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Expression in Biological News

Antibody targeting of glioblastoma shows promise in preclinical tests, say Lombardi researchers

... and other brain tumor tissues also recorded expression of PTN and ALK, as well as genes along this ... drive cancer. But in the case of PTN and ALK, the expression data suggest that these are drivers patients with increased expression of these genes had significantly poorer outcomes ...

Fox Chase researchers uncover one force behind the MYC oncogene in many cancers

... development, promotes cancer by activating the expression of the known oncogene, MYC, according to ... After their previous studies demonstrated that expression of the protein encoded by the DLX5 gene ... for cancer showed that they could promote the expression of MYC by transfecting cells with DNA strands ...

Will IVF work for a particular patient? The answer may be found in her blood

... Dr. Allen and her team chose to examine the gene expression patterns in RNA extracted from peripheral ... genes showed a more than two-fold difference in expression in early clinical pregnancy compared with a ... pathways that were most over-represented in this expression were concerned with angiogenesis (the growth of ...

Gene expression findings a step toward better classification and treatment of juvenile arthritis

... Scientists have discovered gene expression differences that could lead to better ways to ... junctions between tendons and bones). Using gene expression technology a method by which scientists can determine the relative levels of expression of thousands of different genes at the same time ...

Recruitment of reproductive features into other cell types may underlie extended lifespan in animals

... response including increased control of gene expression through RNA interference (RNAi) in somatic ... signaling pathway did exhibit somatic cell expression of genes usually active only in germline cells. ... and stress response also increased the expression of germline markers. "The idea that somatic ...

Protein linked to mental retardation controls synapse maturation, plasticity, CSHL team finds

... experiments have shown that "knocking-down" expression of the gene that encodes the production of the ... found to be abnormally short and misshapen when expression of the OPHN1 gene was acutely reduced. A ... a mutation." By manipulating OPHN1 gene expression on the postsynaptic side of the gap, the team was ...

MicroRNAs grease the cell's circadian clockwork

... clock, a group of genes displaying a cyclic expression pattern that reaches a peak once a day. A large ... in the brain. It allows synchronising gene expression and physiological functions with geophysical ... oscillators, a group of genes displaying a cyclic expression pattern that reaches a peak every twenty-four ...

Tips from the American Journal of Pathology

... demonstrate the role of stromal caveolin-1 expression as a prognostic marker for breast cancer ... tumorigenesis. However, although calveolin-1 expression has been extensively studied in epithelial cells ... al and Sloan et al therefore examined caveolin-1 expression in the stromal microenvironment of human breast ...

MIT reels in RNA surprise with microbial ocean catch

... while preserving the microbes' natural gene expression has yielded an unexpected boon: the presence of ... of RNA that act as switches to regulate gene expression in these single-celled creatures. Before now, ... will allow us to get an even deeper view of gene expression and microbial response to environmental changes. ...

SUMO protein guides chromatin remodeler to suppress genes

... alters the structure of chromatin to regulate expression of genes. Chromatin is a compacted mass of DNA ... diseases such as Alzheimer's, where aberrant gene expression and altered SUMO function are thought to be ... for preventing aberrant expression. Aberrant gene expression is a common feature of cancer and other disorders ...

A biological basis for the 8-hour workday?

... cycle. The investigators saw similar 12-hour gene expression patterns in five other tissues. "There is an ... more likely to cry with them." The shift in gene expression controlled by these harmonics can help an animal ... appears to control one of the 12-hour gene expression peaks. Mice consume about 20% of their daily ...

Genetic switch potential key to new class of antibiotics

... arising from riboswitches regulate gene expression at the level of the mRNA by changing shape in ... organisms, queuosine or "Q" enables accurate gene expression by overcoming a built-in defect (tRNA wobble) in ... In some cases, preQ1 riboswitches regulate the expression of a gene that codes for the enzyme queF, which ...

New nucleotide could revolutionize epigenetics

... "This is another mechanism for regulation of gene expression and nuclear structure that no one has had any ... arise in part from the dynamic regulation of gene expression rather than the genes themselves. Epigenetics, a ... it may have a positive role in regulating gene expression as well. The reason that this nucleotide had not ...

