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Drugs in Biological News

Pinhead-size worms + robot = new antibiotics

... existing methods for identifying germ-fighting drugs involve adding the potential drug to cultures of ... well. They may give passing grades to potential drugs that are toxic, or that fight bacteria in the ... a robot to test the effects of 37,000 potential drugs on C. elegans (a type of worm) infected with ....

Neuropathic pain: The sea provides a new hope of relief

... controlled by the usual analgesics (aspirin like drugs (NSAIDS) or even opioids like morphine) and novel ... given relief in neuropathic pain; similarly, two drugs designed for treating epilepsy - gabapentin and ... structure is very different from pain-relieving drugs currently in use. Initial experiments suggested ...

Stem cell 'daughters' lead to breast cancer

... it opened the way for the development of new drugs or therapies to treat breast cancer, one of the ... she said. "It may even be possible to develop new drugs that target c-KIT, since drugs are already available that target different forms ...

UCSF researchers identify new drug target for Kaposi's sarcoma

... re-opening the possibility of using the class of drugs called protease inhibitors against the full ... . Most current antiviral drugs target the active sites of viral proteins, where ... new site as a viable option for small-molecule drugs to treat Kaposi's, as well as other members of ...

Chasing tiny vehicles

... example, tiny nanovehicles could one day ferry drugs or even genes into cells. So far, the only way of ... will one day be put to work in therapies carrying drugs directly to the seat of a disease. "Even genes ... hand, have been tailored to deliver genes or drugs directly to the target without side-effects. ...

Study explains potential failure of oral contraceptives with obese women

... their ideal body weight. "When we first test drugs for safety and efficacy, we generally do not ... can seriously change the pharmacokinetics, or way drugs act and are processed in the body. There's a ... surprised to find that the affinity of these drugs for fat tissue was not significantly different ...

22nd Congress of the European College of Neuropsychopharmacology, Sept. 12-16, 2009, Turkey

... involved in understanding the brain, and how drugs can be made to affect it, is ... to neurosciences and psychopharmacology (how drugs affect the mind), it includes research of ... investigates the effect of drugs on the central nervous system (CNS) and their use ...

University of Leicester researchers discover new fluorescent silicon nanoparticles

... and may ultimately help track the uptake of drugs by the body's cells. Dr Klaus von Haeften ... They are aiming to link nanoparticles to drugs involved in the diagnosis and treatment of ... sensors that could help track the uptake of drugs by cells." The benign nature of silicon also ...

New nanoparticles could revolutionize therapeutic drug discovery

... Kell, said: "The attrition rate in developing new drugs is phenomenal. Only a tiny fraction make it into ... a larger pipeline for scientists to develop new drugs from and, ultimately more, better drugs for patients. Fundamental bioscience working in ...

UBC researchers develop new method to study gambling addictions

... decisions can be impaired or improved with drugs that affect brain dopamine and serotonin levels ... The study found that rodents treated with drugs that reduced their levels of serotonin levels ... humans by giving us a working model to explore drugs and therapies," says Winstanley. In future ...

Slicing chromosomes leads to new insights into cell division

... move, we can better understand how these drugs interfere with those movements and we can design ... us to have a better handle on what makes these drugs work. There are a lot of drugs that interfere with mitosis, but only a few are ...

NIH announces new program to develop therapeutics for rare and neglected diseases

... the work. We are eager to begin." Developing drugs The drug development process is complicated ... Numerous obstacles impede the development of new drugs for rare and neglected diseases. In addition to ... policies to transfer licenses for TRND-discovered drugs to private companies or others for development, ...

New tool for next-generation cancer treatments using nanodiamonds

... moderate the release of highly toxic chemotherapy drugs and other therapeutics. This provides a platform ... patch that could be used to deliver chemotherapy drugs locally to sites where cancerous tumors have been ... nanomaterials coated with a broad range of drugs and other biological agents," Espinosa says. "The ...

SRI International to screen drugs that fight 2009 H1N1 influenza A

... it will screen a library of well-characterized drugs against the 2009 H1N1 influenza A virus, ... to treat this H1N1 infection. Identifying drugs from other chemical and mechanistic classes could ... it easier to provide sufficient quantities of drugs to a broad population, should the need arise. The ...

