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Initiation in Biological News

Xie Lab uncovers molecular machinery related to stem cell fate

... with the function of the protein translation initiation factor eIF4A. EIF4A and BAM antagonize each other ... author on the paper. "Many protein translation initiation factors have been reported to be unregulated in ... study may help to understand how translational initiation factors participate in stem cell misregulation ...

Scientists discover why teeth form in a single row

... it was indeed the mesenchyme that carried tooth initiation signals later in development, but how those ... 4 (BMP4) to be an important factor for the initiation of teeth, and that a protein called Msx1 ... regulation of competing pro- and anti-tooth initiation signals controls how mammalian teeth come one by ...

Impaired energy metabolism linked with initiation of plaques in Alzheimer's brain

... that BACE1 activity may play a key role in the initiation of AD pathogenesis and identified BACE1 as a ... of the stress-inducible translation initiation factor, eIF2?. Further, direct phosphorylation of ... implicate phosphorylated eIF2? in both the initiation and progression of sporadic AD. Future ...

The Burnham Buzz, February 2009

... showed that the protein kinase complex known as Ddk is responsible for initiation of DNA replication, as well as controlling the S-phase of the cell cycle. ... molecules in the complex acts as a control switch for DISC formation and initiation of apoptosis. Riedl's study was published December 31, 2008 in Nature . ...

Human genomics in China

... the far-sighted Chinese medical geneticists were still promoting the initiation of a human genome project in China. Academician WU Min, at that time, the ... the genetic mechanisms of human diseases and other phenotypes. The initiation of HGP is due to the lesson learnt from the failure of the cancer project ...

Burnham researchers discover 'on switch' for cell death signaling mechanism

... that Fas opening itself acts as a control switch for DISC formation and initiation of apoptosis. "We found an explanation for why binding of Fas ligand is ... for receptor signaling solely by protein clustering. Understanding the initiation of the death inducing signaling complex is of great interest because if ...

August 2008 Geology and GSA Today media highlights

... Triggering of the Lusi mud eruption: Earthquake versus drilling initiation Mark Tingay et al., Dept. of Applied Geology, Curtin University of ... is based on the presumption that the marine connection was coeval with initiation of Antarctic glaciation at the Eocene-Oligocene boundary, the latter ...

Researchers discover critical detail of cellular defense against genetic mistakes

... UPF1 interacts directly with and inhibits the function of eukaryotic initiation factor 3 (eIF3), which would otherwise direct protein building based on ... mRNA sequence does not. Researchers found that the non-eIF3 translation initiation directed by the cricket virus sequence in mammalian cells was resistant to ...

Girls who begin dieting twice as likely to start smoking

... Journal of Health Promotion. Dieting was a significant predictor of initiation of regular smoking among females, said Mildred Maldonado-Molina, Ph.D., a ... were most interested in, seeing how the start of one behavior related to initiation of smoking, Maldonado-Molina said. Researchers also found that girls ...

Drug-proof zebrafish reveal secrets of addiction

... a major step in the development of addiction is the switch from drug use to drug abuse, we aimed to gain insight into the mechanisms triggering the initiation of addictive behaviour". The team used the mutagenic chemical ENU to generate hundreds of mutant zebrafish. From these, they bred a line that did ...

Stuff of stink bombs investigated for role in pregnancy

... has been shown to relax the uterus and it can be produced by the placenta, uterine tissue and the amniotic sac." Dr Carson's interest is in the initiation of term labour, premature labour and pre-eclampsia, which are still poorly understood. He said: "It is possible that research on hydrogen ...

Tulane receives grant to study limb regeneration

... area for many decades. The shorter term goal is to modify the body's natural healing process to transition from a scar-forming response to the initiation of a regenerative response. Muneoka says this might involve cell-based therapies with regeneration-promoting cells, and/or factor-based therapies, ...

Society for Prevention Research Meeting in Washington, D.C., May 27-29, 2009

... other newsworthy presentations at this meeting. Some of the other interesting topics are: Youth Suicide Prevention, Preventing Sexual Violence, Early initiation and Health-Risking Sexual Behavior, and New Drug Prevention Approaches. ...

New tool isolates RNA within specific cells

... we get a more accurate idea of what the cell is saying." That, Doe added, could be helpful for 'listening' to host cells before and after the initiation of a disease to determine how cells respond, or, for example study healthy immune cells versus bacterially-challenged immune cells or neurons before ...

Food security: It starts with seed

... soybean and Sinorhizobium fredii USDA257. The publishing of Modification of Seed Composition to Promote Health and Nutrition coincides with the initiation of the Biomedical, Health-Beneficial and Nutritionally Enhanced Plants division in the Crop Science Society of America. This division of CSSA focuses ...

Heart attacks: The tipping point

... was able to paint a more accurate picture of a heart's health than could be deduced from even an MRI or CT scan. "This coupling is crucial to the initiation of fibrillation," he says. Indicating how the electrical impulses move in a healthy heart, in a synchronized ordered manner, he compares that to a ...

