2 Fred Hutchinson Cancer Research Center scientists receive Presidential Early Career Award
... components may play in preventing prostate and colorectal
Selenium, for example, found in ... consortium for genomewide association studies of colorectal
cancer that combines data from several ... aims to determine whether genetic variants affect colorectal
cancer and whether environmental factors, ...
... associated with the formation of metastases in colorectal
cancer. Now, researchers of the Max Delbrck ...
Beginning in glands in the bowel lining, colorectal
cancer often remains undiscovered initially. ... via the blood vessels or the lymphatic system. In colorectal
cancer, these cells usually settle in the liver, ...
Study finds colorectal cancer rates increasing worldwide
... ATLANTAJune 9, 2009A new study finds colorectal
cancer incidence rates for both males and females ... the first in a peer-reviewed journal to present colorectal
cancer incidence trends across all five ... of urbanization that affect most of the globe.
cancer is the fourth most common cancer in men ...
No insurance? No colonoscopy
... John M Inadomi highlights the disparity in colorectal
cancer screening (CRCS) among different ... Reports ( www.f1000medicine.com/reports ).
cancer is the second leading cause of ... blood testing (FOBT) have been shown to reduce colorectal
cancer incidence or mortality. Inadomi draws ...
Hormone therapy associated with reduced colorectal cancer risk
... risk of breast cancer, may decrease their risk of colorectal
cancer, according to a report published in the ... progestin was associated with a reduced risk of colorectal
cancer," said Jill R. Johnson, M.P.H., a doctoral ... and colleagues identified 960 new cases of colorectal
cancer in this population.
Any use of estrogen ...
Scientists discover major genetic cause of colorectal cancer
... CHICAGO -- About one-third of colorectal
cancers are inherited, but the genetic cause of ... of these cancers is unknown. The genes linked to colorectal
cancer account for less than 5 percent of all ... is present in 10 to 20 percent of patients with colorectal
cancer. The findings strongly suggest that the ...
Colorectal cancer screening rates still too low
... PHILADELPHIA Although colorectal
cancer screening tests are proven to reduce colorectal
cancer mortality, only about half of U.S. men and ... been shown to significantly reduce mortality from colorectal
cancer, but a lot of people are still not getting ...
Novel therapeutic strategy for colon cancer treatment
... is often lost (or transcriptionally
silenced) in colorectal
Apart from the findings on DACT3, ... of the Wnt/β-catenin avenue for future colorectal
Edison Liu, M.D., Executive ... discovery. It suggests a novel therapy for colorectal
cancer, an important
step towards clinical ...
How what and how much we eat (and drink) affects our risk of cancer
... effect of in utero folic acid supplementation on colorectal
cancer in the offspring in a chemical ... folic acid may increase ones risk of developing colorectal
cancer. A new study suggests that folic acid ... may protect offspring from developing colorectal
This study provides important ...
Multi-institutional study identifies new form of inherited risk of cancer
... Signatures of Autozygosity Among Patients with colorectal
Cancer," to be published online on March 28, and ... sequence (autozygous) among individuals who have colorectal
cancer. About half the cases are of Jewish ... The investigators compared IBD regions among 74 colorectal
cancer patients to two control groups, and found ...
Curry-derived molecules might be too spicy for colorectal cancers
... first test of these molecules in a mouse model of colorectal
cancer today at the American Association for ... induction of programmed cell death (apoptosis) in colorectal
Unfortunately, natural curcumin has ... enhanced growth suppressive abilities against colorectal
cancer cell lines, up to 30 times greater than ...
Interleukin-8, key marker for colorectal cancer treatment
cancer (CRC) is currently one of the three most ... to cancer progression and metastatic potential in colorectal
This issue was addressed by ... IL-8 in the development and metastatic spread of colorectal
cancer in the October 7 issue of the World ...
Bilberry extract -- can it help prevent certain cancers?
... of patients about to undergo surgery for colorectal
and liver cancer.
Among his research team are ... model Mirtoselect decreases the development of colorectal
Now, working with Mr Dave Berry, ... it really does interfere with the onset of colorectal
or liver cancer.
Ms Thomasset explained: ...
A search for biomarkers for early detection of colorectal cancer
... 5 (TXNDC5) were differentially expressed in colorectal
adenoma. The research article describing this ... and Thioredoxin Domain-Containing Protein 5 in colorectal
Adenoma and Cancer: A Proteomic Study will be ... Adenoma is the major precursor lesion of colorectal
cancer, one of the most common cancers worldwide. ...
