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Infective in Biological News

Potential new drug target to fight tuberculosis identified

... with bone marrowderived macrophages during the infective process. "That's a huge change from standard ... to see if biochemical actors would emerge in the infective process that might be inoperative in the usual in ... by targeting an element involved directly in the infective process, we may develop a line of drugs that work ...

Lymph nodes can be key in spreading prion infectivity

... nodes can be crucial for spreading low doses of infective prion agents -the pathogens responsible for ... within six days after a high or a medium dose of infective agent has been administered, the animal still ... study). The results suggest that for low doses of infective agent the lymphoreticular system is important in ...

New step forward in search for solution to infection puzzle

... in the development of new treatments for serious heart conditions such as infective endocarditis. The researchers studied the way a protein found on the ... development of new treatments for rare but serious conditions such as infective endocarditis, an infection of the lining or valves of the heart." ...

MU scientists 'see' how HIV matures into an infection

... It has to be activated to do its job," Tang said. "What we were able to see is how it self-activates from an immature form when the virus is not infective into a mature form when the virus gains infectivity." Tang and his colleagues used a novel NMR method called paramagnetic resonance relaxation ...

Worm genome offers clues to evolution of parasitism

... the worms live in a "resting" stage in which they don't eat or reproduce. This suspended state, called dauer diapause, is thought to be the infective state of parasitic nematodes. According to the World Health Organization, parasitic nematodes infect about 2 billion people worldwide and severely ...

Caltech researchers find dual-use sexual attraction and population-control chemicals in nematodes

... dauer stage." In this alternate state, the worm larvae can withstand harsh environmental conditions. "The dauer stage is important because it is the infective stage in a lot of parasitic nematodes," he says. The scientists found that purified samples of the chemicals, dubbed ascr#2, ascr#3, and ascr#4, ...

Fight weeds with plant pathogens

... that are isolated from weeds and are grown to produce large numbers of infective propagules (such as spores). infective propagules are applied at rates that will cause high levels of infection, ...

Worm hormone discovery may aid fight against parasitic disease

... because the dauer diapause stage of C. elegans is very similar to the infective state of parasitic nematodes. According to the World Health Organization, ... million, at least 50 percent of whom are school-age children. In the infective state, parasitic nematodes, such as hookworms, remain in a larval, ...

Mass production of human papillomavirus could lead to gains against cervical cancer

... to producing HPV in the laboratory has been that in the early stage of its infective cycle, the virus lurks in undifferentiated basal epithelial (skin) cells, ... epithelial cells begin differentiating does the virus emerge as distinct, infective viral particles, called virions. Thus, said Ahlquist, infectious HPV virus ...

Ebola outbreaks killing thousands of gorillas and chimpanzees

... routes other than direct social encounter. For instance, as many as four different gorilla groups fed in the same fruit tree on a single day. Thus, infective body fluids deposited by one group might easily be encountered by a subsequent group. Chimpanzees and gorillas also fed simultaneously in the same ...

Prion disease treatable if caught early

... Prion disease—such as the version of Creutzfeldt-Jakob disease believed to be contracted from cattle with "mad cow disease"—is caused by aberrant, infective proteins. It has been thought that the disease is untreatable. However, in previous studies with prion-infected mice, Mallucci and colleagues ...

New human retrovirus originated in mice

... leukemia virus is known as an endogenous virus because it normally exists as an integrated part of the mouse genome, rather than as independent, infective particle. MuLV is also a retrovirus, meaning its genetic material is in the form of RNA. The RNA is then reverse transcribed into DNA that is ...

Major WHO study concludes calcium supplements can reduce complications during pregnancy

... after failure of treatment with protease inhibitors, drugs that block the action of the enzyme protease and prevent the virus from making mature, infective copies of itself. When protease inhibitors fail -- as they often do with a fast-mutating virus like HIV -- new drug targets become vital. ...

Computer simulation hints at new HIV drug target

... after failure of treatment with protease inhibitors, drugs that block the action of the enzyme protease and prevent the virus from making mature, infective copies of itself. When protease inhibitors fail -- as they often do with a fast-mutating virus like HIV -- new drug targets become vital. ...

New evidence questions the simple link between prion proteins and madcow disease

... in to the lymph. It was not, however, taken up by structures called Peyer's nodules, that are believed to be the places where animals amplify the infective agent. "The fact the PrP isn't taken up by the Peyer's nodules questions whether PrP is really infectious, or whether PrP is really just a ...

Metal-containing compounds show promise as HIV weapon

... the rays are deciphered. The metallacarboranes appeared to occupy the portion of the protease used to hold key proteins in place as part of the infective cycle of HIV, preventing the proteases from working. Other advantages are that the compounds are stable and can be modified in many ways by ...

Visceral Leishmaniasis: Successful Vaccine Trial In Dogs

... Lemesre J.L. (1999). Leishmania Spp: completely defined medium without serum and macromolecules (CDM/LP) for the continuous in vitro cultivation of infective promastigote forms. Am. J. Trop. Med. Hyg., 60 (1), 41-50. Brevets : Lemesre J.L. (1993). "Procédé de culture in vitro de différents stades ...

Nanobacteria in clouds could spread disease, scientists claim

... to be inevitable," said Dr Sommer. The scientists argue that their occurrence in clouds could play a crucial role in the global dispersal of infective agents, and might also play a prominent role in the nucleation of cloud drops. "This happens because nanobacteria, lifted from the ground by ...

Stealth Worms May Improve Insect Pest Control

... a perfect environment for the EPN to grow and multiply. One or more adult generations live entirely inside the decaying insect. The third stage infective juvenile is the only one that can live outside the insect host. Numbering about 150,000 strong or more, these juveniles exit the dead larva, carrying ...

Fibril Shape Is The Basis Of Prion Strains And Cross-species Prion Infection

... event led to a new strain of Candida prion fibrils that could in turn infect Saccharomyces. Although fibril shape appears to be the deciding infective factor, amino acid sequence is still important because it defines a set of possible preferred fibril shapes that prions can adopt, Weissman says. ...

Reducing malarial transmission in Africa

... its low cost. Altogether, the six-dose regimen of co-artemether was highly effective at reducing whether and how long children had gametocytes - the infective form of the malarial parasite - in their blood. The numbers of gametocytes carried and how able they were to infect mosquitoes 7 days later was also ...
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