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Herpes in Biological News

UCSF researchers identify new drug target for Kaposi's sarcoma

... identified a new potential drug target for the herpes virus that causes Kaposi's sarcoma, re-opening ... drugs called protease inhibitors against the full herpes family of viruses, which for 20 years has been ... however, including those for HIV and the herpes virus family, take the form of a dimer, or two ...

Study characterizes eczema patients most at risk for dangerous viral infections

... eczema patients who have suffered widespread herpes simplex viral infections of their skin. It is ... to widespread infections of their skin by herpes simplex and vaccinia viruses. The herpes simplex virus is common but only rarely causes ...

Potential new herpes therapy studied

... designed RNA enzyme to inhibit strains of the herpes simplex virus. The enzyme disables a gene ... Virology in August. The HSV-1 strain of the herpes virus causes cold sores or fever blisters around ... more common cause of genital herpes. Existing herpes treatments work because the active ingredients ...

Deadly rugby virus spreads in sumo wrestlers

... may get more than just the ball out of a scrum herpes virus can cause a skin disease called "scrumpox" ... Journal of General Virology . "Scrumpox", or herpes gladiatorum , is a skin infection caused by the herpes virus, which can cause coldsores. It is spread ...

Herpes drug inhibits HIV in patients infected with both viruses

... HIV to other people. And if you're infected with herpes alone, it makes it easier for you to acquire ... hope of indirectly treating HIV by reducing the herpes load. Surprisingly, the NIH team discovered that in the presence of herpes virus HHV-6, acyclovir actually attacks HIV ...

Penn researchers shine the light of venus to learn how the herpes virus invades cells

... have uncovered an important step in how herpes simplex virus, HSV-1, uses cooperating proteins ... that gD somehow signals to three other herpes proteins -- gB, gH and gL -- to swing into ... interact tells us a lot about HSV and other herpes viruses and how they attack the body, Roselyn ...

Clinical trials for shingles drug take an important step forward

... FV-100, which could alleviate the suffering of millions of people with herpes zoster or shingles, has entered the second stage of clinical testing in ... the treatment has the potential to improve the lives of over 2.5 million herpes zoster patients worldwide. Shingles is caused by the same viral ...

Childhood chicken pox could affect oral health years later

... can lie dormant in the body for decades, and if activated can lead to herpes zoster (HZ), more commonly referred to as shingles, according to a study ... nearly 1 million Americans each year, 50 percent of all new cases of herpes zoster occur in individuals over the age of 60. "Herpes zoster ...

Viruses, start your engines!

... accomplished the DNA packaging. According to Rao, "Since the assembly of herpes viruses closely resembles that of T4, this research might provide insights on how to manipulate herpes infections." While many questions remain, adds Rossmann, the virus may ...

Biologists learn structure, mechanism of powerful 'molecular motor' in virus

... however, also is likely present in other viruses, including the human herpes virus. "Molecular motors in double-stranded DNA viruses have never been ... up with a hypothesis of how this motor works," Rossmann said. Because herpes and other viruses contain similar DNA packaging motors, such findings ...

A card-swipe for medical tests

... disease," Granger says. A rapid, card-reader test for genital or oral herpes could help reduce the number of Caesarean sections. If obstetricians ... transmission to the newborn, Porter says. A conclusive, rapid test for herpes can tell doctors if a C-section is really necessary. Porter envisions ...

Scripps research team sheds light on immune system suppression

... this infected condition, a secondary opportunistic agent, in this case the herpes virus murine cytomegalovirus, which the mice could have otherwise fought off, grew unchecked. Remarkably, opportunistic infections with herpes viruses are frequently observed in patients infected with HIV and the ...

Virus weaves itself into the DNA transferred from parents to babies

... of Rochester Medical Center shows that some parents pass on the human herpes virus 6 (HHV-6) to their children because it is integrated into their ... rather than passed through the placenta. "This is the first time a herpes virus has been recognized to integrate into the human genome. To think ...

