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Colon in Biological News

Colon cancer screening technique shows continued promise in new study

... Recent clinical trials show that a new colon cancer screening technique created by ... successful than a colonoscopy in screening for colon cancer. The technique uses optical technology, ... detect the presence of growths elsewhere in the colon even though it just analyzed tissue from the base ...

Suppressing cancer with a master control gene

... of those genes, Atonal homolog 1 (ATOH1), causes colon cancer in mice. The gene regulates the last step ... to epithelial cells of the colon. Humans with colon cancer frequently have an inactivated ATOH1 gene, ... researchers could reactivate the gene in human colon cancer cells grown in culture. This caused the ...

Gene switch sites found mainly on 'shores,' not just 'islands' of the human genome

... colleagues searched for new methylated areas in colon tumors as well as normal colon tissue removed from 13 different cancer patients. ... cells. However, comparing the tumor and healthy colon cells' entire genomes, including CpG islands as ...

Tips from the American Journal of Pathology

... 174:297-308 Inflammation Contributes to colon Cancer Researchers led by Dr. Brian Iritani ... Smad3, may therefore increase susceptibility to colon cancer. To examine whether Smad3 signaling contributes to development of colon cancer, Maggio-Price et al examined mice ...

Newly identified gene powerful predictor of colon cancer metastasis

... for the first time with high probability if colon cancer is going to metastasize. Assistant ... that the gene MACC1 (Metastasis-Associated in colon Cancer 1) not only promotes tumor growth but also ... is low, the life expectancy of patients with colon cancer is longer in comparison to patients with ...

Women double fruit, veggie intake with switch to Mediterranean diet plan

... also leading a study called Healthy Eating for colon Cancer Prevention, in which she and colleagues ... diet can have preventive effects in the colon in persons at increased colon cancer risk. The diet used in the newly published ...

Sibling study could lead to better treatments for inherited form of colon cancer

... step closer to understanding how certain forms of colon cancer develop. In a study using siblings who have been diagnosed with colon cancer, scientists discovered similarities on a ... of genetic material may be causing a subset of colon cancers that run in families. "It's those ...

Breakthrough optical technology to assess colon cancer risk, accuracy

... potential applications for analyzing risk of colon cancer. The study appears in the October 2008 ... polyp detection and could lead to improvements in colon cancer prevention. "Our premise is that since the lining of the large intestine -- rectum and colon -- is contiguous, if you see an abnormality in ...

Cancer-causing gut bacteria exposed

... Normal gut bacteria are thought to be involved in colon cancer but the exact mechanisms have remained ... sheds light on the way gut bacteria can cause colon cancer. There are more bacteria in our bodies ... Earth. In fact, there are more bacteria in the colon than there are human cells in our bodies. Most of ...

'1-hit' event provides new opportunity for colon cancer prevention, say Fox Chase researchers

... Patients with FAP, which predisposes people to colon cancer, carry mutations in one of their two ... gene. The APC gene acts to prevent the colon cells from growing out of control and becoming ... into cancer." This is the first time the human colon proteome has been characterized to this depth, ...

Researchers identify cancer-causing gene in many colon cancers

... linked a previously unsuspected gene, CDK8, to colon cancer. The discovery of CDK8's role in cancer ... and are involved in the proliferation of colon cancer cells, the research team ran three ... the cells stopped growing. They then analyzed colon cancers for genes that had extra copies. When ...

The pepperoni pizza hypothesis

... nerves. Nerves from this region -- the bladder, colon and prostate -- are bunched together like ... cord: a steady beep, beep, beep. But when the colon is irritated by pepperoni pizza or another type of food, colon nerves also send a pain signal to the same area ...

Early stage colon cancer characterized by inactivation of gatekeeper gene

... paves the way for the growth and development of colon cancer, Singapore scientists report in the Sept. ... of RUNX3 occurs at a very early stage of colon cancer, according to the Singapore scientists' ... test as well as a therapeutic target for colon cancer. Prior to these new findings, ...

