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Genotype in Biological News

Known genetic risk for Alzheimer's in whites also places blacks at risk

... in future studies that explore why the APOE genotype is a risk factor for Alzheimer's disease, a ... By understanding the mechanism by which the genotype confers risk, scientists could potentially ... the risk of developing Alzheimer's disease, APOE genotype alone is not enough to predict the disease," she ...

Common gene variants influence risk factor for sudden cardiac death

... said Newton-Cheh. The QTGEN investigators examined the effect of a genotype score comprised of all 14 variants tested together. The top 20 percent of the population with the highest genotype scores had 160 to 210 percent higher risk of prolonged QT interval ...

Identifying mega-targets for high-yield plant breeding

... evaluate every single candidate genotype. Predicting the performance of a genotype is difficult due to the multiple breeding objectives and the many environmental conditions of genotype evaluation. Therefore, finding adapted elite genotypes is challenging if ...

SNPs affect folate metabolism in study of Puerto-Rican adults

... previous work showing that, under certain conditions, those with the TT genotype have a significantly lower risk for colorectal cancer than CC and CT ... for other potentially confounding factors, those with the MTHFR 677TT genotype displayed folate concentrations 4.6% lower than CC genotypes and CT ...

How 'hidden mutations' contribute to HIV drug resistance

... was funded by the Canadian Institutes for Health Research (CIHR). HIV genotype testing is now widely established in HIV drug resistance screening. ... for some time. "It's extremely time-consuming and expensive to validate genotype testing," he said. "However, we probably will be testing these areas in a ...

Student study bolsters case for adding a rare sunflower to the endangered species list

... consists of about 20 to 40 genetic individuals. If they have the same genotype then they are the same genetic individual. There can be ten stalks growing together that you would think are ten plants. But, when you genotype them, you find they are all the same genetic individual. The fact that ...

Mutation of the COX2 gene can double or treble a woman's risk of ovarian cancer

... the -765G>C COX2 polymorphism: the GG, GC and CC genotypes. An individual genotype is composed of two distinct parts, the inherited sequences from the ... be a CC, GC or GG genotype. The G allele is the most common, while the CC genotype is rare; therefore, it is usual to pool the GC and CC genotypes together ...

Gene determines whether male body odor smells pleasant

... which differ by two amino acids. As a group, participants with the RT/RT genotype perceive androstenone's odor as foul and intense. Those with the RT/WM ... smell androstenone at all. Although some participants with the RT/WM genotype can smell androstenone, they experience the smell very differently than ...

Student study bolsters case for adding a rare sunflower to the endangered species list

... consists of about 20 to 40 genetic individuals. If they have the same genotype then they are the same genetic individual. There can be ten stalks growing together that you would think are ten plants. But, when you genotype them, you find they are all the same genetic individual. The fact that ...

Genes, Environment and Health Initiative invests in genetic studies, environmental monitoring

... view study documents, such as protocols, questionnaires and summaries of genotype and phenotype data. The second is the controlled-access portion of the database, which allows approved researchers to download individual-level genotype and phenotype data from which the study participants personal identifiers, ...

Who will recover spontaneously from hepatitis C virus infection

... withdrawal. Several different genotypes of HCV were discovered. The HCV genotype studied by Dr. Milms group is type 1b, which is the prevalent genotype in Germany, and in China. ...

Virus-resistant grapevines

... and prevent them from spreading in the plant and causing damage." To enable the plant to produce the antibodies, the scientists have to modify its genotype and channel genetic information for the antibodies into it. This task is performed by tiny helpers called agrobacteria, which genetic engineers have ...

CSHL scientists harness logic of 'Sudoku' math puzzle to vastly enhance genome-sequencing capability

... and combinatorial number-placement rules used in the popular game. The method, which the CSHL team has patented, is currently best suited for genotype analyses that require only short segments of an individual's genome to be sequenced to find out if the individual is carrying a certain variant of a ...

Did the North Atlantic fisheries collapse due to fisheries-induced evolution?

