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Bases in Biological News

Baylor researchers unravel mystery of DNA conformation

... who asked how the information encoded by the bases could be read if it is sequestered inside the DNA ... underwind a spring, the forces induce one of two bases adenine or thymine to "flip out" of the ... the DNA turns itself inside out to expose the bases -- much in the way Pauling had predicted. ...

Genetic switch potential key to new class of antibiotics

... RNA composing part of its structure aligns the bases in its chain such that they stack on top of each ... form of an RNA base, it stacks on the RNA bases in the riboswitch binding pocket with high ... to decode genetic information. The order of bases in a typical aptamer domain of the riboswitch ...

Covering the bases: Quantum effect may hold promise for low-cost DNA sequencing, sensor applications

... helix and reading a few hundred to a few thousand bases at a time. Finally, all of the information from ... in the substrate, the hydrogen bonds stick the bases together and they attach, like tiny magnets (see ... the strength of the glue fastening complementary bases differs for A-T and C-G pairs. While two hydrogen ...

CSHL scientists clarify editing error underlying genetic neurodegenerative disease

... target RNA and pairing a segment of its own RNA bases with the splice site's RNA bases following a set of rules: U pairs with A or G, ... start of the intron is strongest when up to 11 bases are paired up. When Krainer and postdoctoral ...

Can genetic information be controlled by light?

... is the interaction between the four chemical bases that make up the DNA molecule. Researchers at ... has been known for many years that the individual bases that code the genetic information contained in ... double-helix structure. The interactions between bases that are stacked one above another within a DNA ...

UI and ISU establish shared DNA sequencing instrumentation

... sequences at the rate of millions to billions of bases in a single run. The two machines each with ... to generate hundreds of millions to billions of bases of sequence information per sequencing run. At ... per run, producing in excess of a billion bases of sequence data, compared to the long-read ...

'Telepathic' genes recognize similarities in each other

... structure containing a pattern of chemical bases - can recognise other genes with a similar ... strands of DNA with hundreds of pairs of chemical bases seem able to recognise each other as a whole ... DNA molecules with identical patterns of chemical bases were approximately twice as likely to gather ...

Liquid crystal phases of tiny DNA molecules point up new scenario for first life on Earth

... bases, that selectively adhere only to specific bases on a second chain. Matching, or complementary ... encoded in sequences of thousands to millions of bases along the chains, which can be microns to ... Clark said. In a sample of chains in which the bases dont match and the chains cant form helical ...

Evolutionary comparison finds new human genes

... to observe the results." Four different bases -- commonly referred to by the letters G, C, A and T -- make up DNA. Three bases in a row can code for an amino acid (the building ... other workers -- stretches up to several thousand bases long that are mostly alike across two or more ...

Finding that 1-in-a-billion that could lead to disease

... a role in the search process of UDG. Although the bases in the DNA double helix resemble the rungs of a ... them to follow the interaction of water with bases that had randomly popped out of the DNA helix. The researchers could then follow which bases pop out, and for how long, using a strong magnet. ...

A new way to assemble cells into 3-D microtissues

... cell surfaces from one group with strands of single-stranded DNA only 20 bases long, and the surfaces of another group with the complementary DNA strand. ... can specify the complexity for example, from a simple repeat of two bases such as cytosine and adenine ... on one strand, which binds to a ...

A simple fusion to jump-start evolution

... slow the RNA could never get more than a few pieces long (for as nucleic bases attach to one end, they can also drop off the other). Ernesto Di Mauro ... barriers to growth and reach a biologically important size; at around 100 bases long, RNA molecules can begin to fold into functional, 3D shapes. ...

Scientists discover small RNAs that regulate gene expression and protect the genome

... helpers to eliminate or modify target molecules. But of the billions of bases in a cells DNA, what determines which RNA snippets are chosen for this ... harnessing highly efficient new machines that determine the sequence of bases in millions of small RNA molecules simultaneously. They then scan the ...

Negligent, attentive mouse mothers show biological differences

... offer a valuable opportunity to investigate the biological and behavioral bases of naturally occurring maternal neglect, say UW-Madison zoology professor ... offers a powerful opportunity to investigate the biological and behavioral bases of maternal neglect. Though he cautions that it's too early to know how ...

