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Infection in Biological News

First genetically-engineered malaria vaccine to enter human trials

... Professor Alan Cowman, head of the institute's infection and Immunity division, said in developing the ... the malaria parasite is halted during its liver infection phase, preventing it from spreading to the blood ... provide protection against subsequent malaria infection in animal models and humans in developing the ...

Discovery to aid in future treatments of third-world parasites

... of the neglected tropical diseases, is caused by infection with parasitic helminths of the genus ... inducing Th2 responses commonly elicited by infection with parasitic worms. Ultimately, these novel ... Thus, understanding the immune response to infection with parasitic worms might aid in ameliorating ...

Researchers capture bacterial infection on film

... living host. Whilst most studies of bacterial infection are done after the death of the infected ... of Exeter is the first to follow the progress of infection in real-time with living organisms. The ... and determine their specific roles in the infection process. The scientists are hoping to use this ...

Parasitic worms make sex worthwhile

... sexual reproduction allows host species to avoid infection by their coevolving parasites by producing ... native worms, but extremely resistant to the infection of worms from other lakes. Furthermore, they ... lake were far more likely to be susceptible to infection if they came from the shallows, where snails ...

Scientists link immune system's natural killer cells to infant liver disease

... by one of the immune system's key weapons against infection natural killer, or NK, cells to the onset of ... been traced to the immune system responding to an infection in the liver and bile ducts. Surface tissues ... experiments, the scientists used a rotavirus infection to induce biliary atresia in newborn mice. ...

Penn-Wistar team gains insight into HIV vaccine failure

... analysis showed no efficacy in preventing HIV infection in at-risk individuals. It was noted that a ... explanation for this increased susceptibility to infection remains a major focus for HIV vaccine ... Antibodies produced in response to previous infection neutralize viruses by binding to them and ...

C. difficile spores spread superbug

... team of scientists have successfully mirrored the infection cycle of C. difficile by generating a 'mouse ... transmitted. The results have implications for infection control measures in the healthcare environment ... dealing with patients who exhibit the symptoms of infection - including diarrhoea and fever. But today's ...

New lab test offers better prediction of HIV microbicide safety

... sulfate actually increased the risk of HIV infection in women. "Our goal was to develop assays ... in the lower chamber, and then monitoring the infection of the T cells over time. When the ... that microbicides can increase the risk of HIV infection through a mechanism other that inflammation ...

Study characterizes eczema patients most at risk for dangerous viral infections

... meningitis. The widespread herpes simplex skin infection is known as eczema herpeticum. Vaccinia virus, ... or had it in the past are susceptible to this infection when they receive a smallpox vaccination. This ... susceptibility of eczema patients to the vaccinia infection and to search for ways to protect against it. ...

Tummy troubles -- gastrin key in bacterial-induced stomach cancer

... deaths world-wide. Helicobacter infection results in increased expression of gastrin, a ... NY examined the contribution of Helicobacter infection to gastric cancer in animal models with either ... gastrin at all. They found that Helicobacter infection in mice with high levels of gastrin resulted in ...

Tips from the journals of the American Society for Microbiology

... human cases and 250 deaths from H5N1 virus infection have been reported since 2003. Much is still ... and H/K 486 virus caused a similar systemic infection in INF-a/β receptor-deficient mice, however, ... specifically, normal injections of L5 prior to infection greatly reduced rates of death and ...

Antibiotics take toll on beneficial microbes in gut

... Clostridium difficile , a growing and serious infection problem for hospitals. Normally, a set of ... of the study, which appears in the June issue of infection and Immunity . The study results suggest that ... are associated with recurring C. difficile infection in human patients. Young cautions against ...

The challenges of avian influenza virus: Mechanism, epidemiology and control

... research field. Early 2009, eight human infection cases of H5N1 highly pathogenic avian influenza ... 19th century. However in 1997, the first human infection case with fatality and the virus identified as ... an H5N1 virus isolation. This is the first human infection case in the mainland China. Now we know many ...

TB -- hiding in plain sight

... million people worldwide die from tuberculosis infection every year. Due in part to inappropriate ... development of clinical disease at the site of infection in human TB. They found that while the immune ... in human TB could be part of the reason why infection is never completely eradicated but instead ...

Glutamine supplements show promise in treating stomach ulcers

... the infection." Eventually, she notes, years of infection result in a combination of persistent gastritis, ... of the stomach pathologies during H. pylori infection [including cancer progression] are linked to high ... global cancer burden is attributed to H. pylori infection and, worldwide, over 900,000 new cases of gastric ...

Bacteria play role in preventing spread of malaria

... gut of the Anopheles gambiae mosquito inhibit infection of the insect with Plasmodium falciparum , the ... the mosquitoes more susceptible to Plasmodium infection because of a lack of immune stimulation. Their ... factors that are needed to control the mosquito's infection from the microbes are also defending against the ...