A gene for metastasis
cancer is one of the most prevalent cancers in ... cancer metastasize.
In a majority of cases, colorectal
cancer is initiated by changes in a key protein ... cell nucleus and activate gene expression. But in colorectal
and other cancers, beta-catenin over-accumulates ...
New technique for cancer screening
... al, "High quality assessment of DNA methylation in archival tissues from colorectal
cancer patients using quantitative high-resolution melting analysis," ... melting analysis (HRM) to detect methylation on archival tissues from colorectal
cancer patients. They found that HRM provided similar results between ...
Rural areas able to increase screening capacity for colorectal cancer
... CAREFREE, A.Z. - Arizona has the ability to expand colorectal
cancer screening capacity; this potential increase was more pronounced in ... paramount.
Benuzillo and colleagues surveyed 105 gastroenterologists and colorectal
surgeons practicing in Arizona. Of these physicians, 89.5 percent ...
Mayo Clinic research on tamoxifen leads to recommendation for CYP2D6 gene test
... jointly by investigators from Mayo Clinic and the Austrian Breast and colorectal
Cancer Study Group (ABCSG) confirmed results from a previous study ... collaboration between the Mayo Clinic team and the Austrian Breast and colorectal
Cancer Study Group."
However, the researchers also demonstrated that ...
SNPs affect folate metabolism in study of Puerto-Rican adults
... conditions, those with the TT genotype have a significantly lower risk for colorectal
cancer than CC and CT genotypes. In addition, a significant association ... blood folate concentrations are associated with several diseases including colorectal
cancer and neural tube defects," Crott said.
This study was a nested ...
New journal shows half-broken gene is enough to cause cancer
... of SMAD4 has to be damaged to put a person at risk of pancreatic and colorectal
Riccardo Fodde led a team of researchers from Erasmus MC, ... investigated SMAD4, a tumor suppressor gene implicated in pancreatic and colorectal
cancer. They found that having one mutated SMAD4 allele was associated ...
Media invitation: 20th EORTC-NCI-ACR Symposium on Molecular Targets and Cancer Therapeutics
... pattern of gene expression that predicts response to treatment in advanced colorectal
New drug shows impressive activity in patients with advanced ... planned;
Researchers discover that a genetic mutation makes metastatic colorectal
cancer patients resistant to anti-EGFR drugs. Potential for a biomarker to ...
'1-hit' event provides new opportunity for colon cancer prevention, say Fox Chase researchers
... some of the earliest known molecular changes that signal the presence of colorectal
cancer, the second leading cause of cancer-related death in the United ... becoming cancerous. The APC gene is also mutated in most cases of sporadic colorectal
According to Yeung, the proteome, the sum total of proteins a ...
To fight the cancer before the tumor grows
... of hereditary colon cancer, the HNPCC syndrome (Hereditary Non-Polyposis colorectal
Cancer Syndrome). The results of their research, which was conducted in ... of hereditary colon cancer, the HNPCC syndrome (Hereditary Non-Polyposis colorectal
Cancer Syndrome). Almost all tumours of this form are affected by the ...
Science expands Science Signaling, featuring research related to medical advances, and more
... diffuse large B cell lymphoma. Science 319, 1676-1679 (2008).
The Wnt signal transduction pathway is a critical player in ... suppressor known as APC, a negative regulator of Wnt signaling, results in colorectal
carcinoma. Although APC is a well known inhibitor of Wnt signaling, now it ...
$2.7 million awarded for metastatic colon cancer research
... response-modifying genes that can be therapeutically targeted to improve colorectal
cancer treatment. Weiners research seeks an analytical and experimental basis for introducing new ways of treating colorectal
cancers with existing agents, specifically EGFR pathway-targeted drugs. ...
Genome update defines landscape of breast and colon cancers
... that were used for their first genome draft - 11 each of breast and colorectal
cancers, removed from patients after surgery. Then, they evaluated all ... and a subset of the most promising mutations were studied in a further 96 colorectal
cancers. They compared the genetic sequence of these tumors with that of ...
Moving to the US increases cancer risk for Hispanics
... most cancers was higher (at least 40 percent) among Hispanics living in the United States compared with those who live in their countries of origin. colorectal
cancer risk among Cubans and Mexicans who moved to the United States was more than double that in Cuba and Mexico. The same was said for lung cancer ...
