Study shows cancer vaccines led to long-term survival for patients with metastatic melanoma
The study entitled "Phase II Trial of dendritic
Cells Loaded with Antigens from Self-Renewing, ... a total of up to eight injections. The patient's dendritic
cells were obtained from their peripheral blood ... (64 vs. 31 months, p=.016). Eight patients in the dendritic
cell vaccine study experienced remarkable ...
Protein linked to mental retardation controls synapse maturation, plasticity, CSHL team finds
... structure. Small knob-like features, called dendritic
spines, that protrude from a neuron's branch-like ... protein is not essential for the formation of dendritic
spines, but that it is needed for the proper ... the team found that OPHN1 is recruited to dendritic
spines, where it locally regulates the actin ...
Peregrine's PS-targeting antibodies highlighted in AACR Annual Meeting studies
... antibody PGN632 to promote the maturation of dendritic
cells, important antigen-presenting cells of the immune system. In the in vitro studies, immature dendritic
cells cultured in the presence of PGN632 ... molecules that are indicative of mature dendritic
cells and that assist in antigen presentation ...
New origin found for a critical immune response
... are induced by rare immune cells, called dendritic
cells. When activated by infection or vaccination, the dendritic
cells were thought to move from peripheral ...
The Duke researchers found, however, that the dendritic
cells that stimulate TH1 responses didn't come ...
Molecule that suppresses immune response under study in type 1 diabetes
... because they have a transient defect in their dendritic
cells that hurts IDO expression. dendritic
cells, which can express IDO, show antigens to ... of Immunology paper last year reported that when dendritic
cells and IDO are depleted in the mouse, the ...
Immune cells reveal fancy footwork
... Suzanne van Helden discovered that before dendritic
cells move to the lymph nodes they lose their ... This helps them to move much faster. Immature dendritic
cells patrol the tissues in search of antigens. ... maturation process. During this maturation the dendritic
cells migrate to the lymph nodes to activate T ...
Scripps research team sheds light on immune system suppression
... with immune cells known as plamacytoid dendritic
cells, which are key producers of one of two ... known as type I.
When plasmacytoid dendritic
cells come in contact with viruses and other ... interferon production, it did not kill the dendritic
cells, instead allowing them to function as ...
UCR researchers propose minocycline as a promising drug for patients with Fragile X syndrome
... on small mushroom-shaped structures called dendritic
During early development dendritic
spines have immature finger-like shapes. But learning stabilizes the synapses and dendritic
spines take on a mature mushroom shape, which ...
Why some primates, but not humans, can live with immunodeficiency viruses and not progress to AIDS
... in immune signaling in a specific type of dendritic
cells in AIDS-susceptible or resistant host species. dendritic
cells are part of the immune system that play a ...
Feinberg's team found that in sooty mangabeys, dendritic
cells produce much less interferon alpha--an ...
Immunotherapy in high-risk pediatric sarcomas shows promising response
... this cancer.
The researchers tested a novel dendritic
vaccine as well as a standard flu vaccine to ... for Cancer Research, show that although the dendritic
vaccine they tested did not perform as well as ... one chromosome to a different chromosome. The dendritic
vaccine included peptides derived from each ...
Immune cells promote blood vessel formation in mouse endometriosis
... Boston and Harvard Medical School, found that dendritic
cellshighly specialized immune cellshelp trigger ... In the mouse model, the researchers observed that dendritic
cells infiltrate endometriosis lesions, and near ... blood vessels form. Injecting mice with excess dendritic
cells caused their lesions to gain more blood ...
News tips from the Journal of Neuroscience
... form between axons and dendrites, even before dendritic
spines take shape, dendritic
filopodia are out there, poking and prodding and ... active ezrin induced the formation of dendritic
KisspeptinGPR54 Signaling in ...
Autopilot guides proteins in brain
Even though the paths point to both axons and dendrites, dendritic
proteins end up in dendrites, and axonal proteins go to the axons. How?
... blindly carry both types of proteins towards the axon.
proteins enable the vesicles transporting them to bind to a second motor, ...