Scientists learn why the flu may turn deadly

... appeared to be specifically a result of influenza infection and was not seen in patients with respiratory ... who die from influenza, die from a bacterial infection occurring on top of the virus. "Despite major ... flu outbreak of 1918 and 1919, influenza virus infection remains a very serious threat," said John Wherry, ...

Mosquito parasite may help fight dengue fever

... by killing the insects before they can pass the infection on, O'Neill and his team successfully infected ... affects Ae. aegypti as they age and the infection takes hold. Working with uninfected and infected ... Most surprisingly, as the mosquitoes aged and the infection took hold, it did not increase their activity ...

Older men more likely than women to die after pneumonia

... April 29 Differing biological response to infection between men and women may explain higher death ... men with CAP were less likely to survive after an infection compared to women and this was not explained by ... largest study comparing biological response to infection between men and women. Our results suggest that ...

Mass Biologic Labs/UMass Med School and Medarex license C. difficile monoclonal antibody to Merck

... A and B, for the treatment of C. difficile infection (CDI). CDA-1 and CDB-1 were co-developed by ... equally. The incidence of C. difficile infection (CDI) in the U.S. is rapidly increasing, with ... of CDI per year by 2010 . " C. difficile infection is the primary cause of infectious diarrhea in ...

HIV dearms protective protein in cells

... that in human cells in which Vpu was formed after infection with HIV, the pool of CD317 was reduced to about ... of Vpu does not affect protection against infection in animals," said Dr. Christine Goffinet, first ... important when one wants to imitate and study HIV infection in rats in an animal model ...

A cure for honey bee colony collapse?

... syndrome. They then went on to treat the infection with complete success. In a study published in ... destructor, IAPV or pesticides), other than infection with Nosema ceranae . The researchers then ... could be responsible, we can look for signs of infection and treat any infected colonies before ...

HIV pays a price for invisibility

... who have certain types of HLA proteins control infection better than others. In people with HLA-B*5703, ... infected with triple-mutant virus passed the infection to a partner who either did or didn't have the ... the avoidance of killer T cells allowed the infection to rapidly proceed to clinical illness. This ...

Gutsy germs succumb to baby broccoli

... sprouts containing sulforaphane did not cure infection by the bacterium Helicobacter pylori ( H. ... researchers assessed the severity of Helicobacter infection at the start of the study, after four and eight ... stomach cancer. But the fact that the levels of infection and inflammation were reduced suggests the ...

Researchers discover primer to plant defense system

... that plants can boost their overall immunity to infection once they have a local exposure to certain ... a series of steps, beginning with a primary infection that causes the plant to induce defenses to contain the spread and growth of the pathogen. The infection causes the plant to produce more azelaic acid, ...

MDC researchers prevent virus induced myocarditis

... Berlin-Buch, Germany, have now abolished the infection by blocking the receptor which is required for ... of the heart muscle associated with this virus infection did not develop," Dr. Shi said. ( Journal of ... mice without CAR were protected from cardiac infection caused by the Coxsackievirus. Moreover, the mice ...

Penn medicine draws road map for elimination of central line-associated bloodstream infections

... combining leadership initiatives, electronic infection surveillance, checklists to guide line insertion ... MD, director of Healthcare Epidemiology and infection Prevention and Control at the 735 bed ... leadership teams to monitor hospital-acquired infection data in real time, and to rapidly identify ...

Press statement on new CDC MMWR on Klebseilla pneumonia Carbapenemase-producing organisms

... Control and Prevention (CDC) today released new infection control recommendations on Klebseilla pneumoniae ... in the MMWR, CDC recommends an aggressive infection control approach to limit the emergence of these ... in most parts of the country, an aggressive infection control approach needs to be taken now. These ...

Cutting-edge amfAR grants fight HIV/AIDS in the lab and on the phone

... networking technologies to the prevention of HIV infection Hongjie Liu, Ph.D. Virginia Commonwealth ... the rhesus form of the protein can inhibit HIV infection while the human form cannot. Dr. Christensen will ... development of therapeutics to slow the spread of infection inside the body. Akira Ono, Ph.D. The ...

A worm-and-mouse tale: B cells deserve more respect

... By studying how mice fight off infection by intestinal worms a condition that affects ... mature into useful cells which can then fight an infection efficiently. In the new paper, Lund's team ... in this case, a mouse actually fights off infection by a parasite. They chose to study the intestinal ...

Scientists identify human monoclonal antibodies effective against bird and seasonal flu viruses

... into the host cell, thereby preventing further infection of host cells and the rise of escape mutants. ... the prevention and early treatment of influenza infection and disease," said Wayne A. Marasco, M.D., Ph.D., ... the same antibody protected mice from a lethal infection with a very different virus such as the H1N1 ...

