Test helps in fight against lung infections and for treating other life-threatening infections
... for serious lung infections in patients with cystic
Fibrosis (CF), a population recognized as having ... Medicine and Dr. Neil Brown, Director, Adult cystic
Fibrosis Clinic conducted the clinical research ... The clinical research involved 14 patients with cystic
fibrosis at the University of Alberta hospital CF ...
New test can detect both genetic and chromosomal abnormalities in embryos
... taken from spare embryos that were known to have cystic
They told a news briefing at the ... caused by a specific gene mutation, in this case cystic
fibrosis, but that it was also capable of ... embryos that have already been diagnosed with the cystic
fibrosis gene mutation using conventional ...
Cystic fibrosis testing -- next steps
... VA Three reports describing advances in cystic
fibrosis genetic testing appear in the May 2009 ... of The Journal of Molecular Diagnostics .
fibrosis is a hereditary disease that affects ... born in the United States is affected with cystic
Two-pronged model could help foil tough cystic fibrosis infections
... that thrive in the lungs of people with cystic
fibrosis (CF), unlocking new possibilities ... microbiology and lung physiology labs studying cystic
fibrosis patients are plagued by infections of ...
Nanoemulsion potent against superbugs that kill cystic fibrosis patients
... drug-resistant infections that cause nearly all cystic
fibrosis is an inherited chronic lung disease ... safely administered to the lungs of people with cystic
fibrosis," LiPuma says. If future trials show ...
New approach to treating cystic fibrosis lung infection shows promise
... of fighting severe lung infections in people with cystic
fibrosis (CF). These findings are published in ...
The research project, funded by the Canadian cystic
Fibrosis Foundation, has led to a real ... Morrison, Chief Executive Officer of the Canadian cystic
Fibrosis Foundation. "In this case, laboratory ...
Rattlesnake-type poisons used by superbug bacteria to beat our defenses
... major cause of death and serious disability in cystic
fibrosis patients which is the most common ... affects about 8,000 people," says Dr Welch.
fibrosis the gene defect means that people are ... treatment can usually control the infection in cystic
fibrosis sufferers but eventually the strain ...
PTC124 shows activity in cystic fibrosis; Phase 2 proof-of-concept data published in Lancet
... PTC124 demonstrates activity in nonsense-mutation cystic
fibrosis (CF). The data show that treatment with ...
Patients with CF lack adequate levels of the cystic
fibrosis transmembrane conductance regulator ... for approximately 10 percent of the cases of cystic
fibrosis worldwide. However, in Israel, nonsense ...
Computer simulations point to key molecular basis of cystic fibrosis
... mechanism that may account for the development of cystic
fibrosis, which about 1 in 3000 children are born ... point the way to new corrective treatments.
fibrosis (CF) is a fatal disease caused by a defective gene that produces a misshapen form of the cystic
fibrosis transmembrane conductance regulator ...
Study uncovers clues to cystic fibrosis gene dysfunction and gastrointestinal disease
... York, offers new insight into the role that the cystic
fibrosis gene plays in the development of gastrointestinal disease.
fibrosis transmembrane conductance regulator ... Mutations of this protein are associated with cystic
fibrosis (CF) and a range of digestive diseases, ...
CU-Boulder technology used to identify unexpected bacteria in cystic fibrosis patients
... the lung fluid of Denver children suffering from cystic
fibrosis, findings that may lead to more ... and classify pathogens found in the lungs of cystic
fibrosis sufferers, said CU-Boulder Professor ... more than 60 species of bacteria in samples of 28 cystic
fibrosis patients in Denver. Thirteen samples ...
Galapagos and Cystic Fibrosis Foundation Therapeutics announce drug discovery collaboration
... 2007 Galapagos NV (Euronext & LSE: GLPG) and cystic
Fibrosis Foundation Therapeutics, Inc. (CFFT), the non-profit affiliate of the cystic
Fibrosis Foundation, announced today a new collaboration aimed at discovering new treatments for cystic
fibrosis. This new agreement between CFFT and ...
Microbial biofilms evoke Jekyll & Hyde effects
... many serious chronic infectious diseases such as cystic
fibrosis and periodontal disease, as well as ... chronic infections, including killers such as cystic
fibrosis, and endocarditis in the heart. In cystic
fibrosis, excess mucus production in the airways ...