... "There is no direct targeting of specific genotypes. Instead the intense selection results from the interaction of fish that select their habitat by genotype and fishermen choosing to fish in the preferred habitat of the fish," said Einar Arnason, professor of population genetics and lead author. In ...

Female mammals follow their noses to the right mates

... dissimilar males. Parents with dissimilar genes in a certain part of the genome tend to produce healthier offspring. So male mammals advertise their genotype via scent, and females pick up the signal and preferentially mate with dissimilar males. This ability to sniff out a good genetic match has been ...

International study identifies gene variants associated with early heart attack

... of atherosclerotic plaque in the coronary arteries. To analyze the effect of inheriting several risk-associated SNPs, participants were assigned a genotype score, which revealed that those with the highest number of risk-associated variants had more than twice the risk of an early-onset heart attack as ...

Effectiveness of progesterone in reducing preterm births may be altered by genetic predisposition

... African-American patients to be predictive of response to progesterone treatment. There was also an interaction between progesterone treatment and genotype of 3 additional polymorphisms for non-African-American women delivering very preterm (less than 32 weeks gestation). Today's award-winning ...

DNA repair patterns may predict risk of pancreatic cancer

... such as reactive oxygen species, there is an increased chance of getting cancer. Researchers found that the presence of a homozygous mutant genotype of LIG3 G-39A was associated with a 77 percent reduction in the risk of pancreatic cancer. By contrast, the presence of the gene ATM D1853N was ...

Genetic predictors of esophageal cancer identified

... of these SNPs in their genetic makeup, putting him or her into low-risk, medium-risk and high-risk groups. The study showed that each unfavorable genotype was associated with an increased cancer risk. Individuals with more than four unfavorable genotypes were more than three times as likely to develop ...

Researchers at UH explore patient preferences for personalized medicine

... Family Center for the Future of Health, a joint initiative between UH and The Methodist Hospital Research Institute. Personalized medicine uses a genotype or gene expression profile to stratify patients into smaller sub-populations to achieve greater prescribing precision, Issa explained. It can be used ...

GUMC and Oak Ridge National Labs announce unique research partnership

... The overarching goal of the project is to determine genetic and mechanistic interactions between adverse responses to stress and risk for obesity. genotype data are integrated with physiological, biochemical and molecular stress response phenotypes to identify components of the stress-obesity interface ...

Study reveals specific gene in adolescent men with delinquent peers

... the effect of DAT1 only in male adolescents from high-risk families," said Beaver, who will continue his research into the close relationship between genotype and environmental factors -- a phenomenon known in the field of behavioral genetics as the "gene X environment correlation." "Perhaps the ...

NIH's Genes, Environment and Health Initiative adds 6 studies

... of phenotype data. The second is the controlled-access portion of the database, which allows approved researchers to download individual-level genotype and phenotype data from which the study participants' personal identifiers, such as names, have been removed. ...

Mate selection more biologically determined in some human populations

... conflicting results. Adding to this debate is the recent study by Raphalle Chaix, Chen Cao and Peter Donnelly. The testing employed genome-wide genotype data and HLA types in a sample of African and a sample of European American couples, enabling the researchers to distinguish MHC-specific effects ...

Study finds connections between genetics, brain activity and preference

... that define our range of behaviors," says Hans Breiter, MD, senior and corresponding author of the study and principal investigator for the Phenotype genotype Project in Addiction and Mood Disorders, an interdisciplinary project involving the MGH Departments of Radiology, Psychiatry, and Neurology. "In the ...

Gaining ground on sickle cell disease

... future clinical implications of their work. "As we find gene variants that regulate HbF levels or predict severity, we might eventually want to genotype patients for these variants, to get more predictive information on their disease," Sankaran says. Finally, once this study is validated, ...

Did the gene for ADHD help our nomadic ancestors?

... population were better nourished than their non-nomadic brethren who carried 7R allele. The results underscore, says Campbell, the complexity of genotype on the expression of behavior. Different environments can determine whether behaviors associated with the gene, such as ADHD, are more or less ...

