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Innate in Biological News

Tips from the journals of the American Society for Microbiology

... research suggests that their ability to evade innate immune responses within the host, such as the ... Antimicrobial Agents and Chemotherapy . innate immunity, the universal defense system shared by ... and antiseptic properties) are part of the innate immune response which kills microorganisms. ...

NIH funds $9.5 million for research on HIV and the human innate immune system

... will unravel changes in the human body's innate immune system in HIV-infected people on ... that human beta defensins (hBDs), frontline innate defense molecules found in epithelial cells ... have against infections, such as hBDs and other innate immune molecules, found in the epithelial linings ...

Strong immune response to new siRNA drugs in development may cause toxic side effects

... and how it is delivered, it may induce a potent innate immune response in humans, stimulating the ... system. In the article entitled, "siRNA and innate Immunity," Marjorie Robbins, Adam Judge, and Ian ... the most comprehensive review on siRNAs and innate immunity to date and a must read for anyone using ...

Microparticle immune response modifier shows broad effects against recurrent or metastatic cancer

... mouse models of lung and breast cancers, innate Therapeutics (formerly Virionyx Corporation) ... Gill Webster, Ph.D., chief scientific officer of innate Therapeutics, who led the poster presentation. ... simultaneously to activate a broad range of innate immune cell types that are central to the ...

Shades of 1918? New study compares avian flu with a notorious killer from the past

... to respiratory tissues while sending the host's innate immune response into a lethal overdrive, ... transcription of genes associated with the innate immune response, the body's first line of defense ... and other factors involved with the host's innate inflammatory response to infection. The result of ...

TGen, Scottsdale Healthcare, Mayo Clinic study new drug to stimulate immune system of cancer victims

... that it may play a key role in augmenting the innate arm of the immune system. There are two broad components of the immune system, the innate arm, and the adaptive arm. Both generally aim to eliminate viruses and bacteria. -- The innate arm senses infectious agents as they infect the ...

Scripps research team sheds light on immune system suppression

... that attack specific infections. In contrast, innate immune responses are genetically encoded and are ... of infection type. One key component of the innate immune system is interferon, which plays a range ... including direct antiviral effects, activating innate natural killer cells and adaptive T lymphocytes, ...

TB bacterium uses its sugar coat to sweeten its chances of living in lungs

... cell. As part of what is called the innate immune response, the macrophage activates ... response to come to the macrophage's aid. The innate response kicks in to fight any pathogen, but an ... proteins that we make without activating the innate immune system. It's a receptor to keep humans ...

No helicopter moms among Rutgers mutant mice

... N.J. First, he discovered a gene that controls innate fear in animals. Now Rutgers geneticist Gleb ... wayward pups is a behavior motivated by innate fear of attack by predators, a likely outcome for ... evidence to the amygdala's role in controlling innate fears specifically, the basolateral complex ...

Genome sequence of small marine creature sheds light on vertebrate origins

... 2. Exploring the evolution of vertebrate innate immunity The immune system of vertebrate animals consists of two components: the innate immune response, a constitutive system ready to ... chordate ancestors had a remarkably elaborate innate immune system, but this system was somehow ...

Worm-like marine animal providing

... pathogensinvertebrates like amphioxus have only innate immune systems. In amphioxus, several of these innate immune genes have been independently duplicated ... invertebrates like amphioxus, are less reliant on innate immunity to ward off infection. The neural ...

Detecting the snake in the grass

... and very young children apparently have an innate ability to very quickly detect the presence of a ... emphasize that their study does not prove an innate fear of snakes, only that humans, including young children, seem to have an innate ability to quickly identify a snake from among ...

Scientists discover a new player in innate immune response

... All multicellular animals have an innate immune system: When bacteria, parasites or fungi ... that plays an important role in triggering the innate immune response of the fruit fly Drosophila, mice ... journal Nature Immunology. The cells of the innate immune system recognize hostile invaders with the ...

