Fate in fly sensory organ precursor cells could explain human immune disorder
In the fly peripheral nervous system, two daughter
cells arise from a single sensory organ precursor mother cell. Among the daughter
cells, Notch is activated in one and not in the ... uses the Notch pathway to specify the fate of two daughter
cells called pIIa and pIIb, which arise from a ...
How an enzyme tells stem cells which way to divide
... acts as a traffic cop that directs which roads daughter
cells will take.
"Wherever aPKC is at on a ... Biology. When a stem cell duplicates into daughter
cells, the side, or cortical domain, containing ... aPKC and helps determine the fates of subsequent daughter
"This process is pretty simple," he ...
Proteins strangle cell during division
... then squeezes the cell into two so that two new daughter
cells are formed. At first it looks like mitosis, ... the chromosomes are distributed between the two daughter
cells. Cell division is the process whereby the two daughter
cells are separated.
It is striking that ...
How molecular muscles help cells divide
... muscle-like structures to pinch itself into two daughter
cells at the end of each cell division, according ... and is always located precisely between the two daughter
This contractile ring is thought ... the cell in two.
Living cells divide into two daughter
cells to reproduce themselves. In one-celled ...
Protein that triggers plant cell division revealed by researchers
... be just as varied. Parent cells must be able to divide in ways that create daughter
cells that are different from each other, a process called asymmetric ... only one cell inherited BASL at the cell periphery and this helped the two daughter
cells become different.
What's more, it wasn't just the stomatal ...
Is this the beginning of the end of plant breeding?
... division (mitosis) because instead of producing two genetically identical daughter
cells, it produces four cells each containing only half of the parental ... one axis of symmetryand these then pass into two genetically identical daughter
cells. In meiosis, there are two lining up and dividing phases. The first ...
Study may aid efforts to prevent uncontrolled cell division in cancer
... of this ring "tightens the belt," pinching the mother cell into two daughter
In early embryogenesis, cell volume and the length of the ... chromosomes which carry the genetic material that is segregated to the daughter
cells remains constant. The discovery that contractile rings constrict at ...
Scientists deconstruct cell division
... mitosis phase, which leads to the duplication of one mother cell into two daughter
cells. In mitosis, the chromosomes condense and the nucleus breaks down. ... equally, but also partition its cellular content properly into daughter
cells," explained co-author Yixan Zheng. "Cell division allows a ...
How do cells count?
... Whenever a cell divides, each centrosome gives rise to a single daughter
centrosome, inherited by one of the daughter
cells. Thus, there is strict control on progeny! By using the fruit fly, ...
Rong Li Lab probes mechanism of asymmetry in meiotic cell division
... requirement for embryonic development after fertilization while the other daughter
cell (called a polar body) resulting from the asymmetric division gets ... required to sustain the earliest stages of development stays with the daughter
cell that retains the identy of the oocyte.
"This work revealed the ...
Cuellar's Safe and Lock Announces Strategic Alliance with Absolute Access and Security
... Christina Pinto, Vice-President of Customer Relations and daughter
the late founder, Robert Cuellar, said of the merger, "I think my ... in 1971 by the late
Robert Cuellar, his successors, wife Xiomara and daughter
maintain the same customer service based mentality today ...
Monash researchers uncover cancer survival secrets
... during growth. An entire genome is replicated and divides equally into two daughter
cells. Sometimes things go wrong. To try to prevent this, nature has ... place where cells distribute their DNA unevenly between the two resulting daughter
cells. As a result, tumour cells can accumulate or lose genes and ...
Great Ape Trust signs agreement with Universitas Nasional in Jakarta
... Pluis, who was estimated to be 7 in 1971 when Ketambe was established, her daughter
and her daughters infant as they traveled about the forest.
Though they ... at Ketambe, of a mature female orangutan named Yet sharing with her daughter
a meal of a slow loris (Nycticebus coucang), a small primate, that she had ...
Methods for gene transfer in stem cells featured in Cold Spring Harbor Protocols
... derived from retroviruses are useful tools for long-term gene transfer because they allow stable integration of transgenes and propagation into daughter
cells. Lentiviral vectors are preferred because they can transduce non-proliferating cellular targets. These vectors can be engineered to target ...