American Chemical Society's Weekly PressPac - Oct. 10, 2007

... DNA viruses, which cause a range of diseases that includes genital herpes and hepatitis. Their report is scheduled for the Nov. 1 issue of ACS ... in cells, opening the door to improved screening tests for hepatitis B, herpes and other diseases. ARTICLE #3 FOR IMMEDIATE RELEASE Single-Molecule ...

Scripps scientists create first crystal structure of an intermediate particle in virus assembly

... that causes all manner of misery and disease, say researchers. While the virus they studied, HK97, only infects bacteria, well-known viruses such as herpes and HIV are also known to assemble an "intermediary" structure before morphing into its final assault-proof, infectious form. "The principles of ...

Nanoemulsion potent against superbugs that kill cystic fibrosis patients

... have already proved to be non-toxic, potent killers of bacteria such as Streptococcus pneumoniae, H. influenzae and gonorrhea, of viruses such as herpes simplex and influenza A, and of several fungi. Nanoemulsion treatments for cold sores and toenail fungus are in Phase 3 clinical trials. "We have ...

Life Sciences Discovery Fund awards health research program grants

... and product planning. Three specific vaccine projects will be initially addressed. One in five adults in Washington State is infected with the herpes simplex virus (HSV)-2. Infectious syphilis cases have doubled in the United States since 2000 and E. coli contamination continues to be a persistent ...

Nature Medicine study shows Peregrine's bavituximab can cure lethal virus infections

... immune response. Researchers have found that PS is exposed on the outer membrane of cells infected with HIV, influenza (including avian flu), herpes simplex viruses, hemorrhagic fever viruses, measles and members of the small pox and rabies virus families. Dr. Barton Haynes, director of Duke ...

Purdue researcher invents molecule that stops SARS

... the molecular compound that inhibits the virus provides new insights into a group of proteins found in a range of diseases including childhood croup, herpes and cancer, Ghosh said. "The molecular inhibitor we developed is very potent against the SARS virus by binding to and blocking the use of a ...

American Society for Microbiology honors Bernard Roizman

... Dr. Roizman has been a leader in the field of virology for nearly half a century. In the 1960s, he was a pioneering investigator in the field of herpes simplex virus (HSV) biology, and he is widely recognized as the leading authority in nearly every area of HSV research. One of Dr. Roizman's most ...

American Society for Microbiology honors Ekaterina Helwein

... recognizes early career scientists for excellence in research in microbiology and infectious diseases. Dr. Heldwein's research is centered on herpes simplex virus and cytomegalovirus. These two viruses have relevance to the susceptibility to and treatment of HIV/AIDS and other diseases of ...

Herpes virus link to complications in pregnancy

... & Infectious Diseases Department. Their work demonstrates, for the first time, that exposure to viral infection -- especially viruses of the herpes group -- may be associated with pregnancy-induced hypertensive disease (pre-eclampsia) and also with pre-term birth. The research discovered the ...

Tumor-targeting viral therapy slows neuroblastoma, malignant peripheral nerve sheath tumors

... data support continuing development and study of our tumor-targeted viral therapy to fight cancer. Previous research has documented that oncolytic herpes simplex virus (oHSV) and similar viruses can infect and kill human cancer cells without harming normal, healthy cells or causing disease. In their ...

UT Southwestern scientist honored among best in Texas research

... is to develop new drugs that will increase beclin 1 expression and autophagy to help treat patients with diseases such as cancer, HIV and the herpes simplex virus, Dr. Levine said. We also hope to understand better the role autophagy plays in protecting individuals from aging and from developing ...

RNA interference therapy heals growth deficiency disorder in a live animal

... for developing highly targeted therapies for a number of genetic diseases including macular degeneration in the eye and to block viruses such as herpes and RSV respiratory viruses. To the best of our knowledge, this is the first time it has been used to correct a dominant negative disorder in a ...

Depression, aging, and proteins made by a virus may all play role in heart disease

... genetics at Ohio State University , said, To me, this suggests a new way of thinking about how these diseases develop. We carry around these latent herpes viruses in our bodies virtually all our lives and periodically they can hurt us, inducing biological events that could lead to an increased risk of ...

