Navigation Links
Chaperone in Biological News

Protein handlers should be effective treatment target for cancer and Alzheimer's

... Mivechi, director of the MCG Center for Molecular chaperone Biology/Radiobiology and Cancer Virology. ... know whether ramping up the activity of molecular chaperone can essentially make them act young again and ... example, when they remove a specific molecular chaperone they find Alzheimer's-like disease accelerates ...

In scientific first, Einstein researchers correct decline in organ function associated with old age

... proteins. After finding such a protein, the chaperone ferries it towards one of the cell's many ... membrane-bound sacs filled with enzymes. When the chaperone and its cargo "dock" on a receptor molecule on ... In previous work, Dr. Cuervo found that the chaperone surveillance system, in particular, becomes less ...

Biophysical Society announces new and notable symposium speakers

... Speakers and Information: The Effect of chaperone SecB on MBP Folding: A Single-molecule Study. ... the first experimental study to show how a chaperone affects a protein folding pathway. The chaperone was shown to interfere specifically with some ...

Sidestepping cancer's chaperone

... of Tumor Cell Mitochondrial Homeostasis by an Organelle-Specific Hsp90 chaperone Network, published in the October 19 issue of Cell, Dario C. Altieri, MD, ... this has not been well understood. And although inhibitors of a specific chaperone known as heat shock protein 90 (Hsp90) have been studied for the treatment ...

First high-res 3D structures of mammalian HSP90 protein solved

... the work shows for the first time how members of the hsp90 family of chaperone proteins can differ from each other, while still being part of the same ... GRP94s place in this family and has already stimulated interest in this chaperone as a drug target. This understanding would allow for the long-term ...

NIH awards researcher $1.5 million 'new innovator' grant for fruit-fly studies of prion proteins

... the protective effects in flies, mammalian cells and mice of so-called chaperone proteins, which work to make sure that other proteins take on their proper ... intend to use their flies to determine whether other possibly protective chaperone proteins work as well. Next, theyll check any promising leads with ...

New study reveals the protein that makes phosphate chains in yeast

... in yeast a protein called Vtc4p is responsible for the production of polyphosphates. Vtc4p is part of a protein complex called vacuolar transporter chaperone complex (VTC) that is usually found in the membranes of vacuoles pouches in which cells store molecules for later use, transport or destruction. ...

Michael J. Fox Foundation awards $2.4M for validation of therapeutic targets for Parkinson's

... and researchers," said Katie Hood, CEO of The Michael J. Fox Foundation. "But to attract an industry sponsor with the resources and expertise to chaperone it through optimization, preclinical work and ultimately clinical testing, that target needs a critical mass of evidence behind it, demonstrating ...

Researchers reveal insights into hidden world of protein folding

... all proteins have to be folded-some in complex configurations-in order to function properly, and many are known to require a molecule called a chaperone to fold them. Frydman estimates that perhaps 10 percent of the proteins needing chaperones must have one that, like TRiC, is part of the subset ...

Key stress protein linked to toxicities responsible for Parkinson's, Alzheimer's

... Disease. That link is Protein Disulphide Isomerase (PDI), a chaperone protein that is necessary for proper protein folding in times of cellular ... accumulation of misfolded proteins due to cellular stress. PDI acts as a chaperone for aggregated proteins, rearranging their chemical bonds and thus ...

While on trail of dioxin, scientists pinpoint cancer target of green tea

... Gasiewicz, and current undergraduate Claire Westlake discovered that a chaperone protein known as HSP90 is involved in conferring green tea's protective ... currently working on ways to block HSP90, which is known as a promiscuous chaperone protein because it binds to many different cells and receptors in the ....

Multi-purpose protein regulates new protein synthesis and immune cell development

... deposited in the ER membrane in response to coded instructions from genes. chaperone proteins fold these amino acid chains into specific shapes and direct them ... ER time to catch up. Second, it induces expression and synthesis of more chaperone proteins to assist with protein folding and help with protein trafficking. ...

In mice, drug protects against diabetes and atherosclerosis

... after a decade of intense efforts to achieve with a chemical what has been observed in mice and humans carrying the gene variant. The lipid chaperone protein aP2 acts as a signal in cells, setting off a chain of inflammatory and metabolic responses to consumption of fatty foods. Some of those ...

Researchers shed light on mechanism of action used by anti-cancer drug

... to ER stress. Interestingly, they also found that sorafenib, by virtue of its ability to inhibit Raf, also prevented an increase in expression of a chaperone protein known as Grp78, which is classically induced in the ER stress response, and which helps to resolve stresses associated with increased protein ...

Why don't all moles progress to melanoma?

