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Homologous in Biological News

Iowa State University researchers develop process for 'surgical' genetic changes

... new technique harnesses a natural process called homologous recombination to precisely introduce DNA at a ... get the research to the point where you can have homologous recombination. Now, we've done it." Using this ... allows scientists to take greater advantage of homologous recombination, according to Wright and Townsend. ...

Is this the beginning of the end of plant breeding?

... up and dividing phases. The first lining up is of homologous chromosomesall chromosomes in an adult cell have ... from the mother and father of the celland these homologous chromosomes are each made up of two chromatids. The first division divides homologous pairs of chromosomes while the second meiotic ...

The structure of the Mre11 protein bound to DNA

... the error-free method of DNA repair called homologous recombination. In an article in the online ... open the door to the predetermined control of homologous recombination for cancer therapeutics and gene targeting." The power of homologous recombination ...

Genome communication

... how paramutagenic alleles communicate with their homologous partners are still unknown, but the work of ... and others suggests that both direct contact of homologous regions and changes induced by intermediary RNA ... intermediary molecule, being sent to silence the homologous allele. A third component is the placement of ...

Enhanced DNA-repair mechanism can cause breast cancer

... repair protein RAD51. RAD51 is involved in homologous recombination, a method used by cells to repair damaged DNA. In homologous recombination, organisms heal broken chromosomes ... of elevated levels of RNAs for genes involved in homologous recombination. They found that the level of RNA ...

Methods for studying DNA repair and protein modification are featured in CSH Protocols

... involved in DNA repair and post-translational modification of proteins. homologous recombination is an important mechanism for the repair of damaged ... provides researchers a biochemical means to dissect the mechanisms of the homologous recombination machinery. The protocol is freely accessible on the website ...

How chromosomes meet in the dark -- Switch that turns on X chromosome matchmaking

... for sexual reproduction to succeed in producing viable cells all of the homologous chromosomes in the process have to, almost simultaneously, bind together ... that involve the recognition and pairing of DNA sequences including other homologous chromosomes. This is of particular importance, e.g., at meiosis, as the ...

Human RecQ helicases, homologous recombination and genomic instability

... in the December 1st issue of G&D detail how human RecQ helicases regulate homologous recombination and protect genome stability. The human RecQ family of ... conditions are associated with defects in the DNA repair pathway of homologous recombination (HR). Dr. Alexander Mazin (Drexel University College of ...

The SIB recognizes the next generation of bioinformaticians

... the number of sequenced genomes has grown exponentially over the last years, multiple alignments of many protein families now contain more than 100 homologous sequences(and some even several thousand), which makes it possible to investigate the evolutionary constraints that act on particular residues in ...

Stress puts double whammy on reproductive system, fertility

... the critical role played by GnIH in birds, teamed up with Kaufer and Kirby to explore whether stress might affect GnIH levels in the brain. The homologous hormones in mammals have been dubbed RFamide-related peptides, or RFRPs. Kirby showed that acutely stressed rats showed increased RFRP levels for ...

Stowers researchers develop whole genome sequencing approach for mutation discovery

... of EMS mutageneseis and into gene conversion events involving balancer chromosomes genetic tools used to prevent genetic recombination between homologous chromosomes during meiosis. Model organisms like fruit flies are used in research for studying both normal biological processes and human ...

Uncooperative voltage sensors

... "promises to unmask some of the previously inscrutable features of the allosteric communication among entwined Kv subunits and between the homologous domains of sodium channels." ...

Recipe for capturing authentic embryonic stem cells may apply to any mammal, study suggests

... the past two decades, embryonic stem cells have been routinely used to create loss of function (knockout) or gene replacement (knockin) mutations by homologous recombination in the mouse, providing an invaluable tool for the functional characterization of genes," Ying's group wrote. "Now, the availability of ...

Mate choice in plants

... They have recently identified and characterized another factor, Stigma Expressed Protein (NaStEP) in N. alata. Sequencing revealed that it is homologous to proteinase inhibitors, enzymes that prevent protein degradation, and that it contains a sequence that targets it to the vacuoles of unpollinated ...

A common aquatic animal's genome can capture foreign DNA

... -- much like the plastic cap on the end of a shoelace. A next step, Meselson says, is to determine whether bdelloid genomes also contain homologous genes imported from other bdelloids. He and his colleagues also hope to examine whether the animals actually use any of the hundreds of snippets of ...

