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Degenerative in Biological News

Massive microRNA scan uncovers leads to treating muscle degeneration

... gene activity linked to each of 10 major degenerative muscular disorders, opening doors to new ... death, inflammatory response and other major degenerative processes in the affected muscle tissue. The ... most poorly understood and least treatable of the degenerative disorders, such as inclusion body myositis. At ...

Jefferson receives $1.7 million grant to study stem cells in intervertebral discs of the spine

... surgical procedures are available to pacify the pain associated with the degenerative disc, but the most common procedures often only provide symptomatic ... are able to do this it could lead to development of new therapies to treat degenerative disc disease providing relief to millions of back pain suffers." ...

Ultrasound imaging now possible with a smartphone

... is for caregivers of patients with Duchene's Muscular Dystrophy. A degenerative disease that often strikes young boys and robs them of their lives by their late 20s, DMD is a degenerative disease for which there is no cure. The leading treatment to slow its ...

Peter Baumann named Howard Hughes Medical Institute Early Career Scientist

... that result in accelerated shortening have been linked to several degenerative diseases. On the other hand, telomerase, a protein central to telomere ... lay the foundation for the development of treatments for cancer as well as degenerative syndromes such as dyskeratosis congenita and aplastic anemia. Dr. ...

Researchers genetically link Lou Gehrig's disease in humans to dog disease

... the Broad Institute have found that the genetic mutation responsible for degenerative myelopathy (DM) in dogs is the same mutation that causes amyotrophic ... curing the human disease, ALS. "We uncovered the genetic mutation of degenerative myelopathy, which has been unknown for 30 years, and linked it to ALS, a ...

NIH EUREKA award funds research at WPI aimed at turning adult skin cells into stem-like cells

... method for replacing tissue lost to injury, growing new organs, and curing degenerative diseases like diabetes and Parkinson's. The grant is one of only 38 ... heal traumatic injuries through regeneration and to reverse the effects of degenerative diseases that affect millions of individuals. We are grateful to the NIH ...

Oxidative stress: Mechanism of cell death clarified

... produced by the body, is well known as a common cause of acute and chronic degenerative diseases, such as, arteriosclerosis, diabetes, stroke, Alzheimer's and ... to mitigate the deleterious effects of oxidative stress in complex degenerative human diseases. ...

New data shows benefits of MitraClip for patients with mitral regurgitation

... new insights about treatment considerations for patients with significant degenerative or functional mitral regurgitation, said Dr. Feldman. We encourage ... in the study is open to a range of patients: Patients with either degenerative or functional MR. Patients who are good surgical candidates and are ...

Stem cell research: From molecular physiology to therapeutic applications

... focuses on the understanding of basic biological properties of stem cells and developing nonhuman primate models for stem cell-based therapy of degenerative diseases. He has developed a stem cell mediated expression system for treating Parkinson's disease and his research using pancreatic progenitor cells ...

LincRNAs serve as genetic air-traffic controllers

... still remains to be done but we could one day envision utilizing RNA to guide personalized stem cells to specific cell fates to restore diseased and degenerative disease tissues," notes Rinn. ...

Work in mice will contribute to the study of hereditary diseases that lead to blindness

... the results of this research work could be very useful for the detection of new factors or molecules originated by microglial cells and related to degenerative processes of the retina. The doctoral thesis of Ana Mara Santos Carro , researcher of the Department of Cell Biology of the University of ...

Engineering innovative solutions for 21st century medicine

... illness, potentially helping millions of people each year; Tissue engineering technology has the potential to use patients' own cells to correct degenerative disease , but the processes of applying these techniques needs to be practical and efficient if they are to achieve their potential. Four ...

New research program BioInterfaces launched

... cells in the organism and in bioreactor systems. These key technologies will ultimately contribute to the development of new therapies for many degenerative diseases that affect muscle, the retina or the central nervous system. In addition, BioInterfaces aims to control or inhibit bacterial cells that ...

Singapore researchers first to transform carbon dioxide into methanol

... product of the carbon dioxide reaction. Our previous research on NHCs has demonstrated their multiple applications as powerful antioxidants to fight degenerative diseases, and as effective catalysts to transform sugars into an alternative energy source. We have now shown that NHCs can also be applied ...

