...
Gene mutation increases drug toxicity, rejection risk in pediatric kidney transplants
... in a gene that helps the body metabolize a kidney
transplant anti-rejection drug may predict which ... the drug's protective effects against kidney
MMF, or Mycophenolate ... rejection in organ transplants, particularly in kidney
transplants. After taken orally, the drug is ...
UC Davis discovery offers hope for treating kidney cancer
cancer is typically without symptoms until it has ... and, in so doing, help make chemotherapy for kidney
cancer more effective and better tolerated. The ... compounds decreased p21 expression, blocking kidney
cancer cells' ability to mend and making them ...
UC San Diego researchers use metagene 'portraits' to reveal distinct stages of kidney formation
... novel computational methods to gain insight into kidney
formation. By performing time-series analyses of ... been previously implicated in orchestration of kidney
"The approach may also be helpful ... of gene expression patterns during kidney
development. Approximately 30,000 genes were ...
Kidney function discovery sheds light on genetic complexity of disease
The researchers looked at two disorders of kidney
function - iminoglycinuria and hyperglycinuria. ... cases have been linked to high blood pressure, kidney
stones, deafness and problems in the brain.
... abnormality of a specific pump on the surface of kidney
cells," Professor Rasko explains.
The teams ...
Scientists identify cell changes leading to impaired 'artificial kidney' function
... may hold the key to freedom for some sufferers of kidney
disease. A new study published in Disease Models ... cellular signals which cause one treatment for kidney
failure to lose its usefulness over time.
One of the most devastating aspects of kidney
failure is the strict, time-consuming treatment ...
Link possible between pet food contamination and baby formula contamination
... of the Society of Toxicology, describes the kidney
toxicity of melamine and cyanuric acid based on ... only on the two compounds being present in the kidney
at the same time, is relevant to other species, ... of the urine in the distal tubules of the kidney
may be a reasonable treatment option.
High blood pressure takes big toll on small filtering units of the kidney
... Take a kidney
out of the body and it still knows how to filter ... the face of high blood pressure.
"How does the kidney
know how to do it and why does it break in ... National Institute of Diabetes and Digestive and kidney
Diseases. But the complete physiology remains a ...
Site used by sodium to control sensitivity of certain potassium ion channels
... channels," Logothetis said. Cells in the kidney
and specific areas in the brain express the Kir5.1 channel, he added. In kidney
cells, the Kir channel is expressed in cells that ... critical characteristic of the sodium-reabsorbing kidney
cells is that they maintain a negative-membrane ...
New gene variant identified for nondiabetic end stage renal disease in African-Americans
... renal disease (ESRD,) which is the near-loss of kidney
function leading to either dialysis of ... is the first gene identified for common forms of kidney
disease. The study was published online September ... States, about 26 million Americans have chronic kidney
disease with nearly 427,000 Americans requiring ...
Rong Li Lab identifies new role of inflammatory protein in PKD and a possible treatment
... of cysts in Autosomal Dominant Polycystic kidney
Disease (ADPKD) one of the most common ... to the plasma membrane and primary cilia in kidney
epithelial cells, thus promoting the formation of ... tubule development to the onset of Polycystic kidney
Disease (PKD) in individuals predisposed for the ...
Early exposure to common weed killer impairs amphibian development
... levels of active caspase-3 in the pronephric kidney
and midbrain. Caspase-3 is a protein needed for ... significant increases in caspase-3 levels in the kidney
and midbrain at 12 hours and beyond when compared ... of apoptosis in the midbrain and pronephric kidney
we observe suggest that atrazine may cause tissue ...
Biomarkers allow doctors to match therapy to patient
... for breast cancer, pediatric neuroblastoma, and kidney
and non-small cell lung cancer.
... of treatment with sunitinib or bevacizumab for kidney
and non-small cell lung cancer.
Our work ... as non-small cell lung cancer, colorectal and kidney
cancer, but it is unclear which subset of ...
Simple screening questionnaire for kidney disease outperforms current clinical practice guidelines
... public is not sufficiently aware that chronic kidney
disease (CKD) is a serious and progressive ... its widespread consequences -- which include kidney
failure, cardiovascular disease (CVD) and even ... at risk for CKD than the current National kidney
Foundation (NKF) clinical practice guidelines, ...