Cystic fibrosis patients may breathe easier, thanks to bioengineered antimicrobials
... of Illinois may have found a way to help cystic
fibrosis patients fight off deadly infections.
... strategy against bacterial infections in cystic
fibrosis, said Gerard Wong a professor of ... that disposes of the debris.
In patients with cystic
fibrosis, however, the mucus is more like ...
Sugar on bacteria surface serves as base for a web of resistance
... COLUMBUS, Ohio The bacteria responsible for chronic infections in cystic
fibrosis patients use one of the sugars on the germs' surface to start ... with these bacteria is what causes the death of most patients with cystic
fibrosis, a genetic disease characterized in part by excess mucus in the ...
Research elucidates way lungs fight bacteria and prevent infection
... inflammation, interfering with breathing and damaging the airways.
fibrosis is one disease where this work might have particular import, Dr. Chun says. People with cystic
fibrosis possess an abnormal gene that causes normal mucus to become thick ...
New test promises quicker, more accurate evaluation for cystic fibrosis patients
... a simple gene-based blood test that more accurately and quickly measures cystic
fibrosis patients' response to therapy than current tests. The test, a ... accurate picture of the biological processes occurring inside the lungs."
fibrosis is the most common lethal inherited disease in the western world, ...
Columbia to award 2008 Horwitz Prize to Arthur Horwich & Ulrich Hartl for cellular protein folding
... folding, and its role in Alzheimer's disease, Huntington's disease, cystic
fibrosis and other life-threatening diseases. Additionally, an Honorary ... with approximately 20 diseases, including Alzheimer's, Huntington's and cystic
fibrosis. Targeting the activity of the chaperones to correct misfolded ...
American Chemical Society's Weekly PressPac -- Aug. 27, 2008
... ARTICLE #5 EMBARGOED FOR 9 A.M., EASTERN TIME, Sept. 1, 2008
fibrosis patients breathe easier
Chemical & Engineering News
... of new drugs that could dramatically improve the health of patients with cystic
fibrosis (CF), which remains difficult to treat with today's drugs, ...
Researchers discover cell's 'quality control' mechanism
... has significant implications for the development of new treatments for cystic
fibrosis (CF) and some other hereditary diseases, the researchers say. ... It's the degradation of the protein, not the mutation itself, which causes cystic
fibrosis. We're hoping this discovery will open up new avenues of research ...
RNA emerges from DNA's shadow
... from mutations that cause genes to be incompletely read, including cystic
fibrosis and muscular dystrophy. A drug based on the molecule is now ... generally available. Results so far indicate dramatic improvements in both cystic
fibrosis and muscular dystrophy sufferers, although it is only suitable ...
Case researcher in RNA biology makes waves by challenging current thinking
... in the treatment of genetic diseases. Many inherited conditions, including cystic
fibrosis, are a consequence of mutations resulting in the recognition of ... patients to have protein of some function rather than no protein at all. cystic
fibrosis clinical trials are currently underway with a goal of producing ...
Cystic fibrosis proteins photographed interacting
... physical evidence of interaction between two proteins involved in cystic
Fibrosis (CF) disease.
Researchers at the University of Alabama at ... Biophysics, High Resolution Imaging Facility and the Gregory Fleming James cystic
Fibrosis Research Center at UAB. Other collaborators are from Ohio State ...
Together we stand: bacteria organize to survive hostile zones
... communities called biofilms. These biofilms play key roles in cystic
fibrosis, urinary tract infections and other illnesses, and the ... with them, Levchenko pointed out. For example, people who suffer from cystic
fibrosisa genetic disorder that affects the mucus lining of the lungsare ...
American Society for Microbiology honors Lucas R. Hoffman
... accomplishments have led to his receiving several awards from the cystic
Fibrosis Foundation, among others. He is particularly known for a paper ... which could have a very profound impact on the care of patients with cystic
fibrosis. A subsequent paper published in the Proceedings of the National ...
MIT unraveling secrets of red tide
... generate red tides, but could also help speed up efforts to develop cystic
fibrosis drugs from a compound closely related to the toxin.
Red tides, ... to the red tide toxins, has shown potential as a powerful treatment for cystic
fibrosis (CF). It can also protect against the effects of the toxins.
ISU researchers find possible treatment for spinal muscular atrophy
... mutation in SMN1.
Singh believes this technology could also work treating other diseases.
