Reprogramming human cells without inserting genes
... cells, back to a more pluripotent state. Called induced
pluripotent stem cells (iPS), these reprogrammed ... out of control and cause tumors.
The first induced
pluripotent stem cells were created in 2007 by ... of the skin cells, precisely as would occur in induced
pluripotent stem cells. "This was an exciting ...
New method developed by UC San Diego bioengineers gives regenerative medicine a boost
... of epigenome," he added. "The application to induced
pluripotent stem cells is one example to ... will have profound implications on the use of induced
pluripotent cells for personalized regenerative ...
"We have already compared fibroblasts with induced
pluripotent stem cells, which was to examine what ...
Peregrine's PS-targeting antibodies highlighted in AACR Annual Meeting studies
... showing that the anti-PS antibody induced
a sequential release of cytokines and ... the researchers showed that in vitro, PGN635 induced
antibody-dependent death of endothelial cells, ... cytokines and chemokines. PGN632 also induced
an increase in the expression of cell-surface ...
HIV-1 protease inhibitor induced oxidative stress in pancreatic B-cells: thymoquinone protection
... (UCP2) levels were up-regulated during nelfinavir induced
oxidative stress and directly affected the ATP ... tested the hypothesis that nelfinavir induced
oxidative stress was responsible for the ... the investigators postulated that nelfinavir induced
oxidative stress may be ameliorated by the ...
'Fish technology' draws renewable energy from slow water currents
... operate efficiently.
VIVACE stands for Vortex induced
Vibrations for Aquatic Clean Energy. It doesn't ... hydrokinetic energy system that relies on "vortex induced
vibrations are undulations that a rounded or ...
Research identifies type of vaccine that holds promise in protecting against TB
... only was it as safe as the standard vaccine, it induced
a better immune response, which suggests it will ...
Researchers compared five immune functions induced
by the vaccines and found that the investigational vaccine induced
more powerful responses that are important for ...
A search for protection against chemotherapy cardiotoxicity
... administration prevents acute cardiotoxic effects induced
by doxorubicin and trastuzumab exposures. The ... an important issue for oncology. Cardiomyopathy induced
by chronic chemotherapy may result, at least in ... rhEPO administration prevents cardiac damage induced
by an acute doxorubicin or trastuzumab exposure, ...
Stem cell research: From molecular physiology to therapeutic applications
... from adult bone marrow, the umbilical cord and the placenta could also be induced
to differentiate into a variety of different tissues. In this issue, we ... avoid immunorejection of either nuclear transfer embryonic stem cells or induced
pluripotent stem cells. On the other hand, recent post mortem analysis of ...
Tummy troubles -- gastrin key in bacterial-induced stomach cancer
... for the protection from mucosal damages caused by gastric acid secretion induced
by gastrin itself, and thus either too much or too little gastrin can ... gastric carcinogenesis. These include specific cytokines and chemokines induced
by Helicobacter infection, and modulated by gastrin, that link ...
Tips from the journals of the American Society for Microbiology
... activity in the abdominal cavity.
"In conclusion, we found that L5 induced
the activation of the host immune responses and protected the mice from ... against the 1918 viral challenge. Mucosal vaccination with 1918 VLPs induced
higher levels of cross-reactivity in mice and complete survival in ferrets ...
Combined stem cell-gene therapy approach cures human genetic disease in vitro
... human genetic disease can be cured using a combination of gene therapy and induced
pluripotent stem (iPS) cell technology. The study, published in the May ... laboratory. They then successfully reprogrammed the repaired cells into induced
pluripotent stem (iPS) cells using a combination of transcription factors, ...
International Serious Adverse Events Consortium announces initial study results in its global research collaboration to identify genetic markers related to drug induced liver injury
... genetic markers that may predict individuals at risk for serious drug induced
liver injury (DILI). The SAEC is a nonprofit research corporation, ... to the discovery that HLA-B*5701 is a major determinant of liver injury induced
by flucloxacillin. Flucloxacillin is an antibiotic widely used in Europe ...
Using high-precision laser tweezers to juggle cells
... system, allows the researchers to study how single cells react to stress induced
by a constantly changing environment.
Studies on how cells react to ...
