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Immunity in Biological News

Penn-Wistar team gains insight into HIV vaccine failure

... that a subset of participants who had previous immunity in the form of neutralizing antibodies to the ... CD4 T-cells in people with pre-existing immunity to Ad5," Ertl says. "When you look at the data ... to explain the link between previous Ad5 immunity and increased acquisition of HIV infection." ...

Tips from the journals of the American Society for Microbiology

... therapeutic intervention that activates the host immunity in infectious diseases and has an advantage in ... virus, but also displayed cross-reactive immunity against the potentially pandemic H5N1 influenza ... vaccine strategies that can induce cross-reactive immunity against multiple strains of influenza viruses. ...

CSHL scientists discover a new way in which epigenetic information is inherited

... and viruses. "We've evolved ways to transmit immunity from mother to child via the secretion of ... via breast-milk. "We now have a way in which immunity (against sterility) is passed on from mother to ... adaptive immunity, however, this small RNA-driven immunity has a long reach. The team's experiments show ...

Hidden infections crucial to understanding, controlling disease outbreaks

... wanted to explore the impact of infection-induced immunity on the dynamics of cholera outbreaks. It's ... suspected mechanisms of disease transmission and immunity and then looked to see which model best fit the ... individuals with mild infections are losing their immunity quite quickly, in a matter of weeks or months." ...

1918 flu antibodies resurrected from elderly survivors

... to revealing the surprisingly long-lasting immunity to such viruses, these antibodies could be ... survived. Although aging typically causes immunity to weaken, "these are some of the most potent ... to a viral infection and the antibody-based immunity that results may last a lifetime, even nine or ...

Nano vaccine for hepatitis B shows promise for third world

... given over a period of six months. Protective immunity with the new vaccine required only two ... nanoemulsion vaccine produced sustained cellular immunity in Th1 cells, which could make the vaccine useful ... team found the same effect of activating mucosal immunity that was seen in their previous studies of other ...

Genome sequence of small marine creature sheds light on vertebrate origins

... evolution of complex biological systems, such as immunity and nervous system development. Primary research ... 2. Exploring the evolution of vertebrate innate immunity The immune system of vertebrate animals ... genome for genes that may be relevant to immunity in order to gain an understanding of what the ...

Disease threat may change how frogs mate

... humans, may use it to choose prospective mates, and improve their immunity to diseases. 'The situation requires directed behavioural research', ... if this new mating strategy could lead to wild frogs in the UK developing immunity to Ranavirus. ...

Plant protein 'doorkeepers' block invading microbes, study finds

... knowledge that can be applied to prevent plant disease." PLANT immunity Plants are continually exposed to bacteria, viruses and other ... Plants, however, only have innate immune systems. Rather than developing immunity as they are exposed to various microbes, plants make use of certain ...

Plant protein 'doorkeepers' block invading microbes, study finds

... knowledge that can be applied to prevent plant disease." PLANT immunity Plants are continually exposed to bacteria, viruses and other ... Plants, however, only have innate immune systems. Rather than developing immunity as they are exposed to various microbes, plants make use of certain ...

Avian flu research sheds light on swine flu outbreak

... antibodies to a virus after being infected with it, so humans have general immunity to human strains of avian influenza strains. But humans do not generally have immunity to avian flu strains because they have not been infected by them before. ...

Researchers discover primer to plant defense system

... of Energy's ORNL reports that azelaic acid has a role in priming the immunity response in Arabidopsis, a small flowering plant related to cabbage and ... Immunity." Among key findings was that plants can boost their overall immunity to infection once they have a local exposure to certain pathogenic ...

Dana-Farber oncologists present at ASCO GU -- predict prostate cancer survival using Source MDx test

... differences in gene transcripts associated with cell-mediated and humoral immunity are associated with survival in CRPC patients. These specific immune system changes were indicative of a decrease in both cell-mediated and humoral immunity in CRPC patients with higher mortality. "The six genes predictive of ...

Immunity stronger at night than during day

... Meeting, Dec. 13-17, 2008 in San Francisco. "These results suggest that immunity is stronger at night, consistent with the hypothesis that circadian ... as the model system to help them define the relationship between innate immunity and circadian rhythm, which is the oscillating protein clock or timing ...

UC Davis researchers exploring gene therapy to fight AIDS

... physicians gave him a bone marrow transplant from a person with natural immunity to HIV. The patient has now lived for 20 months since the transplant without any detectable traces of HIV. To establish similar immunity in HIV patients, the UC Davis team manipulated human skin cells to give ...

New study indicates smallpox vaccination effective for decades

... and Infectious Diseases, National Institutes of Health found permanent immunity was conferred by vaccination or by survival from an active smallpox ... were to occur, it would be critical to know who already had effective immunity and would not need to be vaccinated, leaving another dose available for ...

