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Inflammatory in Biological News

Scientists uncork a potential secret of red wine's health benefits

... derivativecan be used to treat potentially deadly inflammatory disease, such as appendicitis, peritonitis, and systemic sepsis. "Strong acute inflammatory diseases such as sepsis are very difficult to ... therapy to help in the treatment of strong acute inflammatory diseases." In this study, researchers ...

Common allergy drug reduces obesity and diabetes in mice

... Zaditor and cromolyn, stabilize a population of inflammatory immune cells called mast cells. In the second ... already reported overabundance in fat tissue of inflammatory immune cells called macrophages. "It seems ... he found mast cells present in a variety of inflammatory vascular diseases. Mast cells are immune ...

NIH expands Human Microbiome Project; funds sequencing centers and disease projects

... skin microbiome may contribute to psoriasis, an inflammatory skin disease. Gregory A. Buck, Ph.D., ... $1 million The relationship between the inflammatory bowel disease, Crohn's disease, the intestinal ... to uncover relationships with Crohn's disease, an inflammatory bowel disease. Huiying Li, Ph.D., University ...

Scientists discover new genetic immune disorder in children

... Stephen I. Katz, M.D., Ph.D. "The abnormal inflammatory pathways seen in this disease may also help us ... IL-1Ra binds to the same cell receptors as the inflammatory protein interleukin-1, and acts as a brake on this inflammatory protein. Without IL-1Ra, the children's bodies ...

Immune genes adapt to parasites

... for making some of our immune proteins into the inflammatory defenders they are today, according to a ... in some of these genes are known risk alleles for inflammatory bowel diseases, such as Crohn's and celiac ... But this type of response also contributes to inflammatory bowel diseases. ...

Key protein regulating inflammation may prove relevant to controlling sepsis

... effective treatments against sepsis, the severe inflammatory condition caused by bacterial infection that ... team. "In doing so, WIP1 minimizes the extent of inflammatory response that could lead to septic shock and ... Dr. Tergaonkar and his colleagues compared the inflammatory response in mice lacking in WIP1 and in a control ...

Older men more likely than women to die after pneumonia

... The researchers measured blood levels of inflammatory indicators, including tumor necrosis factor (TNF) ... biomarkers that suggest men generate a stronger inflammatory and coagulation response and, perhaps, break up ... were gathered from the multicenter Genetic and inflammatory Markers of Sepsis (GenIMS) study. Participants ...

Peregrine's PS-targeting antibodies highlighted in AACR Annual Meeting studies

... resulting in the mobilization of important inflammatory and other anti-tumor components of the immune ... to tumors and causes an increase in several inflammatory cytokines while decreasing an important ... a significant increase in the production of inflammatory cytokines and chemokines. PGN632 also induced an ...

Laughter remains good medicine

... Care, Increases HDL Cholesterol and Attenuates inflammatory Cytokines and hs-CRP and Possible CVD Risk. They ... epinephrine and norepinephrine; HDL cholesterol; inflammatory cytokines TNF-α IFN-γ and IL-6, which ... to standard diabetes care may lower stress and inflammatory response and increase "good" cholesterol levels. ...

Laughter remains good medicine

... Care, Increases HDL Cholesterol and Attenuates inflammatory Cytokines and hs-CRP and Possible CVD Risk. They ... epinephrine and norepinephrine; HDL cholesterol; inflammatory cytokines TNF-α IFN-γ and IL-6, which ... to standard diabetes care may lower stress and inflammatory response and increase "good" cholesterol levels. ...

Team identifies a molecular switch linking infectious disease and depression

... levels of certain immune system proteins, called inflammatory cytokines, in the blood and brain. Mice ... that the depression seen in patients with inflammatory disease was due to a decrease in serotonin in the ... It supports interdisciplinary research on how inflammatory processes in the immune system and brain ...

UC Davis bench-to-bedside research: Promising treatment in clinical trials

... Davis to treat diabetes, hypertension and inflammatory has entered Phase II of human clinical trials to ... molecule implicated in diabetes, hypertension and inflammatory disorders. "It's an enzyme in the same ... drugs to treat type 2 diabetes, hypertension and inflammatory disorders, Hammock said. It is billed as the ...

La Jolla Institute signs exclusive license agreement with Medimmune on major asthma discovery

... diseases, including rheumatoid arthritis and inflammatory bowel disease. It is therefore possible that ... such as OX40L, might benefit some patients with inflammatory diseases, including asthma. MedImmune has a ... prevention and treatment of respiratory and inflammatory diseases, and currently has multiple programs ...