6 young ASU faculty earn NSF Career awards

... be used to study the binding mechanism of sequence specific DNA-binding proteins. These proteins are crucial for gene regulation, transcription initiation and DNA replication. Their binding is characterized by large conformational changes, involving the (partial) folding or unfolding of the protein and ...

truTV and Cox Offer Free Digital Fingerprinting to Help Prevent Crimes Against Children

... Gary McCollum, Senior Vice President and General Manager, Cox Hampton Roads. truTV has fingerprinted thousands of children since the program's initiation in 2002. Each child receives an 8 x 10 printout with photo, fingerprints, and personal information such as height, weight, and hair color. ...

Penn biologists discover how 'silent' mutations influence protein production

... molecules that could not be accessed by the protein-making machinery. According to their analysis, mRNA folding and associated rates of translation initiation play a predominant role in shaping expression levels of individual genes, whereas codon bias influences global translation efficiency and cellular ...

Image processing and mathematical morphology in new text by NJIT professor

... Recognition and Artificial Intelligence and Journal of Information Hiding and Multimedia Signal Processing . Shih received the Research initiation Award from the National Science Foundation (NSF) and has received numerous grants from NSF, U.S. Navy and Air Force and industry. ...

Image processing and mathematical morphology in new text by NJIT prof

... Recognition and Artificial Intelligence and Journal of Information Hiding and Multimedia Signal Processing . Shih received the Research initiation Award from the National Science Foundation (NSF) and has received numerous grants from NSF, U.S. Navy and Air Force and industry. ...

truTV and Cox Offer Free Digital Fingerprinting to Help Prevent Crimes Against Children

... Gary McCollum, Senior Vice President and General Manager, Cox Hampton Roads. truTV has fingerprinted thousands of children since the program's initiation in 2002. Each child receives an 8 x 10 printout with photo, fingerprints, and personal information such as height, weight, and hair color. ...

Team IDs genesis of mass migrations

... CAMBRIDGE, Mass.--For the first time, MIT engineers and colleagues have observed the initiation of a mass gathering and subsequent migration of hundreds of millions of animals in this case, fish. The work, conducted using a novel imaging ...

Van Andel Research Institute and TGen undertake alliance to promote science and health

... will enable both to maximize their worldwide contributions to science and health. The non-profit researcher institutes jointly announced today the initiation of an "alliance and affiliation agreement.'' The partnership between Grand Rapids, Mich.-based VARI and Phoenix, Ariz.-based TGen will enable ...

NYU Langone Medical Center researchers find micro RNA plays a key role in melanoma metastasis

... melanoma cell lines and tissues. The lab found that the elevated expression of miRNA 182 turns it into an oncogene (a gene involved in cancer tumor initiation or progression), by increasing the invasive capacity of melanoma cells in vitro and stimulating the cell's metastatic potential in a mouse model. ...

GKSS to invest 12 million euros ($15.48 million) in a new observation system for the North Sea

... network, the Helmholtz Association is providing money in the amount of EUR 12 million. COSYNA is later to be extended to the Arctic Ocean. A national initiation workshop will be held on 15 January 2009 at the Federal Maritime and Hydrographic Agency (BSH) in Hamburg. Observing, understanding, predicting ...

Genetic testing not cost-effective in guiding initial dosing of common blood thinner

... P450 CYP2C9 and vitamin K epoxide reductase, or VKORC1. The hope is that more accurate dosing will translate into decreased major bleeds during the initiation phase of warfarin dosing, which is the first month or so." Eckman says the study looked at whether the benefit of testing is worth the costs ...

International copper industry defines role in the fight against hospital infections

... taking a lead role in this international effort through two main initiatives: EPA registration of copper and copper alloys as antimicrobial and the initiation of clinical trials in three U.S. hospitals. The EPA registration was granted based on independent laboratory tests demonstrating that copper, brass ...

Forsyth scientist receives major grant to support rapid, accurate, affordable test for tuberculosis

... in the world, including the most remote locations the test result is easy to read and obtained in less than five minutes, enabling the immediate initiation of treatment urine is a far easier sample to collect and, unlike current sample collection, is completely non-invasive the presence of TB antigens ...

Study links nicotine with breast cancer growth and spread

... or defect of different tumor suppressors, to further explore the effects of nicotine in relation to first- and second-hand exposure, on breast cancer initiation and development. ...

New Systems Biology Awards enable detailed study of microbes

... understanding of the complex molecular processes of microbes and their interactions with the host, including how molecular-level events lead to the initiation and progression of disease," says Anthony S. Fauci, M.D., director of NIAID. "We anticipate that these projects will generate new insights that will ...

Fossils and layers: Solving the terrane puzzle of the North American cordillera

... terranes. "Terrane studies remain integral to understanding the geological evolution of western North America," says Blodgett. "Since the initiation of the concept of terranes, summarized in 1979 by Norman J. Silberling and the late David L. Jones, the significance of fossils and stratigraphy has ...

Vitamin A pushes breast cancer to form blood vessel cells

... that previous research on retinoids implied that they may be effective in a preventative setting, but may actually have a negative effect after tumor initiation and during progression." The researchers demonstrated that treating the cells with RA turns on 81 genes that are associated with endothelial ...

