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Estrogen in Biological News

Evolution of a contraceptive for sea lamprey

... insights into the early evolution of the estrogen receptor, research by a team at the University of ... characterized the estrogen-binding site on the estrogen receptor in the sea lamprey. To accomplish this, ... a 3-D model of the structure of the lamprey estrogen receptor. The ...

Dual role in breast tissue for a protein involved in leukemia

... in developing breast cancer cells that are estrogen receptor-positive as compared to estrogen receptor-negative. When estrogen receptor levels were overexpressed, loss of ...

Lab study shows THC exposure as adolescents linked to negative effects of THC as adults

... at Louisiana State University had found that estrogen or more precisely, having ovaries made adult ... during the equivalent of adolescence, however, estrogen loses its protective effect. When these rats were ... results indicate that the effects of THC and estrogen are different, depending on age, and, even more ...

Internationally acclaimed researcher joins UH faculty thanks to $5.5 million grant

... bring an internationally recognized team to study estrogen action in normal and diseased tissues that will ... and expressed. Gustafsson discovered a major estrogen receptor protein and has worked in a variety of ... discovered the existence of a previously unknown estrogen receptor that plays a pivotal role in the ...

Hormone therapy associated with reduced colorectal cancer risk

... PHILADELPHIA The combination of estrogen plus progestin, which women stopped taking in ... who had never taken these hormones, the use of estrogen plus progestin was associated with a reduced risk ... was seen among women who had completed use of estrogen plus progestin five or more years previously. ...

HWI scientist first in world to unravel structure of key breast cancer target enzyme

... all three of the enzymes involved in controlling estrogen levels that can serve as drug targets for ... of all breast cancer tumors are estrogen-fed. estrogen is a female sex hormone and androgens are the ... was not known, nor the mechanism of androgen to estrogen conversion, the AIs currently in use have been ...

'New' estrogen receptor found to be key player in tamoxifen resistance

... resistant to tamoxifen display few of the "alpha" estrogen receptors that the drug is designed to bind on to ... (Estrogen-receptor positive cancer means that estrogen is the primary fuel that promotes cancer development and growth.) Tamoxifen binds to the estrogen receptors (alpha) that stud tumors and other ...

Birth control has long-term effect on hormone exposure

... of post-menopausal dietary soy consumption on estrogen metabolism in cynomolgus monkeys, Latanya M. ... control earlier in life had a reduced amount of estrogen excreted in their urine. The research was done in ... affected, they do know that both the level of estrogen in the blood and the amount ...

The dietary supplement genistein can undermine breast cancer treatment

... a soy isoflavone that mimics the effects of estrogen in the body, can negate the effectiveness of ... precursor molecules to estradiol, the main estrogen in the body. About two-thirds of all cases of breast cancer diagnosed in the U.S. are estrogen dependent ...

Is that song sexy or just so-so?

... than the "non-breeding" ones. But the effects of estrogen were not identical in every region. "If every ... the presence of estrogen, then we'd conclude that estrogen acts as an on-off switch," Maney says. "But what ... estrogen, and some goes down. We are seeing how estrogen changes the big picture as the brain processes ...

Gap junction protein vital to successful pregnancy, researchers find

... detail the mechanism by which the steroid hormone estrogen spurs cell differentiation and blood-vessel ... genes that are activated in the presence of estrogen in uterine cells. They found that Cx43 was ... is to identify the genes that are regulated by estrogen and progesterone precisely at the time when the ...

Songbirds may hold key to advances in treatment of brain degeneration

... (NIH) for "Synaptic Aromatase: A Novel Form of estrogen Delivery." The $1.8 million grant extends a ... adipose tissue and neurons. These modes of estrogen delivery underlie many, but not all, of the ... in females. "All songbirds make high levels of estrogen in their brains," says Saldanha. "The parts of ...

Chronic exposure to estrogen impairs some cognitive functions

... week that chronic exposure to estradiol, the main estrogen in the body, diminishes some cognitive functions. ... on the prefrontal cortex because it is rich in estrogen receptor beta (ER-beta), a protein that spurs ... risk of stroke and blood clots in women taking estrogen alone, and a higher than average incidence of ...

