Improved method developed to test carcinogen risk
... how to determine what level of a cancer-causing compound
can be considered safe.
The study found that ... not accurately predict the actual risks of the compound
when exposure in the real world is at lower ... see how many more cases of cancer appear when a compound
is administered at a very low dose. So, ...
Drug prevents seizure progression in model of epilepsy
... researchers have identified a new anticonvulsant compound
that has the potential to stop the development of ... channel.
"We have found a new anticonvulsant compound
that eliminates seizures in a model of epilepsy," ... Sheehan and Brett Benedetti discovered that the compound
was effective at completely blocking subsequent ...
UNC study: Scientists identify chemical compound that may stop deadly brain tumors
... Chapel Hill School of Medicine have identified a compound
that could be modified to treat one of the most ... dehydrogenase-1 (IDH1) by replenishing a compound
called α-ketoglutarate (α-KG).
"When ... have this specific gene mutation. The α-KG compound
is already there; it only needs to be modified to ...
Penn researchers demonstrate a new model for drug discovery with a fluorescent anesthetic
... have identified a fluorescent anesthetic compound
that will assist researchers in obtaining more ... Academy of Sciences .
Using the fluorescing compound
1-aminoanthracene, or 1-AMA, the team developed a ... anesthetic research.
Researchers confirmed the compound
as anesthetic after testing it successfully in ...
Ocera Therapeutics licenses novel treatment for acute hepatic encephalopathy from UCLB
... and all assets and technologies related to the compound
for the treatment of acute hepatic encephalopathy (AHE).
recently demonstrated that it directly reduces ... of AHE.
Ocera will develop the licensed compound
as its second ...
UC Davis bench-to-bedside research: Promising treatment in clinical trials
... laboratory moving through target validation and compound
optimization all the way to the clinic," he said. ... to occur together in vascular biology. "So, a compound
that addresses heart failure, as we have shown, ... inflammatory disorders."
Hammock agrees. "The compound
looks quite promising and it's an example of how ...
Queen's chemist sheds light on health benefits of garlic
... they found that an acid produced when the compound
decomposes rapidly reacts with radicals.
Their ... Angewandte Chemie .
"Basically the allicin compound
has to decompose in order to generate a potent ... Alliaceae. All of these other plants contain a compound
that is very similar to allicin, but they do not ...
... doses of chemicals, such as the neurotoxic compound
methylmercury, can harm the developing brain to a ... the adult brain.
Methylmercury is a chemical compound
formed in the environment from released mercury. ... of brain damage associated with exposure to this compound
as well as numerous others. Professor Grandjean ...
UI researchers find potentially toxic substance present in Chicago air
... http://pubs.acs.org/journals/esthag/ .
is ubiquitous in air throughout the city of ... are any health concerns associated with this compound
but there are very few published studies of its ... air is consistent with volatilization of this compound
from painted surfaces although the actual source ...
New way to make malaria medicine also first step in finding new antibiotics
... which bacteria make this particular phosphonate compound
His results are reported in the ... issue of Chemistry & Biology .
Although the compound
has already been chemically synthesized, that is ... means the genes can be manipulated to make the compound
even more effective against the malaria parasite ...
Synthetic moleculues could add spice to fight against cancer
... improve on nature, scientists used a spice-based compound
as a starting point and developed synthetic ... are derived from curcumin, a naturally occurring compound
found in the spice turmeric.
Centuries of ... pursue.
"Most of the interaction between our compound
and the overactive protein comes from what are ...
Analysis of Lake Washington microbes shows the power of metagenomic approaches
... with a heavy isotope of carbon, and fed each compound
to a separate sediment sample. The microbes that could consume the compound
incorporated the labeled carbon into their DNA, ... said, while organisms that couldn't use the compound
did not incorporate the label. The labeled DNA ...
Researchers find cancer-inhibiting compound under the sea
... of Pharmacy researchers have discovered a marine compound
off the coast of Key Largo that inhibits cancer ... July 2.
"It's exciting because we've found a compound
in nature that may one day surpass a currently ... company Merck & Co. Inc. However, UF's compound
does not inhibit all HDACs equally, meaning a ...
