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Failure in Biological News

NIH announces new program to develop therapeutics for rare and neglected diseases

... these types of illness because of high costs and failure rates and the low likelihood of recovering ... drug from discovery to the marketplace. And the failure rate is high. "This initiative is really good ... This is also an expensive process, but the failure rate is lower at this stage. "NIH ...

Eating fatty fish once a week reduces men's risk of heart failure

... the association with the reduced risk of heart failure found in our study." A life-threatening ... pump enough blood to meet the body's needs, heart failure (also known as congestive heart failure) is ... blood pressure and coronary artery disease. Heart failure is the leading cause of hospitalization among ...

Ocera Therapeutics licenses novel treatment for acute hepatic encephalopathy from UCLB

... led by Professor Rajiv Jalan and the Liver failure Group at the Institute of Hepatology, UCL ... pressure in models of AHE in acute liver failure and cirrhosis. The data was published online in ... with AHE due to cirrhosis and acute liver failure will be carried out at University College ...

Plasminogen activator inhibitor type-1 -- a potential link between heart failure and diabetes

... contributing to the high incidence of heart failure after myocardial infarction in people with ... increased incidence and severity of heart failure following myocardial infarction in patients with ... lead to increased incidence and severity of heart failure following myocardial infarction. This is a major ...

While focusing on heart disease, researchers discover new tactic against fatal muscular dystrophy

... that a new class of experimental drugs for heart failure may also help treat the fatal muscular disorder. At first glance, heart failure and the muscle-wasting Duchenne disease couldn't ... their twenties. In people without Duchenne, heart failure typically starts much later in life, robbing the ...

UC Davis research shows that newly discovered drug reduces heart enlargement

... failure. "This holds promise to treat heart failure and other cardiovascular as well as kidney ... "The study of rat models showed that heart failure is driven by high angiotensin associated with ... progression of heart failure." Heart failure weakens the heart's pumping ability, she said. ...

Gene therapy reversed heart damage in heart failure

... GRK2 is a kinase that is increased in heart failure myocardium. Enhanced GRK enzymatic activity ... ARKct was sufficient to reverse heart failure even without concomitant metoprolol. The rats ... then a new class of drugs to treat heart failure could possibly even replace beta blockers. ...

News from the November 2008 Journal of the American Dietetic Association

... care cost will remain uncontrolled." Heart failure Risk Higher in High-Fat Dairy and Egg Eaters; ... whole-grain intake have a lower risk of heart failure than those who eat more high-fat dairy and eggs, ... investigated the relationships between heart failure incidents (death or hospitalization) and intake ...

Grapes may aid a bunch of heart risk factors, animal study finds

... pressure related to diet, and who develop heart failure over time because of prolonged hypertension. ... downhill sequence to hypertension and heart failure was changed by the addition of grape powder to a ... that occurred over time characteristics of heart failure and found that the high-salt grape group had ...

2 beta blockers found to also protect heart tissue

... drug development and in particular help heart failure patients, says Howard Rockman, M.D., senior ... fully developed as a beta blocker drug for heart failure patients. Beta blockers now are part of a standard of care for heart failure patients, who have weakened hearts and cannot ...

New evidence on the robustness of metabolic networks

... Other authors of the paper, titled "Cascading failure and robustness in metabolic networks," are Lus A. ... it is possible for a single reaction failure (which may be precipitated by a gene deletion or ... of snow that may trigger a large avalanche or the failure of a single transmission line in an electric ...

Biodegradable polymers show promise for improving treatment of acute inflammatory diseases

... illnesses as acute lung injury, acute liver failure and inflammatory bowel disease by delivering ... the use of polyketals to treat acute liver failure a condition when the liver stops functioning ... environment. "Patients with acute liver failure need drugs as soon as possible or else they'll ...

NJIT architect professor advocates best-building practices for high wind regions

... between the structure and foundation. Structural failure is often progressive where the failure of one structural element triggers the failure of another. Connections can be inexpensively ...

Vitamin D: New way to treat heart failure?