"We know that Parkinson's disease, Alzheimer's disease, cystic
fibrosis, multiple sclerosis and cancer all come from genes that are aberrantly spliced," he said.
"If this is a model disease, meaning we succeed ...
Brain malformations significantly associated with preterm birth, Wake Forest research shows
... resulting in the absence of a major portion of the brain, skull, and scalp (57.7 percent); multicystic encephalomalacia, the formation of multiple cystic
cavities of various sizes in the cerebral cortex (50.5 percent); and hydranencephaly, a rare condition in which the brain's cerebral hemispheres are ...
Single thawed embryo transfer after PGD does not affect pregnancy rates
... offered single embryo transfer together with freezing of surplus blastocysts to couples seeking PGD for single inherited genetic disorders such as cystic
fibrosis. All the embryos were biopsied for the purposes of PGD on the third day after fertilisation, which is the time that they start to divide. ...
CSHL scientists harness logic of 'Sudoku' math puzzle to vastly enhance genome-sequencing capability
... collected DNA from thousands of members of orthodox Jewish communities. The organization's aim is to prevent genetic diseases such as Tay-Sachs or cystic
fibrosis that occur frequently within specific ethnic populations. The team's new method will now allow the many thousands of DNA samples gathered by ...
American Society for Microbiology honors Melissa B. Miller
... outstanding laboratory research in clinical microbiology or antimicrobial agents.
Dr. Miller has contributed significantly to the fields of cystic
fibrosis microbiology and detection and epidemiology of MRSA, and is known for her research on the development and application of molecular assays ...
'Disordered' amino acids may really be there to provide wiggle room for signaling protein
... NHERF1 is representative of a large class of proteins with an array of biological roles, including signaling pathways implicated in diseases such as cystic
fibrosis and breast cancer.
"Here we have a molecule that serves an important role in how cells function and survive, but it contains these ...
Simulated gene therapy
... to replace these specific genes, swapping out the bad for the good. If doctors could safely do this, they could treat or even cure diseases like cystic
fibrosis, certain types of cancer, sickle cell anemia, and a number of rare genetic disorders.
Safety is a primary concern when working with gene ...
No hiding place for infecting bacteria
... difficult to treat. P. aeruginosa biofilms cause disease in burns, wounds, contact lens infections and are particularly prevalent in the lungs of cystic
"We specifically targeted the F-actin protein with a negatively charged peptide, and the DNA with the enzyme DNase, which both ...
Tiny samples could yield big predictive markers for pancreatic cancer
... techniques, such as magnetic resonance imaging (MRI), are used more often in clinical medicine, doctors are finding many more small, fluid-filled cystic
lesions of the pancreas.
"Many of these cysts are completely benign and have little or no risk of becoming cancerous. However, a subset of ...
Gene therapy demonstrates benefit in patients with rheumatoid arthritis
... and led by an investigator at Beth Israel Deaconess Medical Center (BIDMC).
Originally conceived as a means of treating genetic diseases, such as cystic
fibrosis and hemophilia, gene therapy involves implanting a normal gene to compensate for a defective gene in the patient. The first clinical trial ...
Swiss Institute of Bioinformatics celebrates 10th birthday by presenting major gifts to human health
... and often early death. Man's knowledge of proteins such as insulin and haemoglobins is crucial to combating diseases such as cancer, Alzheimer's, cystic
fibrosis and haemophilia.
Professor Bairoch said, "The general public would understand some of the entries in our protein encyclopaedia. Insulin, ...
Leader of Human Genome Project honored with the Inamori Ethics Prize
... laboratory is dedicated to researching both rare and common diseases and has discovered a number of important genes, including those responsible for cystic
fibrosis, neurofibromatosis, Huntington's disease, adult onset diabetes and Hutchinson-Gilford progeria syndrome, a dramatic form of premature aging. ...
Gaining a better understanding of kidney diseases
... This press release is available in German .
kidney disease, renal fibrosis, or renal cell carcinoma: Many diseases of the excretory organs are characterized by overproduction or on the ...
Consortium develops new method enabling routine targeted gene modification
... also stimulate additional research into the potential application of ZFNs for gene therapy of single-gene disorders, such as sickle cell anemia and cystic
fibrosis." Joung's lab has already begun to explore ways to further simplify the OPEN method so that it can be performed more quickly and for a ...