Molecular typesetting -- proofreading without a proofreader
... and Bristol (UK) have developed a model of how errors
are corrected whilst proteins are being built.
... we would expect to see a hundred-fold more errors
than we actually do, so we know that some error ... out the last few letters of RNA.
So how are errors
corrected? Intelligent typesetters would remove ...
Research yields new clues to how we locate objects in space
... guide a needle to the bead. The subjects made errors
in locating the bead; they consistently picked ... What was interesting, however, was that the errors
from the first two experiments predicted the outcome of the third experiment; the sum of the errors
of the individual components (direct perception ...
Various species' genes evolve to minimize protein production errors
... shaped by genes' efforts to prevent or tolerate errors
in protein production.
Their study also suggests that the cost of errors
in protein production may lie in the malformed ... need to avoid misfolded proteins resulting from errors
Protein molecules must fold ...
Killer whales, blind bats, discriminating dolphins, mating birds
... room 342B.
7) HOW BATS COMPENSATE FOR RANGING errors
Echolocating bats obtain 3D images of their ... has found that combining the two types of errors
-- both of which depend upon flight speed -- ... the bat have zero ranging errors, while ranging errors
increase for closer or more distant objects. This ...
Researchers discover critical detail of cellular defense against genetic mistakes
... processes that detect and eliminate processing errors
are vitally important to effective gene ... the process such that it catches more genetic errors
in some cases, or leaves more templates for ... built mRNAs for errors, and initiates NMD when errors
are detected. Subsequent steady-state rounds then ...
Device prevents potential errors in children's medications
Five potentially serious medication errors
were averted over an 18-month period in a test at ... this technology in place we've deterred five errors
that might have happened. I really believe having ... Stevenson said. "If we wanted to eliminate errors
completely we knew we couldn't continue to rely ...
No convincing evidence for decline in tropical forests
... and found some serious problems.
and inconsistencies I have discovered in the area ... of that in the 1980s, said Dr Grainger. The errors
involved in making estimates for forest area ... enormous care, as FAO does, I argue that large errors
are inevitable if you produce global estimates by ...
Finding that 1-in-a-billion that could lead to disease
in the genetic code can give rise to cancer and a host of other diseases, but finding these errors
can be more difficult than looking for the ... what properties of DNA itself might lead to errors
that are not repaired. The finding may help ...
Results from trials of DHA in Alzheimer's disease and age-related cognitive decline
... the study participants taking DHA supplements made significantly fewer errors
on the PAL compared to when they started the study (-1.63 0.76, p
They ... took algal DHA capsules for six months had almost double the reduction in errors
on a test that measures learning and memory performance versus those who ...
Caltech researchers train computers to analyze fruit-fly behavior
... caught, and how many it missed," says Anderson. "By looking at the errors
the computer made, we were able to further refine our descriptions to ... of video," Perona adds. "And while previous experiments showed numerous errors
in tracking, we get very few. We are able to give accurate performance ...
Lost in translation
... ribosomes, Green and her team watched them react to lab-induced chemical errors
and were surprised to see that the protein-manufacturing process didn't ... the ribosomal assembly line begets another, and it's this compounding of errors
that leads to the partially finished protein being tossed into the ...
Case Western Reserve University uncovers genetic basis for some birth defects
... relatively common congenital defects and frequently arise due to genetic errors
that affect a key developmental pathway.
The research, titled "Mouse ... said Landreth. "This work sheds light on how these developmental errors
Remarkably, Dr. Sulagna Saitta, a human geneticist at ...
Brain recognizes verbal 'oh dear' wave
... It seems that our brain can correct speech errors
in the same way that it controls other forms of behaviour. Niels Schiller ... such as grabbing or walking are carried out. The 'Oh-dear' wave registers errors
so rapidly that they can sometimes be corrected in time. In this way you ...