Study reveals a reprogrammed role for the androgen receptor
... process, becomes especially active, the researchers report. This pause, or "checkpoint," ensures that cell division progresses normally; without it, daughter
cells may grow even more aggressively and be harder to stop.
"The evolution of prostate cancer from an androgen-dependent state to an ...
Researchers gain insight into mechanism underlying Huntington's
... his colleagues identified a novel DNA repair pathway referred to as DNA hairpin repair (HPR), which specifically targets TNR hairpin removal in the daughter
DNA strand, ensuring the fidelity of the TNR sequences in the parental strand. It is proposed that defects or inadequacies in the HPR system may be ...
Double success for Instituto Gulbenkian de Ciencia scientists working on chromosome segregation
... new insights into the scaffold of proteins that ensures accurate segregation of chromosomes during cell division - a fundamental step to ensure that daughter
cells have the same genetic information as their mother, with reduced risk of cancer.
When segregating, chromosomes attach and move along proteins ...
UC Davis grant zeroes in on novel asthma diagnosis and treatment
... why we moved from the Riverside area, in the South Coast Air Basin, to Davis -- to alleviate their asthma," Hammock said. Kenyon's six-year-old daughter
has asthma, as does Yang's father-in-law.
Co-investigator is asthma specialist and researcher Nicholas Kenyon,
co-director of the UC Davis ...
Slicing chromosomes leads to new insights into cell division
... fungi, and animalsincluding those in the human bodydivide through mitosis, during which the DNA-containing chromosomes separate between the resulting daughter
cells. Forces in a structure called the mitotic spindle guide the replicated chromosomes to opposing sides as one cell eventually becomes two.
Author says challenging simple concepts can save planet
Lapp, made famous in the 1970s by her bestselling vegetarian cookbook Diet for a Small Planet, is an activist, author and co-founder with her daughter
Anna Lapp of The Small Planet Institute. She says many people today are frightened by the potential for disaster, ecological and otherwise, and ...
Genetic testing for breast or ovarian cancer risk may be greatly underutilized
... not have a personal history of breast or ovarian cancer, and around 1 percent of them were determined to be at high risk because a mother, sister or daughter
had such a tumor. Among these high-risk women, about half were aware that genetic testing was available, but only 10 percent had discussed it with a ...
Native Americans descended from a single ancestral group, DNA study confirms
... signature the team discovered.
"There are a number of really strong papers based on mitochondrial DNA which is passed from mother to daughter
and Y-chromosome DNA which is passed from father to son that have also supported a single ancestral population," Schroeder said. "But this is the ...
For cancer cells, genetics alone is poor indicator for drug response
... cell to cell, even among cells that are identical genetic twins. What's more, these protein levels and their subsequent traits can be passed down to daughter
cellsa heritability that has nothing to do with genetics.
"Genetics are permanently heritable, while these protein levels are temporarily ...
Selected personal letters of Max Perutz are released in new book
... of science. A compilation of his personal letters has just been released by Cold Spring Harbor Laboratory Press. Selected and edited by his daughter
Vivien Perutz, the letters in the book What a Time I am Having: Selected Letters of Max Perutz chronicle his adventurous life through his own ...
Brain building: Study shows brain growth tied to cell division in mouse embryos
... neurons were differentiating prematurelya suspicion confirmed in vitro.
The progenitor pool is maintained by asymmetrical divisionone daughter
cell becomes a neuron, the other self-renews. This fate asymmetry is thought to depend on the orientation of cell division, and the authors observed ...
States expand newborn screening for life-threatening disorders
... the District of Columbia screen for 26 or more of these conditions.
"Newborn screening saved Giana's life," said David Swift, of California, whose daughter
was diagnosed with 3MCC (3-methylcrotonyl-CoA carboxylase deficiency) because of newborn screening. "It was only thanks to March of Dimes advocacy ...
CSHL researchers identify gene that helps plant cells keep communication channels open
... can be fatal too, especially when it happens in meristems.