American Chemical Society's Weekly PressPac -- Aug. 27, 2008

... New evidence on folic acid in the diet and colon cancer Journal of Proteome Research ... low folate intake and an increased risk for colon cancer, the second leading cause of cancer death ... in the diet increases the risk of developing colon cancer in adults. However, scientists lack an ...

'Smothered' genes combine with mutations to yield poor outcome in cancer patients

... have identified a set of genes in breast and colon cancers with a deadly combination of traditional ... Some 189 mutated genes in breast and colon cancers, previously identified by a Kimmel Cancer ... were "hyper"methylated, often in both breast and colon cancers. After reviewing samples from 30 ...

NCI grant launches clinical trials for colon cancer screening

... shown to be effective for the early detection of colon cancer has received a $7.5 million grant over ... that potentially could become a routine colon cancer screening test and to launch large-scale clinical trials. colon cancer is the second-leading cause of cancer ...

Synthetic cocoa chemical slows growth of tumors in human cell lines

... The strongest response was seen in two different colon cancers; growth was cut in half and most of the ... says. They found sensitivity to GECGC in both colon cancer cell lines they tested, in cervical cancer ... that it demonstrated the most killing power in colon cancer suggests the chemical "could serve as a ...

To fight the cancer before the tumor grows

... studied the most frequent form of hereditary colon cancer, the HNPCC syndrome (Hereditary ... journal Gastroenterology. In Germany, colon cancer, with about 65,000 new cases per year, is ... suffer from the most frequent form of hereditary colon cancer, the HNPCC syndrome (Hereditary ...

Inherited cancer mutation is widespread in America

... responsible for the most common form of inherited colon cancer is older and more common than formerly ... syndrome, also known as hereditary nonpolyposis colon cancer, is responsible for about one third of hereditary colon cancers, and almost 3 percent ...

Vitamin D and calcium influence cell death in the colon, researchers find

... diet can stimulate or prevent the appearance of colon cancer. Emory investigators will present their ... on biological markers that could influence colon cancer risk in three abstracts at the American ... shown that calcium and vitamin D tend to reduce colon cancer risk. "We were pleased that the effects ...

New study finds uncontrollable stress worsens symptoms of endometriosis

... and damage to the adjacent organs (including the colon and small intestine). The presence of the enzyme ... stress. the endo-stress rats had the shortest colon length, the highest levels of MPO, the greatest ... of the observed levels of mast cells in the colon and the increased levels of inflammatory cells in ...

Where college students live can impact their weight, eating and exercise habits

... and damage to the adjacent organs (including the colon and small intestine). The presence of the enzyme ... stress. the endo-stress rats had the shortest colon length, the highest levels of MPO, the greatest ... of the observed levels of mast cells in the colon and the increased levels of inflammatory cells in ...

Gene dose affects tumor growth

... of a particular gene can affect the severity of colon cancer in a mouse model. Publishing in the Jan. 3 ... intestinal tumors, similar to those seen in colon cancer in humans. The trisomic, colon cancer mice had 44 percent fewer intestinal ...

It is important to demonstrate the influence of the microenvironment in the process of metastasis

... (UPV/EHU), an in vitro culture model of human colon cancer was created in order to reproduce the gene ... drugs that block this route. Cancer of the colon is the third most common kind of cancer in our ... is already in quite an advanced state. Of those colon cancer patients who suffer metastasis, ...

DNA methylation shown to promote development of colon tumors

... on regions of DNA) and the development of colon tumors in mice. The research directly ... are known to be silenced by methylation in human colon cancer cells. If we can switch on the gene that ... increases in methylationand the development of colon tumors. The scientists did this by giving mice ...

Potential new therapeutic molecular target to fight cancer

... to improve the efficacy of chemotherapy for colon and breast cancer. In the Nov. 1 issue of the ... Cancer Research, researchers examined human colon and breast cancer cells and established a role of ... on p53- independent mechanisms to induce death in colon and breast cancer cells. Understanding how ...

