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Injury in Biological News

Experimental treatment halts hypoxic-ischemic brain injury in newborns

... brain proteases, or enzymes, play in adult brain injury following stroke, but very little has been known ... for therapeutic intervention to shut down the injury process early. To test the importance of ... fluid. In human newborns, hypoxic brain injury usually occurs right before, during or shortly ...

LSUHSC's Bazan awarded ARRA grant to preserve vision

... that are released in response to tissue injury in the cornea is lost. Dr. Bazan's research will ... US Department of Health and Human Services, eye injury is a leading cause of monocular blindness ... of age (57%). Common causes of occupational eye injury include blunt trauma, chemical burns, corneal ...

Alzheimer's disease drug treats traumatic brain injury, report GUMC researchers

... of neurons in animal models of traumatic brain injury and protected the animals against motor and ... has also been found in a third of traumatic brain injury victims, some of whom are children, Burns says. ... known that people who experience such a brain injury have a 400 percent increased risk of developing ...

International Serious Adverse Events Consortium announces initial study results in its global research collaboration to identify genetic markers related to drug induced liver injury

... at risk for serious drug induced liver injury (DILI). The SAEC is a nonprofit research ... are a large number of drugs that can cause liver injury in a very small subset of patients, and in rare ... that HLA-B*5701 is a major determinant of liver injury induced by flucloxacillin. Flucloxacillin is an ...

New center at Georgia Tech aims to improve recovery of soldiers with severe injuries

... require technologies for treatment at the time of injury and in the ensuing days and months. "These ... be most effective if used immediately following injury or at some later time after scar tissue has been ... do not yet exist for delivering them to an injury site and of ensuring that they survive and remain ...

Tips from the American Journal of Pathology

... uPAR may be a novel strategy to reduce the lung injury that accompanies oxygen therapy." van Zoelen ... 2009, 174: 2234-2245 Repair After Eye injury Drs. Sandrine Joly, Charlotte Rem, and ... the potential for autoimmune reactions after injury leading to or enhancing retinal degenerations." ...

Tips from the American Journal of Pathology

... Tracking Acute Kidney injury Dr. Eisei Noiri and colleagues at the ... American Journal of Pathology . Acute kidney injury may be reversible if treated promptly and ... therefore need to be developed to identify injury at early time points as well as to estimate the ...

Codeine use and accident risk

... involved in a traffic accident with personal injury is significantly higher among codeine users than ... traffic accidents were registered with personal injury where the driver had been exposed to codeine and ... involved in a road traffic accident with personal injury was twice as high in the period after having a ...

Alzheimer's disease therapeutic prevents long-term damage from TBI in pre-clinical studies

... to reduce damage caused by traumatic brain injury in animals, researchers at Georgetown University ... continuing damage that often follows a serious injury to the brain. That is because the agents, ... found during an autopsy in about a third of brain injury victims, some of whom were children who would ...

Multiple route bone marrow stem cell injections show promise to treat spinal cord injury

... can be an effective treatment for spinal cord injury (SCI) that returns some quality of life for SCI ... millions globally. Tissue loss from the primary injury and the complexity of cell types required for ... the disruption of the blood-spinal cord injury barrier, swelling and the release of molecules ...

UT to develop fracture putty for traumatic leg injuries

... bombs or other explosive devices. This type of injury is called a non-union fracture and generally will ... who now heads the Center for Translational injury Research at the UT Health Science Center at ... all the victims of any bone-related traumatic injury and reduce the number of wartime amputations in ...

Nearly a century later, new findings support Warburg theory of cancer

... His theory that cancer starts from irreversible injury to cellular respiration eventually fell out of ... in 1924 that the prime cause of cancer was injury to a cell caused by impairment to a cell's power ... "can underlie the irreversible respiratory injury in tumors and link mitochondrial lipid defects to ...

New dummy design and development wins US Department of Defense award

... Biomedical Engineering and Science's Center for injury Biomechanics has received the Army Modeling and ... developers the ability to assess face and eye injury risk, determine the benefit of potential face and ... protection devices, and characterize any residual injury risk due to behind-armor effects or novel ....