Protecting cells from their neighbors

... mechanisms that participate in the repression and activation of the genomes of distinct species because failures in these mechanisms are at the bases of many diseases, such as certain types of cancer." FROM FLY TO HUMANS The mechanism of transcription protection in somatic cells has been ...

LincRNAs serve as genetic air-traffic controllers

... classical examples known for decades and some recently discovered classes of tiny RNAs, such as microRNAs. By contrast, lincRNAs are thousands of bases long. Because only about 10 examples of functional RNAs were previously identified, they seemed more like genomic oddities than key players. With ...

A Canada-wide technology platform for mapping the human interactome

... dynamic networks that proteins form when they interact together and with other molecules such as RNAs or DNA will allow us to better define the very bases of life and the misfunctions that lead to illness and eventually death. "There is even hope that this knowledge of the intricate molecular ...

Scholar unconvinced new lie-detection methods better than old ones

... suspect in custody, out comes the polygraph, or lie detector. But in today's forensically sophisticated, "CSI"-influenced world, polygraphy which bases its results on functions of the autonomic nervous system is increasingly dismissed as dated and unreliable. Rapidly replacing older truth-seeking ...

Demonstration Features Commercial Technology for Combating Terrorism

... Since the first FPED was hosted by Quantico in 1997, many items demonstrated at FPEDs have been employed in Iraq and Afghanistan, at military bases and other locations throughout the United States and at other critical sites around the world. This release was issued through ....

Demonstration Features Commercial Technology for Combating Terrorism

... Since the first FPED was hosted by Quantico in 1997, many items demonstrated at FPEDs have been employed in Iraq and Afghanistan, at military bases and other locations throughout the United States and at other critical sites around the world. This release was issued through ....

A genomic CluE for cloud computing

... may take forever and cost too much to make whole thing worthwhile," said Pop. A Different Kind of Puzzle DNA is made up of nucleotide bases that are abbreviated by the letters A, C, G, and T. Lined up in a double helix structure, they make up a code that is translated into the proteins ...

Sequencing the cow's genetic code -- a new agricultural era dawns

... biology, reported an international consortium of researchers in the April 23 issue of the journal Science . A companion study on the genetic bases of mammalian milk is published in parallel. The large-scale undertaking mobilized more than 300 scientists from 25 countries over six years. The ...

Ma and Pa solutions to global warming

... The Great Plains are dotted with oil patches, public utilities, farms, ranches, feed lots, meat-packing plants, medium-size cities, military bases and tiny towns feeding on agricultural activity, explains Griffin. Hidden in this vast region are major resources yet to be tapped aside from the ...

Demonstration Targets Terrorism

... explosions have been completed. Many items demonstrated in previous FPEDs have been successfully employed in Iraq and Afghanistan, at military bases and other locations throughout the United States, and at bases, embassies and other critical locations around the world. The demonstration was ...

New data suggest 'jumping genes' play a significant role in gene regulatory networks

... structural RNA genes stand out because of their distinctive pattern of base substitutions and "indels"--the insertions and deletions of nucleic acid bases that can change the message in a genome. According to Haussler, however, most of the DNA under negative selection in vertebrate genomes does not ...

Complete Genomics releases proof-of-concept data for its sequencing technology for the first time

... (reads), which is the most reported for one human genome. This technology also demonstrated an average run rate of more than 70 billion mapped bases (70 Gb) per run or 8.8 Gb per machine run per day. The entire sequencing process required nine machine runs with a single run taking just eight days. ...

New open-source software permits faster desktop computer simulations of molecular motion

... are never still. Simulating molecular motions provides researchers with information critical to designing vaccines and helps them decipher the bases of certain diseases, such as Alzheimer's and Parkinson's, that result from molecular motion gone awry. In the past, researchers needed either ...

New vaccine developed for preventing 'uncommon cold' virus

... countries. It may also emerge in less likely locales with dense populations, such as schools, health care facilities and military training bases in the U.S. Determined to stamp out this devastating infection, researchers from George Mason University, the University of Hong Kong, Guangzhou ...

