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Cellular in Biological News

Stem cell research: From molecular physiology to therapeutic applications

... of differentiation and de-differentiation, cellular plasticity and totipotency of pluripotent cells, ... of somatic cells. He intends to build various cellular and animal models for human diseases, to uncover mechanisms underlying these different cellular processes and to discover new ways to improve ...

Spontaneous assembly

... what controls their size and density, and how the cellular location of clusters is robustly maintained in ... PALM, Liphardt and his colleagues mapped the cellular locations of three proteins central to the ... large polar clusters. Analysis of the relative cellular locations of more than one million individual ...

Researchers observe single protein dimers wavering between two symmetrically opposed structures

... by proteins is a common way of regulating cellular activities. This direct view provides a neat ... different, a feature very important in cellular regulation and function." A deeper ... systems use protein shape shifting to control cellular processes would allow better design of ...

Research explores interactions between nanomaterials, biological systems

... nanoparticles and their effects on cells after cellular uptake without any detailed understanding of ... These properties and their relationships to cellular function can induce cellular damage or induce ...

Test detects molecular marker of aging in humans

... a crucial discovery in the understanding of cellular aging. They found that as cells and tissues age, ... cancer researchers are interested in its role in cellular aging and cancer prevention. Now the team has ... know whether this test is a good reflection of cellular age in all types of human tissues, we believe it ...

Protein regulates movement of mitochondria in brain cells

... part of the cell that supplies energy, supports cellular activity, and potentially wards off threats from ... to a pathological state." Mitochondria are cellular power plants that generate most of the cell's ... prominent example is neurons which have a complex cellular structure that consist of a main cell body and ...

UCSF discovers new glucose-regulating protein linked with diabetes

... light on what goes wrong in type 2 diabetes on a cellular level. Establishing the function of this ... relevant to human diabetes, but what happens on a cellular level is now found to be different between the ... to be instrumental in moving proteins between cellular compartments. CHC22 was observed to be associated ...

Tumor growth and chemo response may be predicted by mathematical model

... systems, with changes at the molecular and cellular levels influencing shape and behavior in ... modeling based on data from the molecular and cellular levels could shed light on tumor development and ... said. The patterns were regulated by changes in cellular characteristics, causing more aggressive tumor ...

KINAXOs Cellular Target Profiling reveals mTOR as a new target of Celebrex

... Biotechnologies GmbH has successfully applied its cellular Target Profiling® technology to identify the protein kinase mTOR as a new cellular target of celecoxib (Celebrex®, Pfizer). ... a drug’s therapeutical applications. Here, cellular Target Profiling® provides a powerful ...

Major international study challenges notions of how genes are controlled in mammals

... understand transcription, the process of cellular copying and reproduction. "This study really challenges the way we understand cellular differentiation," explained Dr. Dostie, who ... is supposed to lead to a cascade that leads to cellular differentiation. "The FANTOM4 studies show ...

Yale researchers uncover secrets of salmonella's stealth attack

... both invade cells lining the intestine and hijack cellular functions to avoid destruction, Yale researchers ... "In evolutionary terms, this hijacking of cellular machinery to diversify the function of a ... makes the bacterial protein recognizable to the cellular machinery that normally moves proteins from the ...

Research yields potential target for cancer, wound healing and fibrosis

... the cell and this contact regulates important cellular activities that are critical for survival, ... tissues and tumors. Integrins are involved in the cellular response to injury and infection and are needed ... two functions -- it connects integrins to the cellular infrastructure and to signaling pathways. ...

HPV vaccine may prevent preterm births

... papilloma virus (HPV)-infections can lead to cellular changes in the cervix that can be a pre-stage to ... with minor cell changes caused by HPV infection. cellular changes can progress and become more serious. ... can cause cervical cancer if untreated. Serious cellular changes are treated by surgically removing a part ...

A new way to assemble cells into 3-D microtissues

... example of a state that depends on sophisticated cellular connectivity and communication is the stem-cell ... Edition week of March 2, 2009. Controlling cellular connections The researchers enabled cells to ... be possible to cluster DNA strands on specific cellular structures. Thus, distribution of DNA on the cell ...

Calculating gene and protein connections in a Parkinson's disease model

... 22, 2009) A novel approach to analyzing cellular data is yielding new understanding of Parkinson's ... traits appear in the cell) and information on the cellular levels of messenger RNA (mRNA, which is the ... biased toward identifying different aspects of cellular response, something that researchers had not ...

