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Atrophy in Biological News

ISU researchers find possible treatment for spinal muscular atrophy

... AMES, Iowa - Spinal Muscular atrophy is the second-leading cause of infant mortality ... Medicine, would like to see Spinal Muscular atrophy lose its high ranking and even slide off the list altogether. Most Spinal Muscular atrophy sufferers -- more than 95 percent -- have a ...

Muscle atrophy through thick but not thin

... Alfred Goldberg, and colleagues show that muscle atrophy is a more ordered process than was previously ... skeletal muscles. The researchers triggered atrophy in mice containing defective MuRF1 (lacking its ... also bears on the practical question of whether atrophy can be halted or reversed with drugs. "It argues ...

Long-term use of mechanical ventilation contributes to the deterioration of human diaphragm muscle

... with diaphragm disuse contributes to muscle atrophy in the diaphragm in as little as eighteen hours. Muscle atrophy in the diaphragm is a major contributor of why ... differences) could only be attributed to marked atrophy caused by a combination of complete diaphragm ...

Motor neuron disease and toxic substances: Possible link?

... the disease, which causes muscles to weaken, atrophy and cease to function, is an important step in ... (tightness) in their legs, as well as muscle atrophy in their hands, shins and feet. James Albers, ... of weakness and spasticity in the legs and muscle atrophy in the hands and lower legs. Next, Fink and ...

As good as it gets: Octogenarian muscles don't get stronger with exercise

... with a sedentary lifestyle, the fast twitch muscles lose functionality and atrophy more quickly than slow-twitch. From the muscle biopsies, the ... to build up the muscle before 80," he said. Next steps Muscle atrophy relates not only to aging, but to people whose muscles are immobilized for ...

NYU Langone Medical Center's tip sheet to the International Conference on Alzheimer's Disease 2008

... 31. Each presentation is embargoed for a specific date and time. Brain atrophy and Biomarkers May Help Identify People at Risk for Alzheimer's Susan ... disease over a two-year period. In a study of 23 people, they found atrophy in areas of the brain involved in learning and memory, and significantly ...

Identification of protein able to stimulate production of T-cells

... news ways to reverse the age-related decline of the immune system. "Thymic atrophy is a major public health problem," said Dr. Perreault. "It compromises ... threat of new foreign bodies, whether they are viruses or tumours." The atrophy of the thymus, a small gland at the base of the neck where T cells mature, ...

An ambulance man for muscle damage

... factor, a protein that plays a crucial role in skeletal muscle atrophy through the induction of genes involved in cell cycle repression and ... speed up the resolution of inflammation and protects muscle cells from atrophy under starvation, says Rosenthal. These effects make CnA1 a promising ...

Mice stressed in simulated weightlessness show organ atrophy

... also simulated weightlessness, demonstrated that OPN is required for the atrophy of immune organs brought on by the stress resulting from hindlimb ... and thymus of the OPN-deficient animals remained normal whereas there was atrophy of the spleen and thymus in the normal controls. This was a novel and ...

Peripheral nerve repair with fat precursor cells led to wider nerves and less muscle atrophy

... group in which nerve guides were left empty. Researchers also observed the formation of a more robust nerve accompanied by modestly decreased muscle atrophy in the APC-transplanted group. No differences were observed after 12 weeks, however. "We found that full regeneration of the sciatic nerve ...

The Prestige oil spill caused changes in the cell structure of mussels

... digestive gland of the mussel. Between 2004 and 2005, serious changes were observed in these tissue in the samples from all the locations studied atrophy of certain parts of the digestive gland, for example Measuring health The health of the mussels was studied through the control of certain ...

Spun-sugar fibers spawn sweet technique for nerve repair

... portion of a nerve cell called the axon, a long fiber attached to the cell body that transmits signals. Fast regeneration is essential to prevent the atrophy of muscles and organs connected to severed nerves. The researchers also discovered that the polymer tubes contain pores that are ideal for ...

Patient-derived induced stem cells retain disease traits

... he couldn't have been more pleased. The dying cells the same type lost in patients with the devastating neurological disease spinal muscular atrophy confirmed that the University of Wisconsin-Madison stem cell biologist had recreated the hallmarks of a genetic disorder in the lab, using stem ...