Scientists identify human monoclonal antibodies effective against bird, seasonal flu viruses

... into the host cell, thereby preventing further infection of host cells and the rise of escape mutants. ... the prevention and early treatment of influenza infection and disease," said Wayne A. Marasco, M.D., Ph.D., ... the same antibody protected mice from a lethal infection with a very different virus such as the H1N1 ...

When acute hepatitis develops into chronic hepatitis

... results can help doctors to discover whether an infection is curable or whether by settling in the liver, ... hepatitis B. The most common symptom of an acute infection is jaundice. In 5% of the infections, the disease ... (Treg). Whilst the effector T cells fight a virus infection and kill off the infected host cells, the Treg ...

Swimmers at public beaches show increased risk of exposure to contagious staph bacteria

... its kind. "This exposure might lead to staph infection since people colonized with the bacteria carry it ... taking precautions to reduce the risk of infection by showering thoroughly before entering the water ... can live in coastal waters, and the uptake and infection rate associated with the beach exposures. ...

Herpes virus: To vaccinate or not to vaccinate

... lifelong latent infections, are resistant to infection with bacterial pathogens. Although ... "We discovered that the effect of herpesvirus infection is transient, lasting only a few months. ... infections. Dr. Virgin suggested that "decreased infection may be associated with unintended negative ...

Shades of 1918? New study compares avian flu with a notorious killer from the past

... was sustained, from the point of initial infection through the 7 days of the study, as seen in ... associated tissue destruction. "The fact that the infection of type II pneumocytes was so protracted directly ... cells, suggesting they were destroyed during the infection process, which would point to H5N1's ability not ...

Brain structure assists in immune response, according to Penn vet study

... time the body's immune response to a parasitic infection in the brain. The findings provide unexpected ... the central nervous system during toxoplasma infection or how the immune system keeps this parasite in ... how the immune system is able to control infection in the brain. Using recent advances in two-photon ...

Research elucidates way lungs fight bacteria and prevent infection

... white blood cells as possible at the site of an infection is beneficial, but on the other hand too many ... thick and sticky, leaving the lung more prone to infection and inflammation, while still killing ... get the optimal number of white blood cells to an infection site without letting inflammation spiral out of ...

UD research study to shed light on emerging seaborne pathogen

... fever and chills for a few days, although the infection can be fatal in those with weakened immune ... "emerging pathogen." An estimated 4,500 cases of infection occur each year in the United States, according ... usually causes a gastrointestinal infection that lasts two to three days, although ...

Uncultured bacteria found in amniotic fluids of women who experience preterm births

... analysis of the placenta to corroborate the infection and inflammation. Intra-amniotic inflammation ... important to identify which germ is causing the infection and inflammation leading to preterm birth so that ... relationship between intra-amniotic bacterial infection and the onset of preterm birth," said Han. The ...
Other Contents
(Date:4/17/2014)... Medical Branch at Galveston are the first to ... cervical cancer should begin colorectal cancer screening earlier ... finding a high incidence of secondary colorectal cancers ... new recommendations that the younger women in this ... after their initial cervical cancer diagnosis instead of ...
(Date:4/17/2014)... way the immune system may fight cancers and viral ... cells to treat illness. , The research, in mice, ... "neighborhood police" specialized squads of defenders that patrol ... entire city, the body. , Scientists at Washington University ... the liver, skin and uterus each has dedicated immune ...
(Date:4/17/2014)... Modern View of Domestication," a special feature of ... Sciences ( PNAS ) published April 29, raises ... our deep history that most of us take for ... people in many spots around the globe shifted from ... livestock and plants. , It seems so straightforward and ...
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(Date:4/18/2014)... prepped to enter the battle against infectious disease. ... in remote areas, thanks in part to knowledge ... International Space Station on the behavior of liquids. ... flow to diagnose infectious diseases such as HIV/AIDS ... at Northwestern University in Evanston, Ill., had been ...
(Date:4/18/2014)... 18, 2014) Benaroya Research Institute at Virginia Mason ... a particular molecule in metastatic breast cancer reduces both ... lung metastases. BRI scientists have found in models of ... by 60 - 80 percent and can keep the ... $1.8 million five-year grant comes from the National Cancer ...
(Date:4/17/2014)... The presence of chronic inflammation in benign ... prostate cancer, and this association was found even ... according to a study published in Cancer ... the American Association for Cancer Research. , An ... participants of the placebo arm of the Prostate ...
(Date:4/17/2014)... a study published today in PLOS Pathogens , ... malaria is common can mount an immune response to ... avoid repeated bouts of high fever and illness and ... bloodstream. The findings may help researchers develop future interventions ... malaria parasite. , Each year, approximately 200 million cases ...
(Date:4/17/2014)... Le Bonheur Children,s Hospital Pediatrician-in-Chief Jon McCullers, MD, ... the April issue of Nature Reviews Microbiology ... Dr. McCullers, a world-renowned infectious disease specialist, ... the University of Tennessee Health Science Center, analyzed ... 1918, 1957 and 1968 pandemics, as well as ...
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