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Epigenetics in Biological News

Cancer's distinctive pattern of gene expression could aid early screening and prevention

... a piece of a relatively new research field called epigenetics that looks more globally at which genes are ... The early and apparently significant role of epigenetics in cancer has made the field a focal point for ... Cancer Center, which recently recruited two new epigenetics researchers with the help of the Georgia Cancer ...

Ants may help researchers unlock mysteries of human aging process

... seem to be a perfect fit for study about whether epigenetics influences behavior and aging." According to ... step was to begin to take a closer look at epigenetics in living organisms. epigenetics absolutely fascinates me. The more that you read ...

'Addicted' cells provide early cancer diagnosis

... "Basic research in the relatively young field of epigenetics is already contributing to our understanding of ... BBSRC funds a range of research in the field of epigenetics and has been encouraging networking amongst members of the European epigenetics research community." ...

$10 million gift to support cutting-edge epigenome center at USC

... will solidify USCs position at the forefront of epigenetics researcha field that holds great promise in the ... to the university because of the large amount of epigenetics research that has already taken place at USC, ... have been unthinkable even a short while ago. epigenetics is the study of how chemicals that attach to DNA ...

New method developed by UC San Diego bioengineers gives regenerative medicine a boost

... sciences, such as the study of cancers or Alzheimer's disease." epigenetics is an emerging frontier of science that involves the study of changes in ... activity and expression that are not dependent on gene sequence. While epigenetics refers to the study of single genes or sets of genes, epigenomics refers ...

New nucleotide could revolutionize epigenetics

... that make up the DNA code. But those are not the whole story. The rise of epigenetics in the past decade has drawn attention to a fifth nucleotide, ... says Heintz, a neuroscientist whose research has not focused on epigenetics in the past. "This finding of an enzyme that can convert 5-methylcytosine ...

Rethinking the genetic theory of inheritance

... carrier of heritable information; a secondary molecular mechanism called epigenetics may also account for some inherited traits and diseases. These findings ... the DNA sequence. CAMH's Dr. Art Petronis, head of the Krembil Family epigenetics Laboratory, and his team conducted a comprehensive epigenetic analysis of ...

Eating eggs when pregnant affects breast cancer in offspring

... A stunning discovery based on epigenetics (the inheritance of propensities acquired in the womb) reveals that ... of The FASEB Journal . "But there's an upside. The emerging science of epigenetics has yielded a breakthrough. For the first time, we've learned that we ...

The epigenetics of increasing weight through the generations

... that chemical changes in the ways genes are expressed a phenomenon called epigenetics -- could affect successive generations of mice. "There is an obesity ... 'epimutations.' That idea is now largely accepted and the field of cancer epigenetics is very active. I would make the same statement for obesity. We are on the ...

Computation to unravel how genes are regulated and shed light on how cells become different

... Approaches to the Role of Epigenetic Marks in Transcription Regulation. epigenetics studies features of the DNA and chromatin that are stably inherited ... determine structure and function. Just as crucially, it is believed that epigenetics also allows changes to these gene expression patterns to be remembered, so ...

New molecules discovered that block cancer cells from modifying cell DNA

... normal cells into cancer cells. This significant discovery in the field of epigenetics has immediate implications in the development of new diagnostic tests and ... well as from the National Cancer Institute and the Avon Foundation. epigenetics refers to changes to genes other than changes to the DNA sequence itself, ...

UD leads $5.3-million research project on rice epigenetics

... in a new direction, to new frontiers in the field of epigenetics. epigenetics refers to a heritable change that is not a result of a change in DNA ... run, has become available over the last year. The application of SBS to epigenetics research was demonstrated in the human genome only within the past few ...

UD leads $5.3-million research project on rice epigenetics

... in a new direction, to new frontiers in the field of epigenetics. epigenetics refers to a heritable change that is not a result of a change in DNA ... run, has become available over the last year. The application of SBS to epigenetics research was demonstrated in the human genome only within the past few ...

In lung cancer, silencing one crucial gene disrupts normal functioning of genome

... causes systemic dysfunction, or hypomethylation, in many genes, said the study's senior investigator, Zdenko Herceg, Ph.D., head of the epigenetics Group at the International Agency for Research on Cancer (IARC). "We found that tobacco-mediated hypermethylation of MTHFR, and consequent partial ...

International public-private partnership offers new paradigm for medicinal chemistry

... at the University of Oxford. The initiative could offer a new model for future interactions between academia and industry. The study of epigenetics tries to understand heritable changes in gene function that occur without a change in the DNA sequence. This signalling is thought to influence the ...

CSHL researchers map changing epigenetic modifications that enable transposons to run amok

... mobile genetic elements) escape these controls is one of the questions driving the research of Professor Robert Martienssen -- a pioneer of plant epigenetics -- at Cold Spring Harbor Laboratory (CSHL). By undertaking the ambitious task of mapping the changing epigenetic landscape of continuously dividing ...

Researchers solve piece of large-scale gene silencing mystery

... of Health and the National Science Foundation. The weird and the wacky Nucleolar dominance is considered an "epigenetic" phenomenon. epigenetics refers to heritable changes in gene expression that arise from changes in the "packaging" of DNA rather than modification of the underlying DNA ...

