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Cofactors in Biological News

Cutting-edge amfAR grants fight HIV/AIDS in the lab and on the phone

... University of Utah, Salt Lake City, UT $125,000 Identifying cellular cofactors of Rhesus monkey TRIM5-alpha: While the evolutionary struggle between ... be favored over time. She will study the evolutionary history of these HIV cofactors to determine which appear to play the most important role and hence show ...

Pliable proteins keep photosynthesis on the light path

... measurements, but she was able to figure out why." "The electron transfer driving force can be determined by either the properties of the metal cofactors themselves or through their interaction with the protein," said Lin. "In the case of the zinc reaction center, the driving force is regulated through ...

Biophysical Society announces winners of 2008 Student Travel Awards

... Bond to Model the Turn Roles in -hairpin Stability. Qianru Yu, The Pennsylvania State University, Fluorescence-based Biochemistry on Intrinsic cofactors in Human Breast Normal and Cancerous Cells. ...

The key to unlocking the secret of highly specific DNAzyme catalysis

... termed deoxyribozymes or DNAzymes. With only four nucleotides as building blocks, versus 20 in proteins, nucleic acid enzymes may need to recruit cofactors (helper molecules) to perform some functions. Metal ions are a natural choice, and indeed most nucleic acid enzymes require metal ions for function ...

Microreactor efficiently regenerates cofactors for biocatalysis

... the continuous regeneration of molecules called cofactors that permit the synthesis through inexpensive and ... a microreactor that efficiently regenerates cofactors through enzyme-catalyzed reactions. "Enzymes ... and Technology. "In those cases, one or more cofactors are required." By continuously regenerating ...

Beyond the DNA: Chemical signatures reveal genetic switches in the genome

... transcription is directly initiated, and enhancer regions - some of which are very distant from the target gene - to which transcription-activating cofactors bind. According to LICR's Dr. Bing Ren, the study's senior author and assistant professor at UCSD's Department of Cellular and Molecular ...

MIT biologists solve vitamin puzzle

... which becomes DMB. Normally, the B2-derived cofactor would assist in a reaction by temporarily holding electrons and then giving them away. Such cofactors are not consumed in the reaction. Cannibalization of a cofactor has very rarely been observed before in vitamin synthesis or any type of ...

Cholera pathogen reveals how bacteria generate energy to live

... of the protein and then determined whether these labels appeared inside or outside the envelope of the cell membrane. The results showed that the cofactors ?important parts of the enzyme’s machinery ?are all located on the inner side of the membrane, which corresponds to the "intake" port of the ion ....

PCRM develops world's first cruelty-free insulin assay

... cells using an animal component-free, peptide- and protein-free, media supplement as a replacement for calf serum--basically a synthetic formula with cofactors and trace elements that promote cell growth. Then, in collaboration with Linco Research of St. Charles, Missouri, Even successfully incorporated ...

An HIV Protein Plays a Surprising Role in Gene Activation

... is called TFIID, a large protein complex containing a protein that binds the TATA box (aptly named the TATA-box-binding protein, or TBP) and several cofactors called TBP-associated factors (TAFs). PIC assembly sometimes also requires activator proteins, which can enhance transcriptional activity by ...

Novel Enzyme Shows Potential As An Anti-HIV Target

... of proteins (mostly histones) and DNA. Another, more widely accepted model proposes that histone acetylation controls transcription by recruiting cofactors required for transcription. Acetylation and deacetylation enzymes can also target other proteins. Of the three classes of deacetylases known to ...
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