Shades of 1918? New study compares avian flu with a notorious killer from the past
... turns its attention next to the body's adaptive response, specifically, dendritic
cells whose job it is to phagocytize protein components from the virus and ... infection. Tissue sampling for the H5N1 found a notable absence of these dendritic
cells, suggesting they were destroyed during the infection process, which ...
New discovery may lead to new class of allergy drugs
... of infection, blocks basic "fighter" cells from transforming into "seeker" dendritic
cells, resulting in a heightened allergic response.
"Our study reveals ... in immune cell type and found that eotaxin inhibits monocytes becoming dendritic
cells (that find foreign invaders so other immune cells can neutralize ...
Implants mimic infection to rally immune system against tumors
... release cytokines, powerful attractants of immune-system messengers called dendritic
These cells enter an implant's pores, where they are exposed to antigens specific to the type of tumor being targeted. The dendritic
cells then report to nearby lymph nodes, where they activate the immune ...
JCI table of contents: Aug. 16, 2007
... in mice, a small population of immune cells known as plasmacytoid dendritic
cells (pDCs) that produce the enzyme indoleamine 2,3-dioxygenase (IDO) and ... of chemotherapeutics in individuals with cancer.
TITLE: Plasmacytoid dendritic
cells from mouse tumor-draining lymph nodes directly activate mature Tregs ...
DOE-funded research projects win 46 R&D 100 Awards for 2009
... enhanced data access capabilities beyond other equivalent operating systems by employing a new technique that targets memory bandwidth.
Platinum Nanostructures - An innovative nanotechnology for producing platinum catalysts that offers unique control over the shape, size, porosity, ...
Building memories with actin
... potent after repeated stimulation, underlies the formation and stabilization of new memories. LTP involves changes in the anatomy of synapses and dendritic
spines, a process that depends on reorganization of the supporting actin cytoskeleton. However, researchers didn't know what controlled these ....
New insight into Alzheimer's disease pathology
... et al have found a new target of gamma secretase, a protein called EphA4.
The product of EphA4 cleavage drove the formation and maintenance of dendritic
spines the nerve cell's receivers for transmitted signals. These results fit with a growing hypothesis that failing nerve transmission might be an ...
DNA component can stimulate and suppress the immune response
... form are smaller and less malignant," Mr. Johnson says.
They've also learned that the cells IDO uses to suppress the immune system IDO-competent dendritic
cells originate from B cells, which produce antibodies to fight infection.
Scientists film inner workings of the immune system
... using high powered multi-photon microscopy which allows real cells to be viewed in real time.
"Using multi-photon microscopy, we studied dendritic
cells in the skin. Under normal conditions we found the cells in the epidermis (top layer) were static, whereas in the dermis (second layer) they ...
What makes an axon an axon?
... dendrites, such as the microtubule polymerizing protein MAP2, also infiltrated the axons.
The AIS appears to serve as a filter that screens out dendritic
proteins, Hedstrom et al. conclude. How the structure bars some proteins from the axon is still uncertain. Injuries and diseases can transform ...
Stress may make you itch
... skin, resulting in inflammatory skin disease. The related report by Joachim et al., "Stress-induced Neurogenic Inflammation in Murine Skin Skews dendritic
Cells towards Maturation and Migration: Key role of ICAM-1/LFA-1 interactions," appears in the November issue of The American Journal of Pathology . ...
Carnegie Mellon MRI technology that non-invasively locates, quantifies specific cells in the body
... fluorine 'tracer' with MRI after the cells are transplanted into the body. The Ahrens' team has recently used the PFPE technology to label and track dendritic
cells and T cells in a mouse model of type I diabetes, a disease in which immune cells infiltrate the pancreas, attacking and damaging the body's own ...
Galiximab in combination with rituximab in patients with previously untreated follicular lymphoma
... in previously treated FL and in combination with rituximab against relapsed FL. The CD80 molecule is found on the surface of activated macrophages, dendritic
cells and cells from various subtypes of NHL. Galiximab's potential mechanisms of action include Antibody-Dependent Cell-Mediated Cytotoxicity (ADCC) ...
Scientists discover a molecular scaffold that guides connections between brain cells
... Huangs team traced the sub-cellular targeting of a different set of cerebellar neurons called stellate cells, which make numerous connections to the dendritic
bush emanating from clumps of Purkinje cells. Unlike the cells they had studied previously, however, these neurons need help to form synapses. The ...
