Fluorescent proteins illuminating biomedical research
... throughout the body or to watch how cells manage intracellular
debris, preventing premature aging.
These new ... interactions, the growth and collapse of intracellular
structures, and many other biological questions," ... to provide accurate insight into the timing of intracellular
processes, such as activation or inhibition of ...
Life Sciences Discovery Fund awards health research program grants
... rural communities, and developing highly-targeted intracellular
drug delivery mechanisms. (See Backgrounder ... $7,163,794
Program title: Center for intracellular
Delivery of Biologics
Program focus: To ... conditions. This program will identify new intracellular
drug vehicles for clinical use that could result ...
Researchers create new class of fluorescent dyes to detect reactive oxygen species in vivo
... created. The dyes vary in their ability to detect intracellular
or extracellular reactive oxygen species and by ... angiotensin II and hydro-Cy3 displayed intense intracellular
fluorescence, whereas control cells incubated ... that the cellular fluorescence was due to intracellular
reactive oxygen species production," said Murthy. ...
Evolution of root nodule symbiosis with nitrogen-fixing bacteria
... for nodulation, as these symbioses both involve intracellular
relationships. One clue was that several genes, ... constituted an important step in the evolution of intracellular
nodule symbiosis, reports Parniske. Most plants ... therefore suggest a common evolutionary origin of intracellular
root symbioses with nitrogen-fixing bacteria.
Paradigm shift in Alzheimers's research: new treatments
... of intraneuronal A" and thioflavine-S-positive intracellular
material but not with extracellular A" deposits. ... degenerative mechanism, which is independent from intracellular
A" aggregation. No intracellular
A" was detected in these neurons. The reduced ...
Features of replication suggest viruses have common themes, vulnerabilities
... virus co-opts a cell's membranes to create an intracellular
lair where it can safely replicate its genes.
... the Wisconsin group found, the virus co-opts intracellular
membranes of mitochondria, critical ... the virus is reorganizing the cell to make a new intracellular
architecture for its own purposes, according to ...
Research explores interactions between nanomaterials, biological systems
... remarkable advances in nanoscience, relatively little is known about the intracellular
activity and function of engineered nanomaterials, an area of study ... an ecosystem or food chain.
Nanoparticles can elicit a wide range of intracellular
responses, depending on their properties, concentrations and interactions ...
Comparative genomics reveals molecular evolution of Q fever pathogen
... compared the sequences of four different strains of C. burnetii , an intracellular
bacterium that can cause acute and chronic Q fever in humans, to build up ... to replicate in a lysosome-like vacuole of macrophages, an extremely harsh intracellular
environment that usually protects the body from infection by breaking down ...
News tips from the Journal of Neuroscience
... both basal and depolarized conditions, due to a greater sensitivity to intracellular
sodium concentration and a higher affinity for intracellular
dopamine. A role for increased dopamine efflux in ADHD was unexpected, ...
Leading scientist named new chair of Cell Biology at Yale
... as vesicles, which fuse with membranes to deliver their molecular cargo to intracellular
organelles or to the extracellular space. This latter process, known as ... and related processes using a "cell-free" approach, in which he isolated intracellular
components crucial to molecular transport in a laboratory dish, ...
Is hybridoma production about to take a quantum leap forward?
Neowater® is a non-toxic form of water that mimics intracellular
water, which is found uniquely in the human body and its cells. NPD water ... been shelved, blocked by the basic difference between regular water and intracellular
water, can now cross the "molecular water barrier", thanks to the ...
Biophysical Society announces 2008 International Travel Awards
... Santiago, Chile, Insulin Stimulates Glucose Uptake Through IP3-dependent intracellular
Calcium Release in Rat Neonatal Cardiac Myocytes.
Jose M. Delfino, ... Heart Cells.
Xu-Long Wang, Shanghai Jiao Tong University, China, intracellular
Calcium Dynamics Mediated by NMDA Receptors in Retinal Horizontal Cells. ...
