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Immune in Biological News

Pitt researchers find promising candidate protein for cancer prevention vaccines

... that some healthy people naturally developed an immune response against a protein that is made in excess ... Mice that were vaccinated to boost their immune response against this cell cycle protein, called ... we noted that many healthy people already had an immune response, or antibodies, against the protein, ...

Got zinc? New zinc research suggests novel therapeutic targets

... Florida found that zinc not only supports healthy immune function, but increases activation of the cells ... University of Florida. "Age-related declines in immune function have also been related to zinc ... light on how zinc may enhance the ability of our immune systems to fight off foreign invaders. Equally ...

Study shows cancer vaccines led to long-term survival for patients with metastatic melanoma

... derived from patients' own cancer cells and immune cells were well tolerated and resulted in ... with a vaccine that included each patient's own immune cells (dendritic cells) and 500 micrograms of granulocyte-colony stimulating factor (GM-CSF), an immune stimulator, three times a week and then monthly ...

Discovery to aid in future treatments of third-world parasites

... strains of tuberculosis. The body's immune response to schistosome infection, as with all immune responses, is coordinated by cytokines, small proteins secreted by immune cells. Due to their fundamental importance, ...

Researchers capture bacterial infection on film

... and observing their interaction with the insect's immune system using time-lapse confocal microscopy. ... By observing how these bacteria interact with the immune system, researchers will gain a better ... and cultured in a petri dish. "In the body, immune surveillance cells such as hemocytes (or ...

Common allergy drug reduces obesity and diabetes in mice

... cromolyn, stabilize a population of inflammatory immune cells called mast cells. In the second study, ... also acts as a liaison between the metabolic and immune systemsin this case, controlling inflammation in ... overabundance in fat tissue of inflammatory immune cells called macrophages. "It seems that ...

Scientists link immune system's natural killer cells to infant liver disease

... have linked an overactive response by one of the immune system's key weapons against infection natural ... "Our findings underscore the developing immune system's role in causing injury to bile ducts ... atresia, although it has been traced to the immune system responding to an infection in the liver ...

Penn-Wistar team gains insight into HIV vaccine failure

... Ad5 neutralizing antibody (nAb) titers, the main immune gatekeeper in most vaccine strategies. Antibodies ... into host cells. They work in concert with other immune cells, including CD4 T-cells, which build a ... phase I safety trial of the STEP HIV vaccine for immune response to Ad5 particles. The blood samples, ...

C. difficile spores spread superbug

... mice with mutations associated with impaired immune defence began to lose weight and became moribund. ... manifestation of the disease, where older or immune impaired patients tend to exhibit the symptoms of ... that can be lethal in patients with weakened immune systems. "What this research essentially ...

The right messenger for a healthy immune response

... also plays a crucial role during an immune response: without Beta-Interferon immune cells are unable to show "wanted posters" of ... cells will not recognize the pathogen and the immune response does not start properly. The group's ...

Children's Hospital of Pittsburgh of UPMC scientists identify enzyme important in aging

... in an enzyme with the ability to promote a robust immune system into old age by maintaining the function ... of the thymus in order to maintain our immune defenses throughout life," said Dr. de Vallejo. ... manipulation of PAPPA could be a way to maintain immune protection throughout life," Dr. de Vallejo said. ...

Toward an explanation for Crohn's disease?

... recognize invading bacteria and then trigger the immune response. This study demonstrates that the NOD2 ... body, they cause an immediate and very strong immune response via the NOD2 receptor. "Now that we ... from being properly recognized by the immune system," explained Dr. Behr. "If mycobacteria are ...

Plant protein 'doorkeepers' block invading microbes, study finds

... , provide a better understanding of plants' immune systems and will likely find application in ... against diseases. "The ability of a plant's immune system to recognize disease-causing ... that are important for regulating the plant immune system but still do not have a good sense of what ...

Plant protein 'doorkeepers' block invading microbes, study finds

... , provide a better understanding of plants' immune systems and will likely find application in ... against diseases. "The ability of a plant's immune system to recognize disease-causing ... that are important for regulating the plant immune system but still do not have a good sense of what ...

New trigger for chronic inflammation in rheumatoid arthritis discovered

... molecule made by the human body that triggers the immune system into action may be important in rheumatoid ... by turning on a molecular switch to set the immune system into action and protect the body from ... the same molecular switch and also activate the immune system. High levels of tenascin-C present in ...

Tips from the journals of the American Society for Microbiology

... suggests that their ability to evade innate immune responses within the host, such as the type 1 ... infections, such as MRSA, by activating the host immune response. They report their findings in the June ... and antiseptic properties) are part of the innate immune response which kills microorganisms. In a ...

Cancer-causing protein can also help fight the tumors it causes

... the ability to transfer from cancer cells into immune cells such as t-cells a transfer that may be ... he says. "Here we show that when cells in the immune system interact with other cells, proteins are ... being secreted from the cell, and act in both the immune and original cells alike." "When Ras ...

Another JDRF partner moves research forward with collaboration agreement for diabetes treatment

... immunotherapeutic designed to reverse the immune response that causes type 1 diabetes. To ... proinsulin designed to target specific pathogenic immune cells involved in the immune response of type 1 diabetes. ...

They are young and need the job: A second chance for dangerous T-cells

... The immune system's T-cells react to foreign protein ... The diversity of these receptors allows the immune system to respond to nearly all pathogens. Since ... own organism, is an important requirement for immune tolerance." But not all autoreactive T-cells ...

NIH funds $9.5 million for research on HIV and the human innate immune system

... will unravel changes in the human body's innate immune system in HIV-infected people on antiretroviral ... against infections, such as hBDs and other innate immune molecules, found in the epithelial linings of the ... on HAART that impact the cell's cycle and immune responses. "We now have proteomic data ...

