MicroRNAs grease the cell's circadian clockwork
... an internal clock, a group of genes displaying a cyclic
expression pattern that reaches a peak once a ... oscillators, a group of genes displaying a cyclic
expression pattern that reaches a peak every ... and lipids, are expressed in liver cells in a cyclic
fashion. Many of them are also influenced by ...
Continuous oral contraceptives better at easing pain, bleeding
... quicker with the continuous pill than with the cyclic
pill. And there is no harmful effect on the ... and behavioral changes compared to women in the cyclic
However, results from the study also ... of birth control pills.
In the case of cyclic
pills, the ovary comes back into the equation ...
UC San Diego researchers eliminate drug discovery bottleneck
If you imagine the structure of an NRP as a cyclic
string of beads, then the new algorithms both ... usual peptide sequencing tools do not work. The cyclic
structures of NRPs, the prevalence of ... extremely complicated in large part due to the cyclic
structure of the compound, he contacted Pevzner. ...
USC researchers identify mechanism that controls activation of stem cells during hair regeneration
... Southern California (USC) have identified a novel cyclic
signaling in the dermis that coordinates stem ... However, most of these works focus on the cyclic
regeneration of one single hair follicle, he ... motivated to analyze the coordinative behavior of cyclic
regeneration in a population of organs," Chuong ...
Green alga genome project catalogs carbon capture machinery
... enzymes that manufacture the signaling molecules cyclic
AMP and cyclic
GMP. These cyclic
nucleotides play key roles in shuttling nutrients ...
The law of the weakest
... would survive. LMU researchers have now simulated the progression of a cyclic
competition of three species. It means that each participant is superior ... conditions and mechanisms that affect the biodiversity of Earth. cyclic
dominance is a particularly interesting constellation of species competing ...
Climate change enhances grassland productivity
... to global warming and a greater absence of an insulating snow cover, these cyclic
processes are likely to increase. In spite of this and apart from a study ... investigations that have conducted research on the significance of these cyclic
processes for plants. Scientists working together with Jrgen Kreyling ...
Turning on cell-cell communication wipes out staph biofilms
... by autoinducing peptides (AIPs), small molecules that contain an unusual cyclic
structure and are shaped like a ring with a tail.
Previous research, ... earlier research he had developed an enzymatic approach for manufacturing cyclic
peptides. Using this chemistry, he was able to prepare large quantities of ...
For some who have lost their sense of smell, a once popular asthma drug could help
... had previously discovered that decreased levels of two proteins V cyclic
AMP (cAMP) and cyclic
GMP (cGMP) -- in nasal mucus inhibited growth and development of olfactory ...
August 2009 Geology and GSA Today media highlights
... present paradoxical results. While ice volumes of similar size to those implied by proxy evidence are simulated, sea-level changes brought about by cyclic
variations in Earth's orbit are minuscule. It is only with large perturbations to atmospheric greenhouse gas concentrations that observed sea-level ...
Scientists find formula to uncover our planet's past and help predict its future
... and Lancaster were able to successfully recreate measurements in a study on a vole-mustelid community.
Many small mammalian species have cyclic
population dynamics, periodically oscillating between large and small communities, a behavioral phenomenon which has puzzled ecologists for decades. ...
New findings in taste and smell
... adaptation in the vomeronasal organ
Emx2 stimulates odorant receptor gene expression and controls OSN axon growth
nucleotide-gated channels in olfactory sensory neurons mediate axon targeting and glomerular formation
Investigations of olfactory receptor ...
Long-sought protein structure may help reveal how 'gene switch' works
... week, the NIST/BNL team reports that it has definedfor the first timethe structure of a "metabolic switch" found inside most types of bacteriathe cyclic
AMP (cAMP) receptor protein, or CRPin its "off" state. CRP is the "binding site" (attachment point) for cAMP, a small molecule that, once attached, ...
