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Joints in Biological News

New trigger for chronic inflammation in rheumatoid arthritis discovered

... It causes painful and persistent swelling in the joints that can result in damage to the bone and ... system. High levels of tenascin-C present in joints therefore may cause the activated immune system ... the immune system may be triggered to attack the joints in patients with rheumatoid arthritis. We hope ...

Gene therapy demonstrates benefit in patients with rheumatoid arthritis

... an extremely painful condition affecting multiple joints throughout the body. Arthritis is a good target ... immune system turns against itself, causing joints to become swollen and inflamed. If the disease is ... far behind: How could he effectively reach the joints to block the actions of this protein? Gene ...

First-ever study: lack of critical lubricant causes wear in joints

... link between increased friction and early wear in joints is a first; no other team of scientists has ... & Rheumatism, sheds important light on how joints work. The discovery also suggests that lubricin, ... be injected directly into hips, knees or other joints inflamed from arthritis or injury a preventive ...

Can a new implant coating technique create a new six million dollar man?

... coatings to those of current commercial coatings. Giving your joints an electrochemical bath Today's surgeons can reconstruct joints in the human body using metal structures implanted to take the place of ...

Exercise no danger for joints

... There is no good evidence supporting a harmful effect of exercise on joints in the setting of normal joints and regular exercise, according to a review of studies published in this ...

1-finger exercise reveals unexpected limits to dexterity

... and clinical reality by helping explain the high vulnerability of dexterous everyday function to disease and injury in spite of the many muscles and joints we have. "In addition, they suggest to engineers that adding redundant motors to robots may actually be the key to making them dexterous." ...

Gene expression findings a step toward better classification and treatment of juvenile arthritis

... cause can be determined, says Robert A. Colbert, M.D., Ph.D., chief of the NIAMS Pediatric Translational Research Branch. Based on the number of joints involved and other clinical features (fever and rash, for example), doctors classify patients into one of four or five major subtypes of JIA, which ...

Engineering innovative solutions for 21st century medicine

... tissue after surgery." Leeds "50 more years after 50": 11m Professor John Fisher said: "While more of us are living longer, our bones, joints and cardiovascular systems continue to degenerate as we age. At Leeds, we are looking how to help the skeleton, muscles and cardiovascular system ...

Laughing hyenas, wailing levees, the sound of cheese and blaring bagpipes

... through exposure to the elements. "If we're successful, this could lead to implanting permanent, inexpensive accelerometers that could monitor joints continuously," says Guarino. The talk "Acoustic detection of bolt detorquing in structures" (3a5A8) by Joe Guarino is at 10:30 a.m. on Wednesday, ...

Bad mix of bacterial remnants and genetics leads to arthritis

... had been genetically modified so that their NOD2 gene was deactivated (commonly referred to as "knocked out"). Then they administered MDP to the joints of mice in each group, and unlike the normal group of mice, the mice with the deactivated NOD2 gene did not experience signs of arthritis. This may ...

World Congress on Osteoporosis 2010 presents outstanding scientific program

... response to therapy, E. Seeman (Australia) What did we learn from genome-wide association studies? T. Spector (UK) Interaction between bone and joints in physiology and disease, G. Schett (Germany) Glitazone and bone: a paradigm to better understand bone physiology, C. Rosen (USA) Extra ...

Tiny details in three dimensions

... structure of the spirochete bacteria can be shown in three dimensions. One finding that borrelia types in North America more often affect the joints and in Europe the skin and nervous system as well seems to stem from the characteristics of their motility system. The research group headed by ...

Sports technology for para-athletes: Closing the gap

... sprinting mechanics data of able-bodied sprinters with that of a double transtibial amputee by examining the overall kinetics and the kinetics at the joints while sprinting at maximum speed. The carbon blade used by the amputee sprinter has a significant advantage in both energy storage and return in ...

Researchers identify 4 genetic hotspots associated with psoriasis

... by researchers at the University of Utah and Celera Group, have a high association with psoriasis, an automimmune disease that can affect the joints and cause sore, itchy patches of skin in an estimated 7.5 million people in the United States. The study was led by James T. Elder, M.D., Ph.D., ...

Superglue from the sea

... have made a synthetic version of this seaworthy superglue, and hope it will be used within several years to repair shattered bones in knees, other joints and the face. "You would glue some of the small pieces together," says Russell Stewart, associate professor of bioengineering and senior author ...

Case Western Reserve receives Ellison Medical Foundation New Scholar in Aging award

... of research in his current laboratory. "A large fraction of older individuals suffer from painful and often debilitating cartilage damage in their joints as a result of prior injury or diseases such as osteoarthritis," he said. "It would significantly improve the lives of these individuals if it were ...

MSU biofilms research helps set standards for everyday products

... harmless, but some have been linked to ailments such as urinary tract infections, gingivitis and infections around implanted devices like artificial joints and heart valves. "In the world that I study, everybody's trying to kill the biofilm," said Goeres, a research professor in the Department of ...

Low-gravity training machine reduces joint, muscle impacts, says CU-Boulder study

... Colorado at Boulder study of a space-age, low-gravity training machine used by several 2008 Olympic runners showed it reduced impacts on muscles and joints by nearly half when subjects ran at the equivalent of 50 percent of their body weight. The new study has implications for both competitive runners ...

Researchers coat titanium with polymer to improve integration of joint replacements

... total hip and knee replacements in the United States in 2004 performed on younger patients 45-64 years old, improving the lifetime of the titanium joints and creating a better connection with the bone becomes extremely important. Current clinical practice includes roughening the surface of the ...

Ancient protein offers clues to killer condition

... distance, such as the bladder or the uterus expanding and contracting. In contrast, skeletal muscles operate over a narrow range, defined by how much joints can move. Professor Knight says: We were puzzled to find that the scallops myosin 2 had retained its ability to fold and unfold, as they dont ...