Plant gene mapping may lead to better biofuel production

... made some interesting observations about gene expression and gene location in their study of the ... prevent the RNA from building its enzyme, so the expression of one gene in the pair appears to inhibit its ... this natural "anti-sense" regulation for gene expression will assist scientists in their attempts to ...

Penn biologists discover how 'silent' mutations influence protein production

... have revealed a hidden code that determines the expression level of a gene, providing a way to distinguish ... previously thought to be the cause for protein expression variance, but it did not correlate with gene expression in these experiments. "At first we were ...

Altered gene can increase risk of schizophrenia

... into the brain-derived cells. Thus, the amount of expression of each SNP would be reflected (via the ... produced and showed a dramatic increase in gene expression in one variant over the others. These results echo the increased expression of NOS1AP that has been observed in postmortem ...

Changes in gene may stunt lung development in children

... online in Physiological Genomics , measured expression levels of the gene and its variants in both mouse ... Drs. Leikauf, Schulz and colleagues compared SOD3 expression levels in strains of mice with poor lung function ... function. One of these SNPs likely alters the expression levels of SOD3. Lung function was tested with ...

Tips from the American Journal of Pathology

... al engineered two new mouse models in which Tie-2 expression was limited to either epithelial cells or ... as choosing appropriate therapies. Decreased expression of the marker galectin-3 has been reported to ... metastasis, cell growth, and tumorigenicity. expression of intact versus cleaved galectin-3 thus might be ...

Researchers take first look at the genetic dynamics of inbreeding depression

... at inbreeding depression as it relates to the expression of all of an organism's genes to see which are ... variation in chromosome three had altered gene expression on the other chromosomes. "These results ... is due to a few key genes that affect the expression of other genes," said animal biology professor ...

Greatest thing since sliced bread: New data offer important clues toward improving wheat yields

... plant to survive and thrive. Understanding gene expression in wheat is complex, not only because there are ... Then they simultaneously measured genetic expression of thousands of genes in the parent strains and ... to feed themselves, exploited variation in the expression of genes in hybrid wheat. The need to foster ...

Scientists discover why teeth form in a single row

... one of the most common birth defects. Gene expression is the process by which information stored in ... and restricted by the effect of Osr2 on the expression of the Bmp4 gene within the mesenchymal cell ... BMP4 concentration gradient. Osr2 restricts Bmp4 expression to the tooth mesenchyme under the dental lamina, ...

UCR scientists identify stem-cell genes that help form plant organs

... of the researchers' work is a genome-scale, expression map of SAMan achievement that paves the way to ... cell walls." Reddy explained that the gene expression map his team generated can help researchers track ... It also will allow researchers to determine the expression patterns of SAM genes by a mere click of a button ...

Plasminogen activator inhibitor type-1 -- a potential link between heart failure and diabetes

... Colchester, Vermont have found that increased expression in the heart of plasminogen activator inhibitor ... to myocardial infarction. It led to increased expression of PAI-1 late after coronary occlusion ... reported findings demonstrating increased expression of PAI-1 in the heart in transgenic mice rendered ...

Researchers identify gene linked to aggressive progression of liver cancer

... of patients with HCC, the team found that the expression of AEG-1 gradually increases as the tumor becomes ... tumor cells and determined that AEG-1 modulates expression of genes relevant to the progression of HCC, ... that are generated from mRNAs to analyze gene expression profiles. "AEG-1 also activates multiple ...

NYU Langone Medical Center researchers find micro RNA plays a key role in melanoma metastasis

... are short pieces of RNA that block the expression of proteins that are encoded by messenger RNAs. ... and tissues. The lab found that the elevated expression of miRNA 182 turns it into an oncogene (a gene ... found that miRNA 182 also represses the expression of two tumor suppressors called FOXO3 and MITF, ...

Mutant host cell protein sequesters critical HIV-1 element

... is highly conceivable that intervention with Nef expression may complement the current anti-HIV therapies ... in the cytoplasm. Stress granules regulate gene expression at the translational level in response to a ... account for this translational suppression of Nef expression and offers a new strategy for development of ...

