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Chaperone in Biological News

Protein handlers should be effective treatment target for cancer and Alzheimer's

... Mivechi, director of the MCG Center for Molecular chaperone Biology/Radiobiology and Cancer Virology. ... know whether ramping up the activity of molecular chaperone can essentially make them act young again and ... example, when they remove a specific molecular chaperone they find Alzheimer's-like disease accelerates ...

In scientific first, Einstein researchers correct decline in organ function associated with old age

... proteins. After finding such a protein, the chaperone ferries it towards one of the cell's many ... membrane-bound sacs filled with enzymes. When the chaperone and its cargo "dock" on a receptor molecule on ... In previous work, Dr. Cuervo found that the chaperone surveillance system, in particular, becomes less ...

Biophysical Society announces new and notable symposium speakers

... Speakers and Information: The Effect of chaperone SecB on MBP Folding: A Single-molecule Study. ... the first experimental study to show how a chaperone affects a protein folding pathway. The chaperone was shown to interfere specifically with some ...

Sidestepping cancer's chaperone

... of Tumor Cell Mitochondrial Homeostasis by an Organelle-Specific Hsp90 chaperone Network, published in the October 19 issue of Cell, Dario C. Altieri, MD, ... this has not been well understood. And although inhibitors of a specific chaperone known as heat shock protein 90 (Hsp90) have been studied for the treatment ...

First high-res 3D structures of mammalian HSP90 protein solved

... the work shows for the first time how members of the hsp90 family of chaperone proteins can differ from each other, while still being part of the same ... GRP94s place in this family and has already stimulated interest in this chaperone as a drug target. This understanding would allow for the long-term ...

NIH awards researcher $1.5 million 'new innovator' grant for fruit-fly studies of prion proteins

... the protective effects in flies, mammalian cells and mice of so-called chaperone proteins, which work to make sure that other proteins take on their proper ... intend to use their flies to determine whether other possibly protective chaperone proteins work as well. Next, theyll check any promising leads with ...

New study reveals the protein that makes phosphate chains in yeast

... in yeast a protein called Vtc4p is responsible for the production of polyphosphates. Vtc4p is part of a protein complex called vacuolar transporter chaperone complex (VTC) that is usually found in the membranes of vacuoles pouches in which cells store molecules for later use, transport or destruction. ...

Michael J. Fox Foundation awards $2.4M for validation of therapeutic targets for Parkinson's

... and researchers," said Katie Hood, CEO of The Michael J. Fox Foundation. "But to attract an industry sponsor with the resources and expertise to chaperone it through optimization, preclinical work and ultimately clinical testing, that target needs a critical mass of evidence behind it, demonstrating ...

Researchers reveal insights into hidden world of protein folding

... all proteins have to be folded-some in complex configurations-in order to function properly, and many are known to require a molecule called a chaperone to fold them. Frydman estimates that perhaps 10 percent of the proteins needing chaperones must have one that, like TRiC, is part of the subset ...

Key stress protein linked to toxicities responsible for Parkinson's, Alzheimer's

... Disease. That link is Protein Disulphide Isomerase (PDI), a chaperone protein that is necessary for proper protein folding in times of cellular ... accumulation of misfolded proteins due to cellular stress. PDI acts as a chaperone for aggregated proteins, rearranging their chemical bonds and thus ...

While on trail of dioxin, scientists pinpoint cancer target of green tea

... Gasiewicz, and current undergraduate Claire Westlake discovered that a chaperone protein known as HSP90 is involved in conferring green tea's protective ... currently working on ways to block HSP90, which is known as a promiscuous chaperone protein because it binds to many different cells and receptors in the ....

Multi-purpose protein regulates new protein synthesis and immune cell development

... deposited in the ER membrane in response to coded instructions from genes. chaperone proteins fold these amino acid chains into specific shapes and direct them ... ER time to catch up. Second, it induces expression and synthesis of more chaperone proteins to assist with protein folding and help with protein trafficking. ...

