NIH stimulus funding supports Emory biomedical scientists
... treatments for humans.
The role of memory T cells
in transplant rejection:
Memory T cells
allow the immune system to respond to infections ... body to fight bacteria and stimulate the muscle cells
that line blood vessels. This project looks at ...
New cancer drug delivery system is effective and reversible
... developers, finding an agent that kills tumor cells
is only part of the equation. The drug must also ... antibody-conjugated liposomes to bind to cancer cells
can be inconsistent.
Some small molecules, ... cisplatin, a drug that effectively kills cancer cells
but has troublesome side effects when ...
Growing evidence of marijuana smoke's potential dangers
... smoke vs. tobacco smoke in terms of toxicity to cells
and to DNA. Scientists exposed cultured animal cells
and bacteria to condensed smoke samples from both ... smoke caused significantly more damage to cells
and DNA than tobacco smoke, the researchers note. ...
Pitt researchers find promising candidate protein for cancer prevention vaccines
... when inflammatory responses are strong. cells
infected with chicken pox virus, for example, look very much like tumor cells
because they, too, overproduce cyclin B1. The ... to the immune system as a marker of infected cells
that must be destroyed.
"Because cyclin B1 is ...
New stem cell research could reduce number of animal experiments
... will be developing a technique using human stem cells
to study this debilitating neurological disease, ... the number of animals used in research.
are the precursor cells
that are able to develop into more ...
La Jolla Institute discovers novel tumor suppressor
... characterized by an overproduction of blood cells
by the bone marrow and include chronic myeloid ... Myeloproliferative diseases develop when myeloid cells
-- which make certain types of white blood ... become overactive and produce too many blood cells
leading to myeloproliferative disease, he ...
Protecting cells from their neighbors
... determined. It is dictated by the separation of cells
that will become sperm and ovules - germ cells-, ... identified the mechanism that protects somatic cells
against the behaviour of germ cells. When this ...
In the first hours of embryonic life, the egg cells
show intense gene transcription activity to ...
Stem cell 'daughters' lead to breast cancer
... scientists have found that a population of breast cells
called luminal progenitor cells
are likely to be responsible for breast cancers ... have discovered that luminal progenitor cells
the 'daughters' of breast ...
Parasites ready to jump
... We now want to find out whether mammalian cells
possess this newly discovered defence mechanism ... in the fertility of the progeny.
are an ideal target for transposons, since these cells
pass their genetic material together with ...
Got zinc? New zinc research suggests novel therapeutic targets
... immune function, but increases activation of the cells
(T cells) responsible for destroying viruses and ... zinc on T cell activation. After isolating the T cells
from the blood, scientists then simulated ... in laboratory conditions. Results showed that T cells
taken from the zinc-supplemented group had higher ...
Nanoparticle-delivered 'suicide' genes slowed ovarian tumor growth
... DNA selectively expressed in ovarian cancer cells
reduced the burden of ovarian tumors in mice, and ... cancer that has promise for targeting tumor cells
and leaving healthy cells
healthy," said lead researcher Janet Sawicki, ...
A crystal ball for brain cancer?
... creates an independent blood supply.
secrete a growth factor called VEGF that spurs ... events that is detectable by MRI. Oxygen-starved cells
produce more VEGF, which causes blood vessels to ... to move freely in the tumor and brain tissue. As cells
disintegrate, they no longer pose a physical ...
'Microfluidic palette' may paint clearer picture of biological processes
... to study the complex biological mechanisms in cells
responsible for cancer metastasis, wound healing, ... of currents. Diffusion gradients allow cells
being studied to remain in the microchamber ... chemical molecules to move in and out of the cells
naturally and eliminates the risk of shear ...
Reprogramming human cells without inserting genes
... discovery opens a new avenue for reprogramming cells
that could eventually lead to treatments for a ... and traumatic injuries by coaxing a patient's own cells
to repair and regenerate the damaged tissues.