Honeybee researcher to unravel properties governing lifespan with support from Norway

... Generally, vitellogenin is described as a conserved yolk protein found across a broad range of egg-laying species. The functions of proteins homologous to honeybee vitellogenin therefore have been studied primarily in the context of female reproduction, Amdam says. New data from my laboratory ...

Gene guards grain-producing grasses so people and animals can eat

... shut off the Hm1 homologue in some barley plants. Next, they infected the test barley with fungus. In barley that no longer had a functioning Hm1 homologous gene, the fungus, with the help of its toxin, caused disease in the plant. The resulting tissue damage on the barley leaves was typical of maize leaf ...

'Telepathic' genes recognize similarities in each other

... This ability to seek each other out could be the key to how genes identify one another and align with each other in order to begin the process of homologous recombination whereby two double-helix DNA molecules come together, break open, swap a section of genetic information, and then close themselves up ...

Plant geneticists find veritas in vino

... sequencing the genome was complicated by the degree of heterozygosity between pairs of chromosomes, some 11.2% of the sequence differing between homologous regions. There was so much variation, in fact, that Velasco describes it as like being in the presence of two genomes. Moreover, the team ...

New technique reveals subtle force-induced changes in biomolecule's conformation

... technique to probe the dynamics of the Holliday junction. The Holliday junction is a four-stranded DNA structure that forms during a process known as homologous recombination, which occurs when damaged DNA is repaired. Understanding how DNA repairs itself is an essential step in ultimately developing ...

Researchers pioneer new gene therapy technique using natural repair process

... initiating a DNA repair process known as homologous recombination, Dr. Matthew Porteus of UT ... the gene therapy only affects the mutant gene. homologous recombination is a fairly rare event that occurs ... therapy technique, researchers took advantage of homologous recombination by introducing a man-made enzyme ...

Common ancestry of bacterium and plants could be key to an effective new treatment for chlamydia

... "But now we have access to more that 500 different genomes in a data base. After having identified a gene in plants, I can quickly identify the homologous gene from any bacteria in the database. As a plant biologist I wouldn't have ever imagined that I would be working with Chlamydia. Yet, with the help ...

Oh, rats! Designer animals reveal possible heart disease genes

... then bred an almost identical designer rat, with one important change: they substituted one chromosome from the parental, hypertensive rat with the homologous chromosome from a healthy rat. Continuing this way, the team generated 22 unique designer rat strains, each bearing one distinct healthy chromosome ...

Open Source Biotechnology alliance for international agriculture

... problem solvers to the table." Thesecould for example be tools for precise, natural genetic enhancements, using non-GM approaches (for example, homologous recombination), new plant breeding methods such as marker assisted selection, or even true breeding hybrids of crop species that would allow farmers ...

Researchers develop new method to help find deadly malaria parasite's Achilles heel

... Plasmodium data, focusing on interacting proteins that have homologs in other species. While the genomes of hundreds of species are filled with homologous proteins, Ideker and his colleagues are eager to understand how they interact with one another as part of a new approach to help in the design of ...

Invitrogen Launches i-Path -- A Unique Systems Biology Platform at BIO 2005

... these oocytes they had undergone a pseudo-fertilisation because the pronuclei were derived from whole foreign nuclei, each one with a complete set of homologous [matching] chromosomes, instead of from sperm and eggs which carry only one set of chromosomes each." Five oocytes divided to the two-cell stage, ...

Scientists succeed in cloning human embryos from eggs matured in the lab

... these oocytes they had undergone a pseudo-fertilisation because the pronuclei were derived from whole foreign nuclei, each one with a complete set of homologous [matching] chromosomes, instead of from sperm and eggs which carry only one set of chromosomes each." Five oocytes divided to the two-cell stage, ...

DNA Recombination and Repair—A New Twist to RecA Function

... Now, Julia Cox, Oleg Tsodikov, and Michael Cox present evidence indicating that filaments of the bacterial RecA protein, long known for their role in homologous recombination and DNA repair, have properties reminiscent of a molecular motor as well. RecA filaments consist of DNA helices lined with RecA ....

Viral DNA sequence a possible trigger for breast cancer

... that trigger the expression of host cancer-causing genes. An intriguing wrinkle to this study is the previously reported presence of sequences highly homologous to MMTV Env protein in the DNA of as many as 40% of human breast tumors, although a human homologue of MMTV has yet to be found. ...
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