Toxicology program features wide range of human health and environment topical sessions

... in several human studies and appear to regulate cellular responses to a variety of physiological and ... Dr. Aaron Ciechanover who will lecture on cellular mechanisms of protein degradation and Dr. Paul Greengard who will lecture on cellular signaling pathways. ...

Engineers create intelligent molecules that seek-and-destroy diseased cells

... go into the cell and do an analysis of the cellular state before delivering the therapeutic punch," ... to translate her technologies into intelligent cellular therapeutics for glioma patients in the next five ... can use this approach by targeting a specific cellular function or behavior they want to control in a ...

UT Southwestern researchers disrupt biochemical system involved in cancer, degenerative disease

... can be used to study and possibly manipulate a cellular pathway involved in many types of cancer and ... of these chemicals and their targets within this cellular pathway represents an important step in ... replenish various body tissues. Misregulation of cellular responses to Wnt proteins, however, is associated ...

CSHL scientists clarify editing error underlying genetic neurodegenerative disease

... new details about how a gene mutation causes a cellular editing error that results in a devastating ... why the mutation causes a defect in an essential cellular function called RNA splicing. RNA splicing is ... leave the nucleus to serve as templates for the cellular machinery to manufacture protein molecules. The ...

Researchers identify new function of protein in cellular respiration

... in the cell nucleus, also plays a key role in cellular energy production. The team examined oxygen ... and produced less ATP, the key molecular form of cellular energy. The findings revealed that Stat3 is ... and expenditure are essential to maintain cellular homeostasis. "We found evidence that Stat3 is ...

Fluorescent proteins illuminating biomedical research

... Remarkable new tools that spotlight individual cellular molecules are transforming biomedical research. ... smaller than 200 nanometers or so. However, many cellular structures, which could hold the key to managing ... enable scientists to study the trafficking of cellular proteins and to provide accurate insight into the ...

Rare disease provides clues about enzyme role in arrhythmias

... The findings, which involved a new cellular model, could help with developing treatments for ... and a Pew Scholar, developed and assessed a cellular model to more clearly reveal the function that ... said. "When CaM kinase II was turned on in the cellular model, the activation was responsible for the ...

Rong Li Lab offers insight into adaptive ability of cells

... normally powers cell division and observed the cellular response. As predicted, blocking division ... division and resume growth. "The ability of cellular systems to evolve is linked to their component ... even as the body's natural mechanisms for cellular regulation or chemotherapeutic drug treatment ...

Columbia to award 2008 Horwitz Prize to Arthur Horwich & Ulrich Hartl for cellular protein folding

... M.D., professor and director of the Department of cellular Biochemistry at the Max Planck Institute of ... work in expanding fundamental understanding of cellular protein folding, and its role in Alzheimer's ... and chairman of the Department of Physiology and cellular Biophysics at Columbia University College of ...

8 National Medals of Science awardees to be honored at gala, then the White House

... Distinguished Service Professor of Molecular and cellular Biology at Baylor College of Medicine where he ... into a unified Department of Molecular and cellular Biology. His laboratory group is interested ... all four international standards for digital cellular telephony utilize the Viterbi algorithm for ...

NIH extends commitment to transformative research with 2008 Pioneer, New Innovator Awards

... who will use groups of RNA molecules to modify cellular properties. Joshua M. Epstein, Ph.D., ... Harvard University professor of molecular and cellular biology, who will use stem cells to examine the ... of random variables in gene expression during cellular development and specialization. 2008 NIH ...

CSHL team traces extensive networks regulating alternative RNA splicing

... RNA transcripts, and how do they engage the cellular machinery that actually splices RNAs--a complex ... in splicing and how can such anomalies result in cellular dysfunctions that culminate in human diseases? ... cases where, because of genetic mutation, vital cellular functions are perturbed. One key to this is our ...

Using novel tool, UD researchers dig through cell 'trash' and find treasure

... Delaware Biotechnology Institute analyzed the cellular waste of one of the world's most-studied plants ... in the lab. The researchers' focus was the cellular targets of tiny molecules of ribonucleic acid ... be distinguished from molecules decayed by other cellular processes. Meyers' lab, led by Manoj Pillay, a ...

Do 68 molecules hold the key to understanding disease?

... Jamey Marth, Ph.D., UC San Diego Professor of cellular and Molecular Medicine and Investigator with the ... life of a cell," said Marth. "And two of the four cellular components are produced by these molecular ... that cannot be encoded by the genes. These cellular components the glycans and lipids may now hold ...