Researchers examine role of climate change in disease spread
... of mosquitoes, the presence of an immunologically vulnerable human population and ease of transportation of infected humans (Chikungunya virus); cyclic
periods of high rainfall, modern irrigation projects, and livestock trade between Africa and southern Arabia (Rift Valley fever virus); and modern ...
Global warming linked to European viral epidemic
... The Netherlands, and Luxembourg. He said, "This animal-borne disease, scarcely known before 1990, has been increasing in incidence in Belgium with a cyclic
pattern, reaching epidemic proportions since 2005. The fact that the growing combined effect of hotter summer and autumn seasons is matched by the ...
Brainy genes, not brawn, key to success on mussel beach
... higher up the rocksthe oscillations in gene expression became more pronounced.
Mussels use genes to weather the heat
In addition to cyclic
expression, the study found that mussels use two sets of genes to respond to heat stresssometimes reacting to temperature changes in seconds.
American Chemical Society's Weekly PressPac -- Sept. 10, 2008
... on new disease targets, including the glutamate neurotransmitter system, a nicotinic acetylcholine receptor, and a signaling pathway mediated by cyclic
These substances appear to help relieve a wider range of symptoms while causing fewer side effects, the researchers note. "We're ...
Normalizing tumor vessels to improve cancer therapy
... from mice prostate tumors, provided by Andrew Dudley, PhD, in the lab of Michael Klagsbrun, PhD, in the Vascular Biology Program, and exposed them to cyclic
mechanical stressmimicking the pulsatile nature of blood flow and matrix distortion resulting from rhythmic heart beats. They found that normal ...
Gene's newly explained effect on height may change tumor disorder treatment
... Neurology, and director of Washington University Neurofibromatosis Center. "However, those mice were normal."
NF1 also increases brain levels of cyclic
AMP (cAMP), an important signaling molecule. Working with the same line of mice where stem cells in the brain do not make the NF1 protein, ...
Brain tweak lets sleep-deprived flies stay sharp
... the flies have periods of inactivity where greater stimulation is required to rouse them. These periods begin at night; like human sleep they are cyclic
over the course of the night, with sleep cycles lasting 20-25 minutes. Also like humans, flies deprived of sleep one day will try to make up for the ...
August 2008 Geology and GSA Today media highlights
... S, reached temperatures of 23 to 25 degrees Celsius, more than 10 degrees Celsius warmer than similar latitudes today. The fossils also record a cyclic
variation in temperature, with warming and cooling by approximately 1.5 degrees Celsius about every 18,000 years, which is thought to be caused by ...
July 2008 GEOLOGY and GSA Today media highlights
... a matter of debate. Abdul Aziz et al. study the color records of these ancient soils, and show in this paper that the color banding was caused by cyclic
climate changes. These climate changes are provoked by Earth's precession cycle of 21,000 years, which influences the distribution of solar energy on ...
Scientists discover stinging truths about jellyfish blooms in the Bering Sea
... A new study helps explain a cyclic
increase and decrease of jellyfish populations, which transformed parts of the Bering Sea--one of the U.S.'s most productive fisheries--into ...
Single-celled bacterium works 24-7
... oxygen, the cells conveniently use up this by-product of photosynthesis, likely helping to protect nitrogenase from degradation.
Through this cyclic
expression of genes, Cyanothece is essentially a living battery, storing energy from the sun for later use. This feat continues to elude scientists ...
Researchers discover the structural alphabet of RNA
... the constraints that are found in known structures.
"We introduced a new first-order object to represent nucleotide relationships, the nucleotide cyclic
motif (NCM). We reasoned that using NCMs could allow us to arrive at better models of the 3D structure of RNA molecules, " explains Franois Major. ...
Researchers visualize complex pigment mixtures in living cells
... this, the way the cells probably work, is that the inner thylakoids primarily make ATP (adenosine triphosphate), the energy currency of the cell, by cyclic
electron transport around photosystem I, and the peripheral ones do linear electron flow resulting in ATP as well as reduced nicotinamide adenine ...
