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Insertion in Biological News

Gene therapy corrects sickle cell disease in laboratory study

... the blood-forming cells, performed the viral gene insertion in a culture dish and then re-introduced the ... "It is far easier to achieve high levels of gene insertion into mouse cells than into human cells," he said. ... inserted into each cell. However, in humans this insertion rate is at least a hundred-fold less." ...

Penn medicine draws road map for elimination of central line-associated bloodstream infections

... initiatives, electronic infection surveillance, checklists to guide line insertion and maintenance, and implementation of the Toyota Production System to ... to the guidelines. New technology to improve management of catheter insertion sites also played an important role in battling the infections. When the ...

Evolution of fruit size in tomato

... protein coding region of the gene but rather the mutation consisted of an insertion in the first intron, which is a non-coding sequence embedded within the ... functionally important, as demonstrated in this locus. The presence of an insertion in this intron reduces expression of the fas gene. The scientists looked ...

After dinosaurs, mammals rise but their genomes get smaller

... Rho and Haixu Tang oversaw the survey of mammalian and non-mammalian genomes. Transposable elements often lose their functionality soon after insertion but nevertheless are disturbingly common. In the human genome, for example, transposable elements constitute as much as 45 percent of an individual's ...

New center at Georgia Tech aims to improve recovery of soldiers with severe injuries

... by needle without loss of cell viability and they remain at the injury site for at least two months," said Boyan. Protecting the cells during insertion is just the first step toward improved tissue repair. The researchers must also examine whether the stem cells will turn into cells typical of the ...

Simulated gene therapy

... are branching molecules that are slightly positively charged. This allows them to be loaded with DNA (which is slightly negative charged) for insertion into a cell. Dendrimers seem to offer many advantages over viruses. They may be much less toxic, and they may offer other advantages in terms of ...

Findings uncover new details about mysterious virus

... feature apparently opens up like a blooming flower when the virus is ready to infect its host amoeba, enabling the virus to eject its DNA for insertion into the host, Rossmann said. "In addition, we think the indentation of the genetic material has something to do with how the genome comes out of ...

Laughing hyenas, wailing levees, the sound of cheese and blaring bagpipes

... 3) GENE-LADEN BUBBLES GROW NEW BLOOD VESSELS Progress in human gene therapy -- the insertion of therapeutic DNA into tissues and cells in the human body -- has been slower than expected since the first clinical trials in 1990. One of the ...

American Chemical Society Weekly PressPac -- April 15, 2009

... Andrea Serra and colleagues note that the most common method for monitoring brain neurochemical levels is microdialysis, a technique that requires insertion of a relatively big probe into the brain. That technique, however, has several disadvantages including low sample rate and the necessity of a complex ...

Ancient diatoms lead to new technology for solar energy

... the interaction between photons and the dye to promote the conversion of light to electricity, and improve energy production in the process. The insertion of nanoscale tinanium oxide layers into the diatom shell has been reported in ACS Nano , a publication of the American Chemical Society, and the ...

Altered gene can increase risk of schizophrenia

... would control the production of that enzyme. The three kinds of DNA (the SNP, the firefly and the human regulatory) were all joined together prior to insertion into the brain-derived cells. Thus, the amount of expression of each SNP would be reflected (via the regulatory DNA) in the intensity of the light ...

200,000 rice mutants available worldwide for scientific investigation

... a mutant for every gene as somewhere between 180,698 and 460,000. Two hundred thousand rice mutants are now available and have been mapped by the insertion of what are known as flanking sequence tags small pieces of DNA or molecular tags that integrate into the rice genome. This approach is useful ...

'Seeing' stem cells helps in fight against peripheral arterial disease

... cholesterol and control pain. Interventional radiologists treat severe cases of PAD with minimally invasive treatments, including angioplasty and insertion of stents. "However, some patients have extensive diseasewith so many blood vessels affectedthat they're difficult to treat," said Frank Wacker, ...