$2.7 million awarded for metastatic colon cancer research

... Jeannik M. Littlefield-AACR Grants for Metastatic colon Cancer Research, totaling $2.7 million. Now in ... and development of new treatments for metastatic colon cancer. colon cancer is the third most common cancer diagnosed ...

Genome update defines landscape of breast and colon cancers

... first large-scale report sequencing breast and colon cancer genes, Johns Hopkins Kimmel Cancer Center ... an average 77 genes are mutated in an individual colon cancer and 81 in breast cancer. Of these, about ... nine genes less frequently mutated in breast or colon cancers. Each of the genes protein products ...

A gene for metastasis

... expression of genes induced by L1-CAM in cultured colon cancer cells to those in 170 samples of ... from patients, and in 40 samples of normal colon tissue. Out of some 160 genes induced by L1-CAM, ... in the cancerous tissue, but not in normal colon tissue. Ben-Zeev plans to conduct further ...

'Western' diet linked to increased risk of colon cancer recurrence

... involved 1,009 patients with stage III colon cancer that has been treated with both surgery and chemotherapy. Stage III colon cancer is characterized as being localized to the ... were three-and-a-half times more likely to have colon cancer recur than those whose diets were least ...

Pitt researchers find promising candidate protein for cancer prevention vaccines

... to boost response against MUC1, a protein that is abnormally produced in colon cancer and in precancerous polyps. The MUC1 colon cancer prevention vaccine is being tested in a clinical trial led by ...

2 Fred Hutchinson Cancer Research Center scientists receive Presidential Early Career Award

... approaches, she also studies vitamin D and calcium in the prevention of colon cancer, the second leading cause of cancer death in the United States. ... genome and is currently conducting genomewide association studies for colon and breast cancer. The goal is to identify new genetic markers that can be ...

Colorectal cancer

... Institute estimates that, alone in the United States, 106,100 cases of colon cancer will occur and 49,920 patients will die both from colon and rectal cancer in 2009. Beginning in glands in the bowel lining, ...

Enzyme involved in inflammatory bowel disease discovered at Penn State College of Medicine

... from healthy people. The amount of enzyme in the IBD patient's inflamed colon was significantly lower than that in normal colon sections. The researchers concluded that their findings strongly correlate ...

Caffeic acid inhibits colitis in a mouse model -- is a drug-metabolizing gene crucial?

... with significant lessening of colitic damage, assessed by examining colon histopathology. In comparison with rutin, an anti-inflammatory flavonoid ... respect to their ability and mechanisms of inhibiting colitis, and perhaps colon cancer, because colitis increases risk for this disease". In summary, ...

Viral 'magic bullet' targets cancer cells with help of new compound

... models of cancer, and also in human tissues from breast, prostate and colon cancer immediately after excision from patients. "Treatment with these ... rapid implementation of new experimental therapies for breast, prostate, colon and other primary cancers that are currently resistant to virotherapy. ...

Weill Cornell science briefs June/July 2008

... do not produce this well-known protein. The scientists studied colon cancer cells within a mouse model to make their observations. Moving ... 99 percent of the active ingredient in the new pill is released in the colon compared to only 70 percent in other common IBD drugs. Dr. Ellen Scherl ...

Weight-loss surgery can cut cancer risk

... group was 85 percent lower for breast cancer and 70 percent lower for colon and pancreatic cancers, and was also distinctly lower for several other ... for increased hormone production, a major risk factor for breast and colon cancer. Thus so modifications to the patient's hormonal metabolism due to ...

Novel therapeutic strategy for colon cancer treatment

... at San Francisco have developed a pharmacological approach to kill colon cancer cells. Genetic and epigenetic defects in the signaling of a ... results in the effective inhibition of Wnt/β-catenin massive death of colon cancer cells. Their discovery was published in Cancer Cell on June 9, ....

A compound extracted from olives inhibits cancer cells growth and prevents their appearance

... Lupiez Cara has analysed the effect of maslinic acid in the treatment of colon cancer, it can be used in different types of tumours. For the moment, their research works have been developed in colon carcinoma lines and transgenic mice, but they have not dismissed the ...
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