Snoozing worms help Penn researchers explain the evolution of sleep
... as a model system to identify a gene that regulates sleep. This gene, which encodes a protein kinase and is regulated by a small molecule called cyclic
GMP, has been previously studied but not suspected to play a role in sleep regulation. The findings suggest a potential role for this gene in ...
Biophysical Society announces winners of 2008 Student Travel Awards
... Molecules across Biological Membranes.
Ling Wu, University of Illinois at Chicago, Conformational Study of Different Beta-turns Coupled to a cyclic
Disulfide Bond to Model the Turn Roles in -hairpin Stability.
Qianru Yu, The Pennsylvania State University, Fluorescence-based Biochemistry on ...
Evolution tied to Earth movement
But Royhan Gani says much previous discussion of how climate affected human evolution involves global climate changes, such as those caused by cyclic
changes in Earths orbit around the sun, and not local and regional climate changes caused by East Africas rising landscape.
A Force from ...
DFG to establish 10 new collaborative research centers
... to market of innovative products and services, sometimes in a very negative way. The projects they have planned cover the entire spectrum of cyclic
processes of innovation, from product planning through to marketing, and from tangible goods to services, for the first time. Vendors and customers ...
Pourquie Lab demonstrates role of growth factor in vertebrae formation
... the FGF receptor Fgfr1. They also published two important secondary findings related to FGF signaling: 1) FGF controls the clock, since the cyclic
genes of all pathways (WNT, NOTCH, and FGF) eventually lose their dynamic expression; and 2) by pharmacological inhibition of FGF signaling, they ...
Immune cells promote blood vessel formation in mouse endometriosis
... as small lesions, or masses, but once blood vessels are recruited, the lesions grow larger and respond to female hormones, resulting in inflammation, cyclic
pelvic pain, and infertility.
In the mouse model, the researchers observed that dendritic cells infiltrate endometriosis lesions, and near the ...
New Delft material concept for aircraft wings could save billions
... costs could lead to worldwide savings as high as $100 billion.
Fatigue is a phenomenon that affects materials after long-term exposure to cyclic
loading. As a result of varying loads, fractures eventually occur. The new, high-quality CentrAl aluminium constructions are stronger than the carbon ...
Lack of key enzyme associated with development of rare tumor
... triggers the cell to produce substances known as cyclic
nucleotides. These function as "second ... begin an activity. In the case of adrenal cells, cyclic
nucleotides, such as cyclic
Supercomputers to focus brains on AIDS dilemma
... to bind at the catalytic site, typically with a cyclic
moiety, or "wing," to the "west" of the active ... to develop inhibitors that bind with their cyclic
moieties to the "east" of the active center as ... "single wing" compounds, whose wings, or cyclic
moieties, can bind to either the west or the east ...
Scientists unravel clue in cortisol production
... the output of the hormone is continuous, the molecular production is cyclic
in nature ?involving a rhythmic binding and unbinding of a protein ... the signal does is cause adrenal cells to increase their production of cyclic
AMP (cAMP), a chemical that encourages proteins to interact. So they began ...
Need to pull an all-nighter?
... promotes sleep is by stimulating production of a signaling molecule called cyclic
GMP, and it may be possible to achieve the same effect by using drugs that block cyclic
GMP's breakdown, Rosenberg says.
One surprise in the research was ...
Pourquié lab identifies genes involved in formation of vertebral precursors
... and last authors, respectively, on a paper that identifies a network of cyclic
genes that shed light on the molecular basis of spine formation in the ... how the clock drives the periodic expression of a large network of cyclic
genes involved in cell signaling. Mutually exclusive activation of the ...
UCLA AIDS Institute researchers find a peptide that encourages HIV infection
... Retrocyclin-1 (RC-100) is a circular peptide that has been shown in previous studies to inhibit the infection of CD4 cells with HIV. RC-111 is also cyclic
and has the same amino acid sequence as retrocyclin-1. In both peptides, the amino acids are strung like 18 beads along the molecule's backbone. The ...