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Inflammation in Biological News

Common allergy drug reduces obesity and diabetes in mice

... and immune systemsin this case, controlling inflammation in fat tissue. Fat tissue from obese and ... into the tissue. This can result in chronic inflammation that causes asthma and certain allergies. As ... an endocrinologist. "It's possible that the inflammation caused by macrophages results in insulin ...

LSUHSC's Bazan awarded ARRA grant to preserve vision

... research project explores the mechanisms of inflammation and repair during corneal wound healing. Sustained corneal inflammation may lead to destruction and corneal ulceration, but inflammation is a component of the corneal wound healing ...

Natural compound stops retinopathy

... The discovery of the compound's function in inflammation and blood vessel formation related to eye disease ... Oklahoma researchers found that this inflammation and leakage is caused by an imbalance of two ... in research models stopped the leakage, blocked inflammation and kept unwanted blood vessels from growing. ...

New trigger for chronic inflammation in rheumatoid arthritis discovered

... to attack the joint leading to the persistent inflammation of rheumatoid arthritis. The molecular switch ... system and that these will reduce the painful inflammation that is a hallmark of this condition," added Dr ... inflammation. The researchers induced joint inflammation in mice with and without the gene for tenascin-C. ...

Enzyme involved in inflammatory bowel disease discovered at Penn State College of Medicine

... their findings strongly correlate the severity of inflammation associated with both Crohn's disease and ... used a mouse model of IBD, replicating inflammation in the intestine like that in human ulcerative ... results indicate that meprin reduces the level of inflammation in the injured intestine. In the mouse model, ...

Omega fatty acid balance can alter immunity and gene expression

... this shift has brought about an increased risk of inflammation (associated with autoimmunity and allergy), and ... agents, resulting in increased systemic inflammation and a higher incidence of problems including ... found that many key signaling genes that promote inflammation were markedly reduced compared to a normal diet, ...

MCG researcher among first to receive NIH stimulus funding

... that cocaine use, which can cause increased inflammation and lead to heart and lung disease, might ... levels with blood levels of several inflammation biomarkers. inflammation is linked to chronic stress, which poses another ...

Key protein regulating inflammation may prove relevant to controlling sepsis

... WIP1, as the molecular "brake" that curbs severe inflammation in the body. The findings may prove ... importance of WIP1 as an effective suppressor of inflammation and explained how the body was able to cope with an excess of inflammation brought on by the hyperactivation of the ...

Vitamin D deficiency related to increased inflammation in healthy women

... that low vitamin D levels negatively impact inflammation and immune response, even in healthy women," said ... of Human Environmental Sciences. "Increased inflammation normally is found in people with obesity or ... healthy women," was published in the Journal of inflammation . ...

Gutsy germs succumb to baby broccoli

... also noted a greater than 50 percent reduction in inflammation of the primary target of this bacterium the body ... of Nrf2 in protection against H. pylori -induced inflammation and gastritis. Classified a carcinogen by the ... bacteria and blood tests to judge the severity of inflammation in the stomach lining; in addition, they looked ...

UC Davis bench-to-bedside research: Promising treatment in clinical trials

... hypertension are often associated with vascular inflammation as is atherosclerosis," Weiss said. "Last year we ... combined with the reduction of blood pressure, inflammation and diabetes is very attractive." The Phase ... failure and vascular inflammation." Vascular inflammation is involved in diabetes and obesity side effects. ...

High-fat diets inflame fat tissue around blood vessels, contribute to heart disease

... inflamed, suggesting that they could trigger inflammation of the blood vessels, an important component of atherosclerosis. They also found that the inflammation of fat tissues around the arteries of mice is ... a direct link between poor dietary habits and inflammation of blood vessels, mediated by the fat cells ...

DNA component can stimulate and suppress the immune response

... way of eliminating invaders. But high doses block inflammation by increasing expression of the enzyme ... the dosage can help them optimize the role of inflammation in fighting invaders such as tumors and harmful ... Center, they've also learned IDO inhibits inflammation by blocking production of interleukin 6, a ...