Most older long-term cancer survivors have poor health habits
... and colleagues reviewed data from a total of 753 older (aged 65 years or over), long-term (five or more years post-diagnosis) breast, prostate, and colorectal
cancer survivors to estimate the prevalence of poor health habits in this population. Participants were recruited through the North Carolina Central ...
Systems biology recommended as a clinical approach to cancer
... a systems-level view can provide important insights related to the disease. The examples, which involve cases of breast cancer, B-cell lymphomas, and colorectal
cancer, demonstrate the various kinds of clinical issues that can arise, as well as the use of different mathematical methods that can be used in a ...
Five outstanding young gastroenterologists receive AGA Foundation 2009 Research Scholars Award
... Branch, Galveston: Colonic CD90+ myofibroblasts/fibroblasts: implication in the enhanced expansion of CD$+ CD25 high FoxP3+ regulatory T cells during colorectal
Andrew Tai, MD, PhD, University of Michigan, Ann Arbor: Functional characterization of a novel role for a phosphatidylinositol ...
When cells reach out and touch
... then examined microRNA production in five additional commonly studied human and mouse cell lines, including human breast cancer cells, human colorectal
cancer cells and human pancreatic cancer cells. They also tested fruit fly cells to determine whether or not the phenomenon is restricted to mammals. ...
Burnham researchers present at 100th AACR Meeting
... two papers: Ileal Bile Acid Binding Protein Mediates the Chemopreventative Effect of Ursodeoxycholic Acid by Activating Nuclear Receptor FXRα in colorectal
Cancer and Genetic Deletion of FXRα Promotes Colon Tumorigenesis in ApcMin/+ Mice
Adam Richardson, Ph.D., will present The Role of Pentose ...
Health benefits, consequences of folic acid dependent on circumstances
... of folate.
Under most circumstances, adequate intake of folate appears to assume the role of a protective agent against cancer, most notably colorectal
cancer. However, in select circumstances in which an individual who harbors a pre-cancerous or cancerous tumor consumes too much folic acid, the ...
Lombardi research: Monoclonal antibodies primed to become potent immune weapons against cancer
Monoclonal antibodies already offer effective treatment for a wide range of cancers, including breast cancer (Herceptin, Avastin), colorectal
cancer (Erbitux, Avastin), lung cancer (Avastin), and blood cancers (Rituxan, Campath), but they have appeared to primarily work by forcing tumor ...
Damon Runyon Cancer Research Foundation awards prestigious fellowships to 13 top young investigators
... Massachusetts, is working to identify new protein networks that interact with the oncogenic Ras signaling pathway, which is rewired in over half of colorectal
cancer cases. Targeting these new interactions in combinatorial therapy may become an effective way to manage this deadly disease in the future.
Human genomics in China
... of disease associated genes, particularly the cloning
and identification of genes related to leukemia, solid tumors (including liver cancer, colorectal
cancer and nasopharyngeal
cancer) and genetic diseases (such as deaf). Furthermore, substantial progresses were made in the
development of ...
Meyskens honored with AACR-Prevent Cancer Foundation award
... trials. Meyskens led the development of the combination of difluoromethylornithine (DFMO) plus Sulindac to dramatically reduce the risk of advanced colorectal
Among his noteworthy accomplishments, Meyskens developed the topical all-trans-retinoic acid for chemoprevention of cervical ...
Genetic Engineering & Biotechnology News reports on growing role of molecular diagnostics
... addition, data was recently presented showing the importance of testing for the K-ras gene to assess the clinical benefit of Erbitux for metastatic colorectal
Of all the larger integrated healthcare companies, Roche has best executed the synergies of molecular diagnostics and biopharmaceuticals ...
Cancer-causing gut bacteria exposed
... to our health. However, for several decades scientists have thought that some microbes living in the gut may play a role in the formation of sporadic colorectal
Enterococcus faecalis is a normal gut bacterium. Unlike most gut bacteria, it can survive using two different types of metabolism: ...
Researchers identify cancer-causing gene in many colon cancers
... CDK8 is such a gene.
The new study began with a focus on a protein called beta-catenin, a transcription factor that is overactive in nearly all colorectal
cancers. Although overactive beta-catenin plays a role in the initial formation of tumors, other genetic abnormalities must occur for tumors to ...