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Glycoprotein in Biological News

New windows opened on cell-to-cell interactions

... allowing precise optical measurements of the orientation of the molecule. Electron microscopy revealed the presence of rigid, rod-like brushy glycoprotein (sugar-containing compounds) -- 30 billionths of a meter long -- similar to natural cell-surface proteins. Interaction between cells occurs when ...

American Chemical Society's Weekly PressPac -- Dec. 17, 2008

... them unusable for transplantation. To address this challenge, the researchers developed synthetic antifreeze materials, called C-linked antifreeze glycoprotein analogues (C-AFGP). These proteins contain a sugar coating and have custom-tailored antifreeze activity. Now the scientists describe the ...

Sarcospan, a little protein for a big problem

... severe form of muscular dystrophy. In Duchenne muscular dystrophy (DMD), the mutated dystrophin protein fails to anchor correctly to its membrane glycoprotein complex. And without this anchoring, muscle cells experience severe contraction-induced damage. Sarcospan is part of the anchoring complex, but ...

Scripps research scientists reveal key structure from ebola virus

... Nature article, though, provides hope that one day modern medicine will have more to offer. The structure of the antibody together with the viral glycoprotein helps reveal the mechanisms by which the molecules assemble on the viral surface and helps explain how the pathogen evades and exploits the human ...

Mate choice in plants

... attached carbohydrate components, have been found to be associated with pollen tubes. These proteins, transmitting-tract-specific (TTS), 120 kDa glycoprotein (120K), and pistil extension-like protein III (PELPIII), may play a role in movement of S-RNases into the pollen tube vacuoles and, if necessary, ...

Findings released from 1 of the largest percutaneous coronary intervention trials ever

... rate of adverse clinical events, a lower rate of major bleeding, and a lower mortality rate than those who were treated with a regimen of heparin and glycoprotein IIb/IIIa inhibitors (GPI). In the landmark global trial, bivalirudin was compared to heparin plus GPI in more than 3,600 patients with ST-segment ...

Sugar linkage could lead to better treatment for autoimmune diseases

... University of New Hampshire Glycomics Center have helped identify a specific carbohydrate structure that confers anti-inflammatory activity to a glycoprotein antibody that could lead to improved treatment of autoimmune diseases like lupus or rheumatoid arthritis. The study, reported in a recent edition of ...

Biosensing nanodevice to revolutionize health screenings

... biotinylated DNA molecule is then attached to its axle. The marker protein, biotin, on the DNA is known to bind specifically and tightly to the glycoprotein avidin, so an avidin-coated gold nanorod is then added. The avidin-nanorod attaches to the biotinylated DNA strand and forms a stable complex. ...

Biophysical Society announces 2008 International Travel Awards

... Stimulation of Pancreatic Acinar Cells. Meera Singh, Indian Council of Medical Research, New Delhi, India, Homology Modeling of Signalling glycoprotein from Camel (SPU-40) and Its Functional Characterization. Chiara Stringari, University of Florence, Italy, Structural Dynamics of the Skeletal ...

Penn researchers shine the light of venus to learn how the herpes virus invades cells

... of Sciences, provide a better understanding of the mechanism that viruses use to conquer healthy cells. Beginning with the knowledge that HSV-1 glycoprotein gD binds to cell receptors in a healthy cell to begin virus-cell fusion, researchers questioned how other proteins combined or cooperated on the ...

Ireland Cancer Center researchers advance stem cell gene therapy

... number of platelets in the blood) using Bax Inhibiting Peptides to rescue the damaged cells. Dr. Keith McCrae and colleagues presented that 2 glycoprotein is a cofactor in the process that dissolves blood clots through the use of the medical agent tPA. ...

American Society for Microbiology honors Joanna Kubler-Kielb

... postdoctoral work. In addition, Kubler-Kielb has received international recognition for her work in the preparation of experimental antibacterial glycoprotein and protein vaccines. Dr. Kubler-Kielb received her M. Sc. Eng. degree from the Technical University of Wroclaw, and her Ph.D. from the Institute ...

Jefferson scientists find rabies-based vaccine could be effective against HIV

... two different viral proteins into the rabies virus genome, and using such viruses-based vaccines in preventing disease in rhesus macaques. One was a glycoprotein on the surface of HIV, while the other was an internal protein from simian immunodeficiency virus (SIV). They used the latter because HIV does not ...

Discovery of an HIV inhibitor in human blood points to new drug class

... excluding the possibility that some other factor was responsible. VIRIP specifically targets a conserved region in the HIV-1 transmembrane glycoprotein known as "gp41 fusion peptide." This peptide, which is normally buried in the viral envelope, becomes exposed during the process of viral entry and ...

UCSD researchers create roadmap to integrin activation

... work to take apart and re-build the signaling pathway that regulates activation of the body's most abundant platelet receptor, an integrin called glycoprotein (GP) IIb-IIIa, provides a powerful and flexible tool for studying therapeutic targets along the pathway that impacts the activation process. This ...

DNA to the defense

... systems, T. brucei continually changes the expression of the proteins on its outer surface. These proteins are encoded by VSGs, or variant surface glycoprotein genes. While the immune system attacks most of the parasites in a given host, some trypanosomes rapidly evolve and express new variants of VSG, ...

Minor mutations in avian flu virus increase chances of human infection

... 16, 2006 by ScienceXpress, the advance online version of the journal Science. Receptor specificity for the influenza virus is controlled by the glycoprotein hemagglutinin (HA) on the virus surface. These viral HAs bind to host cell receptors containing complex glycans-carbohydrates-that in turn contain ...

GlycoFi announces the first production of antibodies with human glycosylation in yeast

... the next decade. GlycoFi is now working to expand its library of glyco-engineered yeast cell lines and expects to obtain a large array of specific glycoprotein variants that were hitherto unobtainable at a commercial scale. The company believes that as the scale-up and recombinant production of proteins in ...

Ebola DNA vaccine produces immune responses in all fully vaccinated volunteers in Phase 1 trial

... dangerous pathogens." The vaccine used in the Phase 1 trial vaccine included three plasmids (closed loops of DNA), one each encoding the surface glycoprotein (GP) from the Zaire strain of Ebola, GP from the Sudan/Gulu strain, and the internal nucleoprotein (NP) from the Zaire strain. Subjects received ...

Have a taste for fat? Yes! A sensor in the mouth promotes preference for fatty foods

... in the oral cavity. The authors combine genetic, morphological, behavioral and physiological approaches to pinpoint the multifunctional glycoprotein CD36 (also termed fatty acid transporter, FAT) as the sensor for fat. They show that lingual stimulation of CD36 by fatty acids influences ...

Breakthrough System for Understanding Ocean Plant Life Announced

... African sleeping sickness. The trypanosome evades the human immune system because it is coated with a surface antigen called variant surface glycoprotein (VSG). The human body makes antibodies for VSG, but trypanosomes randomly switch to another antigen when the organisms divide and reproduce. ...

Newly discovered protein an important tool for sleeping sickness research

... African sleeping sickness. The trypanosome evades the human immune system because it is coated with a surface antigen called variant surface glycoprotein (VSG). The human body makes antibodies for VSG, but trypanosomes randomly switch to another antigen when the organisms divide and reproduce. ...

Scientists discover how Ebola virus infects cells

... these inhibitors may facilitate development of an anti-Ebola-virus therapy." Reference: K Chandran et al. Endosomal proteolysis of the Ebola virus glycoprotein is necessary for infection. Science Express. Published online April 14, 2005. DOI: 10.1126/science.1110656. ...
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