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Fragile in Biological News

Telomeres resemble DNA fragile sites

... They resemble unstable parts of the genome called fragile sites where DNA replication can stall and go awry. But what keeps our fragile telomeres from falling apart is a protein that ... striking similarity between telomeres and common fragile sites, parts of the genome where breaks tend to ...

Measuring intellectual disability

... and quantitative means of measuring levels of the fragile X mental retardation 1 (FMR1) protein (FMRP), which is mutated in fragile X syndrome. The related report by Iwahashi et al, "A quantitative ELISA assay for the fragile X mental retardation 1 protein," appears in the ...

Promising new drug being evaluated as possible treatment option for fragile X syndrome

... new treatment option for adult patients with fragile X syndrome (FXS). Findings of the open label, ... antagonist, in adult males and females with fragile X syndrome showed there were no adverse side ... metabolism of an mGluR5 antagonist in humans with fragile X syndrome," said Dr. Elizabeth Berry-Kravis, ...

'Fly guy' makes memory breakthrough

... in people with intellectual disabilities like fragile X syndrome, and there are currently no clinically available treatments. fragile X syndrome is the most common cause of ... 4,000 males and 1 in 8,000 females. Children with fragile X syndrome may have learning and memory problems, ...

M.I.N.D. Institute researchers call for fragile X testing throughout the lifespan

... urge physicians to test for mutations of the fragile X gene in patients of all ages. That's because, ... professionals, of the potential impact of the fragile X mutation at different times in patients' lives," said Randi Hagerman, director of the fragile X Research and Treatment Center at the UC Davis ....

UCR researchers propose minocycline as a promising drug for patients with Fragile X syndrome

... acne and skin infections, can be used to treat fragile X syndrome , the most common inherited cause of ... that will test minocycline in patients with fragile X. Neurons in the brain communicate with each ... more efficient. The brains of patients with fragile X syndrome have an overabundance of immature ...

Researcher helping to pioneer medical therapy for Fragile X Syndrome presents latest findings

... findings in basic and clinical research for fragile X at the 11th International fragile X Conference, to be held July 23-27 in St. Louis. Families with children who are diagnosed with fragile X also will be attending the ...

UCI researchers restore memory process in most common form of mental disability

... identified how a mutated gene linked to fragile X syndrome blocks brain cells from locking new memories into lasting ones. The gene -- called fragile X mental retardation 1 (Fmr1) -- is turned off in people with fragile X syndrome. This genetic mutation disrupts ...

Deep into the machinery of adult fragile X

... by alterations in the same gene that causes fragile X syndrome. fragile X tremor/ataxia syndrome (FXTAS) overwhelmingly ... symptoms and cognitive decline. In contrast, fragile X syndrome manifests itself from birth and is the ...

Researchers identify proteins involved in new neurodegenerative syndrome

... genes into proteins, triggers the appearance of fragile X-associated tremor/ataxia syndrome (FTAX), a ... disorder associated with the gene that causes fragile X syndrome in children, said researchers from ... professor of molecular and human genetics at BCM. fragile X syndrome is the most common inherited form of ...

Scientists link fragile X tremor/ataxia syndrome to binding protein in RNA

... protein in the toxic brain pathway that leads to fragile X tremor/ataxia syndrome (FXTAS), an inherited ... in the Aug. 16 issue of the journal Neuron. fragile X tremor/ataxia syndrome was first recognized ... the mutated FMR1 gene, the same gene that causes fragile X syndrome--the most common inherited cause of ...

Satellite imagery shows fragile Wilkins Ice Shelf destabilized

... data showed that the first icebergs had started to break away from the fragile ice shelf. A very rough estimate suggests that, so far, about 700 sq km of ... that have formed over the last 15 years and which turned Wilkins into a fragile and vulnerable ice shelf. "The retreat of Wilkins Ice Shelf is the ...

Researchers describe protease inhibitor that may aid in diabetic retinopathy treatment

... time, the disease progresses to its advanced or proliferative stage, and fragile new blood vessels grow along the retina. However, these fragile vessels can hemorrhage easily, and blood may leak into the retina and the ...

Biologists discover link between CGG repeats in DNA and neurological disorders

... because it is associated with hereditary neurological disorders such as fragile X syndrome and FRAXE mental impairment. In a study to be published in ... checkpoints. As a consequence, chromosomes under-replicate, become fragile and break. ...

New UGA invention effectively kills foodborne pathogens in minutes

... wash rapidly kills Salmonella and E. coli O157:H7 on foods ranging from fragile lettuce to tomatoes, fruits, poultry products and meats. It is made from ... immersion solution, and its concentration can be adjusted for treatment of fragile foods such as leafy produce, more robust foods such as poultry, or food ...

Are there rearrangement hot spots in the human genome?