Shades of 1918? New study compares avian flu with a notorious killer from the past

... and other factors involved with the host's innate inflammatory response to infection. The result of this ... despite the broad and sustained upregulation of inflammatory genes, they were of no use in limiting the H5N1 ... which contribute directly to the overall inflammatory response." In this way, H5N1 delivers a ...

Jefferson scientists discover a key protein regulator of inflammation and cell death

... then binds to the foreign DNA and causes a rapid inflammatory reaction that sends a danger signal alerting the ... in the production of interleukin1beta and other inflammatory cytokines that cause inflammation. ... reacts to DNA and causes inflammation. The inflammatory response triggered when AIM2 binds to foreign DNA ...

The quest for specific anti-inflammatory treatment

... drugs affect the cells taking part in inflammatory processes, but also those that do not. This is ... in mind, the Basque research team, annulling the inflammatory capacity of the C1P molecule, was able to use it ... molecules. Inflammation and cancer inflammatory processes may have various causes, an infection, ...

Apolipoprotein(a): A natural regulator of inflammation

... as a natural and cell specific suppressor of the inflammatory response in vivo. In addition, a mechanism for ... functions as a cell specific suppressor of the inflammatory response." Dr. Steven R. Goodman, ... regulation of neutrophil recruitment during the inflammatory response". Experimental Biology and Medicine is ...

Researchers create new class of fluorescent dyes to detect reactive oxygen species in vivo

... oxygen that have been implicated in a variety of inflammatory diseases, including cancer and atherosclerosis. ... and either lipopolysaccharide endotoxin (LPS), an inflammatory molecule that binds to aortic cells and causes ... patients who are more likely to suffer from these inflammatory diseases," added Murthy. ...

New therapeutic target identified for rheumatoid arthritis

... therapeutic target that could be used to treat inflammatory disorders, such as rheumatoid arthritis. The ... new therapeutic target in the treatment of inflammatory disorders," said Lionel Ivashkiv, M.D., director ... Toll-like receptors leads to the production of inflammatory proteins or cytokines. Researchers have also ...

Researchers apply systems biology and glycomics to study human inflammatory diseases

... in cells is leading to new ways to understand how inflammatory illnesses and cardiovascular disease develop in ... molecular therapies to combat a broad range of inflammatory diseases. The binding of white blood cells to blood vessels is a key step in the progression of inflammatory diseases, explained Sriram Neelamegham, Ph.D., UB ...

Stress may make you itch

... activate immune cells in your skin, resulting in inflammatory skin disease. The related report by Joachim et ... in skin can over-react, however, resulting in inflammatory skin diseases such as atopic dermatitis and ... trigger an outbreak in patients suffering from inflammatory skin conditions. This cross talk between stress ...

New test promises quicker, more accurate evaluation for cystic fibrosis patients

... than current tests. The test, a measure of inflammatory gene expression, could improve patient care and ... through the lungs in the blood they encounter the inflammatory environment and alter their gene expression as a ... is associated with tissue destruction that allows inflammatory cells to move through tissue. This process is ...

LIAI launches new division to look at novel approaches to heart disease and inflammation

... system. "This opened up the possibility that the inflammatory process was important in heart disease," said Ley. Further study found that inflammatory T cells not only contributed to plaque formation, ... a heart attack. It is this aspect of the inflammatory process that draws Ley's primary attention. He ...

Dark chocolate: Half a bar per week to keep at bay the risk of heart attack

... of inflammation. It is known how a chronic inflammatory state represents a risk factor for the ... might have beneficial effects on the inflammatory state. Our results have been absolutely ... protein in their blood. In other words, their inflammatory state is considerably reduced." The 17% average ...

UC Davis researchers discover new drug target for inflammatory disease

... integrins, in order to measure changes in the inflammatory response due to sPLA2-IIA-integrin binding. They ... system. The involvement of integrins to the inflammatory process is of particular interest to study ... this blockage is enough to shut down an unwanted inflammatory response. "We cannot ignore integrins ...

US Air Force grant targets medical evacuation procedures

... believe there may be a direct link between inflammatory changes in the body and the timing of strategic ... of combat casualties affects the body's inflammatory response, possibly predisposing already ... weapon fire. "Each model has a different inflammatory response, all of them severe and relevant to ...