Scientists uncover new class of non-protein coding genes in mammals with key functions

... for decades and some recently discovered classes of tiny RNAs, such as microRNAs. By contrast, the newly discovered lincRNAs are thousands of bases long. Because only about ten examples of functional lincRNAs were known previously, they seemed more like genomic oddities than critical components. ...

Human genomics in China

... has caused several rounds of revolution in DNA sequencing technology in the past 40 years, which directly led the first sequencing trial of 4 bases of the λ phage cos to the current program of sequencing the genomes of a thousand individuals. Second, the integration with computational ...

New research shows how gene function drives natural selection in important class of genetic elements

... element called the LTR retrotransposon. (LTR refers to the "long terminal repeat"a repetition of a recognizable sequence of nucleotides, the chemical bases that make up strands of DNA.) "The lab of Professor Jeff Bennetzen at UGA discovered that this class of mobile DNA comprises more than half of ...

Researchers shed new light on catalyzed reactions

... Protection Agency's Superfund National Priorities List, and the Pentagon has estimated the cost of cleaning up TCE contamination at U.S. military bases to be in the billions. Wong's research group developed a new palladium-gold catalyst several years ago that helps break TCE into nontoxic ...

Washington University scientists first to sequence genome of cancer patient

... be relevant for disease risk. What's striking about the new research is that the scientists were able to sift through the 3 billion pairs of chemical bases that make up the human genome to pull out the mutations that contributed to the patient's cancer. "Until now, no one has sequenced a patient's ...

Heart valves that grow with the patient

... illness and comparable with healthy children in terms of their physical development. Haverich and his colleagues have documented the scientific bases of their new treatment in great detail in numerous publications. A series of patents and the establishment of two companies also testify to the ...

Researchers develop new self-training gene prediction program for fungi

... pattern is not deterministic. Locating the branch site which is nine nucleotides in length, almost always contains an adenine and is located 20-50 bases upstream of the acceptor site helps to accurately identify an intron. An initial run of the program with a reduced model containing heuristically ...

Worm genome offers clues to evolution of parasitism

... sicken some 300 million. The genome of P. pacificus is substantially larger and more complex than C. elegans . It has nearly 170,000 chemical bases and contains 23,500 protein-coding genes. By comparison, C. elegans and the human parasitic nematode Brugia malayi , whose genome was sequenced in ...

Caltech scientists create DNA tubes with programmable sizes for nanoscale manufacturing

... has designed a series of flexible, single-stranded DNA molecules, called single-stranded DNA tiles. Each single-stranded tile is exactly 42 bases long and contains four modular binding sites. By pairing up the complementary binding sites, these single-stranded tiles bind with each other in a ...

NHGRI seeks DNA sequencing technologies fit for routine laboratory and medical use

... in Nanopores Several groups are developing nanopores (holes about two nanometers in diameter) that may be able to recognize individual DNA bases by their electrical or ionic signals to achieve high-accuracy sequencing of individual DNA molecules. The goal of this group is to design and ...

AGU journal highlights -- August 6, 2008

... find that at latitudes less than 55 degrees, wind speeds remain constant, with velocities of 60?? meters (200-230 feet) per second at the clouds' bases and about 105 meters (344 feet) per second at the clouds' tops. This creates strong vertical wind shear at low latitudes. Poleward of 55 degrees ...

MicroRNA implicated as molecular factor in alcohol tolerance

... the findings in the July 31 issue of the journal Neuron . "This is an intriguing contribution to efforts aimed at identifying the molecular bases of alcohol tolerance," noted NIAAA Director Ting-Kai Li, MD. Tolerance is the decrease in sensitivity to alcohol that develops with repeated ...
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(Date:9/30/2014)... Health (NIH) awarded Lawrence Livermore National Laboratory (LLNL) ... system that will enable researchers to better understand ... scale. , LLNL,s grant-funded project is part of ... (Brain Research through Advancing Innovative Neurotechnologies) Initiative , ... of the human mind and uncover ways to ...
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