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Bacteriophage in Biological News

NYU scientists discover dangerous new method for bacterial toxin transfer

... bacterial viruses did the completely unexpected. "We have found that a bacteriophage can transfer genetic elements, or DNA, between unrelated bacterial species ... aureus genes. In addition, they plan to follow the fate of an S. aureus bacteriophage once it injects its own DNA into L. monocytogenes, and they would like to ...

Biologists learn structure, mechanism of powerful 'molecular motor' in virus

... Hanley Distinguished Professor of Biological Sciences. The motor is needed to insert DNA into the capsid of the T4 virus, which is called a bacteriophage because it infects bacteria. The same kind of motor, however, also is likely present in other viruses, including the human herpes virus. ...

Collegiate Inventors Competition recognizes top student inventors

... and Massachusetts Institute of Technology (Advisor: J.J. Collins) Combating Antibiotic-resistant Bacteria and Bacterial Biofilms with Engineered bacteriophage and Synthetic Gene Sensors An engineered bacteriophagea virus that infects bacteriathat works in conjunction with antibiotics, making them much more ...

Scientists discover DNA knot keeps viral genes tightly corked inside shell

... UCSD chemists Jinghua Tang, Norman Olson and Timothy Baker, a professor of chemistry and biological sciences, have determined the structure of a bacteriophage called phi29 with a resolution finer than 8 Angstroms (one Angstrom equals a tenth of a nanometer). Their project was part of a long-term ...

Scientists spy enzyme that makes us unique

... The discovery of the T7 endonuclease 1 enzymes structure was made by using x-ray crystallography techniques. The enzyme is derived from a bacteriophage a naturally occurring virus-like agent that attacks bacteria but the molecular processes are expected to be similar in other organisms, including ...

Society for General Microbiology 161st Meeting, University of Edinburgh

... control, tracking Yersinia and microbe-identifying microchips, novel insecticides and drug-producing sponge bacteria, hepatitis C vaccine research, bacteriophage therapy and the control of coastal pollution. Individual press releases for all of the above presentations are available. Please contact SGM if ...

Tips from the Journals of the American Society for Microbiology

... Phage Therapy May Control Staph Infections in Humans Including MRSA Researchers from Italy have identified a bacteriophage active against Staphylococcus aureus, including methicillin-resistant strains, in mice and possibly humans. They report their findings in the August ...

The structure of a virus infecting bacteria resembles a human virus

... viruses that infect people. Studying this bacteriophage reveals various characteristics about viruses and ... viruses. The newly described structure of the bacteriophage furthers researchersâ?super>TM understanding of ... molecules. Studying these events with the bacteriophage will help the understanding of similar events in ...

Unraveling the viral mechanism

... ball-like surface protein shell of the episilon15 bacteriophage that infects Salmonella bacteria and describe ... human viruses," said Chiu. In fact, he said, this bacteriophage appears structurally similar although smaller ... him and his co-authors at MIT to see through the bacteriophage at very high resolution. "It turns out that, ...

Engineers improve plastic's potential for use in implants by linking it to biological material

... surface of a harmless type of virus called a bacteriophage that was purchased commercially. To hunt for ... that something else on the outer surface of the bacteriophage virus wasn't responsible for its perceived ... new blood vessels. In addition, they will use the bacteriophage analysis approach, called high-throughput ...

Hundreds of thousands of viral species present in the world's oceans

... The ocean is full of life--large, small, and microscopic. bacteriophage (phage) viruses are minute, self-replicating bundles that alter ... Rohwer, and colleagues detail their metagenomic study of the diversity of bacteriophage present in water samples collected from 68 sites over 10 years from four ...

Pitt phage hunter takes on tuberculosis

... The researchers made this discovery by infecting M. smegmatis with a bacteriophage nicknamed the "Bronx Bomber," which Jacobs had isolated from his back ... prolonged treatment," said Hatfull, who also codirects the Pittsburgh bacteriophage Institute. "An ideal scenario would be to develop drugs that would ...

Newly discovered protein kills anthrax bacteria by exploding their cell walls

... natural predators called bacteriophage. Just as viruses infect people, bacteriophage infect bacteria, reproduce, and then kill their host cell by bursting out to find their next target. The bacteriophage use special proteins, called lysins, to bore holes in the bacteria, ...

A virus-like hitchhiker may trigger bacterial meningitis

... now discovered that many hyperinvasive stains of N. meningitidis contain a bacteriophage (a virus-like organism that infects bacteria) inserted into their genetic ... this virus-like stowaway were more likely to have caused disease. How this bacteriophage causes N. meningitidis to become more dangerous is unknown. It may help ...

Genes and biomarkers that allow doctors to choose the right therapy for the right patient

... peptides ?or protein fragments ?were active in the tissue environment surrounding the tumors. This phage displayed library ?called so after the bacteriophage viruses used to capture protein fragments ?was then isolated and tested. With the library, Dr. Diaz and his colleagues could select peptides ...

The connector rotation hypothesis? Phage do not pack their DNA by rotation

... Thorsten Hugel, Jens Michaelis, Craig Hetherington, and Carlos Bustamante present their detailed investigation into how the Bacillus subtilis bacteriophage ö29 crams its DNA into the capsid following replication. Using their innovative system, Hugel and colleagues were able to observe capsids as ...

New approach could lower antibiotic requirements by 50 times

... gentamicin was administered in the presence of bacteriophages. None survived without the phages (Microb. Drug Resist., 2006, 12 (3), 164). The bacteriophage approach would also be particularly useful for treating cases of food poisoning, because the lower doses of antibiotic needed would not disrupt the ...

Harmless virus may hold key to more effective HIV drug discovery

... its expansion. Because of this, the development of effective HIV drugs has been difficult and expensive. Weiss and Olszewski found that the bacteriophage can model millions of different mutational variants of an HIV protein called Nef. Knowing how the entire population of Nef variants responds to new ...

Basis for DNA ejection from single phage particles

... of the DNA during morphogenesis ?for example, another group recently showed that the pressure at the final stage of encapsulation for a particular bacteriophage reached a value of 60 atomospheres, which is close to ten times the pressure inside a bottle of champagne. In the new work reported this week, ...
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