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Haplotype in Biological News

Preliminary DNA analysis completed on California wolverine

... Range. Scientists determined the sample is a haplotype A, which is a genetic type that is found ... at the Rocky Mountain Research Station. He said haplotype A is not found in historic California samples or ... and the Southern Sierra Nevada populations from haplotype A, but more information about the population of ...

First individual genome sequence published

... ability to begin to do better and more informed haplotype assemblies. Haplotypes are groups of linked ... million variant set and new algorithms to build haplotype assemblies that, when compared to the HapMap ... of new seque ncing technologies. Long-range haplotype linkages will enable much more complete analysis ...

HapMap browsing and DDDP methods for genetic analysis featured in CSH Protocols

... To aid in the study of genetic diseases, scientists with the International haplotype Map Project have developed a haplotype map of the human genome, a tool that displays common patterns of genetic ...

International study identifies gene variants associated with early heart attack

... healthy controls. The current study took advantage of several scientific tools developed over the past decade. These include the International haplotype Map, a comprehensive map of SNPs across the genome; genotyping arrays that allow screening of hundreds of thousands of SNPs at once; and a gene chip ...

How what and how much we eat (and drink) affects our risk of cancer

... cancer, Lew said. Still, more study is needed to clarify the effect of alcohol on other tumor types. Association Between ADH1B and ADH1C haplotype Tag SNPs and Breast Cancer Risk, and the Interaction with Alcohol Drinking: Abstract 5814 Specific variations within two genes involved with ...

U-M researchers release most detailed global study of genetic variation

... SNPs; haplotypes; and CNVs. If the human genome is viewed as a 3-billion-letter book of life, then SNPs represent single-letter spelling changes, haplotype variations equate to word changes, and CNVs are wholesale deletions or duplications of full pages. The patterns revealed by the new study support ...

Researchers map of genetic variations implicated in disease

... "Data generated by projects such as the MHC haplotype Project will feed into the recently announced ... diabetes and rheumatoid arthritis." The MHC haplotype Project is creating a public resource to assist ... most variable region of our genome. The MHC haplotype Project is studying in fine detail the sequence ...

Maine Researchers Find Exceptions to Old Rules of Genetic Inheritance

... be more significant than mapping the genome. The haplotype map could allow researchers to look for a single ... that proposal, demonstrating that genes within a haplotype function independently. The group included Dr. ... of the population carries one copy of the t haplotype whereas the remaining 80 percent carries the wild ...

International team analyzes human genetic variation in key immune region

... inherited together in groups called "haplotypes." To characterize the haplotype patterns of the MHC, the researchers analyzed the variability in its DNA ... analyzed had been previously examined as part of the International haplotype Map ("HapMap") Project, a worldwide scientific collaboration to catalogue ...

U-M scientists identify major psoriasis susceptibility gene

... 11 genes was linked to psoriasis, U-M scientists used a technique called haplotype mapping. Haplotypes are clusters of alleles that tend to be inherited ... ancestor, are often passed intact from generation to generation. If a haplotype contains genetic changes that make people more susceptible to a disease, ...

U-M scientists say fused genes trigger the development of prostate cancer

... HapMap Consortium in the journal Nature. The group's HapMap is a map of haplotype blocks and the tag SNPs that identify the haplotypes from a database of ... in UCSD's Jacobs School of Engineering. "We have demonstrated that haplotype phasing can be done routinely every time there is a new release of data ...

California computer scientists double volume of data in NIH biotech repository

... HapMap Consortium in the journal Nature. The group's HapMap is a map of haplotype blocks and the tag SNPs that identify the haplotypes from a database of ... in UCSD's Jacobs School of Engineering. "We have demonstrated that haplotype phasing can be done routinely every time there is a new release of data ...

Human brain is still evolving

... Blocks of linked polymorphisms are called haplotypes, whereby each haplotype is, in essence, a distinct genetic variant of the gene. They found that ... To produce more informative statistical data on the frequency of haplotype D among population groups, the researchers applied their methods to a ...

International HapMap consortium expands mapping effort

... group already will have reached completion of its first draft of the human haplotype map, or HapMap, which will consist of 1 million markers of genetic ... result of this public-private collaboration will be an outstanding human haplotype map that will provide a major new tool in the effort to combat human ...

DNA analysis reveals rapid population shift among Pleistocene cave bears

... changes). The findings indicated that while four sequence types (known as haplotypes) corresponded to bears 28,000 to 38,000 years old, a fifth DNA haplotype was found only in bears that were 28,000 years old or younger. These data suggested that what had been a stable, long-established cave bear ...

Biologists find regions of rice domestication

... 9, 2006, in the on-line issue of the Proceedings of the U.S. National Academy of Science. "We look where the genetic signature of clusters on a haplotype tree (family tree)," explained Londo. "We chose samples across the entire range of rice and looked for DNA sequences that were shared by both wild ...

New analysis shows three human migrations out of Africa

... based on an examination of specific haplotypes, clusters of genes that are inherited as a unit. In 2002, Templeton analyzed ten different haplotype trees and performed phylogeographic analyses that reconstructed the history of the species through space and time. Three years later, he had 25 ...

NHGRI expands effort to revolutionize sequencing technologies

... restriction maps to help assemble the genome once it is sequenced. The group will then demonstrate how to combine the sequence and maps into distinct haplotype sequences. Gregory L. Timp, Ph.D., University of Illinois at Urbana-Champaign. $2.1 million (3 years) "Sequencing a DNA Molecule Using a ...
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