Weill Cornell science briefs June/July 2008
... reboxetine may alleviate their symptoms. The compound
works by boosting the level of the ... splenectomy. After giving mice with Cooley's a compound
called JAK2 inhibitor, the researchers found that ... normal red blood cells. The chemical (a similar compound
is already in a Phase I clinical trial for ...
Compound has potential for new class of AIDS drugs
... compound, and then confirmed in the lab that the compound
does indeed inhibit HIV protease, which is an ... who also has an appointment in chemistry. "This compound
is too weak to work in the human body. The key is ...
In addition to a new class of drugs, the compound
is key because smaller molecules have better ...
Chemical compound prevents cancer in lab
... Health Sciences Center, have discovered a compound
that has shown to prevent cancer in the ... would be taken as a cancer preventive.
was effective against the 12 types of cancers ... and hope to start clinical trials for the compound
within 5 years. If ...
UF scientists discover compound that could lead to new blood pressure drugs
... of Florida researchers have identified a drug compound
that dramatically lowers blood pressure, improves ... and laboratory medicine. We discovered a compound
that reverses the fibrosis that makes the blood ... beneficial, UF scientists set out to discover a compound
that enhances the enzymes activity.
Climate changing gas from some surprising microbial liaisons
... of the dimethyl sulphide gas is another sulphur compound
made by many seaweeds and marine plankton as an ... Some marine bacteria can break down this compound
to release chemical energy, and dimethyl sulphide ... types of bacteria could degrade the sulphurous compound
made by phytoplankton in different ways. We even ...
Plant gene clusters for natural products
... Using a gene cluster that makes an antifungal compound
in oats as a template, they uncovered a previously unknown gene cluster making a related compound
in a very different species, and now want to ... found that the genes needed to make an antifungal compound
in oats, called avenacin, were next to each other ...
American Chemical Society's weekly PressPac -- Jan. 9, 2008
... EASTERN TIME, Jan. 14, 2008
may have medical role in preventing diabetes complications
Chemical & Engineering News
formed during insulin production and once ... now bolsters that view, suggesting that the compound
may work by enhancing the ability of red blood ...
100 percent of people carry at least 1 type of pesticide
... had at least one kind of persistent organic compound
(POCs), substances internationally classified as ... in Spain until the 80s); hexachlorobenzene, a compound
used as fungicide and currently released by ... samples of the population, which means that some compound
levels in the general population are unknown. ...
Protein protects brain against compound in lead poisoning, liver disease
... from a naturally occurring but potentially toxic compound
present in lead poisoning and in a class of liver ... of Michigan found that when dosed with the compound
called 5-aminolevulinic acid (5-ALA), mice ... up to 30 times higher concentrations of the toxic compound
in their cerebrospinal fluid than did mice with ...
New form of compound stimulates research on hydrogen storage
... 300C). The team has found a new form of the compound
that could possibly release hydrogen in mild ... next step is to apply chemical engineering to the compound
to freeze the new form at ambient conditions and ... predictions and suggests the novel form of the compound
to be instrumental in obtaining improved hydrogen ...
Synthetic compound promotes death of lung-cancer cells, tumors
... or disappear when treated with a synthetic compound
that mimics the action of a naturally occurring ... todays issue of Cancer Cell , suggest that the compound
might one day be used in targeted therapies for ... In 2004, Dr. Wang and his colleagues developed a compound
that mimics the action of Smac. They found that ...
American Chemical Society's Weekly PressPac - Oct. 10, 2007
... to report development of a nonsteroidal compound
that shows promise as a new treatment for loss of ... gels.
The new study describes a nonsteroidal compound
that in lab rats attaches to testosterone ... to other testosterone replacement treatments, the compound
showed similar improvement in muscle mass and ...
Natural insecticide re-created in the lab
... the first synthesis of azadirachtin, a natural compound
that stops predatory insects from feeding. ... with interesting biological properties. One such compound
is azadirachtin, which was first isolated from ... research effort, but all attempts to make this compound
have thus far been unsuccessful. The difficulty ...