Field-hospital-on-a-chip project awarded to nanoengineer from UC San Diego

... battlefield injuries such as trauma, shock, brain injury or fatigue. Once the system detects a battlefield ... biomarkers and make decisions about the type of injury a person has sustained and then begin treating ... and glucose are examples as the kinds of injury biomarkers that will serve as biological input ...

Wake Forest plays integral role in effort to revolutionize vehicle safety

... Virginia Tech-Wake Forest University Center for injury Biomechanics. Stitzel will be the lead ... together some of the leaders in the field of injury biomechanics and computer modeling to create a world standard model of the human for injury prediction," Stitzel added. "It has the real ...

Human embryonic stem cell secretions minimized tissue injury after heart attack

... of secretion from stem cells minimized heart injury by enhancing reperfusion therapy (angioplasty and ... addressed the longstanding problem of reperfusion injury in the most clinically relevant experimental ... pig research model, this approach minimised heart injury after a heart attack, a particularly important ...

Arbor Vita and WRAIR sign CRADA for traumatic brain injury collaboration

... and development of treatments for traumatic brain injury (TBI). The alliance is based on discoveries made ... as a novel neuroprotective agent for severe brain injury of soldiers and civilians injured in explosions ... neuroprotection research in a model of brain injury that mimics some types of battlefield injuries. ...

Resuscitation technique after brain injury may do more harm than good

... 100 percent oxygen after a hypoxic-ischemic brain injury suffered far greater rates of brain-cell death ... in 100 percent oxygen after this sort of brain injury would exacerbate neuronal injury and impair functional recovery, and in these ...

Technique used in human ankle injuries modified to treat dogs' knees

... COLUMBIA, Mo. A common sports injury in human knees is even more common in dogs. Each ... to the anterior cruciate ligament (ACL) injury in humans. The common method of treatment by many ... of the canine knee, techniques used to repair the injury in humans do not work well for dogs. The new ...

Engineer to spearhead research into cell metabolism and medical injuries

... share of grants totalling over 1m to target lung injury and cancer. In an unusual move, Dr. Declan ... The first will be used to examine how lung injury can be prevented in patients who are on ... and as a result, ventilator-associated lung injury (VALI) is a common and significant occurrence. ...

Promising new nanotechnology for spinal cord injury

... CHICAGO -- A spinal cord injury often leads to permanent paralysis and loss of sensation below the site of the injury because the damaged nerve fibers can't ... gel inhibits the formation of scar tissue at the injury site and enables the severed spinal cord fibers ...

An ambulance man for muscle damage

... damage and wasting. Muscle regeneration after injury is complex and requires a coordinated interplay ... molecule called calcineurin. It is activated by injury and controls the activity of other key proteins ... active and uncouples the proteins activity from injury signals. The expression of CnA1, however, is ...

Club drugs inflict damage similar to traumatic brain injury

... Fla. --- What do suffering a traumatic brain injury and using club drugs have in common" ... is like inflicting a traumatic brain injury on yourself, said Firas Kobeissy, a postdoctoral ... research has already shown how traumatic brain injury affects brain cells in rats. They found similar ...

Knee injuries may start with strain on the brain, not the muscles

... reflexive responses---may be necessary to counter the fatigue induced ACL injury risk," said McLean, who also has an appointment with the U-M Bone & Joint injury Prevention Center. McLean says that most research and prevention of ACL ...

Stem cell surprise for tissue regeneration

... as well as normal muscle stem cells. They even performed a second round of injury and found that the stem cells were still active. The scientists then ... suggest that since the adult muscle stem cells are only activated when injury occurs (by trauma or exercise), they use a new set of genes from those ...

Activated stem cells in damaged lungs could be first step toward cancer

... DURHAM, N.C. Stem cells that respond after a severe injury in the lungs of mice may be a source of rapidly dividing cells that lead ... our observation that stem cell activation leads to clonal expansion after injury could, in the context of additional mutations, promote the development of ...

