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Factor in Biological News

Grant supports LSUHSC research on how like cell receptor systems determine very different functions

... molecules that assemble the pathway around growth factor receptors." The supplement was funded through ... movement and cell division activity of growth factor receptors as a novel phosphorylation target. ... that are dependent upon specific growth factor receptors, like some breast cancers in which the ...

Journal of Vascular and Interventional Radiology increases impact, international reach

... past five years, and the increase in its impact factor to 2.217 in 2008 ranks JVIR in the top half of 90 ... and experience," said Stainken. JVIR's impact factor is a direct measure of the number of times ... arterial disease, and its five-year impact factor is 2.956, based on citations in 2008 to items ...

UAB study reveals bone coupling factor key to skeletal health

... (UAB) have discovered a molecular coupling factor that helps bones grow and remodel themselves to ... drugs, the researchers said The coupling factor is a human protein called transforming growth factor beta-1, or TGF beta-1. Previously, scientists had ...

UT scientist receives hemophilia research award

... a shortage of a blood-clotting protein called factor VIII and current treatments include injections of synthetically-produced, replacement factor VIII. Symptoms include uncontrolled, sometimes ... immune systems that are resistant to replacement factor VIII and produce antibodies that attack the ...

Women with endometriosis need special care during pregnancy to avoid risk of premature birth

... has found that the condition is a major risk factor for premature birth, the 25th annual conference ... and need to receive ART, which is itself a risk factor for adverse pregnancy outcome. Among women ... ART 1.37. "Endometriosis appears to be a risk factor for preterm birth, irrespective of ART," said Dr. ...

Elsevier announces 2008 journal impact factor highlights

... announced the highlights of its journal impact factor performance in 2008. Elsevier overall saw 75% of ... editors and our societies. This year's impact factor growth is one indication of the hard work and ... some of the best in their fields." The impact factor is a measure of the frequency with which the ...

Impact Factor names Cell top research journal

... In the report released June 19, Cell 's impact factor increased to 31.3 from 29.2 the previous year. ... ranking also reveals that the inaugural impact factor for Cell Stem Cell scored at 16.83 only two ... other Cell Press titles increased their impact factor in the past year: Cancer Cell (+4.627%), ...

Caltech researchers explore how cells reconcile mixed messages in decisions about growth

... those are growth signals such as epidermal growth factor (EGF). When Asthagiri and his colleagues ... to raise or lower the levels of growth factor or, as Asthagiri and colleagues showed in their ... "which means they need a higher level of growth factor before they will divide." The relationships ...

Gene activity reveals dynamic stroma microenvironment in prostate cancer

... The researchers also found changes in growth factor pathways, including those for fibroblast growth factor and transforming growth factor beta as well as pathways linked to the growth and ...

Enzyme involved in inflammatory bowel disease discovered at Penn State College of Medicine

... meprin is able to activate an inflammatory serum factor produced by white blood cells, and this factor is elevated in both the mouse model of IBD and in ... the first association of meprin levels as a key factor in the severity of IBD." ...

The evolution of gene regulation

... organisms. In the simplest case, a transcription factor will activate the gene in question at the right ... genes are directly activated by a transcription factor that binds to them. These are only two simple ... in our example may now prove to be an important factor in regulatory development. Many questions are ...

Older men more likely than women to die after pneumonia

... inflammatory indicators, including tumor necrosis factor (TNF) and interleukins 6 and 10, coagulation indicators including factor IX, and fibrinolysis indicators including D-dimer ... CAP. "Macrophage migration inhibitory factor is a molecule that plays an important role in ...

Gladstone scientists identify key factors in heart cell creation

... scientists were unable to identify a single factor that could turn nonmuscle cells into beating ... enough. "When we finally identified the key factor that could work with GATA4 and TBX5 to turn cells ... to us," said Dr. Bruneau. The surprising factor was a cardiac-specific protein called BAF60c, ...

Newly discovered epidermal growth factor receptor active in human pancreatic cancers

... Pandey has identified an epidermal growth factor receptor aberrantly active in approximately a ... treatment. Phosophorylated epidermal growth factor receptor (pEGFR), the receptor identified by Dr. Pandey, is closely related to HER-2, a growth factor receptor found and used as a drug target in a ...

How tumor cells move

... discovered the previously unknown cell signal factor SCAI (suppressor of cancer cell invasion), which ... (DFG) at the Pharmacology Institute. The new factor could be an interesting starting point for ... as metastasizing breast cancer. "The cell signal factor SCAI controls the formation and function of ...

