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Immunoglobulin in Biological News

Scientists discover a molecular scaffold that guides connections between brain cells

... Huangs team established that a protein from the immunoglobulin family directs one group of cerebellar neurons to connect with a specific part of Purkinje cells. immunoglobulin proteins are best known for acting as antibodies ... is that there is a lot of capacity for variety in immunoglobulin molecules, Dr. Huang explains. In the nervous ...

Sugar linkage could lead to better treatment for autoimmune diseases

... University. The work revolves around immunoglobulin G (IgG), the most abundant antibody in blood plasma. Intravenous immunoglobulin (IVIG) has within it a trace amount of a very ... These carbohydrate structures are linked to the immunoglobulin and referred to as glycans, and on the tip of ...

Reversing cognitive deficits: Injectable antibody may attack source of problem

... Louis University researchers have found. The protein -- part of the immunoglobulin M (IgM) class -- is an antibody that grabs onto the amyloid beta protein ... findings are surprising because IgM is five times bigger than the antibody immunoglobulin G (IgG), which has already been studied as a potential therapy for ...

Gene decides whether coral relative will fuse or fight

... different varieties that predict how Hydractinia colonies will interact with one another, they show. The gene sequence is most closely related to the immunoglobulin (Ig) superfamily of proteins, which include antibodies of the mammalian immune system. "Relationships have often been suggested between cnidarian ...

Tailor-made recombinant proteins in mammals

... interested in attaching to a protein." Because of their obvious therapeutic importance, the researchers used antibodies in their first tests. immunoglobulin G (IgG) is the most widely used, clinically important type of antibody. For example, it can be rendered anti-inflammatory by chemically modifying ...

Munich researchers discover key allergy gene

... Mnchen and Dr. Thomas Illig from the Helmholtz Zentrum Mnchen found that certain variations of the FCER1A gene decisively influence the production of immunoglobulin E (IgE) antibodies. IgE antibodies are a particular type of antibody that is normally used to protect against parasites. In Western lifestyle ...

American Society for Microbiology honors Stephen C. Edberg

... usage in clinical microbiology laboratories are: constitutive enzyme testing for the rapid identification of Gram-negative species, the refinement of immunoglobulin coating of latex particles for the direct detection of antigens, and the use of hydrolysable substrates to directly identify bacterial and mycotic ...

Genome of marine organism tells of humans' unicellular ancestors

... higher organisms, for example, have been found in simple organisms that lack a centralized nervous system. Likewise, choanoflagellates have five immunoglobulin domains, though they have no immune system; collagen, integrin and cadherin domains, though they have no skeleton or matrix binding cells together; ...

UAB microbiologist wins top Czech science honor

... exploration of the human immune response involving proteins and other molecules in bodily secretions. Mestecky and his lab focus on a protein called immunoglobulin A, or IgA. The 1971 Science study spelled out the basic molecular characteristics of IgA, which in later years turned out to be a first step ...

NIH selects LIAI for major study on allergy molecular causes and possible treatments

... thats what causes many of the symptoms of the disease the sneezing, sniffling, coughing and so forth, he said, noting that the discovery of the immunoglobulin E (IgE) antibody in 1966 by Kimishige Ishizaka, M.D., Ph.D. and his wife, Teruko Ishizaka, Ph.D., who later helped launch LIAI, revolutionized ...

HGS announces positive Phase 2 LymphoStat-B at ACR meeting

... of autoantibody at baseline. A separate poster presentation reported that LymphoStat-B also promoted progressive normalization of autoantibody, immunoglobulin and complement levels over 2.5 years of therapy in SLE patients (Stohl et al), including: Stable reductions in immunoglobulins, with no increase ...

Biologists Crack Genetic Code for Specialized Spider Silk

... doctors diagnose the conditions by measuring immunoglobulin levels and excluding other causes for lowered immunoglobulin levels; there are no specific tests to detect the ... and/or low levels of another type of antibody, immunoglobulin G (IgG). TACI mutations interfere with two ...

Agreement will speed research on microbicides for women

... doctors diagnose the conditions by measuring immunoglobulin levels and excluding other causes for lowered immunoglobulin levels; there are no specific tests to detect the ... and/or low levels of another type of antibody, immunoglobulin G (IgG). TACI mutations interfere with two ...

Defective Gene Linked to Two Inherited Immune Deficiencies

... doctors diagnose the conditions by measuring immunoglobulin levels and excluding other causes for lowered immunoglobulin levels; there are no specific tests to detect the ... and/or low levels of another type of antibody, immunoglobulin G (IgG). TACI mutations interfere with two ...

Protein amplification in melanoma is possible drug target

... deficiency, in particular two syndromes known as immunoglobulin A (IgA) deficiency and Common Variable ... infections and were found to have low levels of immunoglobulin A (IgA), immunoglobulin G (IgG) or both. TACI mutations interfere with ...