New hope for the red squirrel

... author of the paper, said, "We were absolutely delighted to find signs of immunity in red squirrels after years of seeing the squirrelpox virus devastating ... survival in the UK. It is imperative that we now discover how widespread immunity to squirrelpox virus in red squirrels is, and begin the work to develop a ...

UCF professor develops vaccine to protect against black plague bioterror attack

... and USDA funded research appear in the August edition of Infection and immunity . The vaccine, which is taken orally or by injection, was given to rats at UCF and the efficacy was evaluated by measuring immunity (antibody) developed in their blood. All untreated rats died within ...

Texas Hospital nation's first to use large-scale 'cocoon strategy' against whooping cough

... to an epidemic of pertussis in adolescents and adults who have lost their immunity from their childhood vaccines and need a booster vaccine. While this ... susceptible to this infection. In addition, young infants do not have full immunity until they have received three doses of the vaccine. ...

New nanoparticle vaccine is more effective but less expensive

... Recent research has also shown that the best way to get sustained immunity is to deliver an antigen directly to specialized immune cells known as ... cells. If, as we hope, this vaccine technique can confer sustained immunity with a single injection for around a dollar a dose, without toxic side ...

Immune police recognize good and bad guys in the body

... Medical College of Georgia immunologists report in the September issue of immunity that Tregs, similarly to other T cells, respond stronger and more ... Drs. Pacholczyk and Ignatowicz reported in the August 2006 issue of immunity that Tregs, like na ve T cells, learn what to recognize in the thymus. ...

Lecture to honor victim of Sept. 11 tragedy

... in the laboratory. His current research explores the regulation of innate immunity and the role of gene expression in brain development and function. Kim ... Her thesis project was an investigation of the role of interleukin-16 in immunity and targeted deletion of the interleukin-16 gene in mice. Her degree was ...

Balzan Foundation announces 2007 winners

... La Jolla, California and Acadmie des Sciences, Paris, for innate immunity Sumio Iijima (Japan), Meijo University, Nagoya, for nanoscience The ... at the Collge de France) justified the assignment of the Prize for Innate immunity jointly to Bruce Beutler and Jules Hoffmann as follows: "for their ...

Pitt researchers find promising candidate protein for cancer prevention vaccines

... in lung cancer patients, and she plans to assess it in the future as a prevention strategy in patients with pre-malignant lung lesions. Natural immunity to other tumor-specific proteins has been found before, Dr. Finn noted. Her team developed a vaccine to boost response against MUC1, a protein that ...

Scientists decoding genomic sequences of H1N1 using isolates from outbreak in Argentina

... July 30, 2009 -- Researchers at the Center for Infection and immunity (CII) at Columbia University Mailman School of Public Health are working with Argentina's National Institute of Infectious Diseases, the National ...

First genetically-engineered malaria vaccine to enter human trials

... equivalent of at least 35 million years of healthy, productive human life every year. Professor Alan Cowman, head of the institute's Infection and immunity division, said in developing the vaccine the research team had deleted two key genes in the Plasmodium falciparum parasite which causes the form ...

Fruit and vegetable intake in pregnant women reduces risk of upper respiratory tract infection

... important because colds are the most common reason for school and work absences. Eating nutritious foods, especially fruits and vegetables, improves immunity but hadn't previously been associated with reducing the risk of URTIs in pregnant women. BUSM researchers studied more than 1,000 pregnant women ...

Impact Factor names Cell top research journal

... show that seven other Cell Press titles increased their impact factor in the past year: Cancer Cell (+4.627%), Current Biology (+2.258%), immunity (+6.815%), Neuron (+5.667%), Structure (+3.173%), Biophysical Journal (+1.210%), and Developmental Cell (+3.586%). The impact factor is a ...

Antibiotics take toll on beneficial microbes in gut

... in the gut microsystem as well," says Vincent B. Young, M.D., Ph.D., senior author of the study, which appears in the June issue of Infection and immunity . The study results suggest that unless medical research discovers how to protect or revitalize the gut microbial community, "we may be doing ...

Amarna Therapeutics B.V. and TNO announce SVac research and development partnership

... fermentors. Because of its immunological inertia in man SVac is the only vector system known that is suitable for for treating genetic disorders and immunity associated diseases. About TNO TNO is a prominent, independent knowledge company whose expertise and research contribute significantly to the ...

Understanding plants' overactive immune system will help MU researchers build better crops

... in these suppressors, the immune system can actually do more damage than good." One way that plants fight pathogens is through effector-triggered immunity (ETI), which relies on the detection of pathogen effector proteins (proteins that are deployed by pathogens to interfere with the plant immune ...

New therapy substitutes missing protein in those with muscular dystrophy

... the muscle cell wall to substitute for missing dystrophin. Because every cell in the body makes utrophin naturally, TAT-utrophin circumvents immunity issues associated with other therapeutic approaches. "Our protein replacement approach most directly and simply addresses the cause of Duchenne ...