... pressure go on to experience a form of heart failure called congestive heart failure, in which the ... found to be deficient in vitamin D. "Heart failure will progress despite the best medications," says ... the high-salt diet were likely to develop heart failure within months. The rats on the high-salt diet, ...

Oocyte-specific gene mutations cause premature ovarian failure

... in a gene called FIGLA cause premature ovarian failure in at least a percentage of women who suffer from ... it with infertility, women with premature ovarian failure face an increased risk of cardiovascular disease, ... screened 100 Chinese women with premature ovarian failure for mutations in FIGLA and found three different ...

Jefferson receives $11.6M NIH grant to study novel mechanisms of heart failure

... mechanisms of cardiac injury that lead to heart failure and potential repair processes that occur in the ... only studying factors that contribute to heart failure but we are also looking for cellular and ... much of the project will focus on the science of failure and repair, it is also clinically relevant in ...

Many African-Americans have a gene that prolongs life after heart failure

... genetic variant that can protect them after heart failure and prolong their lives, according to research ... beta blockers have no additional benefit in heart failure patients with the variant, they are equally ... arrhythmias. While Caucasians with heart failure participating in clinical studies of beta ...

Genetic variant mimics effect of heart failure medications

... the researchers found that African American heart failure patients with the genetic variation had a natural ... heart failure, says Dr. Liggett. Heart failure refers to the hearts inability to pump adequate amounts of blood through the body. Heart failure can be the result of hypertension or a heart ...

New strategies against bird flu

... and showed that ACE2 can protect from acute lung failure in disease models (Imai et al. Nature 2005; Kuba ... influenza may cause severe and often lethal lung failure with similar pathologies. To identify these ... entire chain reaction which ends with the fatal failure of the lungs. Surprisingly, mice challenged with ...

Children's Hospital leads projects to develop nation's first heart assist devices for young children

... assist devices (VADs) for children in heart failure is part of a collaboration that recently has ... our options for treating young children in heart failure have been extremely limited. Our hope is that ... designed to support pediatric patients in heart failure for days to four weeks. Dr. Wearden also is ...

Taking the fight against cancer to heart

... hormones. Started with congestive heart failure research Vesely began his research on cardiac ... congestive heart failure, acute renal failure and cancer, also features presentations by other ... cardiac hormone orally to treat congestive heart failure and to reduce damage to heart tissue as a result ...

Cell Therapy for Cardiovascular Diseases

... infarction, or STEMI) and congestive heart failure (CHF). Each will cover strategies using ... from the MYOHEART trial in patients with heart failure will be presented for the first time by Dr. Warren Sherman Stem cells in patients with heart failure on left ventricular assist devices, presented by ...

Top scientists meet for global conference on stem cell therapy for cardiovascular diseases

... infarction, or STEMI) and congestive heart failure (CHF). Each will cover strategies using ... from the MYOHEART trial in patients with heart failure will be presented for the first time by Dr. ... Stem cells in patients with heart failure on left ventricular assist devices, presented by ...

RAND study finds evidence disease management programs

... conditions like diabetes and congestive heart failure by offering a system of coordinated healthcare ... evidence that patients with congestive heart failure and depression reported improved quality of life. ... programs reduce costs for congestive heart failure patients because many programs reduce hospital ...

Fourth Annual International Conference on Cell Therapy for Cardiovascular Diseases

... infarction, or STEMI) and congestive heart failure (CHF). Each will cover strategies using ... Nabil Dib Stem cells in patients with heart failure on left ventricular assist devices, presented by ... into the heart of a patient with congestive heart failure due to a previous heart attack. At Columbia ...

Human clones: New U.N. analysis lays out world's choices

... Kuppuswamy, Darryl Macer, Mihaela Serbulea. failure to outlaw reproductive cloning means it is just a ... National University of Ireland, Galway. If failure to compromise continues, the world community must ... production and destruction of embryos. failure to deal with the cloning issue reflects on "the ...

Socioeconomic position associated with effectiveness of HIV drugs

... lower levels of education reached initial regimen failure faster than participants with a college- or ... experienced a reduction in initial regimen failure by 15 to 17 percent. Adherence self-efficacy was ... and determine what proportion of treatment failure is modifiable through social variables, in ...