New 'chemically-sensitive MRI scan' may bypass some invasive diagnostic tests in next decade
... A new chemical compound
which could remove the need for patients to ... Chemical Communications, reveals that this new compound
could be used in a chemically-sensitive MRI scan ... naturally in the body so the signal from our compound
stands out. When it is introduced in this form it ...
Carbon nanoparticles toxic to adult fruit flies but benign to young
... stuck to their bodies, covered their breathing holes, and coated their compound
eyes. Scientists are unsure whether any of these afflictions led directly ... them. In other adults, the nanoparticles covered the surface of their compound
eyes, which may have blinded them.
The nanoparticles "glom onto the ...
Neuropathic pain: The sea provides a new hope of relief
... A compound
initially isolated from a soft coral ( Capnella imbricata ) collected at ... published today in the British Journal of Pharmacology is that this new compound
could be a candidate.
Recent research suggests inflammation in the ...
Natural compound stops retinopathy
... of Oklahoma Health Sciences Center have found a way to use a natural compound
to stop one of the leading causes of blindness in the United States. The ... of two systems in the eye. To restore balance, they delivered the new compound
to cells using nanoparticle technology. The treatment in research models ...
Researchers describe 'implausible' chemistry that produces herbicidal compound
... in the chemical pathway that produces phosphinothricin (PT), a bacterial compound
that is widely used as an agricultural herbicide. This compound, which is ... to any new drugs that are developed, he said.
"Knowing how a compound
is made may allow you to make an analog that can overcome that ...
NIH announces new program to develop therapeutics for rare and neglected diseases
... new approaches to accelerate it and make it less expensive.
If a compound
does survive this preclinical stage and receives Investigational New Drug ... with the disorder to participate in clinical trials once a candidate compound
reaches the stage where it can be tested in people. Moreover, for many ...
Chemical found in medical devices impairs heart function
... suspected that the trigger for these side effects might be a chemical compound
of some kind.
To test their theory, Shoukas and his team of researchers ... can identify unknown chemicals and found the liquid to contain a chemical compound
called cyclohexanone. The researchers thought that the cyclohexanone in ...
A dirty job but ...
... for truckloads of contaminated earth to be cleaned in a cement mixer. The compound
not only leaves life-sustaining nutrients in the soil, but it's also ... solution keeps all these factors in mind," he says.
The special compound
developed by the Tel Aviv University team relies on advanced chemical ...
New drug agent knocks out multiple enzymes in cancer pathway
... who led the new study.
Oldfield's team also wanted to design a compound
that would inhibit multiple enzymes in the tumor cell survival pathway, ... Papapoulos, of Leiden University, the Netherlands, showed that the compound
had a very low chemical affinity for bone.
In humans, compounds like ...
AGU journal highlights -- March 12, 2009
... by large seismic velocity jumps. Using forms of a synthetic, solid compound
containing calcium, iridium and oxygen as analogs for perovskite and ... from postperovskite deformation textures. If the analogue between the compound
used in the experiments and the perovskite crystal-packing system holds ...
Termite killer lingers as a potent greenhouse gas
... Research on March 12.
Mhle said he started detecting an unknown compound
in air samples taken in early 2004 at the Scripps pier with a newly developed measurement instrument. He identified the compound
as SO2F2 and concluded that the large fluctuations seen at the pier were ...
A natural, alternative insect repellent to DEET
... Lanham, MD; February 5, 2009 Isolongifolenone, a natural compound
found in the Tauroniro tree ( Humiria balsamifera ) of South America, has ... oil feedstock," the authors write, "we are therefore confident that the compound
has significant potential as an inexpensive and safe repellent for ...
In India: A search for more effective tuberculosis drugs
... Rajesh Gokhale has created a compound
in his lab in India that stops tuberculosis in its tracks. In a test tube, ... and ultimately destroying the pathogen.
The problem is that Gokhale's compound
will not work in humans. Not willing to set aside seven years of work, he ...
Grape-seed extract kills laboratory leukemia cells, proving value of natural compounds
... tumors in rats and skin tumors in mice, they looked at the effect of the compound
in leukemia cells.
Using a commercially available grape seed extract, ... seed extract's lethal attack in leukemia cells.
"This is a natural compound
that appears to have relatively important properties," Shi said.