GARP makes the difference

... Hannover, Germany have succeeded in treating immune cells in a way that enables them to inhibit unwanted immune reactions such as organ rejection. Their results ... of Cellular and Molecular Medicine . The immune system keeps us healthy: day and night it ...

Tracking down the causes of multiple sclerosis

... that MS is triggered by an autoimmune reaction: immune cells that should actually protect the body ... now available can attenuate the harmful immune reaction and thus delay the progress of the ... can differentiate in a targeted way between the immune cells that cause the disease and those that ...

Understanding plants' overactive immune system will help MU researchers build better crops

... COLUMBIA, Mo. A plant's immune system protects the plant from harmful pathogens. ... that negatively regulate the responses of the immune system in the plant species Arabidopsis thaliana . Understanding the immune system of plants would allow breeders to create ...

One size does not fit all

... the effects of central nervous system-accessible immune therapies on the myelin repair processes in ... of the central nervous system (CNS), in which immune cells attack the myelin sheath (the protective ... In the early stages of MS, following an immune system attack on myelin, oligodendrocyte ...

Immune genes adapt to parasites

... Thank parasites for making some of our immune proteins into the inflammatory defenders they are ... of multiple SNPs) is maintained within certain immune genes over time helps ensure that the host can ... sift through 1,052 SNPs in genes that code for immune proteins called interleukins from roughly 1000 ...

Opposites attract -- how genetics influences humans to choose their mates

... humans and also improving the efficiency of the immune system, the scientists say. The MHC is a ... vertebrates. It plays an important role in the immune system and also in reproductive success. Apart ... to ensure that children are born with a strong immune system better able to cope with infection." ...

Tips from the American Journal of Pathology

... et al hypothesized that uPAR, which attracts immune cells, plays a role in oxygen toxicity in the ... oxygen had an increased number of uPAR-expressing immune cells in their lungs and that mice that lacked ... of Pathology . MS is a disease where the immune system attacks the central nervous system, ...

TB -- hiding in plain sight

... that Mycobacterium tuberculosis can evade the immune response. The related report by Rahman et al, "Compartmentalization of immune responses in human tuberculosis: few CD8+ ... needed to treat these dangerous infections. immune responses to tuberculosis rarely result in ...

Strong immune response to new siRNA drugs in development may cause toxic side effects

... new drug candidates can also induce a strong immune response, causing toxic side effects. Understanding how siRNA stimulates this undesirable immune activity, how to test for it, and how to design ... it is delivered, it may induce a potent innate immune response in humans, stimulating the release of ...

Novel vaccine approach offers hope in fight against HIV

... used a leapfrog strategy, bypassing the natural immune system response that was the target of all ... used substances aimed at stimulating the body's immune system to produce antibodies or killer cells that ... HIV vaccines have not elicited protective immune responses, just as the body fails on its own to ...

Allergy season: Cigarettes to the rescue?

... prevent allergies by decreasing the reaction of immune cells to allergens. Smoking can cause lung ... activity of mast cells, the major players in the immune system's response to allergens. Researchers at ... to allergens, without affecting other mast cell immune functions. The mast cells used in the study ...

Bacteria play role in preventing spread of malaria

... to Plasmodium infection because of a lack of immune stimulation. Their study is published in the May ... the microbial flora of mosquitoes is stimulating immune activity that protects the mosquito from Plasmodium infection. The same immune factors that are needed to control the mosquito's ...

Scientists learn why the flu may turn deadly

... the influenza virus can actually paralyze the immune systems of otherwise healthy individuals, leading ... which serve as the first line initiators of immune response, in the blood plasma. Although they ... response of toll-like receptors, which activate immune cell responses as a result of invading microbes. ...

Genetic study confirms the immune system's role in narcolepsy

... sleep at night. The gene has a known role in the immune system, which strongly suggests that autoimmunity, in which the immune system turns against the body's own tissues, ... dot the surface of the body's cells and help the immune system identify foreign proteins. Some ...

Just in time for spring: Scientists find the cellular on and off switch for allergies and asthma

... cord blood that ultimately help create a type of immune cell (mast cells). Too many mast cells lead to an over-aggressive immune response, which causes allergies and asthma. The ... (cytokines IL-4 and IL-10) used to initiate an immune response (the "on switch") are added to ...

Limping rat provides sciatica insights

... "This finding suggests a possible role for immune system activation in contributing to symptoms of ... published online in the journal Spine . "If immune system activation is involved, and it turns out ... that existing or new drugs that can block this immune response could offer relief to patients," Setton ...

Avian flu research sheds light on swine flu outbreak

... without causing disease. These prime the body's immune system to recognize and fight against the virus. The immune system produces antibodies against the vaccine ... or lessening symptoms of the virus. The immune system also retains antibodies to a virus after ...

Lice can be nice to us

... such as lice, for the conditioning of a "natural" immune system. Jan Bradley, Professor of ... and stress-free conditions. Analysing the immune response in wild populations can give crucial insights into how the immune system functions in its natural context." Many ...

New mediator of smoking recruits

... lung exposure to cigarette smoke leads to immune cell recruitment and tissue fibrosis, how ... if osteopontin, a molecule that attracts immune cells, mediates cell recruitment in smokers, ... in rat lung resulted in recruitment of immune cells, resulting in symptoms similar to ...

Microparticle immune response modifier shows broad effects against recurrent or metastatic cancer

... 21, 2009) MIS416, a novel microparticle-based immune response modifier, demonstrated the ability to ... significantly induced an anti-tumor cellular immune response without the reintroduction of previously ... tumor reoccurrence or metastatic disease." immune response modifiers (IMRs) are agents that target ...
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