Team finds breast cancer gene linked to disease spread

... used recombinant DNA technology to enhance the expression of individual genes in the region, one by one, in ... altered the cancer cells to reduce the expression of MTDH, these tumor cells become less able to ... population of breast cancer patients." Gene expression is the translation of information encoded in a ...

Tips from the American Journal of Pathology

... Einstein College of Medicine have explored the expression of an immune molecule (CXCL1) that interacts with ... Clevenger and colleagues inhibited cyclophilin B expression in breast cancer cells. They found that absence ... in cyclophilin B levels can profoundly alter the expression of genes and cellular functions relevant to the ...

Krumlauf Lab demonstrates modulation of gene expression by protein coding regions

... at the Stowers Institute has discovered how the expression of one of the Hox master control genes is ... of the adult brain. Their studies discovered how expression of the key regulatory protein, encoded by the ... that encode proteins and those that control gene expression are usually separate from each other," explained ...

Real-time gene monitoring developed

... military commanders could compare gene expression in victorious and defeated troops. Retailers ... in BMC Biotechnology correlates real-time gene expression with movement and behavior for the first time. ... track it over time, and you could look at the expression of that gene. It's much easier than looking at it ...

The medium is the message: Manipulating salmonella in spaceflight curtails infectiousness

... mechanisms and produce illness. Through their expression of genesthe fundamental building blocks of ... experiments have shown that Salmonella gene expression and virulence are profoundly altered by ... importance of the microbial growth medium to gene expression and virulence during spaceflight. "Pathogenic ...

UC San Diego researchers use metagene 'portraits' to reveal distinct stages of kidney formation

... researchers are relying on portraits of gene expression patterns but, in this case, the images are ... and analyzed visual representations of gene expression patterns during kidney development. Approximately ... SOMs cluster genes with similar temporal expression profiles into metagene portraits. In this case, ...

Computation and genomics data drive bacterial research into new golden age

... such as yeast and bacteria to orchestrate expression of many genes simultaneously involved in a ... of a single factor initiating coordinated expression of multiple genes in turn determines the level of expression within a wide range, enabling a flexible response ...

Researchers solve piece of large-scale gene silencing mystery

... the chromosomes inherited from the other parent. expression of ribosomal RNA genes drives the formation of ... involved in nucleolar dominance to limit the expression of rRNA genes, they could potentially slow the ... Epigenetics refers to heritable changes in gene expression that arise from changes in the "packaging" of DNA ...

Reprogrammable cell type depends on a single gene to keep its identity

... change its identity that it requires the constant expression of a gene called Prox1 to dissuade it. The ... differentiated cell types that require constant expression of a specific gene to maintain their identity. ... their reprogramming into BECs as indicated by the expression of specific LEC and BEC proteins. In addition, ...

Scientists shed light on evolution of gene regulation

... as GATA1, DNA regulatory regions influence the expression of genes. But now researchers at Penn State have ... among mammals do act to control the level of expression of certain genes. To make their discovery, the ... bound by proteins that can influence gene expression are not under strong purifying selection. To ...

Exercise helps overweight children reduce anger expression

... Ga. - Regular exercise seems to reduce anger expression in overweight but otherwise healthy children, ... their usual inactive routine. The Pediatric Anger expression Scale, used to gauge common anger expressions ... "Exercise had a significant impact on anger expression in children," said Dr. Catherine Davis, clinical ...

December 2008 highlights from Biology of Reproduction

... suggesting that SOHLH2 production requires full expression of these important factors. Therefore, SOHLH2 is ... range of intermediate phenotypes and gene expression patterns (such as the augmentation of Stra8 expression by C57BL/6J background noted by others). ...

Social interactions can alter gene expression in the brain, and vice versa

... write, social information also alters gene expression in the brain to influence behavior. Thanks to ... David Clayton. He and his colleagues found that expression of a specific gene increases in the forebrain of ... , codes for a protein that itself regulates the expression of other genes. The finding was not ...

New test promises quicker, more accurate evaluation for cystic fibrosis patients

... the inflammatory environment and alter their gene expression as a result. By measuring mRNA, scientists can ... 10 genes that differed significantly in their expression before and after therapy. Using real-time ... contribute to permanent tissue destruction. "The expression of these genes correlated with FEV1, other ...
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