Lecture to honor victim of Sept. 11 tragedy

... titled, Mechanisms of Signal Integration in innate Immunity, will focus on how innate immune cells respond to viral infections by ... His current research explores the regulation of innate immunity and the role of gene expression in brain ...

Balzan Foundation announces 2007 winners

... California and Acadmie des Sciences, Paris, for innate immunity Sumio Iijima (Japan), Meijo ... France) justified the assignment of the Prize for innate Immunity jointly to Bruce Beutler and Jules ... of the genetic mechanisms responsible for innate immunity. They have worked in close cooperation ...

Plant protein 'doorkeepers' block invading microbes, study finds

... and defend against disease-causing microbes. Plants, however, only have innate immune systems. Rather than developing immunity as they are exposed to ... against microbial invasion and related diseases. This type of innate immune system has two branches: one makes use of receptor proteins outside ...

Plant protein 'doorkeepers' block invading microbes, study finds

... and defend against disease-causing microbes. Plants, however, only have innate immune systems. Rather than developing immunity as they are exposed to ... against microbial invasion and related diseases. This type of innate immune system has two branches: one makes use of receptor proteins outside ...

Songbird study from CSHL, CCNY provides concrete measure of biology's impact on culture

... heard in the wild is the product of genes and learning a combination of innate song that would be learned even in isolation, and the effects of a ... comprising a large dataset of several terabytes, which show that the innate song of an isolated bird is gradually transformed over multiple ...

Lombardi research: Monoclonal antibodies primed to become potent immune weapons against cancer

... alter the antibodies so that they induce both kinds of human immunity the innate immune response that is short-lasting and which directly kills tumor ... long thought that monoclonal antibodies are capable of stimulating the innate immune system, but we now have evidence that the therapy can prime an ...

Immunity stronger at night than during day

... as the model system to help them define the relationship between innate immunity and circadian rhythm, which is the oscillating protein clock or ... when to eat, sleep and mate over a 24-hour cycle. In phagocytosis, the innate immune response targeted by the Stanford researchers, specific immune ...

Vitamin D found to fight placental infection

... varies widely among women. Their discovery suggests that placental innate immunity can be enhanced if pregnant women supplement their diets with ... understood. This study presents a new mechanism for activation of innate immune responses in the placenta to protect it from infectious bacteria ...

Genetic finding implicates innate immune system in major cause of blindness

... by AMD. These proteins are involved in regulating a part of the body's innate immune system known as the "complement system". The findings suggest that ... retina and choroid layer. "It seems counterintuitive that a generalised innate immunity defence system should result in a localised disease of the eye in ...

Previous claims of siRNA therapeutic effects called into question by report in human gene therapy

... the disease-modulating effect of an siRNA from its ability to stimulate an innate immune response. siRNAs have been highly touted for their ability to ... immunologic processes. However, siRNA also has the potential to activate innate immunity and the production of interferons, which can in turn bring about ...

Genetic cause of innate resistance to HIV/AIDS

... KIR3DL1 and HLA-B*57 is thought to be at the root of some cases of this innate resistance to HIV infection. Depending on which versions of these two ... "In the future, our findings could be used to somehow 'boost' the innate immune system and thus fight the virus as soon as it enters the body," ...

BWF awards $7 million to infectious disease investigators

... recognition of infected cells by natural killer cells of the innate immune system Stephen Girardin, Ph.D. University of Toronto The Nod-like receptor Nod9 links mitochondrial dynamics and innate immunity to bacterial pathogens Chuan He, Ph.D. University of Chicago ...

New strategies against bird flu

... in multiple lung injuries and directly links oxidative stress to innate immunity. They also report for the first time a common molecular disease ... as danger-signals by the receptor TLR4. Subsequently, the bodys innate immune system is activated. This defense machinery in turn leads to a ...