A paradigm shift in immune response regulation

... a linear ubiquitin chain is crucial for nuclear factor kappa B activation. Their findings may also ... They have been investigating how a transcription factor known as the nuclear factor kappa-B (NF-κB) coordinates the gene ...

Turning sunlight into liquid fuels

... metal itself was important, Frei said the major factor behind the enhanced efficiency and speed of the ... (where catalysis takes place) was the main factor behind their increased efficiency," he said, ... to Photosystem II," said Frei. "When you factor in the abundance of cobalt oxide, the stability ...

Rett Syndrome Research Trust advisor makes significant discovery

... that MeCP2-deficient astrocytes secrete a toxic factor that impacts the entire neighborhood of neurons, ... growth; in ALS glia appear to release a toxic factor that kills motor neurons." Maniatis stated that ... halting the secretion of this potential toxic factor could restore health, in particular to the MECP2 ...

Mammals can be stimulated to regrow damaged inner retina nerve cells

... mouse retina, and the effects of specific growth factor stimulation on the proliferation of Mller glia ... Then by injecting the eye with epidermal growth factor (EGF), fibroblast growth factor 1 (FGF1) or a combination of FGF1 and insulin, ...

Exercise increases brain growth factor and receptors, prevents stem cell drop in middle age

... a decrease in brain-derived neurotrophic growth factor leads to a decline in new neural stem cells. ... levels and brain-derived neurotrophic factor (BDNF) and its receptor TrkB levels in the ... on these results, it appears that nerve growth factor has more to do with these findings than the ...

Statins may prevent miscarriages

... the fetus. Using an antibody that blocks tissue factor interaction with PAR-2, they inhibited white ... cholesterol levels, could downregulate tissue factor (diminish the number of molecules expressed on ... "The study reveals a relationship between tissue factor and PAR2 in inflammation that could have ...

Cold Spring Harbor Laboratory scientists trace a novel way cells are disrupted in cancer

... ways not yet fully understood, this same splicing factor acts on a group of other molecules that has long ... levels in some tumors. For example, a factor known as SF2/ASF was elevated in more than 20% of ... the pathway. Krainer cautioned that the splicing factor may act on other proteins or in other ways in the ...

Compound that helps rice grow reduces nerve, vascular damage from diabetes

... the Journal of Lipid Research , shows the growth factor acylated steryl glucosides or ASG, helps ... watched as the resurrected ASG, a growth factor and lipid, helped normalize metabolism. "When ... author. "Part of the way we know this growth factor works is by increasing levels of good enzymes ...

NYU Langone Medical Center's tip sheet to the International Conference on Alzheimer's Disease 2008

... Institute suggests that a major genetic risk factor for Alzheimer's disease, apoE 4, may exert its ... surprisingly, those with the apoE 4 genetic risk factor significantly outperformed those without it. By ... containing the digestive enzymes is an important factor in Alzheimer's disease. Amyloid beta and another ...

Significant impact factor boost for scientific journal Genome Research

... Laboratory Press, was reported with an impact factor of 11.224, a considerable gain over 10.256 in 2006. An impact factor is a measure of a journal's significance in an ... example, Genome Research 's 2007 journal impact factor takes into account citations that occurred in ...

Impact Factor names Cell top research journal

... the report, released this month, Cell 's impact factor increased to 29.9 from 29.2 in prior year, ... Press, an imprint of Elsevier. The impact factor is a measure of the frequency with which the ... has been cited in a particular year. The impact factor helps to evaluate a journal's relative ...

Known genetic risk for Alzheimer's in whites also places blacks at risk

... that the gene APOE epsilon 4 allele is a risk factor for African-Americans as well as whites. Until ... a mainstream belief that the gene is only a risk factor for whites. "The results of our study have ... that explore why the APOE genotype is a risk factor for Alzheimer's disease, a progressive and fatal ...

Neural cell transplants may help those with Parkinson's disease

... engineered to produce glial derived neurotrophic factor (GDNF) in the brain following hNPC transplants. ... Tissue distribution of trophic factor is a critical variable to achieve optimal effects ... The volume of GDNF distribution in the trophic factor recipients significantly correlated with motor ...

Genetic 'tag team' keeps cells on cycle

... and off), acting one after another. Transcription factor one turns on the genes under its control along with transcription factor two; transcription factor two turns on its set of genes plus ...