Stem cells offer cartilage repair hope for arthritis sufferers

... people over 75 years of age. Osteoarthritis affects over 2M people in the UK and occurs when changes in the make up of the bodys cartilage causes joints to fail to work properly. At its worse it can cause the break up of cartilage, causing the ends of the bones in the joint to rub against each other. ...

Study suggests genetic connection between short stature and arthritis

... that both extremes of height may be associated with osteoarthritis for different reasons. Shorter bones and/or less cartilage may render the joints more susceptible to damage, while longer bones may produce greater levels of damaging stress on the joints. The findings are exciting for several ...

Blood clotting protein linked to rheumatoid arthritis

... system seem to play a major role in its onset and early progression, according to researchers. Fibrin deposits are a prominent feature of arthritic joints and the protein appears to be a link between systems that control inflammation and bleeding within joints. Dr. Degen and his colleagues explained ...

New Actemra data shows significant benefit for patients suffering from rheumatoid arthritis

... About rheumatoid arthritis Rheumatoid arthritis is a progressive, systemic autoimmune disease characterized by chronic inflammation of multiple joints and fatigue as well as the possibility of osteoporosis, anaemia, and lung, skin and liver effects. ...

Study reveals 2 genes linked to disabling arthritis

... The most significant findings, however, were in ankylosing spondylitis, a type of arthritis that not only affects the spine but also can attack other joints and organs, including the heart, lungs and eyes. The condition afflicts an estimated one in 200 males and one in 500 females and typically strikes ...

New engineered drug may offer prolonged arthritis relief

... heightens the activity of enzymes that damage joints by breaking down their collagen "framework," ... ELPs, Betre developed a protein for use in joints that would precipitate out of solution and clump ... to fall to the 10 percent level in the animals' joints -- a "really substantial increase," she said. ...

Results of world's first gene therapy trial for arthritis show approach safe, feasible

... and lymphocytes colonize the lining of joints where they release proteins called cytokines that ... Core Facility. According to their results, joints treated with the genetically modified cells ... IL-6 and PGE 2 than cells within joints that were not treated with the gene. The nine ...

Woven scaffolds could improve cartilage repair

... that could greatly improve the ability of physicians to repair damaged joints with the patient's own stem cells. "If further experiments are ... Laboratory who designed and built the weaving machine. "The first joints to be treated this way would likely be hips and shoulders, though the ...

Gene therapy research switches off joint inflammation; switches on genetic process of joint repair

... can trust and try". Coauthor Paul Bobrowski emphasized that "If joints are like a brick wall made from bricks of glucosamine, and then it makes ... of getting more bricks." Elaborating Bobrowski said, "By activating the joints master bricklayer Reparagen offers a more effective approach for regaining ...

Stem cells from muscles can repair cartilage

... of Pittsburgh School of Medicine, researchers induced damage to the knee joints in 36 12-week-old rats and divided them into three groups. Group 1 was ... have suggested that fatty tissue and tissue lining the space between joints (synovium) might also be sources of stem cells, obtaining these cells is ...

Breakthrough developments in rheumatoid arthritis reported

... Peter K. Gregersen, MD, stares at x-rays of hands, searching out the telltale signs of inflamed joints and wrists from his research subjects with rheumatoid arthritis. With these clinical features at his side, he turns to the basic building blocks of ...

Experimental gene therapy 'abolishes' arthritis pain and lessens joint damage

... model. In addition, researchers were surprised to find that the therapy also brought about a nearly 35 percent reduction in permanent structural to joints caused by round and after round of osteoarthritic inflammation. To date, treatment of arthritis is dominated by drug treatments like ...

Bones in motion: Brown scientists to create new 3-D X-ray system

... The system will fill a void in medical and scientific imaging. Right now, researchers trying to understand the complex motions of bones and joints are held back by technology. Computed tomography, or CT, delivers detailed 3-D images, but CT scanners are too slow to capture rapid motion. ...

OHSU surgeon implants donated tissue allografts

... areas to benefit these communities," he said. JRF prepares and coordinates fresh osteochondral allografts that can be used in a variety of joints to treat a variety of conditions. Allocation of these tissues is performed on a priority basis back to the communities that the donors came from. The ...

Researchers show that veins stiffen as we age

... As if creaking joints and hardening of the arteries weren't bad enough, a research team from the University of Delaware and the Christiana Care Health System in Newark has ...

Proteins anchor memories in our brain

... cradle of the immune system, and not only at the sites where autoimmune diseases emerge, such as the pancreas in the case of type 1 diabetes, or the joints in rheumatoid arthritis. The discovery, from a mouse model of a human autoimmune condition, suggests that effective strategies to treat autoimmune ...

Cigarette smoking impedes tendon-to-bone healing

... in their shoulders following rotator cuff repair. Measuring properties called maximum stress and maximum force, the researchers found that shoulder joints in the nicotine-exposed rats were weaker. "Those changes were most apparent at earlier time points, and shoulder strength tended to equalize ...

Autoimmune disease triggered if T cells miss a single protein early on

... cradle of the immune system, and not only at the sites where autoimmune diseases emerge, such as the pancreas in the case of type 1 diabetes, or the joints in rheumatoid arthritis. The discovery, from a mouse model of a human autoimmune condition, suggests that effective strategies to treat autoimmune ...

The appearance of your hands can reveal your age, study finds

... younger. However, alterations to photos of very elderly hands ?characterized by thin skin, age spots, wrinkles, deformity, veins and prominent joints ?did not change the participants' ability to distinguish the person's age. Overall, the physical characteristic which most commonly gave away ...
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