Redefining what it means to be a prion

... of prions. Over the years, researchers have identified a small number of other prions in humans and other animals, most of which cause degenerative neurological diseases, including scrapie in sheep and goats, and Creutzfeldt-Jakob disease in humans. A few prions have also been found in model ...

Study offers clues to beating hearing loss

... of deafness. Mutations in this protein have been linked to hearing loss, particularly of the type connected to Usher syndrome, which is a form of degenerative deaf-blindness." There are around 40 myosin motor proteins in the human body, the most familiar of which is the type of myosin found in skeletal ...

Antioxidants in Midwestern black raspberries influenced by production site

... have been studied for decades by scientists and medical researchers interested in the fruits' apparent ability to limit the onset or severity of degenerative diseases, including cancer. The fruit of many popular berries, including blackberries, blueberries, strawberries, elderberries, grapes, and plums, ...

UT Southwestern researchers disrupt biochemical system involved in cancer, degenerative disease

... Center have identified two new classes that can be used to study and possibly manipulate a cellular pathway involved in many types of cancer and degenerative diseases. "The identification of these chemicals and their targets within this cellular pathway represents an important step in developing ...

Genetic mutation causes familial susceptibility for degenerative brain disease

... of a gene that helps proteins migrate in and out of the cell's genetic command center the nucleus puts some families at higher risk for the degenerative brain disease acute necrotizing encephalopathy (ANE). This is the conclusion of a global study to be published Jan. 9 by the American Journal of ...

Protein folding researcher David Baker to receive Sackler Prize in Biophysics

... genetic information directs protein formation, how proteins work, and how misfolded, misshapen, and malfunctioning proteins might underlie serious degenerative diseases. Baker has developed computer programs to predict protein structures from amino acid sequences in DNA. His program, Rosetta, is among ...

Mounting evidence shows health benefits of grape polyphenols

... . "Consumption of grape and grape extracts and/or grape products such as red wine may be beneficial in preventing the development of chronic degenerative diseases such as cardiovascular disease," write Wayne R. Leifert, Ph.D., and Mahinda Y. Abeywardena, Ph.D., of Commonwealth Scientific and Industrial ...

Fried purple tomatoes

... says Prof Cathie Martin from the John Innes Centre. Anthocyanins offer protection against certain cancers, cardiovascular disease and age-related degenerative diseases. There is evidence that anthocyanins also have anti-inflammatory activity, promote visual acuity and hinder obesity and diabetes. ...

Duke team finds compounds that prevent nerve damage

... DURHAM, N.C. Duke University Medical Center scientists have made a significant finding that could lead to better drugs for several degenerative diseases including Huntington's disease and Alzheimer's disease. Compounds that block the activity of a specific enzyme prevented brain injury and ...

Iron-moving malfunction may underlie neurodegenerative diseases, aging

... accumulation of lipofuscin is associated with a range of disorders including Alzheimer's disease, Parkinson's disease, and macular degeneration (a degenerative disease of the eye) and also contributes to the aging process. "In a sense we can think of ML4 as really early onset of aging," Xu said. Now ...

NIH extends commitment to transformative research with 2008 Pioneer, New Innovator Awards

... who will study molecular mechanisms of cell energy production and cell death to open new avenues in the treatment of age-related metabolic and degenerative diseases. Sanjay Kumar, M.D., Ph.D., University of California, Berkeley, assistant professor of bioengineering, who will combine approaches from ...

Key component of debilitating lung disease identified

... in a key component of the lung's antioxidant defense system and the progression of chronic obstructive pulmonary disease (COPD) in humans. COPD is a degenerative condition that decreases the flow of air through the lungs as the lung's air sacs are damaged. A study of lung tissue samples from COPD patients by ...

UGA researchers win $9.2 million stem cell grant from NIH

... biology of stem cells, their utility as a model for studying mammalian development and their potential as a cell source to develop therapies for degenerative disease and repair of chronic injury. Focus areas include diabetes, cardiovascular disease, spinal cord injury and neurodegenerative disease. ...