Scientists trace molecular origin of proportional development
... embryos showed even a precise Bicoid gradient still has positional errors
that go beyond the boundaries set up by its target Hunchback. Dr. Ma's team suggests that Bicoid can self correct its positional errors
through a coupling that develops between Bicoid's forming gradient and the ...
Diabetes linked to male infertility; excess sugars in the body have direct effect on sperm quality
... translating the genetic information into a cellular function. If there are errors
in transcription, there will also be errors
in the function of the gene. "We were particularly interested to see a ...
Known genetic risk for Alzheimer's in whites also places blacks at risk
... one APOE epsilon 4 allele and those who had no epsilon 4 allele. Cognitive errors
on a standardized test were measured in four in-person interviews over a ... the gene -- both blacks and whites -- made increasingly more cognitive errors
over time on a questionnaire that assessed knowledge of items such as the ...
Wanted: 40,000 more health IT professionals
... technology systems to control health care costs, reduce medical errors
and improve patient care, it will need at least 40,000 additional health ... that they would improve clinical decisions and thereby reduce medical errors
and improve healthcare quality. All three major presidential contenders ...
Scientists debate the accuracy of Al Gore's documentary 'An Inconvenient Truth'
... states that the film gets the fundamental science right. The minor factual errors
do not undermine the main message of the film, which explains the theory ... and storms in particular (3). He concludes that there are significant errors
in the film, owing to alarmism and exaggeration, which give a false ...
'Telepathic' genes recognize similarities in each other
... recombination may shed light on how to avoid or minimise recombination errors
in evolution, natural selection and DNA repair. This is important because such errors
are believed to cause a number of genetically determined diseases ...
Cilia: small organelles, big decisions
... up, fully-finned fish.
The more they blocked, the more developmental errors
- for example, the growing fish would not properly extend their tails - ... branch, which controls messages to refine cell shape and growth. The errors
seen in the fish pointed to an imbalance where canonical signaling ...
New molecular clock from LLNL and CDC indicates smallpox evolved earlier than believed
... in DNA, the genetic material.
As cells multiply and divide, occasional errors
creep in to new copies of the genetic instructions. Some errors
are more critical than others. The variation allows some individuals among ...
Ants more rational than humans
... have not changed."
"Typically we think having many individual options, strategies and approaches are beneficial," Pratt adds, "but irrational errors
are more likely to arise when individuals make direct comparisons among options."
Studies of how or why irrationality arises can give insight ...
New research shows dinosaurs may have been smaller than we thought
... produces fairly accurate results when determining the mass of smaller animals, but when used on larger animals our research shows that many errors
have occurred," says Birchard. "The new equation shows that dinosaurs are much smaller than we thought, but there is no mistaking that they were ...
Genetic finding could lead to targeted therapy for neuroblastoma
... of the Cancer Center at The Children's Hospital of Philadelphia, researchers performed what's known as a genome-wide association study to uncover errors
in DNA that could be associated with neuroblastoma.
To do this, researchers analyzed the genetic makeup of 846 patients with neuroblastoma, whose ...
A Canada-wide technology platform for mapping the human interactome
... the researcher.
"Canadian scientists are at the forefront of research aimed at deciphering how proteins inside the cell interact, and how errors
in this process underlie disease states. This generous funding from the CFI will allow leading scientific groups in Canada to collaborate in ...
Small molecules mimic natural gene regulators
... counterparts. These molecules can help scientists probe the transcription process and perhaps eventually be used to correct diseases that result from errors
in gene regulation.
In previous work, Mapp and coworkers showed that an ATF they developed was able to turn on genes in living cells, but they ...
Capturing the birth of a synapse
... over and over among the estimated 100 billion neurons that make some 100 trillion synapses in a single human being. That leaves a lot of room for errors
in the DNA-driven instructions for synthesizing molecules responsible for synapse formation, Washbourne said.
"Basically," Washbourne said, "we ...