'The method can be used to reveal how a cell reacts to stress induced
by a change in its environment. The information gained from this may ...
Drug prevents seizure progression in model of epilepsy
... Barth asked whether paxilline could reduce or prevent experimentally induced
seizures, as it could normalize aberrant brain activity induced
by previous seizures. Remarkably, Barth and colleagues Jesse Sheehan and ...
Novel electric signals in plants
... out that the new electrical signal they called "system potential" was induced
and even modulated by wounding. If a plant leaf is wounded, the signal ... "We may be on the trail of an important signal transmission system that is induced
by insect herbivory. Within minutes the whole plant is alerted and the ...
Researchers uncover 'obesity gene' involved in weight gain response to high-fat diet
... liver damage, in humans.
The researchers found that a diet rich in fat induced
production of this gene, called protein kinase C beta (PKC beta), in the ... than did mice eating a regular diet.
"So we now know this gene is induced
by a high-fat diet in fat cells, and a deficiency of this gene leads to ...
Cancer-causing gene discovery suggests new therapies
... increased protein production could slow or stop cancer's runaway growth induced
by Myc. Rapamycin, for example, an immunosuppressant drug already in ... process is for cancer formation."
To test whether protein production induced
by Myc played a role in cancer, the UCSF- led team genetically crossed two ...
JDRF-funded researchers discover proteins regulating human beta cell replication
... scientists thought that these important pancreatic cells could not be induced
to regenerate, or could only replicate very slowly," explained Dr. ... model.
"The question as to whether and how human beta cells can be induced
to proliferate is a fundamentally important one for JDRF's Regeneration ...
Human beta cells can be easily induced to replicate, according to study in Diabetes
... at the University of Pittsburgh School of Medicine have successfully induced
human insulin-producing cells, known as beta cells, to replicate robustly ... scientists thought that these important pancreatic cells could not be induced
to regenerate, or could only replicate very slowly," explained senior ...
AGU journal highlights -- Dec. 31, 2008
... First, a reduction of monsoon intensity in the lower troposphere induced
by the dust surface cooling can cause a reduction of precipitation. Second, an "elevated heat pump" effect in the higher troposphere induced
by warming dust caused an increase of precipitation. In standard models, ...
James Thomson receives 2008 Massry Prize honoring stem cell researchers
... of human embryonic stem (ES) cells and his subsequent work in developing induced
pluripotent stem (iPS) cells.
The Meira and Shaul G. Massry Foundation ... for contributions to stem cell science that led to the 2007 discovery of induced
pluripotent stem (iPS) cells. "I am honored to be among the scientists ...
New molecular insight into vertebrate brain development
... on vertebrate neural tube development. Increased YAP/TEAD activity induced
neural progenitor cell overproliferation and the formation of an expanded ... led to increased cell death, while repression of YAP/TEAD target genes induced
premature neuronal differentiation.
Owing to the evolutionary ...
Previous abortions and exercise: Do they affect pregnancy?
... Women who have had two or more induced
abortions have a reduced risk of pre-eclampsia by 60 %. It is not ... who have aborted
One study shows that women who have had two or more induced
abortions reduced their risk for pre-eclampsia by 60 percent. That is, ...
Ben-Gurion University of the Negev researchers help find that hypnosis can induce synesthesia
... rather, their brains may simply do more 'cross talking' which can be induced
by changing inhibitory processes in the average brain.
The research, ... posthypnotic suggestion to show that people who are not synesthetes can be induced
to have synesthetic experiences.
After inducing digit-color ...
Landmark study unlocks stem cell, DNA secrets to speed therapies
... said. "We also can make a kind of artificial embryonic stem cells, called induced
pluripotent stem cells, out of many adult cell types, but there are two ... so that we can efficiently and safely create patient-specific induced
pluripotent stem cells or even coax the body's cells to change their ...
October 2008 GEOLOGY and GSA TODAY media highlights
... new way to concentrate gold. GSA TODAY compares present microbially induced
sediment structures to microbial communities preserved in Earth history ... on past sedimentary environments and processes is provided by microbially induced
sedimentary structures (MISS). MISS are produced by the interaction ...
Relearning process not always a 'free lunch'
... to the particular method used to induce forgetting.