Improved estrogen reception may sharpen fuzzy memory

... GAINESVILLE, Fla. estrogen treatments may sharpen mental performance in ... suggest that recharging a naturally occurring estrogen receptor in the brain may also clear cognitive ... to offset "senior moments" related to low estrogen levels, as well as to protect against ...

Researchers identify cancer preventive properties in common vitamin supplement

... to prevent the first step that occurs when estrogen starts the process that leads to cancer by blocking the formation of the estrogen DNA adducts. We believe that this could stop the ... called quinone reductase, which reduces the estrogen metabolite back to inactive form. By ...

Estrogen helps drive distinct, aggressive form of prostate cancer

... College scientist have pinpointed the hormone estrogen as a key player in about half of all prostate ... on our new data, we now believe that inhibiting estrogen may be one way of doing so," he says. The ... aggressive subset of prostate cancer. While estrogen is typically thought of as a "female" hormone, ...

How what and how much we eat (and drink) affects our risk of cancer

... that are classified as positive for both the estrogen and progesterone receptors (ER+/PR+). ... have shown that alcohol increases the amount of estrogen metabolites available in a womans body, which can ... evidence for the notion that alcohol affects estrogen metabolism, which increases risk of hormone ...

High levels of estrogen associated with breast cancer recurrence

... back after treatment had almost twice as much estrogen in their blood than did women who remained ... The findings suggest that high levels of estrogen contribute to an increased risk of cancer ... that they should do as much as they can to reduce estrogen in their blood, such as exercising frequently and ...

Cold Spring Harbor Laboratory's lung cancer research program awarded $100,000 grant

... possibility that interactions between EGFR and estrogen might be important in the development of tumors ... will build upon preliminary observations that estrogen provokes EGFR activity in non-small cell lung cancer, Sordella said. We hypothesize that normal estrogen levels prevent the development of tumors ...

Too much sugar turns off gene that controls the effects of sex steroids

... regulates the levels of active testosterone and estrogen in the body, shows a new study in mice and human ... in controlling the amount of testosterone and estrogen thats available throughout the body. If theres less SHBG protein, then more testosterone and estrogen will be released throughout the body, which is ...

Linchpin gene may be useful target for new breast cancer therapies

... in the effectiveness of current treatments. estrogen causes hormone-responsive breast cancer cells to grow and divide by interacting with estrogen receptors made by cancer cells. Interfering with estrogen signaling is the basis of two common breast ...

American Chemical Society's Weekly PressPac -- Aug. 15, 2007

... research on the effects of the female sex hormone estrogen in the brain lend credence to what many women ... Deborah J. Clegg and colleagues showed how estrogen receptors located in the hypothalamus serve as a ... This research seems to support a link between estrogen and regulation of obesity, especially the ...

Targeting helpers of heat shock proteins could help treat cancer, cardiovascular disease

... shock protein 90 gets steroid receptors into shape to use hormones like estrogen and testosterone could lead to targeted therapies for hormone-driven ... also have a role in cardiovascular health, including the protective role estrogen seems to have in women before menopause and the fact that testosterone ...

Protein linked to change in tissue that surround and support breast tumors

... has found that AIB1 acts as a co-activator of growth proteins, such as estrogen receptor alpha and HER2/neu, which are also often over-expressed in tumor development. "AIB1 and its more active variant potentiate both estrogen and HER2/Neu at different stages of breast cancer. We knew that AIB1 delta ...

Statin therapy ineffective in breast cancer prevention

... or 500 mg/kg in the diet of rats, and it did not alter the incidence of estrogen receptor-positive mammary cancers or its multiplicity. Similarly, no effect of atorvastatin was observed in an estrogen receptor-negative model in mice. By contrast, when these mice were ...

National Lung Cancer Partnership and LUNGevity Foundation announce 2009 grant recipients

... fund the scientist's research on visceral pleural invasion and the role of estrogen in lung cancer tumors, respectively. Dr. Adusumilli, a general thoracic ... Additional research will use new technology to address other ways that estrogen may affect lung cancer in order to identify future therapies. "Only by ...