... track" paper from the journal Cloning and Stem cells
"We show that by manipulating culture ...
Stem cell research: From molecular physiology to therapeutic applications
... disease to paralysis. Totipotent embryonic stem cells
have great potential for generating a wide range of different human cells
that can be used to restore malfunctioning or damaged cells
and tissues in patients. Recent studies have ...
Fox Chase researchers uncover one force behind the MYC oncogene in many cancers
... messenger RNA and then proteins. Studies in both cells
and a mouse model for cancer showed that they could promote the expression of MYC by transfecting cells
with DNA strands containing DLX5.
Too much DLX5, ... of MYC, they found they could turn those cells
From this, Testa and Xu were ...
Study shows cancer vaccines led to long-term survival for patients with metastatic melanoma
... cancer vaccines derived from patients' own cancer cells
and immune cells
were well tolerated and resulted in impressive ... The study entitled "Phase II Trial of Dendritic cells
Loaded with Antigens from Self-Renewing, ...
Comprehensive look at rare leukemia finds relatively few genetic changes launch disease
... to several types of immature and maturing cells
that give rise to this cancer. James Downing, ... the push to chart the genetic changes that free cells
from normal controls and allow the uncontrolled ...
For this study, researchers analyzed leukemia cells
from 111 St. Jude AML patients representing the ...
Study reveals a reprogrammed role for the androgen receptor
... One such gene, called UBE2C, which causes cells
to ignore a natural pause in the division ... progresses normally; without it, daughter cells
may grow even more aggressively and be harder to ... external androgen.
One of the ways such cells
re-start their growth is by producing their own ...
Placenta-derived stem cells may help sufferers of lung diseases
... , has found that stem cells
derived from human placenta may ultimately play a ... the fibrotic process.
Placenta-derived stem cells
are known to be able to engraft in solid organs, including the lungs. Human term placenta stem cells
also demonstrate characteristics of high ...
Cancer's distinctive pattern of gene expression could aid early screening and prevention
... off or left on in healthy versus cancerous cells
could enable early screening for many common ... in healthy colon, breast, brain and lymphatic cells
and their cancerous counterpart to find telltale ... of the aberrant adjustments that enable cancer cells
to thrive. Epigenetic changes actually are more ...
Scientists track impact of DNA damage in the developing brain
... also provides the first evidence that cells
known as cerebellar interneurons are targeted for ... system. While the results suggest certain brain cells
are particularly vulnerable, investigators report ... to single-strand DNA damage. Because brain cells
do not divide, they cannot use the backup repair ...
Researchers capture bacterial infection on film
"In the body, immune surveillance cells
such as hemocytes (or macrophages in vertebrates) ... a battery of signals from different sources. The cells
integrate these signals and react to them accordingly.
"Once these cells
are removed from this complex environment and ...
Common allergy drug reduces obesity and diabetes in mice
... stabilize a population of inflammatory immune cells
called mast cells. In the second study, ... in fat tissue of inflammatory immune cells
"It seems that we're ... abnormalities in the insulin-producing beta cells
of the pancreas, but their root causes are ...
Scientists closer to making implantable bone material, thanks to new research
... in the laboratory from different types of bone cells
and stem cells. All of these cell types are ... 'bone-like' materials that were grown from bone cells
from mouse skull and mouse bone marrow stem cells
successfully mimicked many of the hallmarks of ...
Airway cells use 'tasting' mechanism to detect and clear harmful substances
... the scientists showed that, unlike taste cells
on the tongue, these airway cells
do not need help from the nervous system to ... is the first to show that motile cilia on airway cells
not only have this "clearing" function, but also ...
Protein that promotes cancer cell growth identified
... helps relay signals that can cause cancer cells
to proliferate, migrate and invade surrounding ... showed that Caspase-8 caused neuroblastoma cancer cells
to proliferate and migrate. For the first time, ... same signaling pathway stimulates neuroblastoma cells
to migrate and invade neighboring tissues--a ...
