Novel approach may protect against heart attack injury
... who showed that HDAC inhibitors reduce ischemic
injury in the brain, they used the same agents in ... injury, even when delivered an hour after the ischemic
event occurred." The size of the myocardial ... how HDAC inhibitors work in protecting against ischemic
injury in larger animals.
Even low levels of air pollution may pose stroke risk
In the study, researchers identified ischemic
strokes and transient ischemic
attacks (TIA), sometimes called mini strokes but that often lead to a stroke later. ischemic
attacks are caused by a blockage of blood flow to ...
Stroke victims may benefit from stem cell transplants
... was likely based on differences in each animals ischemic
We speculate that the extensive ... artery into the scar area and border zone of the ischemic
We evaluated vascular density in the ischemic
region in all animals seven days after cell ...
Single gene defect can cause stroke, other artery diseases
... aneurysms and dissections as well as early onset coronary artery disease, ischemic
stroke and Moyamoya disease. The research is led by scientists at The ... mutation carriers, while 26 had premature coronary artery disease, 15 had ischemic
stroke, including Moyamoya disease, and 15 had more than one vascular ...
National and international doctoral training
... from nature in modern technology, and work on better treatments for ischemic
heart disease. Other topics deal with changes in the clerically based ... of Giessen is working on the topic of vascular diseases. Its focus is on ischemic
heart disease, which is the most common cause of death in industrialised ...
ADA releases updated position paper on vegetarian diets
... maternal and infant health outcomes. Additionally, an evidence-based review showed a vegetarian diet is associated with a lower risk of death from ischemic
A section in ADA's paper on vegetarian diets and cancer has been significantly expanded to provide details on cancer-protective ...
Neural stem cell differentiation factor discovered
... which are important for the formation of tumors, especially in the human brain. EGFL7 might also be applied as a neuronal differentiation factor in ischemic
insults or neurodegenerative diseases such as Alzheimer or Parkinson predict both researchers. Future work will unravel in which diseases EGFL7 can ...
'First aid' for brain cells comes from blood
... In acute ischemic
stroke, the blood supply to the brain is restricted. Initially, brain cells die from lack of oxygen. In addition, ischemia activates harmful ...
Penn research team tests bedside monitoring of brain blood flow and metabolism in stroke victims
... from stroke patients and also suggests that blood flow responses vary significantly from patient to patient," lead author Turgut Durduran said.
stroke is the leading cause of morbidity and long-term disability in the United States, with projected cost of stroke care estimated at trillions of ...
Repeat C-section before 39 weeks raises risk of neonatal illness
... including respiratory distress syndrome and/or transient tachypnea of the newborn, newborn sepsis, seizures, necrotizing entercolitis, hypoxic ischemic
encephalopathy, required ventilator support within 24 hours of birth, had umbilical cord arterial pH (a measure of oxygenation) below 7.0, an Apgar ...
A little wine boosts omega-3 in the body: Researchers find a novel mechanism for a healthier heart
"Several studies have shown that moderate alcohol consumption, including wine, is associated with protection against coronary heart disease and ischemic
stroke - says Romina di Giuseppe, lead author of the study, from the Research Laboratories at Catholic University of Campobasso - Although the ...
Mechanisms of cardiovascular disease and cancer give clues to new therapies
... tumour, under study. "The Positron Electron Tomography Laboratory started years ago has been used to study the field of cardiac microcirculation and ischemic
myocardial metabolism, and yet later on it also became a powerful tool in oncological diagnostic procedures," said Trivella.
There is also overlap ...
12-month ATLANTA trial data show sustained benefit of Catania Stent
... 55 patients (76 lesions) treated with the CATANIA™ Coronary Stent System with NanoThin Polyzene®-F surface modification for symptomatic ischemic
heart disease due to de novo, obstructive lesions of native coronary arteries. The trial was sponsored by CeloNova BioSciences, Inc., maker of the ...