"Meristems that are blocked and thereby starved of nutrients won't give rise to daughter
cells and spawn new organs, thus stunting the plant's growth," explains Jackson. "What we've found now is probably the mechanism that normally ...
Cancer-causing gene discovery suggests new therapies
... Myc is overexpressed, this leads to changes in protein levels of a key gene that is essential for normal distribution of genetic material between daughter
cells during cell division."
The findings are a positive step, he emphasizes, because they suggest that halting Myc's action on protein production ...
New drug holds out promise of normal diet for sufferers of devastating PKU genetic disease
... crying for more food at supper. Sadly, Margie Fischer doesn't have to imagine it; that was normal life at her family's dinner table for years. Her daughter
Maggie, now 20, suffers from phenylketonuria (PKU), a genetic disease that means her body can't tolerate anything more than a low-protein diet.
UCSB scientists show how certain vegetables combat cancer
... cell division during mitosis. Mitosis is the process in which the duplicated DNA in the form of chromosomes is accurately distributed to the two daughter
cells when a cell divides.
Hundreds of tiny tube-like structures, called microtubules, make up the machinery that cells use to separate the ...
Plants display 'molecular amnesia'
... without changing the actual DNA sequence. However, like changes in DNA sequence, epigenetic modifications can be passed on from parent cell to daughter
cell, ensuring each cell line has the proper characteristics consistently over many generations.
This process must be repeated each generation, ...
New cell division mechanism discovered
... genes form a sharp band in the middle of the cell, between newly segregated chromosomes, and then gradually constrict the cell such that two new daughter
cells are formed.
- This is the first time in decades that a novel cell division mechanism has been discovered, and the gene products display no ...
Are you phonagnosic?
... reported in the online issue of the journal Neuropsychologia , is of a woman who is unable to recognise people by their voice, including her own daughter
whom she has great difficulty identifying over the phone. The woman, known as KH, avoids answering the phone where possible, and for many years has ...
Newly-discovered mechanism can explain the Beckwith-Wiedemann syndrome
... the silenced domain to a specific area in the cell nucleus. There it is protected during cell division and the genes will stay silenced also in the daughter
We show for the first time how a long RNA molecule can establish and maintain silencing of multiple genes in a large domain on the ...
Columbia to award 2008 Horwitz Prize to Arthur Horwich & Ulrich Hartl for cellular protein folding
... and biochemistry. Awarded annually since 1967, the prize is named for the mother of Columbia benefactor S. Gross Horwitz. Louisa Gross Horwitz was daughter
of Dr. Samuel David Gross, author of "A System of Surgery" and a founder of the American Medical Association. For additional information about the ...
New research center at Brandeis to combine materials science and biology
... to a small volume within a cell. How does this affect the dynamics of this molecule, for instance in division of an e.coli bacterium into two daughter
cells? Likewise, the scientists want to understand how tethers added to the DNA in a cell nucleus affect how it can move to carry out important ...
ETH Zurich study on salmonella self-destruction
... between the two groups is a result of random molecular processes during cell division. Cellular components are randomly distributed between the two daughter
cells with each cell receiving a different amount. The resulting imbalance can be amplified and lead to different properties of the clonal siblings. ...
'Top Secret' Technology To Help U.S. Swimmers Trim Times at Beijing Olympics
... U.S. Summer Nationals and be on deck with the
swimmers. "How often does a researcher get to do something like this?" said
Wei, whose young son and daughter
also swim competitively. "It's been a
journey into a world that someone like me would have never before gotten
the privilege to see first-hand."
'Top secret' technology to help US swimmers trim times at Beijing Olympics
... U.S. Summer Nationals and be on deck with the swimmers.
"How often does a researcher get to do something like this?" said Wei, whose young son and daughter
also swim competitively. "It's been a journey into a world that someone like me would have never before gotten the privilege to see first-hand."
Death, division or cancer? Newly discovered checkpoint process holds the line in cell division
... it can divide.
If the checkpoint proteins themselves are faulty, however, mitosis results in aneuploidy, the loss or gain of chromosomes in the daughter
cells. This increases the risk of cancer, and promotes the resistance of cancer cells to chemotherapies.
Certain cancer drugs, such as ...