Breast cancer treatment resistance linked to signaling pathway

... subsets of patients with high Src activation who expressed low levels of estrogen receptor, progesterone receptor and HER2, also known as triple negative breast cancer, as well as subsets expressing the estrogen or progesterone receptors. These patient sets had lower overall ...

Growth factor predicts poor outcome in breast cancer

... the effect of IGF was independent of whether the tumor was affected by estrogen or not. "This is very important," said Lee. "Once patients are ... a drug called exemestane (Aromasin or an aromatase inhibitor that blocks estrogen production) in postmenopausal women. One group of women take the ...

July 2008 highlights

... infants. While these changes occurred in the absence of elevations of estrogen levels in the fetusessuggesting androgen-mediated prenatal programming ... of symptoms that define PCOSlocal tissue conversion of androgen to estrogen may provide additional programming. David H. Abbott, Deborah K. ...

Biomarkers allow doctors to match therapy to patient

... for prevention of disease, they say. These genes are found in estrogen receptor-positive (ER+) breast cancer, which investigators say is usually ... Center in Rotterdam hypothesized that cell proliferation in the absence of estrogen and in the presence of tamoxifen would be regulated at a molecular level ...

National Lung Cancer Partnership and LUNGevity Foundation

... lung cancer. Dr. Schullers research will evaluate the relationship between estrogen and the nicotine-derived carcinogen, NNK, in lung tumor formation. She hypothesizes that estrogen and NNK cause more DNA damage in lung cells than NNK alone. ...

Purdue research finds similarities in dog, human breast cancer pre-malignant lesions

... a lesion is identified, it can be treated with hormonal therapy if it is estrogen receptor (ER)-positive, but for low-risk and ER-negative lesions, we can't ... they wanted to examine each type of mammary intraepithelial lesion for estrogen receptors expression. Recently, scientists have concluded that breast ...

Short stressful events may improve working memory

... the transmission of glutamate in the prefrontal cortex of male rodents, which is opposite to the facilitating effect of acute stress, and that estrogen receptors in female rodents make them more resilient to chronic stress than male rats. "All these studies should bring new insights into the ...

Plastics chemical retards growth, function of adult reproductive cells

... of food containers and baby bottles. The chemical structure of BPA is similar to that of estradiol, a key steroid hormone, and it can bind to estrogen receptors on the surface of some cells. It is not known whether BPA blocks, or mimics or enhances estrogen's activity on these cells, Flaws said. ...

International collaboration by scientists culminates in novel ion channels database

... of the GPCR database which has been publicly available since 2005. GPCR pages updated in the current release are melanin-concentrating hormone, estrogen and P2Y receptors. ...

Bisphenol A exposure in pregnant mice permanently changes DNA of offspring

... subsequent fertility in both mice and humans (HOXA10). Furthermore, these changes in the offspring's uterine DNA resulted in a permanent increase in estrogen sensitivity. The authors believe that this process causes the overexpression of the HOXA10 gene in adult mice that they found in previous studies. ...

Lombardi scientist brings 'dream team' breast cancer research effort to GUMC

... breast cancer cells to preventive and treatment agents. He is recognized by many as the "father" the anti-cancer drug tamoxifen, a drug that blocks estrogen from fueling some breast cancers. Millions of women around the world continue to be treated with tamoxifen. Jordan's team, led by Dennis Slamon, MD, ...

Hormone-mimics in plastic water bottles -- just the tip of the iceberg?

... They then carried out a reproduction test with the New Zealand mud snail to determine the source and potency of the xenoestrogens. They detected estrogen contamination in 60% of the samples (12 of the 20 brands) analyzed. Mineral waters in glass bottles were less estrogenic than waters in plastic ...

Researchers may have found why women have an edge on salt-sensitive hypertension

... but females experienced a significant improvement. When they took out the ovaries, female rats responded more like the males. Dr. Pollock says estrogen seems to drive the beneficial action of the ETA receptor. Additionally, researchers found stimulation of the ETB receptor increased urine output and ...

BioScience tip sheet, December 2008

... and laboratory studies support a mechanism based on endocrine-disrupting chemicals, which interfere with the formation of gonadal steroids such as estrogen and the development of the reproductive tract. Of Mice and Men (and Mosquitofish): Antiandrogens and Androgens in the Environment. Andrew K. ...
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