Gene for immune deficiency syndromes found

... deficiency, in particular two syndromes known as immunoglobulin A (IgA) deficiency and Common Variable ... infections and were found to have low levels of immunoglobulin A (IgA), immunoglobulin G (IgG) or both. TACI mutations interfere with ...

Scientists learn the origin of rogue B cells

... antibodies. Antibodies are generated from the cutting and splicing of immunoglobulin genes early in B-cell development, and have the potential to develop ... B cells. The problem occurs when the random cutting and splicing of immunoglobulin genes results in an antibody that recognizes a component of one's own ....

Antibody signal may redirect inflammation to fuel cancer

... cancer-promoting pathway. Part of the receptor for the antibody known as immunoglobulin appears to be involved, Coussens said. The good news, she adds, is ... there is no evidence and no likelihood that periodic booster shots of the immunoglobulin antibody, or even blood transfusions from someone with precancerous tissue ...

Do plants have the potential to vaccinate against HIV?

... ?a fusion of the HIV-1 p24 protein and part of another protein, human immunoglobulin A (IgA) - a major component of the immune system. The team found that the ... also lead to the development of more effective vaccines. By using specific immunoglobulin sequences in the fusion molecule, antigens could be targeted to specific ...

Newly discovered antibody may be body's natural defense against Alzheimer's

... of clinical neurology at Weill Cornell Medical College. Dr. Relkin's team has been testing an antibody-based immunotherapy called Intravenous immunoglobulin (IVIG) as a potential new treatment for Alzheimer's. IVIG is made from the blood of healthy donors and was previously reported to contain small ...

Hay fever can send work productivity down the drain

... reaction, which could indicate an allergy. About one out of five participants in the study underwent a blood test that evaluates the reaction of immunoglobulin E (IgE) to specific allergens, such as pollen from grass and trees. IgE is an antibody that triggers allergic reactions. In a previous study, ...

A key antibody, IgG, links cells' capture and disposal of germs

... Scientists have found a new task managed by the antibody that's the workhorse of the human immune system: Inside cells, immunoglobulin G (IgG) helps bring together the phagosomes that corral invading pathogens and the potent lysosomes that eventually kill off the germs. The ...

Friendly bacteria in alcoholic milkshake could fight food allergies

... 10.1002/jsfa2469)] in the SCI's Journal of the Science of Food and Agriculture has shown that the milk drink inhibits the allergen specific antibody immunoglobulin E (IgE). IgE is involved in immune responses to inactivate organisms that might cause disease. However, in the presence of allergens it can also ...

Experimental vaccine protects mice against deadly 1918 flu virus

... this had no effect on the immunity of the vaccinated mice to the 1918 virus. In contrast, the researchers discovered that transferring antibody-rich immunoglobulin (IgG) from immunized mice to non-immunized mice resulted in antibody levels in the animals at levels only slightly lower than those that were ...

A single sugar found responsible for an antibody's ability to treat inflammation

... have struggled to understand how IVIG worked. It's ability to treat autoimmune diseases seemed to bean apparent contradiction. Intravenous immunoglobulin (IVIG) is a complex mixture of IgG antibodies made from human plasma that contains the pooled antibodies from thousands of people, and is only ...

Heat-shock protein vaccine reduces alveolar bone loss

... by infection with multiple periodontopathogenic bacteria. There was a very strong inverse relationship between post-immune anti-P. gingivalis HSP immunoglobulin G levels and the amount of alveolar bone loss induced by either P. gingivalis or multiple bacterial infection (p = 0.007). Analysis of data from ...

'Nano-keys' bind cell receptors and trigger allergic reactions

... and they are the gatekeepers for the allergic immune response. This system can be manipulated experimentally. Specifically, Baird works with immunoglobulin E (IgE) antibodies, which mount membrane proteins on mast cells to form receptor complexes that sense the environment and sensitize the cell to ...

New antibody shows promise as cure for anthrax

... remove it from the body. This antibody was licensed to Elusys Theraputics, a New Jersey-based biopharmaceutical company, who turned it into a full immunoglobulin G (IgG). In trials, Elusys has found that the IgG protects test animals from anthrax when administered both before and after exposure to the disease. ...

Multi-purpose protein regulates new protein synthesis and immune cell development

... but their mature B lymphocytes were defective. Without IRE1, lymphocytes don't develop a B cell receptor and don't have the right rearrangements of immunoglobulin genes to function properly. "Our findings show that IRE1 is required for both the early and late stages of B lymphocyte development, and that it ...

U of M researcher examines newly emerging deadly disease

... before irreparable tissue injury occurs. In addition, because toxic shock syndrome is mediated by superantigens, it is possible that intravenous immunoglobulin therapy may be indicated. Of the five patients observed in the Minneapolis-St. Paul area during the period of 2000-2004, four of the patients were ...
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