The quest for specific anti-inflammatory treatment

... molecule, they secrete molecules that generate inflammation - prostaglandin and cytokine cells, for example. ... an anti-inflammatory function without causing inflammation in other cells These analogues do not generate ... response to pro-inflammatory molecules. inflammation and cancer Inflammatory processes may have ...

Uncultured bacteria found in amniotic fluids of women who experience preterm births

... the infection and inflammation. Intra-amniotic inflammation is known to set off spontaneous births of preterm ... identify which germ is causing the infection and inflammation leading to preterm birth so that antibiotics are ... it was not just one bacterial species causing the inflammation but an abundance of different species in the ...

Tips from the American Journal of Pathology

... 174:164-176 New Candidate to Prevent inflammation Dr. Sonia Oliani and colleagues at So Paulo ... issue of The American Journal of Pathology . inflammation of the peritoneum is characterized by severe abdominal pain. This inflammation can be prevented by annexin A1, which inhibits ...

Scientists find link between inflamed gums and heart disease

... for some time that a protein associated with inflammation (called CRP) is elevated in people who are at risk for heart disease. But where's the inflammation coming from? A new research study by Italian and ... observed a reduction in oral bacteria, immune inflammation and the thickening of the blood vessels ...

LSUHSC research identifies key contributor to Alzheimer's disease process

... to be no more than a byproduct, in regulating inflammation and the development of Alzheimer's disease. The ... that it plays a crucial role in the regulation of inflammation and disease-related neuropathology thought to be ... amount and bioavailability of CFH, promoting the inflammation of brain cells and contributing to the ...

Vitamin C lowers levels of inflammation biomarker considered predictor of heart disease

... C-reactive protein (CRP), a central biomarker of inflammation that has been shown to be a powerful predictor of ... a daily dose of vitamin C lowered levels of the inflammation biomarker after two months compared with those ... percent of obese participants. "The low-grade inflammation that characterizes obesity is believed to ...

Drug-embedded microparticles bolster heart function in animal studies

... attack, the drug-embedded "microparticles" reduce inflammation and scarring, the researchers found. Injecting ... kinase, which is important during the damaging inflammation that occurs after a heart attack. Davis says ... to be broken down in the body, polyesters cause inflammation exactly what the drugs are supposed to stop, he ...

Statins may prevent miscarriages

... (aPL) antibodies in female mice caused inflammation that injured the placentas and induced abortions. ... a relationship between tissue factor and PAR2 in inflammation that could have implications for understanding ... is a characteristic feature of acute and chronic inflammation in conditions such as sepsis, atherosclerosis, ...

LIAI launches new division to look at novel approaches to heart disease and inflammation

... director of the Institute's recently launched inflammation Biology Division. "We hope we can bite off ... a scientist of Dr. Ley's stature lead our new inflammation Biology Division," he said. "Its creation puts ... immune-based approaches to heart disease, said inflammation caused by the immune system is also an important ...

UC Davis researchers discover new drug target for inflammatory disease

... have defined a cellular process that promotes inflammation and, at the same time, found an important ... impact of the finding on our ability to block inflammation and stop the disease process in its tracks is ... another. "We need to know the mechanisms of inflammation to be able to disrupt it," said Takada. "Now that ...

Scientists suspect omega-3 fatty acids could slow acute wound healing

... health and other diseases related to chronic inflammation because of their anti-inflammatory properties. But insufficient inflammation during the initial stage of wound healing may ... associated with initiating and sustaining inflammation were higher in the blister fluid in people who ...

Weill Cornell science briefs June/July 2008

... Crohn's Disease: Stem Cells Heal Chronic inflammation in the Gut May Help Restore Immune System to ... the ability of the immune system to control inflammation by secreting anti-inflammatory proteins into the ... immune response, leading to uncontrolled inflammation in the tissues of the intestine. Diarrhea, ...

Failure to bridle inflammation spurs atherosclerosis

... the ability of blood vessels to recover from inflammation atherosclerosis or hardening of the arteries can ... are produced in the blood vessel where the inflammation occurs, the researchers said. Chronic inflammation of the artery wall can cause atherosclerosis, a ...