Senescence in liver cells is found by CSHL scientists to help limit acute tissue damage

... are the first to establish a specific role for cellular senescence in a non-cancer pathology, and, the ... provides an example In technical terms, cellular senescence is described by team leader Scott W. ... drawn almost inexorably to this curiously quiet cellular state for its potential implications in cancer ...

Carnegie Mellon MRI technology that non-invasively locates, quantifies specific cells in the body

... clinical translation of the emerging field of cellular regenerative medicine, by tracking stem cells for ... autoimmune diseases like type I diabetes, but our cellular MRI agents also can be adapted to label other ... we would label therapeutic cells with our cellular MRI agents before they are implanted into a ...

NYU Langone Medical Center's tip sheet to the International Conference on Alzheimer's Disease 2008

... Medical Center, Graduate Training Program in cellular and Molecular Biology, Nathan S. Kline Institute ... the calpain enzyme, which is involved in various cellular processes, led to a robust decrease in amyloid ... and head of the Laboratory of Molecular and cellular Cognition, Center for Dementia Research at the ...

Weill Cornell science briefs June/July 2008

... recycling works. Observing proteins within cellular vesicles labeled with a fluorescent marker in the ... to the researchers, the explanation for this cellular feat is a simple matter of distance. "Think of ... hopes that by understanding the mechanics of the cellular trafficking machine, he and other scientists will ...

Study of marine snail leads to new insights into long-term memory

... UCLA cellular neuroscientists are providing new insights into ... something, you have to produce fairly detailed cellular changes. It looks like you can't just change one ... said. "However, in terms of learning, all the cellular and molecular processes seem to be very, very ...

Forum to focus on math and mechanics behind life processes

... explain life processes like embryo development, cellular migration and growth could open doors to a new ... faint pushes and pulls play a much larger role in cellular signaling than previously thought, researchers say. "The dominant view in biology has been that cellular behavior is largely chemistry-driven, but there's ...

A common aquatic animal's genome can capture foreign DNA

... fractures their genetic material and ruptures cellular membranes. Miraculously, bdelloids can then ... in Harvard's Department of Molecular and cellular Biology. "In principle, this gives them an ... Gladyshev, a graduate student in molecular and cellular biology at Harvard. While the scientists have ...

UF researchers develop improved gene therapy agent

... H. Kitzman professor of genetics and the chief of cellular and molecular therapy in the UF College of ... particles as junk proteins and sends them into cellular trash cans called proteasomes, where they are ... group, it sends a signal to the proteasome the cellular equivalent of taking the trash out to the curb. ...

Mouse can do without man's most treasured genes

... percentage are located in the vacuole, a sac-like cellular structure that functions as a garbage dump---but ... function of the vacuole is to contain and degrade cellular wastes and toxins," Zhang said. "In humans, the ... metabolic rate (a measure of how fast cellular waste products are generated) and reproductive ...

UMass Medical School's Craig Mello elected to American Academy of Arts and Sciences

... a particular form of ribonucleic acidRNA, the cellular material responsible for the transmission of ... potential for understanding and manipulating the cellular basis of human disease, and is now the ... biochemistry from Brown University and his PhD in cellular and Developmental Biology from Harvard ....

Mitochondrial dysfunction and redox signaling in atrial tachyarrhythmia

... Atrial ischemia produces an increase in cellular calcium load and oxidative stress in the atria. ... are effective and useful to attenuate atrial cellular remodelling especially under conditions of increased cellular calcium load and oxidative stress. The authors ...
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(Date:8/20/2014)... Research UK scientists have discovered that acral melanomas the ... Marley,s death are genetically distinct from other more common ... external) published in the journal Pigment Cell & Melanoma ... of the hands, soles of the feet, nail-beds and other ... of melanoma, it,s not caused by UV damage from the ...
(Date:8/20/2014)... aroma of sunscreen and seawater signals a relaxing trip ... the idyllic beach vacation comes with an environmental hitch. ... the sea, they can become toxic to some of ... for many other marine animals. Their study appears in ... , Antonio Tovar-Sanchez and David Snchez-Quiles point out that ...
(Date:8/20/2014)... Wu Feng has built upon a National Science Foundation ... Cloud" program, and synergistically complemented it with subsequent collaborative ... Force on "big computing" for mini-drones and a $1 ... Health on "big data" for the life sciences. , ... each grant, he was able to tell a much ...
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