Molecular Biology of the Cell celebrates 25 years of publication
... of Small Molecules and the Electrical Properties of Membranes
Compartments and Protein Sorting
14. Energy Conversion: Mitochondria and Chloroplasts
Ireland Cancer Center researchers advance stem cell gene therapy
... Dr. Kevin Buntings laboratory gave two important presentations on how intracellular
STAT5 (an intracellular
signaling protein) influences normal pathologic hematopoiesis (blood cell ...
Study finds blocking angiogenesis signaling from inside cell may lead to serious health problems
... there is no VEGF signaling inside the cell, the endothelial cells die. The intracellular
part of the VEGF signaling loop is required for cell survival. This is the first demonstration that intracellular
signaling is an important event.
It had been unclear why some patients ...
Little-known protein found to be key player
... healthy cells. Even more surprising, their report in the journal Nature shows that the protein, called "atlastin," does its work by fusing intracellular
membranes in a previously undocumented way.
"If you'd asked me a year ago whether this was possible, I would have said, 'No,'" said study ...
Grant supports LSUHSC research on how like cell receptor systems determine very different functions
... targets are involved in the development of disease.
Dr. Ashok Pullikuth in Catling's lab has recently identified a protein that functions in the intracellular
movement and cell division activity of growth factor receptors as a novel phosphorylation target. Understanding this novel mechanism might be ...
'Normal' cells far from cancer give nanosignals of trouble
... fellow in Backman's research group.
PWS can look inside the cell and see those critical building blocks, which include proteins, nucleosomes and intracellular
membranes, and detect changes to this nanoarchitecture. Conventional microscopy cannot do this, and other techniques that can (to some degree) are ...
Slicing chromosomes leads to new insights into cell division
... cells' microtubules. Microtubules are long, thin tubes that form a central component of the cytoskeleton and the mitotic spindle. They serve as intracellular
structural supports and as railways along which molecular motors move cargoes such as chromosomes.
Hunt's group hypothesized that polar ejection ...
Visualizing virus replication in three dimensions
... encapsulation in new virus particles are directly linked," said Professor Bartenschlager. The new virus genomes are secreted through pores into the intracellular
space where they are incorporated into pre-stages of viruses and then penetrate the endoplasmic reticulum a second time. There they are enveloped in ...
KINAXOs Cellular Target Profiling reveals mTOR as a new target of Celebrex
... target of rapamycin) acts as a central regulator of cell proliferation, cell survival, angiogenesis and cell metabolism. Moreover, mTOR is a key intracellular
convergence point for a number of signaling pathways that are abnormally activated in many types of cancer.
As traditional drug development ...
New findings in taste and smell
... multipolar and elongated neurons in hamster nucleus of the solitary tract (NST) project differentially to targets in the brainstem: an in-vivo intracellular
recording, labeling, and tracing study
Pregnancy and olfactory sensitivity
Expansion, engraftment and multi-lineage potency of mouse neonatal ...
2009 ASPB Summer Undergraduate Research Fellowship award announcement
... interaction is responsible for SAUR19's functionality.
Eric Johnson, University of Massachusetts Amherst Mentor: Alice Cheung
Hydrogen Peroxide Condition in Wild type and Mutants Defective in Stress-signaling
I hope to finish up my current research by the end of my senior ...
CSHL-led team identifies key decision-point at which cells with broken DNA repair themselves or die
... Ph.D., F.R.S., of Cold Spring Harbor Laboratory (CSHL), this week revealed results of experiments suggesting at least one way in which cascades of intracellular
signals are regulated at what they call a decision point as cells decide whether to repair broken DNA strands or commit suicide following DNA ....
Ambati study published in PNAS
... moiety such as cholesterol. This is important, because siRNA must enter cells in order to function as intended by specifically degrading intracellular
messenger RNA bound for protein-forming machinery. Furthermore, this finding strengthens their finding that TLR3 positioned on the cell surface is ...
CSHL team develops mouse models of leukemia that predict response to chemotherapy
... use in the clinic."
The Lowe team's mouse models also provide valuable insights into how leukemia develops and progresses. Their study traces the intracellular
network controlled by the p53 gene, a linchpin of the cell's anti-tumor defense response, as the key determinant of AML's aggressiveness and response ...