... production factory. The process begins when chains of amino acids are deposited in the ER membrane in response to coded instructions from genes. chaperone proteins fold these amino acids into specific shapes. When too many of them build up in the membrane, or when something goes wrong with the folding ...

Proteins may behave differently in natural environments

... "This sort of expansion has never been observed before," he said. In terms of native GroEL, the finding may indicate the need to look at the chaperone itself more closely. "The expansion was directly related to the function of the assembly. From a more global perspective, this is strong ...

What's next for gene therapy? Plastic

... agents," said Tim Long, professor of chemistry in the College of Science at Virginia Tech. "We are trying to understand how the structure of the chaperone impacts the efficiency of its ability to transfer DNA across the cell membrane." Entire texts have been devoted to the subject, Long said. "But ...

Understanding how bacteria communicate may help scientists prevent disease

... experimentally by his colleagues at Princeton. "We showed that the crucial missing element was a group of genes called small RNAs. ("The small RNA chaperone Hfq and multiple small RNAs control quorum sensing in Vibrio harveyi and Vibrio cholerae," by D.H. Lenz, K.C. Mok, B.N. Lilley, R.V. Kulkarni, N.S. ...
Other Contents
(Date:10/17/2014)... release is available in German . ... a very few drugs. When treating overdoses, doctors are often ... especially difficult if there is a combination of drugs involved. ... and accidentally swallows his grandmother,s pills? ETH professor Jean-Christophe Leroux ... to find an answer to this question. "The task was ...
(Date:10/16/2014)... they are anything but sustainable: environmental damage to ... becoming increasingly evident. Despite their disadvantages, however, monocultures ... as the sole possibility of achieving higher yields ... Schmid, an ecology professor at the University of ... and forestry. After all, a new study carried ...
(Date:10/15/2014)... ability to assess the pandemic risk from strains of ... must not allow ourselves to become complacent that the ... consortium of scientists. , Influenza pandemics arise when a ... to develop widespread immunity – spreads in the human ... past 100 years, the worst of which – the ...
Breaking Biology News(10 mins):Emergency aid for overdoses 2Emergency aid for overdoses 3Plant communities produce greater yield than monocultures 2Plant communities produce greater yield than monocultures 3Scientists 'must not become complacent' when assessing pandemic threat from flu viruses 2
(Date:10/22/2014)... King of Prussia, PA (PRWEB) October 22, 2014 ... Group, is recognized as an industry leader with over ... industry award winning team leader in the areas related ... In addition, Mr. Carlson is an Editorial Advisory Board ... Group Healthcare Council Educator. Blue Fin Group is ...
(Date:10/22/2014)... Maureen Salamon HealthDay Reporter , ... in vitro fertilization (IVF) are only about half as likely ... reproduction technique, new research indicates, and the racial disparity persists ... about 31 percent of white patients became pregnant after IVF, ... more than 4,000 IVF cycles over two years to tease ...
(Date:10/22/2014)... Maureen Salamon HealthDay Reporter ... crucial part of conventional in vitro fertilization (IVF) -- the ... take place in a device inside the vagina, new research ... that the device, called an INVOcell, might sharply cut costs ... make the technology more accessible to those who don,t live ...
(Date:10/22/2014)... By Dennis Thompson HealthDay ... freelance cameraman who was diagnosed with Ebola while working for ... system and can leave the special isolation unit at Nebraska Medical ... two weeks, the hospital said Tuesday. A blood test confirmed ... Ashoka Mukpo, 33, can head home to Providence, R.I., NBC ...
(Date:10/20/2014)... Allegheny General Hospital’s (AGH) Cardiovascular Institute is offering ... a damaged mitral valve as the heart continues to ... Abbott Vascular , is designed to treat degenerative ... which the heart’s mitral valve leaflets fail to close ... left ventricle into the left atrium. The heart must ...
Breaking Medicine News(10 mins):Health News:Rich Carlson and Marc Duey to Hold Workshop at CBI’s Specialty Pharmacy and Distribution Networks Conference 2Health News:Black Women Fare Worse With Fertility Treatments, Study Says 2Health News:Black Women Fare Worse With Fertility Treatments, Study Says 3Health News:Experimental Infertility Treatment Seems Effective, Cheaper 2Health News:Experimental Infertility Treatment Seems Effective, Cheaper 3Health News:Experimental Infertility Treatment Seems Effective, Cheaper 4Health News:U.S. Cameraman Treated for Ebola 'Free' of the Virus 2Health News:U.S. Cameraman Treated for Ebola 'Free' of the Virus 3Health News:Allegheny General Hospital Introduces New, Beating-Heart Procedure for Mitral Valve Repair 2Health News:Allegheny General Hospital Introduces New, Beating-Heart Procedure for Mitral Valve Repair 3
Other TagsOther Tags