University awarded £1.7M to develop nanotechnology for use in health care

... investigate the possibility of creating viable drugs in nanoparticle form each particle being ... if nanotechnology can reduce the toxicity of drugs by using smaller doses without losing effect. ... the development of resistance to the drugs. HIV drugs are a lifelong commitment and the doses currently ...

Drugs needed to preserve eggs for reproduction need to be given in stages

... a two-step process of easing into and out of the drugs needed to help protect eggs at subzero ... eggs. Faster permeability is better with these drugs which must be given at room temperature when ... Reproduction & Development . All of the drugs worked best when used incrementally: putting some ...

Stem cell focus for IBD wound healing

... could eventually lead to the development of new drugs which use natural molecules to spark the recovery ... a mixture of lifestyle changes, anti-inflammatory drugs and, in severe cases, surgery. Professor Ilyas ... gut lining reverts to normal. Anti-inflammatory drugs help this process along and allow the wound ...

Our brains make their own marijuana: We're all pot heads deep inside

... ), may lead to new marijuana-like drugs for managing pain, stimulating appetite, and ... abuse. "Ideally, this development will lead to drugs that bind to and activate the THC receptor, but ... the possibility that this will lead to effective drugs with fewer side effects." Scientists made ...

American Chemical Society Weekly PressPac -- April 15, 2009

... RELEASE "Determining the Effects of Lipophillic drugs on Membrane Structure by Solid-State NMR ... become the basis for tiny devices to help test drugs and other treatments for patients with traumatic ... has changed, with a nonprofit organization called drugs for Neglected Diseases Initiative (DNDi) leading ...

Male impotence drugs may deserve a second look in women

... AUGUSTA, Ga. New studies indicate the three drugs used to treat male impotence also appear to work ... Medical College of Georgia researchers showed the drugs relax the artery in male and female rats. "It shows the drugs need to be investigated more for women and small ...

Early isolation linked to enhanced response to cocaine

... 18-22, 2009 in New Orleans. The Study drugs of abuse act on the reward centers of the brain. ... and also regulate the psycho-stimulant effects of drugs such as cocaine. Stress is known to enhance drug ... susceptibility to the psychostimulant effects of drugs of abuse, such as cocaine. Rats were ...

Early isolation linked to enhanced response to cocaine

... 18-22, 2009 in New Orleans. The Study drugs of abuse act on the reward centers of the brain. ... and also regulate the psycho-stimulant effects of drugs such as cocaine. Stress is known to enhance drug ... susceptibility to the psychostimulant effects of drugs of abuse, such as cocaine. Rats were ...

Alzheimer cell death in Zebrafish: Demise of neurons observed live for the first time

... now allows us to perform a targeted search for drugs that can stop the extensive cell death, and ... have already shown that we can in principle use drugs to block at least some of the disease-related ... to watch and test directly whether potential drugs actually do have a protective action. First ...

American Chemical Society Weekly PressPac -- April 8, 2009

... April 13, 2009 Developing safer, more effective drugs to fight obesity Chemical & Engineering News Safer and more effective drugs to fight obesity appear to be around the corner, ... have led to the development of promising new drugs that are more targeted for key appetite-control ...

New drug shows promise in treating drug-resistant prostate cancer

... is resistant to further treatment by anti-hormone drugs such as Casodex and Eulexin. In an article ... androgens, spur the growth of prostate cells, and drugs that block the receptors for these hormones are ... cancer becomes resistant to anti-androgen drugs when cancer cells begin to increase production of ...

New medications show promise in treating drug-resistant prostate cancer

... Of 30 men who received low doses of one the drugs in a multisite phase I/II trial designed to ... patients with metastatic prostate cancer. The drugs are second-generation antiandrogen therapies that ... to existing antiandrogen therapies. The drugs were discovered in the laboratory of Howard ...

American Chemical Society Weekly PressPac -- April 1, 2009

... of these proteins may lead to better drugs and a vaccine for river blindness and other ... proteins could serve as the basis for developing drugs or vaccines against diseases transmitted by the ... TIME, April 6, 2009 Bonanza of new oral drugs offers hope for MS patients Chemical & ...