Cell's split personality is a major discovery into neurological diseases

... occur as a result of high glutamate levels include hypoxicischemic brain injury (stroke), trauma, seizures, various forms of dementia and ... cell death induced by glutamate is a key step in a large number of injury and disease settings and this study is important because it provides a ...

Risk of vibration-induced vascular injuries linked to vibration frequency differences

... durations. Dr. Krajnak's team looked at two aspects of vibration injury about which very little is known: the mechanisms of injury and the differences in response to frequency of vibration. The researchers ...

Novel veterinary procedure detecting life-threatening injuries touted

... Assessment with Sonography for Trauma) to diagnose PTX and other related injury in dogs. TFAST proved to be a highly accurate method for detecting PTX and ... emergency and critical care, evaluated 145 dogs within 24 hours of their injury which included automobile accidents and bite and gunshot wounds. High ...

Researchers explore new driver of transplant rejection: Platelets

... also during organ harvest, presents new opportunities for attacking organ injury and rejection head-on, says Rabb. The traditional target of current ... platelet and it represents an opportunity to target the effectors of organ injury rather than only the general." ...

Transplanted fat cells restore function after spinal cord injury

... factors contributed to promotion of functional recovery after spinal cord injury (SCI)," said Ohta. "Transplanting DFAT cells into SCI rats significantly ... ability to obtain stem cells from a patient's own fat that can help repair injury to the spinal cord," said Paul R. Sanberg, PhD, DSc, at the University of ...

Common treatment to delay labor decreases preterm infants' risk for cerebral palsy

... are not well understood, though cerebral palsy is attributed to brain injury or developmental abnormality during pregnancy, birth or in early ... protects against damage from oxygen depletion, and protects against injury from swelling and inflammation, all of which threaten the vulnerable ...

LSUHSC research reports new method to protect brain cells from diseases like Alzheimer's

... diseases and worsening of damage from such insults as traumatic brain injury and stroke. Chen and research associate Jian Zhang show that ... to pro-inflammatory and certain types of toxic stimuli, resulting in the injury or death of brain cells. The researchers also revealed the specific ...

Researchers block damage to fetal brain following maternal alcohol consumption

... for balance and muscle coordination, is particularly vulnerable to injury from alcohol during development. The researchers also found that ... the brain of the developing fetus. Alcohol is the most common cause of injury to the fetal brain. Children born with fetal alcohol syndrome may have ...

Novel approach may protect against heart attack injury

... work by other researchers, who showed that HDAC inhibitors reduce ischemic injury in the brain, they used the same agents in mice with induced heart damage. ... will be to test how HDAC inhibitors work in protecting against ischemic injury in larger animals. ...

Scientists learn how food affects the brain

... said Gmez-Pinilla, a member of UCLA's Brain Research Institute and Brain injury Research Center. Synapses in the brain connect neurons and provide ... A healthy diet and exercise can also reduce the effect of brain injury and lead to a better recovery, he said. Recent research also ...

Jefferson receives $11.6M NIH grant to study novel mechanisms of heart failure

... Heart, Lung and Blood Institute to study molecular mechanisms of cardiac injury that lead to heart failure and potential repair processes that occur in ... little is known about what part it plays in healing the heart after injury and in heart failure. Two major adenosine receptor types in the heart ...

New strategies against bird flu

... a paper published by Cell this week, the authors describe an essential key injury pathway that is operational in multiple lung injuries and directly links ... failure and felt utterly helpless, Imai says. Since we found a common injury pathway, our hopes are high that we may be able to develop a new and ...

Blood vessel protein reverses macular degeneration, diabetic retinopathy in mice

... Li believes it merits investigation. Many diseases are caused by injury or inflammation destabilizing blood vessels and causing them to leak fluid ... (angiogenesis) is critical in human development and as a response to injury or disease. In earlier research, Li had shown that a family of proteins, ...

Skull survey could improve vehicle safety

... between skull thickness and shape and how well a person tolerates a head injury have not been settled with most studies simply extrapolating from smaller ... of the human skull can help us to better understand the problem of head injury during an impact," the researchers say, "and help in the design of better ...
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