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Endocytosis in Biological News

Scientists unveil mechanism for 'up and down' in plants

... only showed up at the bottom of a cell. endocytosis An international group of scientists from labs ... Subsequently they produced cells in which the endocytosis was disrupted in two different ways. The PIN ... was distorted. When these plants with disrupted endocytosis grew further, roots developed where the first ...

Researchers close in on origins of main ingredient of Alzheimer's plaques

... called synaptic activity. "Blocking endocytosis isn't a viable option for treatment because cells throughout the body, including brain cells, need endocytosis for healthy function," says first author John ... new treatments for Alzheimer's disease." While endocytosis is necessary for normal function of brain cells, ...

A key enzyme helps keep the synapse on track

... at Weill Cornell Medical College. Here's how endocytosis works: Within brain cells, information is stored ... "We found that it does," Dr. Ryan says. In fact, endocytosis slows down once synj1 is disabled in any key way, ... machinery," Dr. Ryan says. In each case, endocytosis slowed to a crawl, due in part, at least, to a ...

Cells use import machinery to export their goods as well

... inhibited three molecules known for their membrane-bending role in endocytosis -- clathrin, dynamin and actin. In the absence of any one of these ... the same machinery for both," Jaiswal says. "This blurs the line between endocytosis and exocytosis. Perhaps we should just call it membrane trafficking." ...

The challenges of avian influenza virus: Mechanism, epidemiology and control

... field with seven reviews and one manuscript of original studies on endocytosis and H5N1 influenza virus. The Website for Avian Flu Information consisting ... human infection and presents their recent work on the clathrin-dependent endocytosis of H5N1 influenza virus. H5N1 virus research is a scientifically ...

First study hints at insights to come from genes unique to humans

... a process cells use to take in material from their surface. endocytosis plays an important role in the Stahl laboratory. His group studies how ... To turn them off, cells take in the combined receptor-protein through endocytosis and put it through a number of different processes before finally breaking ...

Breakthrough technology observes synapse in real time, supporting theory of vesicular recycling

... laid to rest a competing theory as to how key cellular processes -- called endocytosis and exocytosis -- work. The scientists published their findings in ... membrane, where they deliver their information-rich cargo to the synapse. endocytosis involves a similar function in the reverse direction, with incoming ...

The downside of microtubule stability

... slow nerve impulses, reduce their strength, or both. One of these mutations leads to production of faulty dynamin 2, a protein that is crucial for endocytosis but also latches onto microtubules. Tanabe and Takei investigated how defective dynamin 2 hampers cells. Normal microtubules are continually ...

Tips from the American Journal of Pathology

... marker for breast cancer progression. These articles are highlighted by an accompanying Commentary. Caveolin-1, a protein that functions in endocytosis and signal transduction, plays a major role in breast cancer tumorigenesis. However, although calveolin-1 expression has been extensively studied in ...

Systems Biology poised to revolutionize the understanding of cell function and disease

... from European-wide programmes on mammalian cell cycle, tissue development and degeneration, stem cell differentiation, organelle function, and endocytosis are paving the way in this rapidly moving field. The EU has emerged as a major world player in Systems Biology, says Alfred Game from the BBSRC in ...

Carnegie Mellon scientists develop nanogels that enable controlled delivery of carbohydrate drugs

... tuned, and we are currently investigating how nanogels of different sizes enter cells. The results may allow us to better understand the mechanism of endocytosis and to target specific tissues, such as cancer cells that have a more permeable membrane. In their most recent advance, the Carnegie Mellon team ...

New, more direct pathways from outside the cell-to-cell nuclei discovered

... functional unit of life.) It was already known that material outside of a cell can migrate into a cell. This occurs through processes known as endocytosis and phagocytosis, in which extracellular material is captured by a pinched-in segment of the cell membrane. This extracellular material then becomes ...

Gene discovery sheds light on causes of rare disease, cancer

... structure called a vesicle. "Phagocytosis and endocytosis may, in fact, be more similar than past research ... scientists believed a cell could take in by endocytosis ?could invade non-phagocytic cells. Other labs ... inside, the cell must bring Met inside through endocytosis in order to dispose of it. As the cell creates ...

Hide and seek: Researchers discover a new way for infectious bacteria to enter cells

... structure called a vesicle. "Phagocytosis and endocytosis may, in fact, be more similar than past research ... scientists believed a cell could take in by endocytosis ?could invade non-phagocytic cells. Other labs ... inside, the cell must bring Met inside through endocytosis in order to dispose of it. As the cell creates ...

Structure-building cell signals also may influence learning and memory

... surrounded with a snippet of the cell's membrane. endocytosis important as it is the process by which cells ... these materials. Synaptojanin-1 enables endocytosis when it disassembles a molecular coating on ... then looked at whether ephrin truly increased endocytosis in cells that were not altered genetically. Using ...

Researchers develop assay that could be applied to drug screening

... for cargo internalization is clathrin mediated endocytosis (CME). CME is of fundamental importance for many ... "Although the basic model of clathrin-mediated endocytosis was proposed 41years ago, there are many basic ... "The role played by actin in clathrin mediated endocytosis has been controversial for a long time," Zenisek ...

Weill Cornell Research Reveals Secrets Of Trafficking Within Cells

... the body -- depends on an internal process called endocytosis to keep the flow of cellular nutrients and ... -- a protein called clathrin -- helps regulate endocytosis like a well-oiled machine. It may also give us ... states that can happen when clathrin-regulated endocytosis goes wrong. The findings, already published ...

Bound for destruction: Ubiquitination protects against improper Notch signaling

... in the cell membrane must first be internalized through a process known as endocytosis before they can be digested by the proteasome, and indeed other types of ubiquitin ligase have been shown to operate in the endocytosis of ligand-activated Notch. The group first showed that an increase in ...

Endosome-mediated signaling in plants

... in the inactivation of receptors and the down-regulation of cell signaling. Work in animal cells over the past several years has shown that receptor endocytosis can actually facilitate signaling through the cell, by bringing signaling components in contact with their activated receptors. Drs. Geldner, ...

Iowa State scientists demonstrate first use of nanotechnology to enter plant cells

... technology had worked more readily in animals cells because they don’t have walls. The nanoparticles can enter animal cells through a process called endocytosis ?the cell swallows or engulfs a molecule that is outside of it. The biologists attempted to mimic that process by removing the wall of the plant ...

A new step towards an AIDS vaccine

... show that pDC activation by HIV-1 requires at least two interactions between the cell and virus. Initially, envelope-CD4 interactions mediate the endocytosis of HIV-1. Next, viral nucleic acids, particularly RNA, stimulate pDCs through Toll-like receptors. A decrease of blood pDC frequency is ...

Researcher uncovers details of how cancer spreads

... may vary. In the model system, the researchers discovered critical differences between cancer cells and normal cells regarding a mechanism called endocytosis -- which cells employ to let materials enter through the cell membrane. The researchers used a protein called v-Src derived from an oncogenic ...
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