Findings released from 1 of the largest percutaneous coronary intervention trials ever
... of the trial were major bleeding and net adverse clinical events, a composite of major adverse cardiovascular events (death, reinfarction, stroke or ischemic
target vessel revascularization) or major bleeding at 30 days. The secondary endpoint was major adverse cardiovascular events at 30 days. Those ...
NIH awards UC $9 million grant to improve patient point-of-care technologies
... Neuro Technologies. This five-year award is renewable for five years.
It is estimated that one million brain cells die every minute during an ischemic
stroke, says Fred Beyette, associate professor of electrical and computer engineering and principal investigator (PI) for the project. Its said that ...
Device helps patients survive, regain function til transplant
Three-quarters of the study participants were men, with an average age of 50. Two-thirds of the patients had heart failure not related to an ischemic
cause such as a heart attack and all were in the most severe stage of heart failure, called class IV. Many had already received other ...
Are one-third of costly implanted heart devices unnecessary? New study suggests yes
... by lack of blood flow -- a condition called ischemic
Each patient received a test ... they published results from the same group of ischemic
cardiomyopathy patients, showing that the MTWA ...
This research has focused on patients with ischemic
cardiomyopathy ?the most common form of ...
Stem cell transplants improve recovery in animal models for stroke, cerebral palsy
... improvement over time." In the newborn model of ischemic
injury, enhanced recovery was found within two ... seven days after the intitial injury. Currently, ischemic
stroke patients may be treated with tPA, the only ... initially occurs. As a result, 95-97 percent of ischemic
stroke victims never receive treatment with tPA. ...
Glucose triggers brain cell death in rats after hypoglycemic coma
... about the causes of oxidative stress in other settings –?especially in ischemic
stroke, where the blood supply to the brain is diminished and there’s a ... and NADPH oxidase as agents of oxidative stress in a rodent model of ischemic
stroke. "So far, the results are very promising," he says. ...
Stem cells decrease ischemic injury and restore brain function
Despite the recent advancements in the management of ischemic
patients (early diagnosis, thrombolysis, stroke units and rehabilitation ... for stem cells to turn into neurons in order to protect the brain from ischemic
injury and restore brain functions. Their presence in brain tissue is ...
Potential heart benefit found in stem cells
... of stress-induced or rest perfusion defect (scar tissue) in patients with ischemic
cardiomyopathy, or blockages in the arteries leading to the heart infarction.
In the study, 17 patients with ischemic
cardiomyopathy were treated with a combined percutaneous injection (both ...
Phenolic compounds may explain Mediterranean diet benefits
... and then deflating a blood pressure cuff. The response is known as ischemic
reactive hyperemia. Poor responsiveness to this sort of blood flow test is ... in the nitric oxide bioavailability are behind the observed improvement in ischemic
reactive hyperemia," Dr. Pérez Jiménez said.
Dr. Pérez Jiménez said ...
Cord blood cells may widen treatment window for stroke
... annual meeting in Washington, DC.
The only drug currently approved for ischemic
stroke treatment is tPA (tissue plasminogen activator), which breaks up ... successful in alleviating, even eliminating, the disabling effects of both ischemic
and hemorrhagic stroke. What's more, the treatment can be delivered much ...
Stem cells bring fast direct improvement, without differentiation, in acute renal failure
The study, "Administered mesenchymal stem cells protect against ischemic
acute renal failure through differentiation-independent mechanisms," ... model of the most common and the most treatment-resistant type of human ischemic
* Current studies are investigating the ...
Human stem cell treatment restores motor function in paralyzed rats
... by side effects and eventual drug tolerance that lessens their efficacy.
“These research findings could offer great hope to people with spinal ischemic
injury who suffer from resulting spasticity and rigidity,” said Marsala.
Mice with a migraine show signs of brain damage
... a heart attack.