What scientists know about jewel beetle shimmer
... because of the light-reflecting properties of the cells
that make up their external skeletons, not ... external skeleton, its five, six and seven sided cells
spontaneously arrange themselves to reflect light ... colors.
Srinivasarao postulates that beetle cells
form similar to a certain kind of liquid crystal ...
Newly discovered gene fusion may lead to improved prostate cancer diagnosis
... genes -- may be at the root of what causes cancer cells
to grow more quickly than normal cells.
The ... expands our understanding of how prostate tumor cells
can hijack androgen-regulated genes by using ... of messenger RNA -- the message that all cells
produce -- the computational team, lead by Dr. ...
Scientists discover gene mutation responsible for hereditary neuroendocrine tumor
... in the chemical reactions that take place within cells
to convert biochemical energy into usable energy. ... are rare, generally benign tumors that arise from cells
called glomus cells, which are located along ... an enzyme complex involved in the ability of cells
to extract energy from nutrients.
Studies in ...
Scientists link immune system's natural killer cells to infant liver disease
... weapons against infection natural killer, or NK, cells
to the onset of biliary atresia in infants, a ... also report that blocking a gene that helps NK cells
attack bile duct tissues lessens damage and may ... to block the disease by targeting certain cells
or pro-inflammatory circuits," said Jorge A. ...
A genetic basis for schizophrenia
... in development, particularly the migration of cells
to their proper location in the brain and ... into their intended fate. During development, cells
need to properly migrate to their final ... integrate into the corresponding network of cells
and function properly. Disruption of cell ...
Researchers design first model motor nerve system that's insulated and organized like the human body
... recognized the need for lab-grown motor nerve cells
that myelinate and form nodes of Ranvier in order ... techniques for growing various nervous system cells
in serum-free media, including motoneurons, and ... with for many years.
In the body, nerve cells
grow in two distinct environments: In the ...
International research team seeks to unravel flatworm regeneration
... lost tissue with the help of their stem cells
(neoblasts) and even grow an entirely new worm ... Schmidtea mediterranea. Full 30 percent of the cells
of this species consists of stem cells, making it ...
The researchers looked for small RNAs in stem cells
as well as in the whole planarian organism. They ...
Skin-like tissue developed from human embryonic stem cells
... the pluripotency of human embryonic stem cells
(hESC) to generate complex, multilayer tissues ... outside of the body using new sources of stem cells
such as hESC, with the goal of advancing ... in structure to those constructed using mature cells
derived from newborn skin, which are the current ...
The right messenger for a healthy immune response
... immune response: without Beta-Interferon immune cells
are unable to show "wanted posters" of pathogens to other cells. As a consequence, these cells
will not recognize the pathogen and the immune ... of Immunology .
During an infection, immune cells
produce Beta-Inferferon. Interestingly, an immune ...
Study by NTU professors provides important insight into apoptosis or programmed cell death
... to the understanding of the process that cells
go through when they die. This process known as ... in the human body which removes perhaps a million cells
According to Professor Li, they ... When programmed cell death does not work right, cells
that should be eliminated may linger around and ...
A matter of density, not quantity
... penetrating. The process of quorum sensing, which cells
use to "sense" cell density, is triggered when ... has now demonstrated that the absolute number of cells
is irrelevant; only the number of bacteria in a ... to trigger quorum-sensing processes in single cells
when these were confined in extremely small ...
New lab test offers better prediction of HIV microbicide safety
... primarily for signs that the chemical inflames cells
of the vaginal lining, or epithelium. That could ... good: When the epithelium becomes inflamed, T cells
flock to the damaged area which might actually encourage HIV infection, since T cells
are the main targets of HIV.
Dr. Herold ...
... lipids, nucleic acids, etc. - are arranged. For cells
to thrive, the organization of these components ... for succeeding generations of cells. Eukaryotic cells
feature distinct subcellular structures, such as ... interiors and membranes," said Liphardt. "Two cells
which are biochemically identical can have very ...