Human Genomics and Proteomics

... Human Genomics and Proteomics with a presentation on Saturday 31st May 2008 at the Human Genome Variation Society symposium: How to Explore Human genotype to Phenotype Relationships, a satellite event of the European Society of Human Genetics 2008 meeting, Barcelona, Spain ...

Quest for better treatment for effects of menopause

... otherwise, depending on the genetic variables carried by the women for the genes analysed. In the case of hormonal therapies, carriers of the GG genotype (a combination highly frequent in the mpo gene) undergo a drop in the antioxidant activity of the serum, which means, in this sense, a favourable ...

Courtship pattern shaped by emergence of a new gene in fruit flies

... said. "Sphinx appears to have evolved to reduce this in one single species." By silencing this gene, the researchers may have generated an ancestral genotype that existed before sphinx originated. D. melanogaster separated from related species about three million years ago, the researchers say. ...

Genetic variation linked to sugary food

... typically consumed during a one month period. Blood was drawn from each participant, and their DNA extracted. The researchers examined the genotype distribution and compared the food intake data each participant provided between individuals with the variation and those without the variation in ...

How body size is regulated

... scientists, Dr. Christian Gieger, Dr. Susana Eyheramendy, PD Dr. Thomas Illig, Dr. Iris M. Heid and Prof. Dr. Dr. H.-Erich Wichmann. In order to genotype 500,000 of the most frequent variants in the human genome, DNA chips were analyzed at the Institute for Human Genetics and the Institute of ...

Mental stress reduces blood flow to the heart in patients with gene variation

... mental stress-induced reduced blood flow to the heart, and about two-thirds of them harbored a particular variation of the adrenergic beta-1 receptor genotype that was associated with a three-fold increased risk of this phenomenon, said Mustafa Hassan, M.D., the studys lead author and a research fellow in ...

Virtual human in HIV drug simulation

... to make critical decisions on life-saving treatments. For example, for an HIV patient, a doctor could perform an assay to establish the patients genotype and then rank the available drugs efficacy against that patients profile based on a rapid set of large-scale simulations, enabling the doctor to ...

Clones on task serve greater good, evolutionary study shows

... Genetics of Microenvironmental Canalization in Arabidopsis Thaliana the group tackled the question of canalization -- a measure of the ability of a genotype to produce the same traits regardless of variability of its environment. As Dworkin puts it, Canalization is the robustness, because in many cases ...

Study outlines genetic differences between potential pandemic influenza strains

... including all the human cases, belonged to genotype Z. There were also small numbers of viruses isolated from avian populations that were genotype V or W or recently identified genotype G. That is where the similarity between the ...

U-M scientists say fused genes trigger the development of prostate cancer

... developed high-throughput genotyping technology, genotype information on an individual's SNPs can be ... or extrapolate these haplotypes from the flood of genotype data produced by DNA sequencing efforts. Eskin ... coincides with the release of a wide-ranging genotype study by the International HapMap Consortium in ...

California computer scientists double volume of data in NIH biotech repository

... developed high-throughput genotyping technology, genotype information on an individual's SNPs can be ... or extrapolate these haplotypes from the flood of genotype data produced by DNA sequencing efforts. Eskin ... coincides with the release of a wide-ranging genotype study by the International HapMap Consortium in ...

Exercise aside, genes may ultimately dictate seniors' mobility

... About a third of the population possesses the DD genotype of the gene, named for the angiotensin-converting ... found. No difference in mobility according to genotype was found among non-exercisers, suggesting ... who reported weight training and had the DD or ID genotype displayed the lowest rate of mobility loss in any ...
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(Date:7/10/2014)... MDBrightFocus Foundation, a nonprofit organization funding cutting-edge, innovative ... of glaucoma and macular degeneration, today announced the ... 55 scientists in 19 U.S. states, the District ... http://www.brightfocus.org/Grants2014 . , With these latest grants, ... in research funding in 2014. , The research ...
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