Immunosuppressant further linked to birth defects
... malformations seen in an infant born to a kidney
transplant recipient who had taken mycophenolate ... births to organ transplant recipients, primarily kidney
transplant patients, have been reported ... a 25-year-old Spanish woman who had undergone two kidney
transplants. Following the second transplant she ...
Northwestern Memorial trial may wean kidney transplant patients off antirejection drugs
... study that seeks to transplant stem cells from a kidney
donors bone marrow into the recipient, with the ... subjects to participate in the study underwent kidney
transplant surgery on Thursday, Jan. 10. Sharon Flood of Pingree Grove, Ill. donated her kidney
to her brother Steven Yelk of Gurnee, Ill., who ...
Researchers' discovery may lead to hypertension treatment
... a human steroid called aldosterone activates the kidney
to reabsorb sodium and excrete potassium, which ... must be another hormone that would trigger the kidney
to do the opposite: excrete sodium and reabsorb ... had given up searching for this "holy grail" of kidney
hormones, until, in 2003, a private company, ...
NIBIB invests in quantum research
... of metastatic lung cancer, a bio-artificial kidney
to eliminate dialysis procedures, ... implantable, and self-regulating bio-artificial kidney
that takes the dialysis machinery and integrates ... The successful development of this bio-artificial kidney
would provide an alternative to the majority of ...
Diet support helps chronic kidney patients
... significant benefits to people with chronic kidney
disease, according to new Queensland University ... small meals.
"People who suffer severe chronic kidney
disease clearly need support with their diets," ... the study ranged for 40 to 80 years old and their kidney
conditions had been affected by primary disorders ...
Story ideas from the Journal of Lipid Research
... report that when people with a transplanted kidney
take fluvastatin, a drug against cardiovascular ...
People who receive a transplanted kidney
are at risk of developing potentially fatal ... efficacy of fluvastatin after patients receive a kidney
transplant, Hallvard Holdaas and colleagues ...
System that regulates blood pressure is amiss in some healthy, young blacks
... participants for a genetic mutation that has been linked to hypertensive kidney
disease to see if that's a factor that can be used to help identify those at risk for hypertension and kidney
Getting down to cancer basics
... class. The finding arose from a study of mutations in 4000 genes in kidney
"UTX is an important component of the transcriptional control ... rare mutations of the UTX gene in clear cell renal cancer - a type of kidney
cancer. When they expanded the search they found mutations in many cancer ...
UC Davis research shows that newly discovered drug reduces heart enlargement
... holds promise to treat heart failure and other cardiovascular as well as kidney
problems," said nephrology professor Robert Weiss, Department of Internal ... angiotensin associated with high blood pressure, artery disease and some kidney
disease," Hammock said.
"When that occurs, a key enzyme called soluble ...
Researchers may have found why women have an edge on salt-sensitive hypertension
The body gets the sodium it needs from food and a healthy kidney
should be able to eliminate excess from a high-salt diet so there is ... pounding away at blood vessels can cause heart attack, stroke and/or kidney
failure, the type of end stage organ damage associated with hypertension, ...
Human beta cells can be easily induced to replicate, according to study in Diabetes
... some of these engineered human beta cells under the outer layer of a kidney
in a diabetic mouse, we saw that replication continued and blood sugar levels normalized," explained Dr. Fiaschi-Taesch. "When we took out the kidney
that contained the insulin-producing cells, the mouse immediately ...
The Marine Mammal Center begins new leptospirosis study in California
... team will collect from wild California sea lions will help them determine kidney
function and exposure rates among these animals," said Dr. Jeffrey Boehm, ... urine, water, or soil. If not treated, the patient can develop kidney
damage, meningitis, liver failure, and respiratory distress. The Marine ...
Gaining a better understanding of kidney diseases
... This press release is available in German .
disease, renal fibrosis, or renal cell carcinoma: Many diseases of the ... food.
To find out whether it is possible to study the development of kidney
diseases in the genetically modified (transgenic) animals, the ...