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Autoimmune in Biological News

Aussie and Kiwi researchers make double MS genetic discovery

... will help to unravel the causes of MS and other autoimmune disease. Their findings will be published ... between genetic susceptibility to MS and other autoimmune diseases including Type 1 diabetes, Rheumatoid ... almost 20,000 in Australia. It is a devastating autoimmune disease as it occurs at the prime of life and ...

Tips from the American Journal of Pathology

... T cells, plays a pathogenic role in MS and other autoimmune diseases. Using a mouse model of MS, Klenmann ... strategy for the acute phase of Th17-mediated autoimmune diseases such as MS." Klemann C, Raveney BJE, ... proteins have long been used to induce ocular autoimmune inflammation. Future studies need to elucidate ...

Genetic study confirms the immune system's role in narcolepsy

... with narcolepsy-cataplexy predispose them to an autoimmune reaction that destroys their hypocretin-producing ... the disorder by stopping the effects of the autoimmune process. "If we can define the changes in the T ... could lead to a better understanding of other autoimmune diseases where HLA genes are known to play a ...

Vitamin D may exacerbate autoimmune disease

... D has been widely regarded as contributing to autoimmune disease, but a review appearing in Autoimmunity ... that low levels of vitamin D in patients with autoimmune disease may be a result rather than a cause of ... with vitamin D may actually exacerbate autoimmune disease. Authored by a team of researchers at ...

Stopping autoimmunity before it strikes

... a new method to track the development of autoimmune diseases before the onset of symptoms. The related report by Zangani et al, "Tracking early autoimmune disease by bioluminescent imaging of NF-κB ... issue of The American Journal of Pathology . autoimmune diseases such as lupus, multiple sclerosis, ...

New discovery paves the way for new diagnosis of serious lung disease

... is important to the immune defense system in an autoimmune lung disorder that is not seldom fatal. The newly ... to study more closely the first phase of the autoimmune disease, that is, when the immune system ... The researchers used an unusual hereditary autoimmune ...

Unexpected finding opens up new way to stop autoimmune diseases and transplant rejection

... to entirely new therapies for a wide range of autoimmune disorders, such as colitis, lupus, rheumatoid ... these antibodies can be used to treat diverse autoimmune diseases with minimal risk of infections ... laboratory and gave them to mice with colitis (an autoimmune disorder). After receiving the antibodies, ...

Tips from the American Journal of Pathology

... of The American Journal of Pathology . The autoimmune disease multiple sclerosis (MS) attacks the ... therefore, may play a neuroprotective role in CNS autoimmune demyelination. In future studies, Dr. Raine's ... Raine CS: Neuroprotection and remyelination after autoimmune demyelination in mice that inducibly overexpress ...

New scientific knowledge on juvenile diabetes

... juvenile diabetes. The alterations preceded the autoimmune response by months to years. The study may prompt ... Experimental Medicine . Type 1 diabetes is an autoimmune disease in which the immune system attacks the ... to overt diabetes. The initiators of the autoimmune response have remained unknown and the mechanisms ...

Researcher tricks immune system in diabetic mice

... Miller and Luo will work with mice that have autoimmune disease that destroys their islet cells, as ... Researchers will use therapies that prevent the autoimmune system's response against its own beta cells ... we can take combined therapies for underlying autoimmune disease and transplanted islets. If we do that ...

New technique eliminates toxic drugs in islet transplant in diabetic mice

... Miller and Luo will work with mice that have autoimmune disease that destroys their islet cells, as ... Researchers will use therapies that prevent the autoimmune system's response against its own beta cells ... we can take combined therapies for underlying autoimmune disease and transplanted islets. If we do that ...

Musculoskeletal center wins $2.2 million for drug safety

... arthritis, Crohn's disease, psoriasis and other autoimmune disorders. The award will allow the UAB CERTs ... in the distribution and acceptance of newer autoimmune drugs, said Kenneth Saag, M.D., M.Sc., director ... on the use of eight biologics used for a range of autoimmune disorders. Among the studied drugs is what's ...

Bayhill Therapeutics and the Juvenile Diabetes Research Foundation announce research collaboration

... Inc., a leading developer of therapies for autoimmune diseases, and the Juvenile Diabetes Research ... DNA vaccine designed to reverse the underlying autoimmune disease process in diabetes, and slow down or ... vaccine protocol has the potential to negate the autoimmune process causing type 1 diabetes, which must be ...

Green tea may delay onset of type 1 diabetes

... Both type 1 diabetes and Sjogren's syndrome are autoimmune diseases, which cause the body to attack itself. autoimmune disorders are the third most common group of ... syndrome can occur alone or secondary to another autoimmune disease, such as lupus, rheumatoid arthritis or ...

'Friendly' bacteria protect against type 1 diabetes, Yale researchers find

... help prevent onset of Type I diabetes, an autoimmune disease in which the patient's immune system ... that produce insulin. The root causes of autoimmune disease have been the subject of intensive ... system to influence whether diabetes and other autoimmune diseases occurs is very important," Li said. ...