Details of bacterial 'injection' system revealed
... hone in on the structure hinted at by the other techniques. STEM also allows only good, intact molecules to be selected for analysis, which avoids errors
inherent in bulk measures of mixtures of intact and broken complexes, a problem that may have affected previous analyses.
"Our reconstruction ...
Learning how the pieces responsible for interpreting the human genome work
... tissues. "Most diseases arise as a result of the incorrect functioning of DNA proteins. For example, cancer is always an error or an accumulation of errors
in DNA caused by the improper work of proteins that should protect, repair or read it". According to Thomas Gingeras, determining the interactions ...
Allscripts Integrates Electronic Health Records with Innovative Patient Kiosk
... pressures including product offerings, pricing and promotional activities; our ability to establish and maintain strategic relationships; undetected errors
or similar problems in our software products; compliance with existing laws, regulations and industry initiatives and future changes in laws or ...
Lab study shows THC exposure as adolescents linked to negative effects of THC as adults
... these rats were again exposed to THC as adults, they performed more poorly on tests of learning and memory diminished response time, increase in errors
-- than did similar rats that had not been exposed to THC when younger.
Dr. Peter Winsauer says these results indicate that the effects of THC ...
After a few drinks, older adults more impaired than they think
... numbered and lettered dots on a paper, in chronological order, without lifting the pen from the paper. They were timed and evaluated for how many errors
they made. The first test involved numbers, while the second involved alternating between numbers and letters. Those tests give clues about a ...
UT Southwestern researchers identify molecule that helps the sleep-deprived to mentally rebound
... both the normal and mutant mice were almost error-free on the maze test. However, when sleep-deprived, the engineered mice made significantly more errors
on the maze test than their normal counterparts. This type of skills test represents the human equivalent of the attention and working memory needed ...
Virtual reality: Keyhole surgeons training could help meet European working time directives
... virtual reality (VR) training to standard 'apprenticeship' training in key-hole surgery learn more quickly, work with greater accuracy and have less errors
than those with no VR training, and perform as well as those who use additional video training. The finding of this Cochrane Systematic Review is ...
Study shows competition, not climate change, led to Neanderthal extinction
... the regions that a past population could potentially have occupied. By repeating the modeling process hundreds of times and evaluating where the errors
occur, this machine-learning algorithm is able to provide robust predictions of regions that could have been occupied by specific human cultures.
Life Sciences Discovery Fund awards health research program grants
... clinical guidelines that rely on what researchers have found to be effective treatment, has grown in all areas of health care in an effort to reduce errors
and improve health. In the field of mental health, most EBTs have been developed for use in urban areas and may not be easily transferable to rural ...
From sheet metal elements to host cells: DFG launches 10 new collaborative research centers
... With the aid of a particularly complex aircraft undercarriage, the Collaborative Research Centre aims to clarify how uncertainty and the resulting errors
of judgement can be managed. This will help to optimise planning, production and utilisation processes. (Host university: Technical University of ...
British scientists go cloud-hopping in the Pacific to improve climate predictions
... over the Pacific are affecting climate and weather all round the world, including the UK. This new 3M project aims to reduce some of the largest errors
currently in our climate models and thus greatly improve predictions of future climate change.
These immense clouds often exceeding the area of ...
Innovations in Pediatric Medicine CME conference brings together national pediatrics experts
... at NewYork-Presbyterian Hospital/Weill Cornell Medical Center and Weill Cornell Medical College
8:00 8:45 a.m.
Newborn Screening for Inborn errors
Dr. Piero Rinaldo, Mayo Clinic College of Medicine, Rochester, Minn.
8:45 9:15 a.m.
Prenatal Pediatrics: How Analysis of Fetal ...
£2 million study to reveal workings of dementia genes
... sufferers can develop problems with grammar and pronunciation or have semantic dementia where they lose the information content of language.
in two genes tau and progranulin have been identified as causes for FTLD but these only account for 10% of cases. The University of Manchester team ...