Device helps patients survive, regain function til transplant

... teenagers and smaller men with end-stage heart failure whose bodies arent big enough for other devices. ... heart status, as measured by their class of heart failure severity and their ability to walk for six ... by the decreased blood flow from a heart failure patients heart. The patients quality of life was ...

JCI table of contents: Aug. 9, 2007

... CARDIOLOGY: Cell death by necrosis leads to heart failure The prevalence of heart failure continues to increase in the Western world, ... in the cardiomyocyte loss that accompanies heart failure in mice. In the study, Jeffery Molkentin and ...

High blood pressure, low energy -- a recipe for heart failure

... production in heart muscle may underlie heart failure in some hypertensive patients. The researchers ... without any ERR alpha developed symptoms of heart failure when their hearts were forced to pump against ... and treatments are now available for heart failure due to high blood pressure, almost all of those ...

Chromosomal problems affect nearly all human embryos

... problems with conception, particularly for advanced maternal age, repeated failure of implantation, repeated miscarriages, or severe male fertility problems. ... chromosomal instability in all early human IVF embryos explains the failure of PGS to improve the live birth rate per embryo transferred. "I think ...

American Chemical Society weekly presspac -- June 10, 2009

... diagnostic and screening tests that literally sniff out chronic renal failure (CRF) in its earliest and most treatable stages. Their report is in the ... progression. ARTICLE #2 FOR IMMEDIATE RELEASE "Sniffing Chronic Renal failure in Rat Model by an Array of Random Networks of Single-Walled Carbon ...

Study finds colorectal cancer rates increasing worldwide

... points toward a failed early detection and prevention strategy as well as failure to address lifestyle and dietary challenges of urbanization that affect ... points toward a failed early detection and prevention strategy as well as failure to address lifestyle and dietary challenges of urbanization that affect ...

Adult bone marrow stem cells injected into skeletal muscle can repair heart tissue

... non-invasive mesenchymal stem cell (MSC) therapeutic regimen for heart failure based on an intramuscular delivery route," said Techung Lee, Ph.D., UB ... for cell growth. "For these reasons, and because patients with heart failure are not good surgical risks, it made sense to explore a non-invasive cell ...

Novel antibody prevents infection by hepatitis C virus

... Boston, Mass. Taking aim at a leading cause of liver failure in the United States, a team of scientists at the Massachusetts Biologic ... powerful antiviral drugs now used to attack HCV prior to end-stage liver failure are not routinely used during surgery due to the patients' weakened ...

Cellular discovery may lead to targeted treatment for rare form of anemia

... 16. DBA is a rare blood disorder characterized by the bone marrow's failure to produce red blood cells. This failure is due to an intrinsic defect that makes the red blood cells prone to cell ...

Fighting global warming offers growth and development opportunities

... secure Japanese harbors against stronger winds and more frequent storms, failure to do so could result in the loss of 1.5 to 3.4 percent of Japan's GDP by ... they must plan for sea defenses that can limit damage caused by waves. failure to do so could lead to bottlenecks in the shipments of products and ...

Children's National research links platelets to sepsis-related organ failure

... Medical Center have identified a previously unknown contributor to organ failure in patients suffering from sepsis: platelets. The finding, published ... perhaps this knowledge will help us find a way to prevent organ failure by targeting interventions directly at the platelets and granzyme B ...

For old or young dialysis patients, AV fistulas remain pure gold

... explained Forauer. A significant number of patients with chronic kidney failure receive dialysis using synthetic bridge grafts that tend to clot or ... Over the past five years, the number of new patients with kidney failure has averaged more than 90,000 annually. Kidneys filter waste from the ...

How chromosomes meet in the dark -- Switch that turns on X chromosome matchmaking

... chromosomes to be very close together and be aligned in a particular way. failure to achieve this close physical colocalization of the two X chromosomes will lead to XCI failure and cell death. Chromosome colocalization events are common in cells. A ...
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