Risk of common vaginal infection linked to preterm birth appears higher for blacks

... minor problem, but in addition to increasing the risk for preterm birth, other studies have shown that women who have BV also are more likely to get herpes and other sexually transmitted diseases, including HIV, said Dr. Simhan, a maternal-fetal medicine specialist at the Magee-Womens Hospital of the ...

Herpes virus hijacks DNA repair process

... have discovered an intriguing surprise: in mice, herpes viruses hijack their host cells' tools for fixing ... dividing. In the murine (or mouse-infecting) herpes virus they studied, researchers at Washington ... They also showed that Epstein-Barr virus, a human herpes virus, has a similar protein. Scientists found ...

New vaccine prevents CMV infection and disease in mice

... (hCMV) infection and disease. CMV, a type of herpes virus, is the leading viral cause of birth ... These genes – which are also found in other herpes viruses such as chicken pox or herpes simplex – have the same or very similar sequence, ...

Herpes infection may be symbiotic, help beat back some bacteria

... Mice with chronic herpes virus infections can better resist the bacterium ... triggered by the long-term presence of a latent herpes virus infection. In latent viral infections, the ... and health risks caused by disease-causing herpes infections. But they noted that several strains ...

Cold sore virus might play role in Alzheimer's disease

... the idea, long suspected by some scientists, that herpes somehow plays a role in bringing about ... for getting Alzheimer's disease, with the form of herpes ?herpes simplex 1 or HSV ?that infects more than ... at risk also creates a fertile environment for herpes in the brain, allowing the virus to be more ...

UCSF study will test new vaginal microbicide for herpes and HIV

... safety of a new a vaginal gel designed to prevent herpes and HIV infection. If it is effective and ... no such products on the market. Women who have herpes are at increased risk of contracting HIV, so diminishing the risk of getting herpes also diminishes the risk of HIV infection. ...

Research holds promise for herpes vaccine

... avenue for developing a vaccine against genital herpes and other diseases caused by herpes simplex viruses. In a study published earlier ... mice vaccinated with a live, genetically-modified herpes simplex virus type 1 (HSV-1) showed no signs of ...

Study shows how herpes infects cornea, evades immune cells

... herpes virus has an unusual strategy for infecting ... Journal of Cell Biology. Both strains of the herpes virus -- HSV-1, the strain that causes cold sores on the mouth, and HSV-2, genital herpes -- can infect the cornea, the clear, domed ...

Inheriting a tendency to brain infection

... a single gene that predisposes individuals to herpes simplex encephalitis, an infectious disease that ... as eight out of 10 adults are infected by the herpes simplex virus. For most, the worst symptom is a ... to it. There was little published evidence that herpes simplex encephalitis ran in families, which ...

Mice lacking key immune component still control chronic viral infections

... genetically engineered mice can control chronic herpes virus infections, researchers at Washington ... Library of Science Pathogens. In chronic herpes virus infections, the body brings the invader ... mice in the study were injected with murine gamma herpes virus 68, ...

Knowledge of infection may prevent spread of herpes virus

... the virus that causes most cases of genital herpes could be cut in half by more testing and ... infection would lead to decreased transmission of herpes simplex virus (HSV) to others. But Anna Wald, ... the virus when they knew they had genital herpes and informed their sexual partners. According ...

Scientists use gene transfer technology and common virus to block neuropathic pain

... to their success is based on a virus called herpes simplex or HSV ?the same virus that causes cold ... use of gene transfer technology, using a herpes viral vector, to treat peripheral neuropathic ... removing genes that make it possible for the herpes simplex virus to infect a human host, VA/U-M ...

Scientists use gene transfer technology and common virus to block neuropathic pain in animals

... to their success is based on a virus called herpes simplex or HSV ?the same virus that causes cold ... use of gene transfer technology, using a herpes viral vector, to treat peripheral neuropathic ... removing genes that make it possible for the herpes simplex virus to infect a human host, VA/U-M ...
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