Sugar linkage could lead to better treatment for autoimmune diseases

... that could lead to improved treatment of autoimmune diseases like lupus or rheumatoid arthritis. The ... of lupus, rheumatoid arthritis, asthma, and other autoimmune disorders. But because of the trace amounts of ... an IVIG with enhanced activity for treatment of autoimmune diseases. In the Science paper, the researchers ...

Type 1 diabetes triggered by 'lazy' regulatory T-cells: McGill researchers

... immunoregulatory T-cells that regulate the bodys autoimmune reactions may lose their effectiveness and become ... potency declined with age, leaving potential autoimmune responses in the pancreas unchecked. It is ... individuals and trigger a full-scale diabetic autoimmune reaction in the pancreas. Once they start, ...

Protein's new role discovered in autoimmune disease

... unknown role of a chemical 'messenger' leading to autoimmune disorders like rheumatoid arthritis and lupus. ... pinpointed an unknown role IL-17 plays in autoimmune and inflammatory responses, aside from its ... without attacking normal, healthy tissue. In autoimmune diseases that regulatory process ...

Cancer and arthritis therapy may be promising treatment for diabetes

... mutant mice indicates that B cells play a role in autoimmune diseases by interacting with T cells of the ... can continue to suppress the inflammatory and autoimmune response even after the B cells return, said Li ... have dual roles in diabetes and possibly other autoimmune diseases. The B cells might promote disease ...

Profound immune system discovery opens door to halting destruction of lupus

... immune system regulation, and treat chronic autoimmune disorders such as lupus. In autoimmunity, ... receptor tyrosine kinasesdeveloped an autoimmune illness similar to lupus in humans. In the ... But in people with lupus and certain other autoimmune illnesses, the TAM signalling network may be ...

Study identifies genetic risk factor for rheumatoid arthritis, lupus

... that increases the risk of two chronic, autoimmune inflammatory diseases: rheumatoid arthritis (RA) ... would be effective in these and perhaps other autoimmune diseases." One variant form of the gene was ... gene plays a fundamental role in these important autoimmune diseases." ...

U of M begins nation's first clinical trial using T-reg cells from cord blood in leukemia treatment

... as offer a potential new paradigm for treating autoimmune diseases. Toward our quest of making ... patients and potentially useful for patients with autoimmune diseases, said Bruce Blazar, M.D., director of ... hope to test T-regs for treatment of various autoimmune diseases, such as type I diabetes and multiple ...

Auto immune response creates barrier to fertility; could be a step in speciation

... Carolina at Chapel Hill have discovered that an autoimmune response, triggered by a small number of genes, ... of flowering.. I said, those look just like autoimmune mutants, Dangl recalled. Bomblies, Weigel and ... during immune response following infection, or by autoimmune mutants. Moreover, further analysis revealed ...

The right messenger for a healthy immune response

... understanding of how immune responses start, but also how diseases like autoimmune diseases may develop," says Wei: without Beta-Interferon, the immune ... "Our findings can help to develop or improve new therapeutics to combat autoimmune diseases such as multiple sclerosis or cancer." ...

They are young and need the job: A second chance for dangerous T-cells

... Possibly, they could then be used as regulatory T-cells in therapies for autoimmune diseases such as type-1 diabetes or multiple sclerosis: these are diseases ... Deciphering these processes could lead to new therapeutic approaches for autoimmune diseases such as multiple sclerosis, rheumatic arthritis and type-1 ...

Researchers identify new risk factor gene for rheumatoid arthritis

... to figure out the genetic triggers and identify treatments that block this autoimmune process. In theory, such advances can point the way to understanding other autoimmune disorders. About one percent of the population will develop rheumatoid ...

Amarna Therapeutics B.V. and TNO announce SVac research and development partnership

... to address the major diseases of our time including genetic disorders, autoimmune diseases, allergies and cancer. Amarna Therapeutics acts at the forefront ... therapeutic vaccinations to treat immunity-associated diseases including autoimmune diseases, allergies and cancer and gene therapies to treat genetic ...

UAB professor receives HudsonAlpha Innovation Prize

... which are now recognized as important participants in a growing number of autoimmune diseases," said Weaver. "By understanding how this class of T cells ... potential as a means to treat patients who suffer from certain types of autoimmune disease and perhaps harness this potential to eradicate certain types of ...

Gene linked to lupus might explain gender difference in disease risk

... at UT Southwestern Medical Center have identified a gene linked to the autoimmune disease lupus, and its location on the X chromosome might help explain why ... associated with lupus, including kidney malfunction, production of autoimmune antibodies and activation of white blood cells. "The extensive ...

Fireflies and jellyfish help illuminate quest for cause of infertility

... are literally shedding light on possible causes of infertility and autoimmune diseases in humans. Scientists are using the luminescent and florescent ... to more than 300 biological functions. It is believed to play a role in autoimmune diseases, such as lupus and rheumatoid arthritis, as well as in the ...

Lancet study supports new, highly effective treatment for blood disorder

... the U.S. diagnosed with chronic immune thrombocytopenic purpura (ITP), an autoimmune disease that dramatically reduces the number of platelets in their blood ... in GlaxoSmithKline. Immune thrombocytopenic purpura (ITP) is an autoimmune disease in which anti-platelet antibodies accelerate destruction of ...

