Stem cell research: From molecular physiology to therapeutic applications
... of differentiation and de-differentiation, cellular
plasticity and totipotency of pluripotent cells, ... of somatic cells. He intends to build various cellular
and animal models for human diseases, to uncover mechanisms underlying these different cellular
processes and to discover new ways to improve ...
... what controls their size and density, and how the cellular
location of clusters is robustly maintained in ... PALM, Liphardt and his colleagues mapped the cellular
locations of three proteins central to the ... large polar clusters. Analysis of the relative cellular
locations of more than one million individual ...
Researchers observe single protein dimers wavering between two symmetrically opposed structures
... by proteins is a common way of regulating cellular
activities. This direct view provides a neat ... different, a feature very important in cellular
regulation and function."
A deeper ... systems use protein shape shifting to control cellular
processes would allow better design of ...
Research explores interactions between nanomaterials, biological systems
... nanoparticles and their effects on cells after cellular
uptake without any detailed understanding of ... These properties and their relationships to cellular
function can induce cellular
damage or induce ...
Test detects molecular marker of aging in humans
... a crucial discovery in the understanding of cellular
aging. They found that as cells and tissues age, ... cancer researchers are interested in its role in cellular
aging and cancer prevention.
Now the team has ... know whether this test is a good reflection of cellular
age in all types of human tissues, we believe it ...
Protein regulates movement of mitochondria in brain cells
... part of the cell that supplies energy, supports cellular
activity, and potentially wards off threats from ... to a pathological state."
Mitochondria are cellular
power plants that generate most of the cell's ... prominent example is neurons which have a complex cellular
structure that consist of a main cell body and ...
UCSF discovers new glucose-regulating protein linked with diabetes
... light on what goes wrong in type 2 diabetes on a cellular
Establishing the function of this ... relevant to human diabetes, but what happens on a cellular
level is now found to be different between the ... to be instrumental in moving proteins between cellular
compartments. CHC22 was observed to be associated ...
Tumor growth and chemo response may be predicted by mathematical model
... systems, with changes at the molecular and cellular
levels influencing shape and behavior in ... modeling based on data from the molecular and cellular
levels could shed light on tumor development and ... said. The patterns were regulated by changes in cellular
characteristics, causing more aggressive tumor ...
KINAXOs Cellular Target Profiling reveals mTOR as a new target of Celebrex
... Biotechnologies GmbH has successfully applied its cellular
Target Profiling® technology to identify the protein kinase mTOR as a new cellular
target of celecoxib (Celebrex®, Pfizer). ... a drug’s therapeutical applications. Here, cellular
Target Profiling® provides a powerful ...
Major international study challenges notions of how genes are controlled in mammals
... understand transcription, the process of cellular
copying and reproduction.
"This study really challenges the way we understand cellular
differentiation," explained Dr. Dostie, who ... is supposed to lead to a cascade that leads to cellular
"The FANTOM4 studies show ...
Yale researchers uncover secrets of salmonella's stealth attack
... both invade cells lining the intestine and hijack cellular
functions to avoid destruction, Yale researchers ...
"In evolutionary terms, this hijacking of cellular
machinery to diversify the function of a ... makes the bacterial protein recognizable to the cellular
machinery that normally moves proteins from the ...
Research yields potential target for cancer, wound healing and fibrosis
... the cell and this contact regulates important cellular
activities that are critical for survival, ... tissues and tumors. Integrins are involved in the cellular
response to injury and infection and are needed ... two functions -- it connects integrins to the cellular
infrastructure and to signaling pathways.
HPV vaccine may prevent preterm births
... papilloma virus (HPV)-infections can lead to cellular
changes in the cervix that can be a pre-stage to ... with minor cell changes caused by HPV infection. cellular
changes can progress and become more serious. ... can cause cervical cancer if untreated. Serious cellular
changes are treated by surgically removing a part ...
A new way to assemble cells into 3-D microtissues
... example of a state that depends on sophisticated cellular
connectivity and communication is the stem-cell ... Edition week of March 2, 2009.
The researchers enabled cells to ... be possible to cluster DNA strands on specific cellular
structures. Thus, distribution of DNA on the cell ...