Biophysical Society announces 2008 International Travel Awards
... Makes Staphylococcus aureus Membranes Resistant to PLA2-IIA.
Ferenc Papp, University of Debrecen, Hungary, CRAC Channels in Developing Human dendritic
Nina Pastor, Universidad Autnoma del Estado de Morelos, Cuernavaca, Mexico, Thermal Stability of the TATA Box Binding Protein.
UT Southwestern secures $5 million NIH grant for lupus research
... how a cluster of genes called the SLAM/CD contributes to SLE.
The fourth group, from the Baylor institute, will work to understand how dendritic
cells and B-cells interact and shape human SLE.
Other UT Southwestern researchers involved in the Center of Research Translation are Dr. Quan Li, ...
Damon Runyon Cancer Research Foundation awards prestigious fellowships to 17 top young investigators
Gianna Elena Hammer, PhD , with her sponsor Averil Ma, MD, at the University of California, San Francisco, California, is investigating how dendritic
cells, the regulators of T cell function, detect infection or cancer and then coordinate protective immune responses.
Yoh Isogai, PhD , with his ...
Anthony S. Fauci awarded Lasker Award for Public Service
... the 2007 Lasker Award for Basic Medical Research honors long-time NIAID grantee Ralph M. Steinman of Rockefeller University for his discovery of dendritic
cells, immune system cells that trigger other components of the immune system to thwart microbial invaders. Further information about the awards and ...
New nanoparticle vaccine is more effective but less expensive
... Recent research has also shown that the best way to get sustained immunity is to deliver an antigen directly to specialized immune cells known as dendritic
This technique is not yet used clinically because there are two difficulties to overcome in targeting the DCs: first, there are not ...
Biodegradable microspheres deliver time release vaccines, stimulate different immune response
... and her colleagues next incubated human dendritic
cells in the presence of polyanhydride microspheres (without ovalbumin). dendritic
cells are responsible for initiating CMIs.
... that the polymer microspheres were activating dendritic
cells," says Wilson-Welder.
The implications ...
Why doesn't the immune system attack the small intestine?
... from the outside environment, cells known as dendritic
cells display the antigens of their normal ... Medical School. "But it has been unclear how dendritic
cells, which are extremely sensitive to microbial ... Turley and her colleagues found that, in fact, dendritic
cells aren't essential in creating tolerance in T ...
Cancer vaccines -- Taking a jab at cancer by stimulating the immune system
... Cancer Institute.
The researchers gave a dendritic
cell vaccine to 12 pancreatic cancer patients. ... a look at the toxicity and feasibility of using a dendritic
cell-based vaccine against pancreatic cancer," ... more practical vaccine formulations."
cell vaccination strategy combines a cancer ...
'Super' enzyme may lead way to better tumor vaccines
... of tumor vaccines by extending the lives of dendritic
cells, the immune-system master switches that ... journal Nature Biotechnology.
"By keeping the dendritic
cells alive longer, you extend the window of ... professor of immunology at BCM. "The longer your dendritic
cells are alive and active, the more likely you ...
T cells activated to fight HIV basis for dendritic cell therapeutic vaccine
... vaccine loaded with a patient's own souped up dendritic
cells, which have been galvanized to rally other ... is key to the approach's success ?modifying the dendritic
cells in such a way that they will get the ... in each individual being treated. A patient's own dendritic
cells together with their unique viral antigens ...
Long-term changes in experience cause neurons to sprout new long-lasting connections
... The researchers followed the growth of dendritic
spines in the region of the neocortex that ... to image changes in fluorescence that revealed dendritic
alterations present on the neurons.
In this ... knew from previous work that a subpopulation of dendritic
spines appears and disappears over time, but we ...
APS lecturer shows rare video of 'teacher-student' immune cell interactions in live animal
A live mouse's T cells and dendritic
cells are the stars of the von Andrian videos, as ... a new infection. His laboratory hones in on how dendritic
cells -- professional antigen-presenting cells -- ... tissues of the immune system recruits T cells dendritic
cells get to the right spot, the lymph node, to ...