Tobacco makes medicine

... using genetically modified tobacco plants to produce medicines for several autoimmune and inflammatory diseases, including diabetes. The research is published ... processes. The next step will be to feed the plants to mice with autoimmune diseases to find out how effective they are. The authors are keen to ...

New origin found for a critical immune response

... "This finding will have important implications in vaccine science and autoimmune disease therapy development," said Michael Gunn, M.D., an immunologist and ... a major goal of immunologists trying to prevent infections or control autoimmune disease, Gunn said. ...

Scientists uncover new genetic variations linked to psoriasis

... Bowcock says. An estimated 7 million Americans have psoriasis, an autoimmune disease that occurs when the body's immune cells mistakenly attack the ... associated with other inflammatory diseases such as Crohn's disease and autoimmune diseases like rheumatoid arthritis and lupus. Additional studies will help ...

Implants mimic infection to rally immune system against tumors

... infectious diseases. They could even redirect the immune system to combat autoimmune diseases such as type 1 diabetes, which occurs when immune cells attack ... infectious diseases) or to promote tolerance (for example, subvert autoimmune disease)." ...

High blood sugar's impact on immune system holds clues to improving islet cell transplants

... of the usual balance between effector T cells which mount an immune or autoimmune response and regulatory T cells which suppress attacks. He's obviously ... But researchers cautioned then that manipulating T-cell levels to treat autoimmune diseases, such as type 1 diabetes and lupus, must be done cautiously and ...

JDRF funded research shows promise for prevention, reversal of type 1 diabetes

... approach for treatment of new onset type 1 diabetes and potentially other autoimmune disorders," said JDRF Director of Immunology Teodora Staeva, Ph.D. The ... it is widely believed that tyrosine kinases are a contributing factor to autoimmune diseases and cancer. The researchers hypothesized that tyrosine kinases ...

Lung airway cells activate vitamin D and increase immune response

... deficiency has been recently linked to increased risk of some infections, autoimmune diseases such as multiple sclerosis and type 1 diabetes, and some cancers. ... inflammation can cause problems such as sepsis and seems to contribute to autoimmune disease." Hansdottir noted that vitamin D insufficiencies and ...

JDRF funded study links 'hygiene hypothesis' to diabetes prevention

... a healthy life, and that susceptibility to type 1 diabetes and other autoimmune disorders may actually be caused by a lack of exposure to certain ... system response in mice. That response is believed to be what prevents autoimmune disorders -- conditions where the immune system attacks healthy cells in ...

NYU Cancer Institute researcher among first NIH EUREKA award recipients

... the different signaling methods T-cells use in the contexts of cancer and autoimmune disease. The EUREKA award will allow Dr. Krogsgaard to explore the complex ... patients with HIV or cancer or diminish T-cell activation in patients with autoimmune disease. ...
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(Date:4/15/2014)... Puerto Rican community is creating a tropical home away ... has caught the attention of scientists. David W. Taylor ... Connecticut) took a close look at the fresh crops ... evidence that gives new meaning to a phrase that ... in the kitchen. , "Culinary preferences tell us a ...
(Date:4/15/2014)... University of Missouri researchers have previously shown that a ... exercise exists. In a new study, Frank Booth, a ... found a potential link between the genetic pre-disposition for ... which mental maturation occurs. , For his study, Booth ... activity or extreme laziness. Booth then put the rats ...
(Date:4/15/2014)... Case Western Reserve University dental researchers have found ... immune cells from the mouth to study how ... inflammation. , By isolating some specialized immune cells ... how they fight diseases in the mouthor reject ... hope to learn more about treating and preventing ...
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(Date:4/14/2014)... A new study identifies a molecule that is a ... the molecule could be an important target for colorectal ... , The study of microRNA-135b (miR-135b) in two animal ... Cancer Cell and was led by researchers ... Arthur G. James Cancer Hospital and Richard J. Solove ...
(Date:4/14/2014)... 14In dense, urban centers around the world, many people ... by tall buildings that block sunlight. And as the ... closer together, the darkness will only spread. , ... corrugated, translucent panel that redirects sunlight onto narrow streets ... hung over the edge at an angle, where it ...
(Date:4/14/2014)... Using antibiotics alone to treat children with uncomplicated acute ... to less pain and fewer missed school days, according ... team at Nationwide Children,s Hospital and published online April ... of Surgeons , is the first prospective study on ... the United States. , Researchers enrolled 77 patients ...
(Date:4/14/2014)... it comes to the cost and quality of hospital ... best care when they are treated in units that ... their current job, according to a study from researchers ... School. The study was published in the current issue ... , The review of more than 900,000 patient ...
(Date:4/11/2014)... insights into the processes that control brain cell production ... and other brain-related disorders. , Scientists have gained new ... that controls how and when nerve and brain cells ... to develop and keeps it healthy. Their findings could ... of control, which is a fundamental characteristic of many ...
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