If forgetting is induced
by random fluctuations in the strength of synaptic connections, then ... will be observed. However, the authors show here that if forgetting is induced
by directional decay in synaptic connectivity,
then negative free-lunch ...
Michael J. Fox Foundation Funds $1.1 Million for Cutting-edge Approaches to Parkinson's Disease
... Gene silencing techniques and induced
pluripotent stem cell technology are among the cutting-edge approaches to ... UK) are conducting two separate investigations using newly discovered induced
pluripotent stem cell (iPS) technology to shed greater light on the ...
Getting better with a little help from our 'micro' friends
... the molecule and its action, the scientists used experimental mice and induced
changes to their intestinal bacteria by exposing them to a pathogenic ... molecule.
In particular, Mazmanian and his colleagues found that PSA induced
particular immune-system cells called CD4+ T cells to produce ...
UCLA stem cell researchers create heart and blood cells from reprogrammed skin cells
... as embryonic stem cells.
The finding is the first to show that induced
pluripotent stem cells or iPS cells, which dont involve the use of embryos ... differentiation potential. MacLellans study proved that iPS cells can be induced
into becoming cardiovascular cells, an important step in the confirmation ...
Cause and affect: Emotions can be unconsciously and subliminally evoked, study shows
... feelings and behavior to determine whether specific emotions were induced
without awareness of their causea study based on the theory implying that, ... the super-quick (40ms) speed exposure, only a general negative mood was induced
without a specific emotion involved. These empirical findings are the ...
How what and how much we eat (and drink) affects our risk of cancer
... developing multiple cancers. However, a negative energy balance state, as induced
by calorie restriction, decreases these risks in most instances, the ... weekly for the duration of the study.
Negative energy balance, as induced
by both 15 percent and 30 percent calorie restriction, led to inhibition ...
3 Columbia University Medical Center faculty elected to Institute of Medicine
... work is an unusual transcriptional repressor called Blimp-1 (B lymphocyte induced
maturation protein). Her studies on Blimp-1 are revealing important ... and cortical excitability and in long-lasting changes in the hippocampus induced
by repeated seizures.
Carolyn L. Westhoff, M.D., is professor of ...
Improved e-jet printing provides higher resolution and more versatility
... CHAMPAIGN, Ill. By combining electrically induced
fluid flow with nanoscale nozzles, researchers at the University of ... fields to pull the fluid out. Although the concept of electric-field induced
flow is not new, the way the research team has exploited this phenomenon ...
A gene for metastasis
... Complex Systems Department, Ben-Zeev then compared the expression of genes induced
by L1-CAM in cultured colon cancer cells to those in 170 samples of ... patients, and in 40 samples of normal colon tissue. Out of some 160 genes induced
by L1-CAM, about 60 were highly expressed in the cancerous tissue, but not ...
Key to out-of-control immune response in lung injury found
... auto-immunity through regulation of T- and B-cells.
When sepsis was induced
in mice with and without the Cblb gene, there was a marked difference in ... that controls the production of inflammatory cytokines, called NF-kB, is induced
in lung tissue after sepsis by that receptor to a much greater extent from ...
New stem cell research could reduce number of animal experiments
... tissues such as neurones or skin cells.
Whilst previously most stem cells were derived from embryos, this new research project will instead use induced
Pluripotent Stem cells (iPS cells) which are made from skin cells from adults.
Dr Subramanian has been awarded a major three year grant by the ...
Humans 'damaging the oceans'
... around one sixth of humanity's protein food and any loss in fisheries production will have a direct impact on us, he adds.
Besides the changes induced
by carbon emissions, the oceans are also under assault from over-fishing, increased UV exposure, toxic pollution, alien species and disease. The ...
Knee injuries may start with strain on the brain, not the muscles
"These findings suggest that training the central control process---the brain and reflexive responses---may be necessary to counter the fatigue induced
ACL injury risk," said McLean, who also has an appointment with the U-M Bone & Joint Injury Prevention Center.
McLean says that most research and ...
Stunting plants' skyward reach could lead to improved yields
... The applications for such research could bear directly on crop productivity and other important issues, Montgomery said. Corn, for example, might be induced
to spend more of its energy on producing cobs and kernels than on growing as the folk standard has it knee-high by the Fourth of July.