... the model was refuted by Pevzner and Tesler, who suggested an alternative fragile breakage model (FBM) of chromosome evolution. FBM implies that the human ... is a mosaic of solid regions with low propensity for rearrangements and fragile regions where rearrangement hotspots reside. The rebuttal of RBM resulted ...

EC unveils new EU maritime policy

... Director of EMSA said. Intentional and accidental discharges threaten fragile coastal ecosystems, impact on tourism and generate significant clean-up ... quality in European coastal areas is important to effectively protect fragile coastal ecosystems. Within the MARCOAST Consortium under the GMES Services ...

'Shifting Sands' highlights past, present and future of Maryland coastal bays ecosystem

... Martin River, Sinepuxent Bay, Newport Bay, and Chincoteague Bay), as well as management activities, history, setting, context and ecology of these fragile lagoons. ...

Genetic marker linked to problem behaviors in adults with developmental disabilities

... to this variation may explain increased autism severity in individuals with it. It is not, however, linked to behavior problems in individuals with fragile X syndrome, pointing to the need for further research on genetic and other contributors to problem behavior in individuals with different ...

New monkey discovered in Brazil

... said Dr. Avecita Chicchon, Director of WCS's Latin America Programs. "We hope that the discovery will draw attention to conservation in this very fragile but biodiverse region." According to the study's authors, the monkey is threatened by several planned development projects in the region, ...

NOAA report finds threats to California's Cordell Bank Marine Sanctuary

... to sanctuary resources. "Global issues of concern such as marine debris, ocean acidification and invasive species have the potential to degrade fragile sanctuary resources and habitats," said Dan Howard, sanctuary superintendent. "This report provides a baseline for monitoring changes to sanctuary ...

Nonstick and laser-safe gold aids laser trapping of biomolecules

... bead that acts as a handle for the laser. Until now, creating the platform for such experiments has generally involved nonspecifically absorbing fragile molecules onto a sticky glass surface, producing random spacing and sometimes destroying biological activity. Its like dropping a car onto a road ...

Caribbean coral reefs flattened

... of East Anglia (UEA). The collapse of reef structure has serious implications for biodiversity and coastal defences a double whammy for fragile coastal communities in the region. It was already known that coral cover in the Caribbean was in decline, but this is the first large scale study ...

In the turf war against seaweed, coral reefs more resilient than expected

... that coral reef ecologists have developed over the past two decades," Precht said. "These findings will change the way we view and manage these fragile yet resilient ecosystems." Said Sweatman: "I hope this study leads to clearer definition of what coral-algal phase shifts are and broadens our ...

Scientists aim to bring indigenous people into climate change monitoring and policy

... resources that are directly affected especially by climate change, and they often inhabit economically and politically marginal areas in diverse, but fragile ecosystems. Local peoples are vital and active parts of many ecosystems and may help to enhance the resilience of these ecosystems. In addition, they ...

Small molecules might block mutant protein production in Huntington's disease

... ataxin-3. A person with Huntington's can have up to 100 CAG repeats. CAG repeats are involved in several other neurodegenerative diseases, including fragile X syndrome, the most common form of mental retardation, and myotonic dystrophy. While these genes are best known for the devastating effects of ...

Afghanistan declares its first national park

... area but vanished due to hunting in the early 1980s. The lakes are under growing threat from pollution and other human-caused degradation to the fragile travertine dams. Creating the national park will provide international recognition essential to helping develop Band-e-Amir as an international ...

The fragility of the world's coral is revealed through a study of the Northwestern Hawaiian Islands

... Northwestern Hawaiian Islands (NWHI) a vast area stretching over 1,200 miles can be used to make informed decisions about protecting the world's fragile reefs. Coral reef ecosystems are at risk due to the direct and indirect effects of human activities. This study was designed to help natural ...

UGA licenses invention that kills food-borne pathogens in minutes

... that are safe for humans and the environment. The new FIT product also will be available as a spray and immersion solution for foods ranging from fragile leafy produce, fruits and vegetables, to more robust foods such as meats and poultry, or food preparation equipment and food transportation vehicles. ...

Concerns about food safety to be spotlighted at U of Minnesota symposium

... include: Jean Kinsey, applied economics professor and center co-director, and research fellow Dennis Degeneffe, who will present "Tracking a fragile Relationship between Consumers and the Industry." Their talk will expand on findings from a February 2009 study that revealed just 22.5 percent of ...

UAB's Lisa Guay-Woodford earns top international nephrology prize

... incredible generosity, especially during a major recession, and the second - because all three passionately strive to save the most vulnerable, fragile and precious of the world's PKD patients." ...