Fountain of Youth to be found in the anthill?

... behavior without some real differences in their DNA? According to Liebig and his collaborators, the answer can be found in the rising field of epigenetics the study of inherited changes in the activity of genes - for example, when they turned on or off; changes not caused by alterations in the DNA ...

Personalized medicine: Innovative online journal leads the way

... research. Genome Medicine will focus on the following areas: Significant advances in the understanding of the genetics, genomics, and epigenetics of disease Computational and systems approaches, including proteomics, metabolomics and transcriptomics, to the understanding and management of ...

Epigenetic research uncovers new targets for modification enzymes

... Enzymes regulating genetic expression can be just as important as the genome itself, increasing evidence shows. The expanding field of epigenetics focuses on the multiple influences on DNA and surrounding molecules that determine whether genes are turned on or off during development and disease ...

Scientists clarify a mechanism of epigenetic inheritance

... of nucleotides in two people can produce different patterns of gene expression if the way the DNA is clumped happens to be different. Probing epigenetics in Yeast We have not understood epigenetic inheritance very well, says Dr. Martienssen, a plant geneticist and one of the pioneers in the study ...

USC researchers explore genetic causes for male infertility

... able to prevent certain types of male infertility, concludes Sokol. This is particularly important because recent animal studies have suggested that epigenetics may have broader implications. Exposures to chemicals as a fetus may lead to adult diseases. Perhaps such exposures may be causing the changes in the ...

Duke scientists map imprinted genes in human genome

... brown, normal weight babies. The babies Agouti genes, the ones responsible for color, were the same as the mothers, yet they looked different. Thats epigenetics in action, says Jirtle. Its estimated that imprinted genes comprise about 1 percent of the human genome, and until now, only several dozen had ...

Human embryonic stem cells remain embryonic because of epigenetic factors

... brain, bone, skin and the other specialize cells crucial to normal human functioning. This discovery will advance our understanding of stem cell epigenetics and chromatin structures, provide potential mechanisms on maintaining the hallmark properties of ES cells, and help researchers with the rich source ...

New prostate cancer research findings

... cancer cells from turning off normal genes in a process that transforms normal cells into cancer cells. This significant discovery in the field of epigenetics has immediate implications in the development of new diagnostic tests and cancer medications. (Embargoed until 11:15pm EDT Thursday, October 11th) ...

Regulating the nuclear architecture of the cell

... University of California at Berkeley. The epigenetics of heterochromatin Controlling functions of ... and spatial rearrangements is known as epigenetics from the Greek for "on, over, or at" the ... perform are still an open question. Even epigenetics ultimately has its roots in the genes; the ...

Researcher gives hard thoughts on soft inheritance

... Genetics, analyzes recent and past research in epigenetics and the history of evolution and proposes that epigenetics should be considered a form of soft inheritance, ... The next level of gene regulation studied in epigenetics is DNA packaging. DNA is wrapped around proteins ...

Protein helps regulate the genes of embryonic stem cells

... is the first step toward understanding how epigenetics influences such occurrences as cancer and birth ... be," Magnuson said. Another application of epigenetics is stem cell therapeutics, in which any specific ... work, one has to begin to understand the epigenetics of the embryonic stem cells, and we really have ...

Exploring the dark matter of the genome

... in chromosome biology will benefit enormously from the new findings: epigenetics -- the inheritance of traits and genetic information as controlled by ... with the chromosomes, rather than by DNA sequence. Starting in the 1920s, epigenetics was discovered through biological studies of heterochromatin, and is now ...

Inheritance outside DNA

... to transmit heritable changes without changing DNA. Among other things, epigenetics is crucial to differentiation, the process which makes one cell from ... John Hopkins School of Medicine, who has been a pioneer in unraveling the epigenetics of cancer. Now Feinberg has taken a new look at genomic imprinting, ...

Turn-ons and turn-offs for neurons

... are all believed to change neuronal gene expression by mechanisms involving gene accessibility without changes in DNA sequences, a process called epigenetics ("above and beyond the gene”). Switching gene expression “on” and “off” is of utmost importance when studying gene function in the adult nervous ...

In a technical tour de force, Salk scientists take a global view of the epigenome

... in a forthcoming issue of Cell. Our view of heredity has largely been written in the language of DNA, but recent discoveries in a field known as epigenetics - the study of heritable changes in gene function that occur without changing the letters of the DNA alphabet - show that how a cell "reads" those ...

New view of cancer: 'Epigenetic' changes come before mutations

... changes and those come first," says lead author Andrew Feinberg, M.D., M.P.H., King Fahd Professor of Medicine and director of the Center for epigenetics in Common Human Disease at Johns Hopkins. Cells affected by epigenetic changes look normal under a microscope at low levels of resolution, ...

It's not all genetic: Common epigenetic problem doubles cancer risk in mice

... present well before tumors appear," says the study's leader, Andrew Feinberg, M.D., M.P.H., professor of medicine and director of the Center for epigenetics in Common Human Disease at Johns Hopkins. "In the mice with a double dose of IGF2, everything is pretty normal except for the extra precursor ...
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