Oh baby, interventional radiology makes childbirth safer

... with obstetricians. The interventional radiologists guided balloon catheters into a woman's left and right uterine artery (preoperative prophylactic insertion of bilateral internal iliac artery occlusion balloons) before deliveryto be ready to inflate (just like in angioplasty), if needed at delivery to ...

Freezing kidney cancer: Hot treatment should be new gold standard for destroying small tumors

... urologist. One or more hollow needles are inserted through the skin directly into a tumor. Interventional radiologists can observe and guide the insertion by combined use of ultrasound and CT. The needle, or cryoprobe, is filled with argon gas, which creates an ice ball, which rapidly freezes the tumor. ...

200,000 rice mutants available worldwide for scientific investigation

... a mutant for every gene as somewhere between 180,698 and 460,000. Two hundred thousand rice mutants are now available and have been mapped by the insertion of what are known as flanking sequence tags small pieces of DNA or molecular tags that integrate into the rice genome. This approach is useful ...

Press statement on new CDC MRSA study from SHEA president

... because hospitals are instituting and adhering to general practices that result in fewer infections, including measures to ensure proper catheter insertion and removal, hand hygiene, environmental cleanliness, and antimicrobial stewardship. "Because MRSA only causes about 8% of healthcare-associated ...

Comparative genomics reveals molecular evolution of Q fever pathogen

... suggest that mobile genetic elements have played a major role in the evolution and function of the C. burnetii genome. Recombination between insertion sequence elements or jumping genes appears to have brought about large-scale generation of non-functional genes, a change that may be associated with ...

New research shows how gene function drives natural selection in important class of genetic elements

... rare episodes of positive selection and even adaption to a host genome when these Clark Kents get busy. It has been known for a long time that the insertion of transposable elements can harm the host, but few studies have been done to determine if there is evidence of selection pressure on LTR ...

Landmark study unlocks stem cell, DNA secrets to speed therapies

... cells, out of many adult cell types, but there are two major hurdles remaining. First, the methods currently used rely on the unnatural retroviral insertion of genes into patients' cells, and these genes are capable of forming tumors. Second, this method is very inefficient as well because only one in ...

Biophysical Society names 2009 award recipients

... the University of California, Irvine, will receive the Avanti Award in Lipids for his novel findings in the areas of membrane structure and protein insertion into membranes. Three candidates have been selected to share the Margaret Oakley Dayhoff Award. They are Teresa Giraldez of the Hospital ...

Biomarkers allow doctors to match therapy to patient

... would be regulated at a molecular level by specific genes. To identify these genes involved in cell growth, they used a functional screen based on insertion mutagenesis with mouse retroviruses. This unique approach in human solid tumor cells took more than a decade of painstaking work. Some of the ...

Bangladesh to dramatically expand technology that doubles efficiency of urea fertilizer use

... useto almost 1 million hectares (ha) of rice land, reaching about 1.6 million farm families, in the coming boro or dry season. UDP is the insertion of large urea briquettes into the rice root zone after transplanting. UDP cuts nitrogen losses significantly. Farmers who use UDP can increase yields ...

Odd protein interaction guides development of olfactory system

... causes neurons to grow wildly off-track. The ligand that binds to the derailed receptor is known as Wnt5 (pronounced wint 5 short for wingless insertion 5). Both derailed and Wnt5 are known to play key roles in the growth and development of the nervous system. In the antennal lobe, derailed is ...

New class of drug offers hope to treatment-resistant AIDS patients

... combinations of HIV drugs attack the first two enzymes to stop replication, no fully approved drugs stop the action of the HIV integrase enzyme, the insertion of HIV DNA into human DNA. Nair calls this step in replication the most devastating in HIVs attack on human cells. Because there is no human enzyme ...