Pathogens use previously undescribed mechanism to sabotage host immune system

... mechanisms for disrupting the ability of host cells to activate innate immune responses that will provide immediate defense against infection. ... protein kinase (MAPK) pathways play key roles in activating host innate immune responses and are frequent targets of pathogenic effectors in both ...

International team compares 12 fruit fly genomes

... species may respond differently to particular bacteria, overall their innate primary immune responses are similar and even share many features in common with human innate immunity. One species, D. willistoni , surprised researchers because it ...

Microbes and their hosts -- exploring the complexity of symbiosis in DNA and cell biology

... of scientific topics and disciplines related to microbial symbiosis. These include "The Oral Microbial Consortium's Interaction with the Periodontal innate Defense System," which describes a process called "local chemokine paralysis," in which the membership and characteristics of the bacterial community ...

LincRNAs serve as genetic air-traffic controllers

... forward in understanding the roles of these molecules in many biological processes, including stem cell pluripotency, cell cycle regulation, and the innate immune response. But even as one question was being answered, another was close on its heels: What, exactly, were these mysterious molecules ...

Our 'caveman logic' embraces ESP over evolution

... advocates a world in which "spirituality" is viewed as a dangerous rather than an admirable quality, and suggests ways in which we can overcome our innate predisposition toward irrationality. Davis points out that, "biology is not destiny." Just as some of us succeed in watching our diets, resisting ...

Battle of the sexes benefits offspring, says research

... course, we are not claiming that fish and birds, or even humans, are necessarily making a consciously calculated decision. "More likely there are innate rules for responding, perhaps modified through learning, that allow successful participation in joint activities without leaving room for being ...

A bad performance is better than no performance at all

... the bad songs of their tutors, but rather developed a version that resembled more the song of normal canaries. "Apparently these birds possess an innate template for species-specific song that needs to be activated by hearing song", says Cornelia Voigt, co-author of the study. When the researchers ...

Gene therapy could expand stem cells' promise

... a certain amount of time," Dr. Crystal says. "Stem cells are the opposite. Once the future stem cell therapist does the therapy, stem cells have the innate potential to produce more cells." The challenge takes on even more urgency with recent developments, including a federal administration now more ...

Using 'dominance' to explain dog behavior is old hat

... Senior Lecturer in Companion Animal Behaviour and Welfare at Bristol University, said: "The blanket assumption that every dog is motivated by some innate desire to control people and other dogs is frankly ridiculous. It hugely underestimates the complex communicative and learning abilities of dogs. It ...

Drugs needed to preserve eggs for reproduction need to be given in stages

... the idea that they may work synergistically and hopefully with reduced toxicity. Scientists also are taking important cues from critters with an innate ability to preserve themselves. Increasingly added to the mix of manmade cryoprotectants are sugars, which are used by a variety of species, such as ...

Older men more likely than women to die after pneumonia

... by Drs. Yende and Angus found that people with certain gene variations associated with higher levels of macrophage migration inhibitory factor, an innate immune response regulator, were less likely to die following CAP. "Macrophage migration inhibitory factor is a molecule that plays an important ...

Vitamin D may exacerbate autoimmune disease

... receptor or VDR. Once associated solely with calcium metabolism, the VDR is now known to transcribe at least 913 genes and largely control the innate immune response by expressing the bulk of the body's antimicrobial peptides, natural antimicrobials that target bacteria. Written under the ...

Caltech researchers train computers to analyze fruit-fly behavior

... aggression and courtship in fruit flies, opening the way for researchers to perform large-scale, high-throughput screens for genes that control these innate behaviors. The program allows computers to examine half an hour of video footage of pairs of interacting flies in what is almost real time; ...

A paradigm shift in immune response regulation

... pathway in diseases such as cancer, inflammation and immunodeficiency. The body's first line of defence against bacteria and viruses is the innate immune system where phagocytes identify the foreign organism and initiate an alarm reaction, often accompanied by inflammation. As a consequence, ...
Other Contents
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