Viruses may play a role in lung cancer development

... agree that smoking is by far the most important factor that contributes to lung cancer development. But ... suggest that measles virus may also be a factor in some lung cancers. Their study included 65 ... of other carcinogens and not as a causative factor by itself." ...

How your mother's emotional legacy impacts your life

... be available to us. Poulter defines the mother factor as our emotional development, functioning, and ... shaped by our mothers. The mother factor can work for or against us. Poulter shows that in ... of our mothers. By focusing on our mother factor from many different angles and perspectives, ...

How what and how much we eat (and drink) affects our risk of cancer

... kind has found that alcohol is a substantial risk factor for development of the most common type of breast ... changes in signaling through the epidermal growth factor receptor (EGFR) and the insulin-like growth factor 1 receptor (IGF-1R). We have demonstrated that ...

MU researcher links hormone replacement therapy to breast cancer

... in HRT, a synthetic progestin, could be a major factor in promoting breast cancer. At the same time, the ... cells to progestin caused an increase in a growth factor that is involved in the formation of new blood ... cancer cells in the body by inhibiting the growth factor that supplies blood vessels to the tumor. ...

First study hints at insights to come from genes unique to humans

... Stahl laboratory. His group studies how growth factor receptors, proteins important for both normal and ... and off. Found on the surfaces of cells, growth factor receptors turn on when they bind to a growth factor protein. To turn them off, cells take in the ...

NHLBI issues first US von Willebrand Disease clinical practice guidelines

... levels of a blood protein called von Willebrand factor affect the bloods ability to clot. Von Willebrand factor also carries with it clotting factor VIII, another important protein that helps blood ...

New mechanical insights into wound healing and scar tissue formation

... need to get at their "spinach" -- the growth factor sitting in the matrix which, once liberated, ... have discovered that the cells unlock the growth factor via a purely mechanical process. With experiments ... rigid that cell-exerted force allows the growth factor to pop out, like candy from a wrapper. Once the ...

Tiny fish can yield big clues to Delaware River health

... the health of the Upper Delaware River and will factor into decisions made about the flow of the river. ... a decline in the beaver population also may factor into the decline. Weve found bridle shiner in ... studies, which will continue into 2008, will factor into the Delaware River Basin Commissions flow ...

Study reveals a key to blood vessel growth and possible drug target

... is needed for the formation of the tumor necrosis factor receptor complex 1, a group of proteins and ... survival by initiating signals. Tumor necrosis factor promotes activation of NF-kB, a protein complex transcription factor involved in the transfer of genetic information. ...

Researchers expand efforts to explore functional landscape of the human genome

... group has two goals: to identify transcription factor binding sites by using chromatin ... These researchers will identify transcription factor binding sites in the human genome using chromatin ... will aim to computationally predict transcription factor binding sites that determine the activities of ...

For honey bee queens, multiple mating makes a difference

... number of times a honey bee queen mates is a key factor in determining how attractive the queen is to the ... that the number of partners appears to be a key factor in making the queen attractive to the worker bees ... that the number of times a queen mates is a factor in altering the composition of a pheromone, or ...
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(Date:7/11/2014)... two different ways that allow unprecedented experimental insights ... of oxygen molecules in photosynthesis. The two studies ... Nature Communications . , "The new knowledge will ... oxidation, which are key components for building artificial ... energy in fuels like hydrogen, ethanol or methanol," ...
(Date:7/11/2014)... that transplantation of mesenchymal stem cells can stimulate neurogenesis ... of Alzheimer,s disease (AD) and improve tissue and function ... are reported on the therapeutic effect of adipose-derived stem ... the effect on oxidative injury and neurogenesis in the ... team, School of Life Sciences, Tsinghua University, China transplanted ...
(Date:7/11/2014)... Evidence exists that cannabinoid receptor type 1 ... Ca2+ influx, and reduce neurotransmitter release. However, ... 1 can increase extracellular Ca2+ influx and ... his team, Tongji Hospital Affiliated to Tongji ... Technology, China used whole cell voltage-clamp and ...
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(Date:7/11/2014)... 2014 As reported by the ... 7/11/14), a significant number of severe adverse events such ... and even death from the highly-promoted and costly immune-system ... Times report , a regulatory filing revealed that ... patients was almost 14% of prescriptions, up from 9.1% ...
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(Date:7/11/2014)... HealthDay Reporter THURSDAY, July ... children from the worldwide scourge of dengue fever was somewhat ... vaccine only prevented dengue fever in 56 percent of the ... it protected more than 88 percent of them from severe ... hospitalization, and sometimes death. "This vaccine has already proven ...
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