Embryonic stem cell strategy advanced with UCSF finding

... in transforming adult cells. Yamanakas strategy -- over-expressing certain genes in mouse skin cells to initiate reprogramming relied on the insertion of a foreign drug resistance gene into the mouse skin cells. This gene would switch on in those cells that successfully converted to embryonic stem ...

Transgenic maize is more susceptible to aphids

... viruses and using Bt maize might amplify this problem. So where does this unexpected difference between conventional and Bt maize come from" The insertion of the Bt gene could have an effect on other genes, but the NCCR Plant Survival researchers rather think that by producing Bt toxin the plant's ...

Science study holds implications for gene therapy and stem cell biology

... study by Dr. Baum and team revealed that the insertion of several such retrovirus vectors into a single ... found that they could use the random genome insertion of disabled retroviruses as a tool to discover ... found to be marked and activated by the random insertion of a disabled retrovirus appear to have exactly ...

Dog genome sequenced

... myopathy, a muscle-wasting disease, is associated with a SINE insertion in a gene called PLPTA . The discovery of highly variable patterns of SINE insertion between individual dogs suggests that SINEs may play a significant role in ...

Scientists fetch useful information from dog genome publications

... myopathy, a muscle-wasting disease, is associated with a SINE insertion in a gene called PLPTA . The discovery of highly variable patterns of SINE insertion between individual dogs suggests that SINEs may play a significant role in ...

Researchers demonstrate way to control tree height

... could be difficult to even find, tiny little “shrublets” among the flowers in the field site. The manipulation of height growth was achieved by insertion of certain genes, mostly taken from the model plant Arabidopsis, which inhibited the action of a class of plant-specific hormones known as ...

pHLIP, a novel technology to locate and treat tumors

... to a report in the Proceedings of the National Academy of Sciences. The researchers show that, the protein fragment, called “pHLIP?(pH (Low) insertion Peptide) can be injected into the abdomen of a mouse, find its way into the blood and then specifically accumulate in tumors. Within 20 hours after ...

Slowing the racing heart

... investigator of the study. Current treatment of arrhythmia requires destruction of tissue surrounding a chaotic pacemaker, followed by insertion of a mechanical pacemaker that can regulate the heartbeat. "Understanding the molecular regulation of the heart's pacemaker opens the ...

Study to explore using magnets to correct 'sunken chest'

... of pectus excavatum, according to Harrison. Current approaches to correcting sunken chest involve major surgery to open and rebuild the chest and the insertion of metal struts to hold the chest in place while it heals. Complications can occur because the struts are under significant pressure, and the painful ...

Largest genomic search finds genes that may contribute to autism

... in the human genome and many of them are believed to be benign. "But until you know the function, you don't know what happens when there is an insertion or deletion of this genetic material," he added. Scientists believe that there may be five or six major genes and perhaps as many as 30 other ...

Cryoablation -- A new treatment option for some kidney tumor patients

... In percutaneous cryoablation, one or more hollow needles are inserted through the skin directly into a tumor. Doctors can observe and guide the insertion by combined use of ultrasound and CT. The needle, or cryoprobe, is filled with argon gas, which results in rapid freezing of the tissue to ...

Does evolution select for faster evolvers?

... insertions," Deem said. "For example, we can trace the development of the adaptive immune system in humans and other jointed vertebrates to an HGT insertion about 400 million years ago." The new mathematical model developed by Deem and visiting professor Jeong-Man Park attempts to find out how HGT ...

Peering into the shadow world of RNA

... ability to copy themselves into RNA, translate themselves back into DNA, and then reinsert themselves back into the DNA at the new location. If their insertion spot happens to be within the coding region for a vital gene, the result can be destruction of the gene, leading to birth defects and genetic ....

Genome archaeology illuminates the genetic engineering debate

... in general," Messing said. "The vast pool of genetic material in plants can be an important resource from which biotechnology can draw genes for insertion into an array of plants, generating unique genomes not achievable by conventional breeding," Messing said. "We could engineer plants to provide a ...
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