CSHL team develops mouse models of leukemia that predict response to chemotherapy

... also serve as an effective test system for new drugs and treatment strategies in AML. Need for a ... these models might help improve how existing drugs are used in people, and spur the design of more ... These standard systems, in which anticancer drugs were tested in human cancer-cell lines, do not ...

Potential new HIV drug may help patients not responding to treatment

... Anti-Retroviral Therapy (HAART), a cocktail of drugs that reduces the viral load by stopping the virus ... partly because some develop resistance to the drugs used in HAART. The researchers, from Imperial ... everyone - some people develop resistance to the drugs and when that happens, we start to run out of ...

International prize for Nottingham spine research

... blood supply, creating issues for the delivery of drugs to the area. To study the way in which drugs may move through the system, the researchers used ... managed in the future this could mean injecting drugs directly into the discs or the development of ...

Skin cancer study uncovers new tumor suppressor gene

... help to explain the disappointing performance of drugs designed to treat cancer by blocking MMP enzymes. ... in people with a wide range of cancers, the drugs failed to slow -- and in some cases even sped up ... that a better approach may be to look for drugs that restore or increase MMP-8 function or ...

Scripps scientists find structure of a protein that makes cancer cells resistant to chemotherapy

... structure is a nice tool for understanding how drugs are transported out of cells by P-gp and for designing drugs to evade P-gp preventing drug resistance. It's ... that are harmful out of the cell, but also drugs targeted to cancer cells and HIV-infected cells, ...

UC Davis bench-to-bedside research: Promising treatment in clinical trials

... commonly occur together and a new class of drugs that addresses both is very attractive." ... that could be exploited by either small molecule drugs or biotechnology. However, society faces a ... the professor said. "There are few good drugs for end organ failure and vascular inflammation." ...

New drug agent knocks out multiple enzymes in cancer pathway

... more active in killing tumor cells than similar drugs used in recent clinical trials. The study ... Society . The new agent belongs to a class of drugs called bisphosphonates. These compounds were ... Drug developers have tried for years to design drugs to inhibit cell survival pathways in tumor cells, ...

Catching the common cold virus genome

... of the virus genome that enable resistance to drugs and the human immune system. The immune system ... genome will help virologists who work to design drugs that target the rhinovirus. "If you've got ... will use these insights to build better drugs to combat the virus in the most effective way. ...

Alzheimer's disease therapeutic prevents long-term damage from TBI in pre-clinical studies

... WASHINGTON, D.C. A class of Alzheimer's disease drugs currently studied in clinical trials appears to ... They say the results suggest that this class of drugs could potentially do something no other drug has ... and the model upon which some Alzheimer's disease drugs now in clinical testing are based. As a result, ...

Twin nanoparticle shown effective at targeting, killing breast cancer cells

... The trick becomes how to deliver cancer-fighting drugs directly to the tumor cells. Brown University ... "Like a missile, you don't want the anti-cancer drugs to explode everywhere," explained Shouheng Sun, a ... the cancer cells and released the anti-cancer drugs into the malignant cells, killing the cells in up ...

LSTM and UoL secure £1.4m ($2m) to develop new 'magic bullet' antimalarial drug

... project grant to begin the development of new drugs to combat malaria. The project, funded by the ... Professor Steve Ward explained: "New drugs to treat malaria are urgently required because ... has evolved to develop resistance to traditional drugs and consequently more people die from malaria now ...

Canadian scientist mines drugs database for new diabetes treatment

... finding could spark a completely new class of drugs to treat type 2 diabetes. In work published ... small academic labs to search a large database of drugs to find treatments for diabetes and many other ... structure is a proven technique and common drugs such as beta-blockers and anti-histamines were ...

Scientists mine drugs database for new diabetes treatment

... finding could spark a completely new class of drugs to treat type 2 diabetes. In work published ... small academic labs to search a large database of drugs to find treatments for diabetes and many other ... structure is a proven technique and common drugs such as beta-blockers and anti-histamines were ...
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