Johnson & Johnson honors 2008 recipients of the Dr. Paul Janssen Award for Biomedical Research

... target for rheumatoid arthritis and other chronic inflammatory conditions. "Thanks to their pioneering ... the lives of millions of patients with chronic inflammatory conditions," said Paul Stoffels, company group ... the treatment of people diagnosed with chronic inflammatory conditions. Feldmann and Maini investigated the ...

Biodegradable polymers show promise for improving treatment of acute inflammatory diseases

... their derivatives may improve treatment for such inflammatory illnesses as acute lung injury, acute liver failure and inflammatory bowel disease by delivering drugs, proteins and ... derivative aimed at enhancing the treatment of inflammatory bowel disease an illness that causes the large ...

Multiple Sclerosis: new MRI contrast medium enables early diagnosis in animal model

... and Wrzburg have been able to visualize inflammatory tissue damage, most of which had remained ... with certainty, especially if no (or very few) inflammatory lesions are present on MRI. "With this new ... demyelination visible in MRI MS is a chronic inflammatory disease of the central nervous system of unknown ...

Scientists suspect omega-3 fatty acids could slow acute wound healing

... difference between men and women in the amount of inflammatory proteins that are produced, because on average, ... level. Chronic wounds are essentially stuck in an inflammatory stage that slows or prevents transition to the ... which signal biological processes during the inflammatory stage of wound healing. The primary cytokines in ...

Weill Cornell science briefs June/July 2008

... neurologic malfunctions. News About inflammatory Bowel Disease, Crohn's Disease: Stem Cells ... at 212-746-5118. Drug for Treatment of inflammatory Bowel Disease New Formula Allows for Greater ... trials for a new drug for those who suffer from inflammatory bowel disease (IBD), say it is the best option ...

Small protein may have big role in making more bone and less fat

... and inflammation suppressor. It inhibits two key inflammatory molecules, NF-kB and AP-1, which turn on inflammatory genes in response to cytokines, such as TNF- and IL-1, involved in rheumatoid arthritis and other inflammatory diseases, Dr. Shi showed in research published on ...

International team identifies 21 new genetic risk factors for Crohn's disease

... 21 new genetic variants associated with the inflammatory bowel disorder, bringing the total number of risk ... Ramnik Xavier, MD, of the Center for the Study of inflammatory Bowel Disease in the MGH Gastroenterology Unit ... to better targeted drugs for Crohn's and other inflammatory bowel diseases." Daly is an assistant professor ...

Getting better with a little help from our 'micro' friends

... bacteria may offer a new type of treatment for inflammatory bowel disease, according to scientists at the ... suppress inflammation--and offer protection from inflammatory bowel disease. "Thus, bacteria help reprogram our ... be developed as a natural therapeutic for inflammatory bowel disease," says Mazmanian. ...

Scientists successfully treat new mouse model of inflammatory bowel disease

... produced the most accurate mouse model to date of inflammatory bowel disease (IBD), a cluster of conditions that ... the mice were incredible. They were filled with inflammatory T cells. We found the mice almost exactly ... into their guts to see if this restarts the inflammatory reaction," says Stappenbeck. Stappenbeck and ...

Lipoic acid could reduce atherosclerosis, weight gain

... for the development of atherosclerosis and other inflammatory vascular diseases in humans. The findings were ... a long-term process that is now seen as a chronic inflammatory disease, which begins when certain types of white ... to enter the arterial wall, there they become inflammatory macrophages that, in the presence of low density ...

Profound immune system discovery opens door to halting destruction of lupus

... and powerful molecular switch that controls the inflammatory response of the immune system. The major finding, ... mistakenly mounts an out-of-control destructive inflammatory attack against the bodys own tissues and organs. ... the immune system from mounting an out-of-control inflammatory response against invading viruses and bacteria. ...

DFG to establish 10 new collaborative research centers

... Research Centres: The Brain as a Target of inflammatory Processes is the topic of SFB/Transregional ... from Berlin and Gttingen. Research will focus on inflammatory and immune reactions in the brain, an area that ... attention in the past than research focussing on inflammatory processes outside the brain. The projects they ...

HATS off to combat asthma

... 700,000 to research transcriptional control of inflammatory gene expression in asthma allowing the team to examine the part inflammatory mediators play in the way asthma sufferers react ... There is also the potential to treat other inflammatory diseases, such as rheumatoid arthritis ...

Blood clotting protein linked to rheumatoid arthritis

... (fibrin), also plays an important role in the inflammatory response and development of rheumatoid arthritis. inflammatory joint disease appears to be driven by the engagement of inflammatory cells with fibrin matrices through a specific ...
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