Scientists deconstruct cell division
... of Embryology have found that two proteins dynein
and Nudelinvolved in other cell-division ... isolated the spindle matrix. Interestingly, both dynein
and Nudel are components of the spindle matrix. ... brings it to microtubules where both Nudel and dynein
then help the lamin-B assemble into the spindle ...
Mutation may cause inherited neuropathy
... in only one copy of a gene coding for one part of dynein
protein have severe defects in proprioception, ... neuropathies.
Mutations in the gene for dynein
heavy chain 1, Dync1h, led to movement defects in ... deformities and various anatomic features.
appears to be a likely suspect, the authors ...
Media highlights in the January issues of Biophysical Journal
... by monitoring their phosphorylation status. Likewise numerous biophysical studies have explored the mechanics of single motor proteins of the myosin, dynein
and kinesin families involved.
Here, a biomechanical approach is taken, where in living cells the tension of the cytoskeletal network is ...
UNC scientists solve mystery of how largest cellular motor protein powers movement
... helps solve a scientific mystery: how the protein dynein
fuels itself to perform cellular functions vital ... or cell division into identical cells.
uses energy derived from ATP, or adenosine ... and detailed molecular structure for dynein
has kept scientists largely in the dark about how ...
Molecular Motors Cooperate In Moving Cellular Cargo, Study Shows
"We discovered that two molecular motors -- dynein
and kinesin -- do not compete for control, even ... individual motors measured outside the cell."
and kinesin are biomolecular motors that haul cargo from one part of a cell to another. dynein
moves material from the cell membrane to the ...
Discovery of agile molecular motors could aid in treating motor neuron diseases
... than in one direction, as previously thought. They report their findings in a recent issue of Nature Cell Biology. The proteins in this motor, dynein
and dynactin, are the "long-distance truckers" of the cell: working together, they are responsible for transporting cellular cargo from the periphery ...
A new way of looking at molecular motors
... employ all three types of motors at the same time, but in different proportions. For example, yeast uses six kinesins, five myosins, and one dynein
while mammals have genes for more than 40 kinesins, 40 myosins and more than a dozen dyneins.
Genetic and acquired defects in the motors cause ...
Marathon of nano-sprinters
... along filaments of the cytoskeleton, consuming energy provided by the hydrolysis of ATP, which can be considered the fuel of the cell. Kinesin and dynein
motors move along microtubules and myosins move along actin filaments. The step sizes of these motors are of the order of 10 nm. By stepping in a ...