UMMS researchers publish DNA identification of czar's children

... The murderers apparently attempted to destroy two of bodies and thus, they were not found in the first grave. "The newly found bone fragments were fragile and difficult to work with, but we were able to extract enough uncontaminated genetic material to conduct the tests. Thus we were able to test the ...

Changing sexes on the sea floor

... is the first in the world to discover that Japanese sea corals engage in "sex switching" too. His research may provide the key to the survival of fragile sea corals ― essential to all life in the ocean ― currently threatened by global warming. In times of stress like extreme hot spells, ...

Cell 'anchors' required to prevent muscular dystrophy

... B. Duke Professor of Cell Biology, Biochemistry, and Neurobiology. Ankyrins are a family of proteins that assist in attaching other proteins to the fragile cell membrane, and in the case of red blood cells, this helps cells resist shearing forces when blood is pumped vigorously throughout the body. ...

Earth's original ancestor was LUCA, not Adam nor Eve

... discovered the more thermostable DNA molecule, which they independently acquired (presumably from viruses), and used to replace the old and fragile RNA vehicle. This invention allowed them to move away from the small cool microclimate, evolved and diversify into a variety of sophisticated ...

Scientists fool bacteria into killing themselves to survive

... compared the survival of the bacterium Escherichia coli with that of a mutant strain of E. coli, which lacked PE lipids in its membrane. The fragile PE-deficient mutant strain out-survived the normal, healthy bacteria, when exposed to a "hole punching" synthetic antibiotic. However, the ...

USGS Science Picks

... Coral Reef Decline in Hawaii A New Look at a Critical Problem New discoveries about how even small amounts of sediment can severely impact fragile ocean coral and suggestions about solutions are illustrated and described in a new book written by a team of USGS scientists and their colleagues. ...

An essay proves that vegetation could recover in the ski resort of Sierra Nevada

... improve the present restoration methodology of the vegetable cover and landscape integration, and favour the preservation of biodiversity in such a fragile area such as Sierra Nevada", explains to SINC Francisco Serrano Bernardo , main author of the study and Researcher in the field of Environmental ...

'Arid aquaculture' among livelihoods promoted to relieve worsening pressure on world's drylands

... Because they do not primarily depend on land productivity, these and other options have the potential to reduce the pressure on the fragile resource base in marginal drylands, says the report. "At the same time, these strategies proved to yield significantly higher income per investment ...

Global methane levels on the rise again

... methane sources have been close to balancing the absorption of methane through atmospheric oxidation and into dry soil," Dr Fraser says. "This fragile balance has resulted in little growth of methane in the atmosphere. Apparently some sources have been increasing, such as from fossil fuel use, ...
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(Date:4/17/2014)... detection cartridge developed at Sandia National Laboratories and recently ... faster and cheaper. , Bacillus anthracis , ... soils all over the world and can cause serious, ... The bacteria can survive in harsh conditions for decades. ... occur through skin contact, inhalation of spores or eating ...
(Date:4/17/2014)... Calif. One day about eight years ago, ... California, Riverside, and her father were on a field trip ... upon an orchid they had never seen before. , Unable ... on orchids. The orchid turned out to be an ... Lophiaris silverarum . , "Lophiaris" is the genus name, ...
(Date:4/17/2014)... France have hit on a novel method to ... correct and most effective treatment possible., Kidney stones ... and developing world. If left untreated, apart from ... failure and other complications. In many patients treated ... a more effective pathological approach to diagnosis and ...
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(Date:4/17/2014)... presence of chronic inflammation in benign prostate tissue ... and this association was found even in those ... a study published in Cancer Epidemiology, Biomarkers ... Association for Cancer Research. , An analysis of ... the placebo arm of the Prostate Cancer Prevention ...
(Date:4/17/2014)... study published today in PLOS Pathogens , children ... is common can mount an immune response to infection ... repeated bouts of high fever and illness and partially ... The findings may help researchers develop future interventions that ... parasite. , Each year, approximately 200 million cases of ...
(Date:4/17/2014)... Le Bonheur Children,s Hospital Pediatrician-in-Chief Jon McCullers, MD, ... the April issue of Nature Reviews Microbiology ... Dr. McCullers, a world-renowned infectious disease specialist, ... the University of Tennessee Health Science Center, analyzed ... 1918, 1957 and 1968 pandemics, as well as ...
(Date:4/17/2014)... (April 16, 2014) The cause of neuronal death ... study proposes that neurons may be mistaken for foreign ... similar to the way autoimmune diseases like type I ... cells. The study was published April 16, 2014, in ... and likely controversial, idea in Parkinson,s disease; but if ...
(Date:4/17/2014)... An international team led by researchers at UC Davis ... plays a key role in cell division, also boosts ... the first time the complex has been shown to ... B1/Cdk1 an excellent target to control cellular energy production, ... was published online today in the journal Developmental ...
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