“In mice, the damage from these episodes looks exactly like the damage that occurs to the brain from repeated TIAs, or transient ischemic
attacks,?said Takano. “It’s long been known that patients having a migraine attack are functionally impaired from the pain. It’s also been shown ...
Free radical cell death switch identified
... recovery. Since oxidative stress in neurons and other cells in the body contribute to tissue damage in a variety of disorders, including stroke, ischemic
heart disease, neurodegenerative diseases, and diabetes, identification of the MST-FOXO switch mechanism could provide potential new targets for the ...
New compound reduces stroke damage
... and Molecular Biology journal.
Stroke is the third leading cause of death in the United States and the most common cause of adult disability. An ischemic
stroke occurs when a cerebral vessel occludes, obstructing blood flow to a portion of the brain. Currently, there is only one approved stroke ...
New tool tracks brain development in babies
... ischemia, a type of brain injury caused by a period of oxygen and nutrient deficiency, usually as a result of complications during delivery. Hypoxic ischemic
injury can result in severe motor problems.
"The pattern and extent of the brain injury largely determine the neurological and developmental ...
Proteins spur diabetic mice models to grow blood vessels, nerves
... the journal Science Express, the Utah researchers and colleagues from other universities showed netrins not only accelerated blood vessel growth in ischemic
mice (those with constricted blood flow) but they also restored blood vessel and nerve growth in diabetic mice. Dean Y. Li, M.D., Ph.D., a ...
Possible brain hormone may unlock mystery of hibernation
... of new techniques for cryosurgery of the heart and brain, as well as the development of hypothermia treatment that is effective for preventing brain ischemic
damage." In cryosurgery, physicians use extreme cold to destroy abnormal tissue, such as cancerous tumors. ...
Serious adverse reactions to smallpox vaccine appear to be limited
... as myocarditis (inflammation of the muscular tissue of the heart) and/or pericarditis (inflammation of a membrane that surrounds the heart) and 10 as ischemic
cardiac events that were not anticipated based on historical data. Two cases of generalized vaccinia (a skin eruption in reaction to vaccination) and ...
Scientists show how thinking can harm brain cells
... with inflammation, which is virtually all of them."
In lab studies, brain cells were treated with diazoxide, a drug investigated for use in ischemic
heart disease and strokes. Pretreatment before exposure to PAF prevented dendritic beading and preserved synaptic functions, the studies showed.
Feds give researchers ok for safety test of adult stem cells in patients with heart disease
... safety of the procedure. It will involve injecting bone marrow stem cells at varying doses into the coronary arteries of patients suffering chronic ischemic
coronary artery disease, a condition in which one or more of the primary arteries supplying blood flow to the heart are clogged. The study will ...
Molecular cabal contributes to stroke damage
... by ischemia, which is known to cause excessive glutamate release and acidosis. Both NMDARs and [calcium permeable] ASICs have now been implicated in ischemic
"Our finding…sheds new light on the development of therapeutic agents against excitotoxic and acidotoxic neuronal damage," ...
Researchers Find Drug May Give Some Cardiac Protection 24 Hours After Heart Attack
... Jefferson Medical College of Thomas Jefferson University in Philadelphia, and his co-workers knew that the drug Darbepoietin alpha would protect the ischemic
heart. Darbepoietin is a long-acting cousin of erythropoietin (EPO), which has been shown to offer some protection to the heart from injury from ...
US life expectancy about to decline, researchers say
... in the United States -- from two to five years in the next 50 years -- that it may eventually exceed the current life-shortening effects of cancer or ischemic
The findings are contrary to what some scientists predict about human life expectancy, which assumes that past increases will ...
Bioartificial kidney under study at MCG
... of oxygen and energy to perform their endless task, which makes them easy targets in the ICU, Dr. Szerlip explains. As examples, kidneys can become ischemic
and begin to fail if blood pressure drops because of a long surgery with significant blood loss. Infection can further reduce blood flow to the ...