TB -- hiding in plain sight

... Brighenti and colleagues plan to "pursue new strategies developed to enhance cell-mediated immune responses that are known to provide protective immunity in patients with TB. Such an approach may involve targeting of certain subpopulations of immune cells with anti-inflammatory or immunoregulatory ...

Strong immune response to new siRNA drugs in development may cause toxic side effects

... demonstrations of systemic siRNA in human subjects will soon be realized." "This is perhaps the most comprehensive review on siRNAs and innate immunity to date and a must read for anyone using siRNAs therapeutically," says John Rossi, PhD, Co-Editor-in-Chief of Oligonucleotides and Professor in the ...

UCI awarded $45 million for infectious disease research

... toxin. It also seeks to train next-generation scientists and educate researchers about lab safety. "While basic research on these infections and immunity to them is at the core of the center, we recognize the importance of the timely translation of our findings into products and other applications that ...

Bacteria play role in preventing spread of malaria

... be exposed to different types of bacteria in different regions. Theoretically, these bacteria could be introduced to the mosquitoes to boost their immunity to the malaria parasite and make them resistant and incapable of spreading the disease. Our current research aims at identifying those bacteria that ...

Rabbits on the back foot -- but naturally they're fighting back

... and the Invasive Animals Cooperative Research Centre has found that some rabbits in cool, high rainfall areas carry a benign virus that gives them immunity to RHD. "We knew that RHD was not as effective in these areas and we suspected from anti-body responses that there was a non-lethal calicivirus out ...

Alzheimer's, asthma, cancer, malaria and TB focus of new Singapore grants

... dust mite will be the focus of her second grant, while the third project will be directed at creating a modified or "recombinant" protein to foster immunity against Blo t 5. "Immunotherapy remains the only truly disease-modifying treatment for asthma and allergic rhinitis," said Dr. Chua. ...

UTSA, Health Science Center collaborate with Merck & Co. to develop chlamydia vaccine

... research for more than 20 years in chlamydia pathogenesis and vaccine development, while Arulanandam has researched vaccine development and mucosal immunity for more than 12 years. Both Zhong's and Arulanandam's laboratories are working hard with the Merck group to identify the most efficacious vaccine ...

Bovine genome provides clues to possible new developments

... years and is one of the team leaders of the project, said the work "opens the door to look at all sorts of specific interests in cattle from disease immunity to better meat quality, better milk production and on and on." "Ten to 20 years down the line, this will lead to new avenues in cattle research ...
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(Date:4/20/2014)... doctors have long known that people with Down syndrome ... (ALL) during childhood, they haven,t been able to explain ... investigators has uncovered a connection between the two conditions. ... journal Nature Genetics , the researchers track the ... in Down syndrome to the cellular havoc that occurs ...
(Date:4/18/2014)... predicted to reach 9 billion by 2050 will ... human-altered landscapes such as farmland, according to Stanford ... supports it might be an increasingly scarce commodity ... the land surface is directly affected by humans ... such as climate change. But what if altered ...
(Date:4/18/2014)... [Brown University] Asteroid and comet impacts can cause ... regional or even global scales. But new research from ... signatures of ancient life at the time of an ... Pete Schultz has found fragments of leaves and preserved ... ancient impacts in Argentina. The material could provide a ...
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(Date:4/18/2014)... (Seattle, WA April 18, 2014) Benaroya Research ... to research how blocking a particular molecule in metastatic ... and the number of lung metastases. BRI scientists have ... protein can shrink tumors by 60 - 80 percent ... to the lung. The $1.8 million five-year grant comes ...
(Date:4/18/2014)... discovery by Northwestern Medicine scientists could lead to potential ... in people with scleroderma. , Fibrosis, or scarring, ... of the skin and lungs can lead to serious ... concept for new therapeutic options centers on findings made ... who identified the role that a specific protein plays ...
(Date:4/17/2014)... new pain relief targets that could be used ... at King,s College London made the discovery when ... periphery of the body. , Dr Marzia Malcangio ... underlying pain generation and our findings could help ... , One potential side effect of some chemotherapy ...
(Date:4/17/2014)... the University of California, San Diego School of Medicine ... have suffered a recent major loss are more likely ... , The study is published in this month,s issue ... , Because compassionate behaviors are associated with better health ... insights into ways to improve the outcomes of individuals ...
(Date:4/17/2014)... University synthetic biology team has created a new ... therapeutics that could travel the body and selectively ... Engineering cell-based, biological devices that monitor and modify ... synthetic biology. However, no existing technology enabled bioengineers ... physiological state and respond in a customized fashion. ...
Breaking Medicine News(10 mins):Health News:Benaroya Research Institute evaluates immunology approach to blocking breast cancer 2Health News:New clues on tissue scarring in scleroderma 2Health News:New pain relief targets discovered 2Health News:The ilk of human kindness 2Health News:Building 'smart' cell-based therapies 2
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