Heinz Maier-Leibnitz Prizes 2009: Six young researchers recognized for outstanding achievements
... has made a name for herself, in particular, through her publications on nucleus-cytoplasm transport and mRNP biogenesis. Building on her studies on intracellular
transfer of genetic information, done while working as a postdoc at Harvard, she has discovered new factors that are essential for the export of ...
Researchers identify gene linked to aggressive progression of liver cancer
... and senescence. cDNAs are complementary DNAs that are generated from mRNAs to analyze gene expression profiles.
"AEG-1 also activates multiple intracellular
signaling pathways that are known to be involved in HCC progression. So, strategies to inhibit AEG-1 that could lead to the shutdown of these ...
Tailor-made recombinant proteins in mammals
... biotech industry." Her team showed that aldehyde tags could successfully label mammalian membrane-associated proteins and proteins occurring in the intracellular
fluid as well.
"What's so appealing about the method is that it's really simple," Bertozzi says. She's sufficiently confident of the value of the ...
UNC study: Tinkering with the circadian clock can suppress cancer growth
... closely examining the series of biological events in the disease's development, they determined that the mutation of this clock gene reactivates the intracellular
signals that can eliminate cancerous cells. Sancar said this tactic essentially makes cancer cells more likely to commit cell suicide through a ...
Dartmouth researchers find new protein function
The researchers studied a protein called NOD, distantly related to the motor proteins that power diverse cellular activities, including intracellular
transport, signaling, and cell division. They used X-ray crystallography to determine its structure, and then they used enzyme kinetics to find out ...
IRB Barcelona to coordinate two European projects on biomedicine
... for the key alterations in a disease".
The six groups that comprise the consortia seek to identify the processes that occur in mitochrondria an intracellular
organelle that transforms molecules from the food we ingest into energy -, and that are responsible for insulin resistance. Insulin is a hormone ...
Shape changes in aroma-producing molecules determine the fragrances we detect
... applications in the design of flavors and fragrances.
When odor-producing molecules, known as odorants, pass through the nose,
they trigger intracellular
changes in a subset of the approximately 400
different varieties olfactory sensory neurons (OSN) housed in the nose's
internal membrane tissue, ...
Computation and genomics data drive bacterial research into new golden age
... of these processes had been thought to operate only within higher organisms, in particular multi-cellular animals and plants.
For example small intracellular
(within cell) signalling molecules called second messengers play a much bigger role in bacteria than had been thought. These molecules are called ...
Maintaining the brain's wiring in aging and disease
... They are homes to the world's smallest transport tracks. Every one of our hundred billion nerve cells continuously shuttles hundreds of proteins and intracellular
packages out along its axons and dendrites, and back again, during every minute of every day. Without this process, the wires cannot be maintained ...
Dictyostelium cells shown to lay 'breadcrumb trail' as first step in multicellular formation
... rear of cells, which prompts fellow cells to align and generate head-to-tail streaming structures. Kriebel et al. now show that ACA is packaged into intracellular
vesicles that cluster at the rear of cells in a process that is dependent on actin and microtubule networks. They also show that de novo protein ...
Scripps research scientists identify blood component that turns bacteria virulent
... induction of virulence gene expression in response to host bicarbonate levels and have used this finding to learn more about the extracellular and intracellular
signals controlling virulence."
Perego's latest discovery builds on her lab's expertise in the study of bacterial virulence ...
Researchers at IRB Barcelona produce more data on key genes in diabetes
... what makes people develop insulin resistance, several studies report that resistant subjects show functional alterations in mitochondria. These intracellular
organelles are responsible for transforming glucose into energy that the cell will then use to perform several functions. A study performed by the ...
Female embryonic sexual development driven by universal factor
... pathway), are all secreted proteins. They are emitted from the cell, Yao said, and yet it appears that their production or secretion relies on an intracellular
"Wnt4, R-spondin1, follistatin these genes all code for secreted proteins," Yao said. "How does the cell know to respond ...
Proteomics study yields clues as to how tuberculosis might be thwarting the immune system
... proteins not previously associated with autophagy), points to autophagy playing a heretofore unknown role in immune response, particularly against intracellular
pathogens such as mycobacterium tuberculosis.
As Shui explained, "After mycobacterium tuberculosis are phagocytosed into the macrophage cell, they ...