In mice, drug protects against diabetes and atherosclerosis

... after a decade of intense efforts to achieve with a chemical what has been observed in mice and humans carrying the gene variant. The lipid chaperone protein aP2 acts as a signal in cells, setting off a chain of inflammatory and metabolic responses to consumption of fatty foods. Some of those ...

Researchers shed light on mechanism of action used by anti-cancer drug

... to ER stress. Interestingly, they also found that sorafenib, by virtue of its ability to inhibit Raf, also prevented an increase in expression of a chaperone protein known as Grp78, which is classically induced in the ER stress response, and which helps to resolve stresses associated with increased protein ...

Why don't all moles progress to melanoma?

... production factory. The process begins when chains of amino acids are deposited in the ER membrane in response to coded instructions from genes. chaperone proteins fold these amino acids into specific shapes. When too many of them build up in the membrane, or when something goes wrong with the folding ...

Proteins may behave differently in natural environments

... "This sort of expansion has never been observed before," he said. In terms of native GroEL, the finding may indicate the need to look at the chaperone itself more closely. "The expansion was directly related to the function of the assembly. From a more global perspective, this is strong ...

What's next for gene therapy? Plastic

... agents," said Tim Long, professor of chemistry in the College of Science at Virginia Tech. "We are trying to understand how the structure of the chaperone impacts the efficiency of its ability to transfer DNA across the cell membrane." Entire texts have been devoted to the subject, Long said. "But ...

Understanding how bacteria communicate may help scientists prevent disease

... experimentally by his colleagues at Princeton. "We showed that the crucial missing element was a group of genes called small RNAs. ("The small RNA chaperone Hfq and multiple small RNAs control quorum sensing in Vibrio harveyi and Vibrio cholerae," by D.H. Lenz, K.C. Mok, B.N. Lilley, R.V. Kulkarni, N.S. ...
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(Date:7/9/2014)... With over 100 diseases that can attack soybean ... of the most wanted list? University of Illinois scientists ... more research is needed on the fungus that causes ... cool, damp growing conditions but Macrophomina phaseolina , ... dry drought conditions. , "As the climate continues to ...
(Date:7/9/2014)... cooks are turning to more healthful alternatives to their ... sometimes mean low satisfaction. Now researchers are reporting new ... that are made with olive oil rather than pork ... of Agricultural and Food Chemistry . , Ana M. ... to expect just the right amount of chewiness and ...
(Date:7/9/2014)... of Adlie penguins shows that the population is ... than previously estimated. Adlie penguins have long been ... understand the effects of climate change and fishing ... satellite imagery, researchers from Stony Brook University and ... that permits regular monitoring of Adlie penguins across ...
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(Date:7/9/2014)... the most common type of lung cancer, researchers have ... role in forming tumors. The new knowledge may expand ... genetic changes already are available or are in clinical ... investigators from The Cancer Genome Atlas (TCGA), including researchers ... Harvard Medical School and other institutions, studied tumors from ...
(Date:7/9/2014)... users in Russia might contribute to HIV transmission ... by researchers from Boston University Schools of Medicine ... Pavlov State University, sought to discover the effect ... a cohort of HIV-positive people with lifetime of ... by police were more likely to share needlesincreasing ...
(Date:7/9/2014)... July 9, 2014 There has been a ... UT Southwestern Medical Center using MyChart, the online, interactive ... results, communicate with their healthcare providers, schedule appointments, and ... of patients actively using MyChart each year ... year increased more than 10-fold, according to a study ...
(Date:7/9/2014)... reputation for being highly toxic, but when used in the ... to offer potential health benefits in a range of issues, ... compound (AP39), designed and made at the University of Exeter, ... of very small amounts of the substance to the right ... have already found that the compound protects mitochondria the ...
(Date:7/9/2014)... printing on prescription labels handed out by pharmacists ... in taking medication, according to new research by ... Institute for the Blind)., The study, published recently ... that labels on prescription medications dispensed by pharmacies ... legibility. , By simply following recommended guidelines for ...
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