Calculating gene and protein connections in a Parkinson's disease model
... 22, 2009) A novel approach to analyzing cellular
data is yielding new understanding of Parkinson's ... traits appear in the cell) and information on the cellular
levels of messenger RNA (mRNA, which is the ... biased toward identifying different aspects of cellular
response, something that researchers had not ...
Toxicology program features wide range of human health and environment topical sessions
... in several human studies and appear to regulate cellular
responses to a variety of physiological and ... Dr. Aaron Ciechanover who will lecture on cellular
mechanisms of protein degradation and Dr. Paul Greengard who will lecture on cellular
Engineers create intelligent molecules that seek-and-destroy diseased cells
... go into the cell and do an analysis of the cellular
state before delivering the therapeutic punch," ... to translate her technologies into intelligent cellular
therapeutics for glioma patients in the next five ... can use this approach by targeting a specific cellular
function or behavior they want to control in a ...
UT Southwestern researchers disrupt biochemical system involved in cancer, degenerative disease
... can be used to study and possibly manipulate a cellular
pathway involved in many types of cancer and ... of these chemicals and their targets within this cellular
pathway represents an important step in ... replenish various body tissues. Misregulation of cellular
responses to Wnt proteins, however, is associated ...
CSHL scientists clarify editing error underlying genetic neurodegenerative disease
... new details about how a gene mutation causes a cellular
editing error that results in a devastating ... why the mutation causes a defect in an essential cellular
function called RNA splicing.
RNA splicing is ... leave the nucleus to serve as templates for the cellular
machinery to manufacture protein molecules. The ...
Researchers identify new function of protein in cellular respiration
... in the cell nucleus, also plays a key role in cellular
The team examined oxygen ... and produced less ATP, the key molecular form of cellular
energy. The findings revealed that Stat3 is ... and expenditure are essential to maintain cellular
"We found evidence that Stat3 is ...
Fluorescent proteins illuminating biomedical research
... Remarkable new tools that spotlight individual cellular
molecules are transforming biomedical research. ... smaller than 200 nanometers or so. However, many cellular
structures, which could hold the key to managing ... enable scientists to study the trafficking of cellular
proteins and to provide accurate insight into the ...
Rare disease provides clues about enzyme role in arrhythmias
The findings, which involved a new cellular
model, could help with developing treatments for ... and a Pew Scholar, developed and assessed a cellular
model to more clearly reveal the function that ... said. "When CaM kinase II was turned on in the cellular
model, the activation was responsible for the ...
Rong Li Lab offers insight into adaptive ability of cells
... normally powers cell division and observed the cellular
response. As predicted, blocking division ... division and resume growth.
"The ability of cellular
systems to evolve is linked to their component ... even as the body's natural mechanisms for cellular
regulation or chemotherapeutic drug treatment ...
Columbia to award 2008 Horwitz Prize to Arthur Horwich & Ulrich Hartl for cellular protein folding
... M.D., professor and director of the Department of cellular
Biochemistry at the Max Planck Institute of ... work in expanding fundamental understanding of cellular
protein folding, and its role in Alzheimer's ... and chairman of the Department of Physiology and cellular
Biophysics at Columbia University College of ...
8 National Medals of Science awardees to be honored at gala, then the White House
... Distinguished Service Professor of Molecular and cellular
Biology at Baylor College of Medicine where he ... into a unified Department of Molecular and cellular
His laboratory group is interested ... all four international standards for digital cellular
telephony utilize the Viterbi algorithm for ...
NIH extends commitment to transformative research with 2008 Pioneer, New Innovator Awards
... who will use groups of RNA molecules to modify cellular
Joshua M. Epstein, Ph.D., ... Harvard University professor of molecular and cellular
biology, who will use stem cells to examine the ... of random variables in gene expression during cellular
development and specialization.
2008 NIH ...
CSHL team traces extensive networks regulating alternative RNA splicing
... RNA transcripts, and how do they engage the cellular
machinery that actually splices RNAs--a complex ... in splicing and how can such anomalies result in cellular
dysfunctions that culminate in human diseases?
... cases where, because of genetic mutation, vital cellular
functions are perturbed. One key to this is our ...