CAPHOSOL relieves oral mucositis and improves quality-of-life in cancer patients

... virtually all patients receiving radiation therapy for head and neck cancer. Oral mucositis usually manifests itself within seven to 14 days after initiation of therapy. Initial signs and symptoms include redness, swelling and ulceration of the mucosa. Oral mucositis can cause mouth pain, xerostomia ...

Sangamo BioSciences to Present at the Bank of America 2008 Healthcare Conference

... differ materially from these forward-looking statements due to a number of factors, including technological challenges, uncertainties relating to the initiation and completion of stages of ZFP Therapeutic clinical trials, Sangamo's ability to develop commercially viable products and technological developments ...

Cell-based therapy shows promise in patients with Parkinson's disease

... been monitored for 6 years and the trial has been extended to 10 years of follow-up. Bakay said positive results in the pilot study prompted the initiation of a Phase IIb, multicenter, double-blind, randomized, sham surgery-controlled study (STEPS) to further evaluate the safety, tolerability and ...

New type of drug shrinks primary breast cancer tumors significantly in just 6 weeks

... chemotherapy; indeed, residual cancers that were exposed to such chemotherapy showed an increase in tumour-causing cells and enhanced tumour initiation by the formation of mammospheres, small tumours that form when tumour-causing cells are cultured in a test tube, which reflect the capacity of the ...

Pediatricians alerted to the developmental nature of underage drinking in special journal supplement

... Sciences and Health Education at Emory University in Atlanta, and his group examined pre- and mid-teen groups during the time when the initial initiation and escalation of alcohol use commonly occurs, in relation to puberty, structural and functional maturation of the brain, and changes in social ...

National Lung Cancer Partnership and LUNGevity Foundation

... lead to cancer. In addition, he will investigate drugs that can block steps governing uncontrolled cell growth, with the goal of blocking lung tumor initiation and growth. Our goal is to increase the understanding of the development of lung cancer and to improve lung cancer treatment, said Dr. Baldwin. ...

Vitamin E may increase tuberculosis risk in male smokers with high vitamin C intake

... dietary vitamin C intake over 90 mg/day. The most dramatic increase in tuberculosis risk by vitamin E was restricted to a one-year period after the initiation of supplementation. The US nutritional recommendations, issued by the prestigious Institute of Medicine, consider that vitamin E is safe in ...
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(Date:8/19/2014)... nutrition rating systems be used in supermarkets to encourage ... researchers sought to answer that very question by tracking ... the Guiding Stars System to rate the nutritional value ... Food and Brand Lab,s David Just, PhD, and Brian ... the sales records of over 150 Hannaford Supermarkets in ...
(Date:8/19/2014)... Long-Term Ecological Research and Network-Level Science, , Imagine if ... range of ecosystems was responding to global changes in ... if it coupled multiple decades of information about ecological ... models from dozens of different ecosystem types. , ... Ecological Research (LTER) Network, which will soon celebrate its ...
(Date:8/19/2014)... leprosy and tuberculosis live side-by-side. Worldwide there are ... with nearly all of them occurring where tuberculosis ... Calmette-Guerin, or BCG, provides only partial protection against ... vaccine is needed to combat both diseases. UCLA-led ... both diseases., In a study published in the ...
Breaking Biology News(10 mins):This week from AGU: Long-term ecological research, predicting cholera outbreaks 2New vaccine shows promise as stronger weapon against both tuberculosis and leprosy 2
(Date:8/21/2014)... effective vaccination, polio is considered nearly eradicated. Each year ... scientists of the University of Bonn, together with colleagues ... that was able to resist the vaccine protection to ... outbreak in the Congo in 2010. The pathogen could ... results appear now in the magazine PNAS . ...
(Date:8/21/2014)... August 21, 2014 Glioblastoma Multiforme ... Therapeutic Approaches Target High Unmet Need in Newly ... of the Glioblastoma Multiforme (GBM) therapeutics market within ... and Japan. The report provides estimates of market ... 2020. It also covers disease epidemiology, treatment algorithms, ...
(Date:8/21/2014)... 2014 One of the emerging trends ... experience is an increasing adoption of non-invasive administration products. ... the patient through their convenient application, they find more ... a medical device used for the administration of drugs ... and paranasal sinus such as allergic and non-allergic rhinitis ...
(Date:8/21/2014)... Hospital officials, community leaders and elected officials ... new building at Mount Sinai Queens, marking the completion ... expansion and modernization project. During the event, hospital ... Kaufman, Chairman of the nearby Kaufman Astoria Studios, for ... will be named. The project, which began late ...
(Date:8/21/2014)... According to a new market research report "Near Field ... Auxiliary), Application (Payment, Transportation, Booking, Data Sharing, Service, Access ... - Global Forecasts to 2022", published by MarketsandMarkets, the ... by 2022 at an estimated CAGR of 8.83% from ... and 105 Figures spread through 298 Pages and in-depth ...
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