New discoveries from Harvard and Baylor get to the heart of cardiovascular disease

... protein, called "ROCK1," profoundly reduces inflammation in the walls of blood vessels provoked by fatty ... when they come into contact with fatty deposits. inflammation is a normal byproduct of the clean-up process ... fatty deposits and mice showed significantly less inflammation and atherosclerosis. This discovery could lead to ...

Early treatment of stomach infection may prevent cancer

... stages of progression from gastritis, an inflammation of the mucous membrane layer of the stomach, to ... did not reverse the damaging changes, such as inflammation and development of precancerous lesions, to the ... from the lower bowel and colonize it, producing inflammation and progression to cancer, he said. . Findings ...

Inflammation triggers cell fusions that could protect neurons, Stanford research shows

... STANFORD, Calif. - Chronic inflammation triggers bone marrow-derived blood cells to ... ulcerative dermatitis. This type of chronic inflammation affects the entire immune system of the animal ... in the numbers of fused cells was related to inflammation by using the traditional radiation/bone marrow ...

Nutrition research unveiled this week shows pistachios are smart for the heart

... cardiovascular health by significantly reducing inflammation in the body, a prominent cardiovascular disease ... from all subjects and genetic expression of inflammation markers was measured. Study Highlights ... a heart-healthy diet also significantly reduced inflammation at the cellular level. ...

DFG to establish 10 new collaborative research centers

... (SFBs) will address a range of topics, including inflammation of the brain, the distribution of oxygen in ... plan include an attempt to find out what role inflammation plays in traumatic and neurodegenerative ... may be of great importance for use in inhibiting inflammation or providing protection against viral infections, ...

HATS off to combat asthma

... that result in the symptoms of asthma and COPD inflammation of the airways which can lead to coughing, ... is these transcription factors which activate the inflammation by causing release of mediators and cytokines. ... and HDACs suppressed with the result that inflammation is switched on. The investigators at the ...

Story ideas from the Journal of Lipid Research

... Progression of Atherosclerosis While chronic inflammation is a known risk factor for atherosclerosis ... have now shown that the sporadic but recurrent inflammation caused by Crohns disease also poses serious ... than healthy individuals, revealing that acute inflammation episodes not only reduce total HDL, but alter the ...

Nanoengineers mine tiny diamonds for drug delivery

... the paper, is that nanodiamonds do not cause cell inflammation once the drug has been released and only bare ... present) and analyzed three genes associated with inflammation and one gene for apoptosis, or cell death, to see ... circuitry of the cell, they found no toxicity or inflammation long term and a lack of cell death. In fact, the ...

Story ideas from the Journal of Lipid Research

... that a lipid known to protect the heart from inflammation and to cause skin allergic reactions also reduces inflammation of the kidneys. The discovery could help devise ... responses that activate proteins that increase inflammation and can even result in the death of the cell. UPR ...

Neuropathic pain: The sea provides a new hope of relief

... that this new compound could be a candidate. Recent research suggests inflammation in the nervous system is a major causative factor for this condition. inflammation activates supporting cells, such as microglia and astrocytes, that ...

Scientists open doors to diagnosis of emphysema

... this test to samples of lung cells from a mouse model of acute lung inflammation showed that MMP12 activity in macrophages was indeed increased. ... the new testing strategy can be extended to other enzymes involved in lung inflammation and that, with a better picture of the processes underlying these ...

Scientists uncork a potential secret of red wine's health benefits

... of sepsis develop a very low quality of life due to the damage that inflammation causes to several internal organs. The ultimate goal of our study was to ... inflammation. They found that resveratrol used a one-two punch to stop inflammation in the mice by preventing the body from creating two different molecules ...

Placenta-derived stem cells may help sufferers of lung diseases

... cells as a therapeutic tool for disorders characterized by inflammation and fibrosis is supported in previous studies," says Dr. Ornella Parolini, ... confer benefits for bleomycin-induced lung injury. While the severity of inflammation did not show an overall reduction, there was a marked reduction in ...

Gene expression findings a step toward better classification and treatment of juvenile arthritis

... a diagnosis of JIA is imprecise and based largely on the presence of joint inflammation persisting for at least six weeks, for which no other cause can be ... five or more joints), systemic arthritis (with fever and rash and inflammation throughout the body) and enthesitis-related arthritis (affecting the ...
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