Researcher helping to pioneer medical therapy for Fragile X Syndrome presents latest findings

... in Chicago and one of the few in the Midwest. Her research program also includes studies of fragile X-associated tremor/ataxia syndrome (FXTAS), a degenerative neurological condition which occurs in fragile X mutation carriers, and she will be presenting research on development of new methods for evaluating ...

Study shows increased education on nanotech, human enhancement increases public concerns

... their position on emerging technologies with "human enhancement" applications such as using nanotechnology to improve therapies for injuries and degenerative diseases. Nanotechnology is generally defined as technology that uses substances having a size of 100 nanometers or less (thousands of times thinner ...

Technique used in human ankle injuries modified to treat dogs' knees

... Medicine researcher. Unlike humans, CCL injuries in dogs typically do not occur because of a single trauma to the knee but are the result of a degenerative process that leads to early and progressive arthritis. For this reason, and the unique biomechanics of the canine knee, techniques used to repair the ...

Stem cell researchers give old muscle new pep

... in a stem cell experiment by bioengineers at the University of California, Berkeley, setting the path for research on new treatments for age-related degenerative conditions such as muscle atrophy or Alzheimer's and Parkinson's diseases. In a new study to be published June 15 in an advanced online issue of ...

Researchers discover architecture for fundamental processes of life

... of life called autophagy. These processes are implicated in diseases such as cancers and autophagy has recently been shown to be involved in degenerative neurological disorders such as Alzheimer's and Huntington's diseases. The discovery will fill gaps in basic knowledge about the workings and ...

1/3 of risk for dementia attributable to small vessel disease, autopsy study shows

... changes of Alzheimer's disease. Another 10 percent of dementia risk was associated with Lewy bodies, neocortical structural changes that indicate a degenerative brain disease known as Lewy Body Dementia, believed by some clinicians to be a variant of Alzheimer's and/or Parkinson's disease. But a third of the ...

New study shows that fetal cells to treat Parkinson's disease may not function long term

... that continues to affect healthy neurons, according to Kordower. This research indicates that mechanisms and molecules responsible for initiating the degenerative process are still present at a late stage and are capable of affecting grafted neurons. In addition, the processes that destroy dopamine neurons are ...

Hope among patients with ALS may take a variety of forms

... disease and how palliative care providers can help initiate discussions aimed at promoting hopefulness. The patients with ALS, a progressive degenerative motor neuron disease that is almost always fatal demonstrated a range of coping capabilities unrelated to the extent of their physical disability. ...

Umbilical cord blood cell therapy may reduce signs and symptoms of Alzheimer's disease

... that this therapeutic approach offers the potential to target the pathogenic inflammatory response that contributes to Alzheimers disease and other degenerative conditions. Jun Tan, PhD, MD, and colleagues from USF (Tampa), Yale University (New Haven, CT), Cedars-Sinai Medical Center (Los Angeles, CA), ...

Umbilical cord blood cell therapy in an animal model of Alzheimer's disease

... the activity of the immune system, offering the potential to target the pathogenic inflammatory response that may contribute to a variety of degenerative conditions, including Alzheimers disease. Jun Tan, PhD, MD, and colleagues from USF (Tampa), Yale University (New Haven, CT), Cedars-Sinai ...

Promising new drug targets identified for Huntington's disease

... to investigate further which encourage cells to "eat" the malformed proteins that lead to the disease. Huntington's disease is one of a number of degenerative diseases marked by build up of a malformed proteins in brain cells, mainly in the basal ganglia and the cerebral cortex. Normally, cells dispose of ...

Researchers uncover new piece to the puzzle of human height

... and other musculoskeletal diseases. Osteoarthritis is by far the most common type of arthritis, affecting nearly 21 million Americans. The degenerative joint disease, which primarily affects cartilage, is seen mostly among older people. The researchers speculate that genetic variants that reduce ...

International scientists tackle obstacles to treating brain disorders

... barrier is overlooked or only viewed as a barrier to drug delivery. The article suggests that brain barriers play a larger role in the progression of degenerative disease, and that researchers should focus on how the changes in the barriers relate to brain degeneration during the aging process. In addition to ...
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