Using novel tool, UD researchers dig through cell 'trash' and find treasure
... Delaware Biotechnology Institute analyzed the cellular
waste of one of the world's most-studied plants ... in the lab.
The researchers' focus was the cellular
targets of tiny molecules of ribonucleic acid ... be distinguished from molecules decayed by other cellular
processes. Meyers' lab, led by Manoj Pillay, a ...
Do 68 molecules hold the key to understanding disease?
... Jamey Marth, Ph.D., UC San Diego Professor of cellular
and Molecular Medicine and Investigator with the ... life of a cell," said Marth. "And two of the four cellular
components are produced by these molecular ... that cannot be encoded by the genes. These cellular
components the glycans and lipids may now hold ...
Senescence in liver cells is found by CSHL scientists to help limit acute tissue damage
... are the first to establish a specific role for cellular
senescence in a non-cancer pathology, and, the ... provides an example
In technical terms, cellular
senescence is described by team leader Scott W. ... drawn almost inexorably to this curiously quiet cellular
state for its potential implications in cancer ...
Carnegie Mellon MRI technology that non-invasively locates, quantifies specific cells in the body
... clinical translation of the emerging field of cellular
regenerative medicine, by tracking stem cells for ... autoimmune diseases like type I diabetes, but our cellular
MRI agents also can be adapted to label other ... we would label therapeutic cells with our cellular
MRI agents before they are implanted into a ...
NYU Langone Medical Center's tip sheet to the International Conference on Alzheimer's Disease 2008
... Medical Center, Graduate Training Program in cellular
and Molecular Biology, Nathan S. Kline Institute ... the calpain enzyme, which is involved in various cellular
processes, led to a robust decrease in amyloid ... and head of the Laboratory of Molecular and cellular
Cognition, Center for Dementia Research at the ...
Weill Cornell science briefs June/July 2008
... recycling works.
Observing proteins within cellular
vesicles labeled with a fluorescent marker in the ... to the researchers, the explanation for this cellular
feat is a simple matter of distance. "Think of ... hopes that by understanding the mechanics of the cellular
trafficking machine, he and other scientists will ...
Study of marine snail leads to new insights into long-term memory
... UCLA cellular
neuroscientists are providing new insights into ... something, you have to produce fairly detailed cellular
changes. It looks like you can't just change one ... said. "However, in terms of learning, all the cellular
and molecular processes seem to be very, very ...
Forum to focus on math and mechanics behind life processes
... explain life processes like embryo development, cellular
migration and growth could open doors to a new ... faint pushes and pulls play a much larger role in cellular
signaling than previously thought, researchers say.
"The dominant view in biology has been that cellular
behavior is largely chemistry-driven, but there's ...
A common aquatic animal's genome can capture foreign DNA
... fractures their genetic material and ruptures cellular
membranes. Miraculously, bdelloids can then ... in Harvard's Department of Molecular and cellular
"In principle, this gives them an ... Gladyshev, a graduate student in molecular and cellular
biology at Harvard.
While the scientists have ...
UF researchers develop improved gene therapy agent
... H. Kitzman professor of genetics and the chief of cellular
and molecular therapy in the UF College of ... particles as junk proteins and sends them into cellular
trash cans called proteasomes, where they are ... group, it sends a signal to the proteasome the cellular
equivalent of taking the trash out to the curb. ...
Mouse can do without man's most treasured genes
... percentage are located in the vacuole, a sac-like cellular
structure that functions as a garbage dump---but ... function of the vacuole is to contain and degrade cellular
wastes and toxins," Zhang said. "In humans, the ... metabolic rate (a measure of how fast cellular
waste products are generated) and reproductive ...
UMass Medical School's Craig Mello elected to American Academy of Arts and Sciences
... a particular form of ribonucleic acidRNA, the cellular
material responsible for the transmission of ... potential for understanding and manipulating the cellular
basis of human disease, and is now the ... biochemistry from Brown University and his PhD in cellular
and Developmental Biology from Harvard ....
Mitochondrial dysfunction and redox signaling in atrial tachyarrhythmia
... Atrial ischemia produces an increase in cellular
calcium load and oxidative stress in the atria. ... are effective and useful to attenuate atrial cellular
remodelling especially under conditions of increased cellular
calcium load and oxidative stress. The authors ...