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Cytomegalovirus in Biological News

UCSF researchers identify new drug target for Kaposi's sarcoma

... "All known herpes virus proteases are structurally similar," Craik explained. "The inhibitor we found knocks out not only KS, but also the cytomegalovirus protease, so the site we've identified here could be a target for a broad-acting inhibitor against the entire viral family." To their knowledge, ...

Nature Medicine study shows Peregrine's bavituximab can cure lethal virus infections

... program of the U.S. Defense Threat Reduction Agency (DTRA). Bavituximab and other anti-PS antibodies are also being studied preclinically in HIV, cytomegalovirus (CMV) and other serious viral infections. "Based on these findings, anti-PS antibodies such as bavituximab may represent a completely new class ...

Caltech biologists spy on the secret inner life of a cell

... laboratory studies how the immune system recognizes its targets, work that is offering insight into the processes by which viruses like HIV and human cytomegalovirus invade cells and cause disease. The electron tomography images revealed that the FcRn/antibody complexes were collected within cells inside large ...

Virus weaves itself into the DNA transferred from parents to babies

... it produces any developmental or immune system problems. Some congenital infections can cause serious problems in fetuses. If a mother contracts cytomegalovirus (CMV) while pregnant, her fetus is at risk of hearing or vision loss, developmental disabilities and problems with the lungs, liver and spleen. Some ...

CMV infections affect more than just patients with compromised immune systems, researchers find

... An infection due to a virus called cytomegalovirus (CMV), which most commonly affects people with compromised immune systems, can also affect hospital intensive-care patients who have no immune-system ...

A viral cloaking device

... in a continual dance for survival--viruses ever seek new ways to evade detection, and our immune system devises new methods to hunt them down. Human cytomegalovirus (HCMV), says Bjorkman, Caltech's Delbrck Professor of Biology and a Howard Hughes Medical Institute (HHMI) Investigator, "is the definition of a ...

BWF awards $7 million to infectious disease investigators

... modulation of bacterial group activities Dong Yu, Ph.D. Washington University School of Medicine Modulation of the DNA damage response by human cytomegalovirus ...

Cytomegalovirus exacerbates atherosclerosis through an autoimmune mechanism

... Italy, confirms the pivotal role played by cytomegalovirus infection in the pathogenesis of atherosclerosis. ... publishes a new study on the relationship between cytomegalovirus infection and atherosclerosis, conducted by Prof. ... The same researchers have already shown that cytomegalovirus infection can be responsible of the initial ...

LIAI scientists make important finding on cytomegalovirus transmission

... at the La Jolla Institute for Allergy & Immunology have shown that cytomegalovirus (CMV) in the salivary glands can be reduced ?and in some cases eliminated ... kind of treatment in humans to block or significantly reduce the spread of cytomegalovirus and other chronic virus infections." Ware noted that the salivary glands ...

Experimental vaccine given during pregnancy reduces stillbirths from common virus

... that reduces stillbirths among rodents born to mothers infected with cytomegalovirus (CMV)—a common virus that can also cause mental retardation and hearing ... Sciences listed as a top priority the development of a vaccine to prevent cytomegalovirus during pregnancy. "An effective CMV vaccine for women of childbearing ...

New vaccine prevents CMV infection and disease in mice

... Diego (UCSD) Skaggs School of Pharmacy and Pharmaceutical Sciences have patented a strategy for developing a human vaccine to prevent against Human cytomegalovirus (hCMV) infection and disease. CMV, a type of herpes virus, is the leading viral cause of birth defects and a serious problem in patients with ...

UCLA scientists discover immune response to HIV differs, even in identical twins

... lead researcher. According to the UCLA researchers, the results of this study have broader implications, and could apply to other viruses such as cytomegalovirus (CMV), a herpes virus that causes opportunistic infections in immunosuppressed individuals, and hepatitis C, the latter being similar to HIV in both ...

MUHC scientists describe genetic resistance to rampant virus

... MUHC researchers have defined genetic resistance to the widespread virus, cytomegalovirus (CMV)--a member of the viral group that causes some of the world's most prevalent diseases, such as herpes, chicken pox and mononucleosis. The ...

Potential Cure for Lymphoma in HIV patients

... heart) and kidney failure due to treatment toxicities and died a few weeks after the transplant. Opportunistic infections, such as herpes zoster and cytomegalovirus infection, also occurred in a few patients after the transplant, but were managed with appropriate therapy. Throughout the study, all patients were ...
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