Rhode Island Hospital study finds link between obesity, type 2 diabetes and neurodegeneration

... weight and a significantly reduced mean brain weight/body weight ratio, providing evidence that obesity with T2DM is sufficient to cause mild global atrophy in the brain. De la Monte says, "In essence, the brain shrinks and several biochemical and molecular abnormalities found in patients with AD, ...

Low-gravity training machine reduces joint, muscle impacts, says CU-Boulder study

... fitness during prolonged space flight. While the NASA technology was designed to effectively increase the weight of the astronauts to stem muscle atrophy and bone loss in low-gravity conditions, the G-Trainer reverses the process, said Grabowski. In the past, sports trainers and researchers have ...

Charcot-marie-tooth disease research funding

... generally appear during adolescence or young adulthood. It is characterized by degeneration of long motor and sensory axons, which results in muscle atrophy and skeletal deformities. Hutson's research will use zebrafish as a model system to investigate disease mutations in two small heat shock ...

Stem cell researchers give old muscle new pep

... at the University of California, Berkeley, setting the path for research on new treatments for age-related degenerative conditions such as muscle atrophy or Alzheimer's and Parkinson's diseases. In a new study to be published June 15 in an advanced online issue of the journal Nature , researchers ...

Leading researchers to reveal comprehensive dos and don'ts for prostate cancer

... is that the specific areas within the organ that develop cancer after exposure to the meat compounds also first become inflamed and develop a form of atrophy that resembles damaged areas in the human prostate that are likely a very early indicator of a problem. According to De Marzo, if scientists can ...

Cigarette smoking may accelerate disability in those with MS

... in any of the clinical findings between active and former smokers. Smoking appears to influence the severity of MS and to accelerate brain atrophy and the disruption of the blood-brain barrier in MS patients, said Zivadinov. MS patients should be counseled to stop smoking, or at least to cut ...

'Smart' genetic therapy helps the body to heal itself

... her team's work on developing therapies for patients with spinal muscular atrophy (SMA). This is a relatively common inherited disease in humans and the ... the motor neurons in the spinal cord patients develop muscle weakness and atrophy of the legs, arms and trunk. In patients with SMA the survival motor ...

Mechanical 'artificial hearts' can remove need for heart transplant by returning heart to normal

... aorta, it can be transported to the rest of the body. Patients were treated with drugs which encourage reverse remodelling of the heart, prevent atrophy and prevent the heart from shrinking beyond its desirable size. The drugs used were lisinopril, carvedilol, spironolactone and losartan in the first ...

A sweet solution for Alzheimer's disease?

... called amyloid â aggregate into plaques, and a protein called tau clumps into neurofibrillary tangles. The brain becomes inflamed and neurons atrophy and die. It's not completely clear what kind of amyloid â peptide (monomers, oligomeric aggregates, or fibrillar aggregates) is responsible for the ...

Injection may prevent infertility in men receiving cancer chemotherapy

... of AS101 a day before that of Taxol prevented the Taxol-induced weight loss. "Tissue analysis of the testes of Taxol-injected mice showed severe atrophy and empty seminiferous tubules, where the sperm-producing cells are contained", said Mr. Carmely. "In contrast, we saw only minimal testicular ...

Memory loss affects more of the brain than previously thought

... in both the frontal and temporal lobes of the brain. Previous studies looking at structural changes alone have shown evidence that brain atrophy in the earliest stages of AD tends to be restricted to the temporal lobe, a region critical to long-term memory formation. "Involvement of both ...

Meditation associated with structural changes in brain

... the MGH Psychiatric Neuroimaging Research Program, the study's lead author. "We also found evidence that mediation may slow down the aging-related atrophy of certain areas of the brain." Studies have shown that mediation can produce alterations in brain activity, and meditation practitioners have ...

U of MN researchers reverse memory loss in mice

... first manipulated the genetic makeup of the mice so they developed dementia; the mice experienced memory loss that worsens over time and had brain atrophy similar to what a person with Alzheimer's disease goes through. The researchers further designed the mice so that the transgene that causes these ...

Big differences in duplicated DNA distinguish chimp and human genomes

... Among the human-only duplications, some of those sections of the genome are implicated in human developmental disorders such as spinal muscular atrophy and Prader-Willi syndrome. Parts of those duplicated segments have only single copies in the chimp genome, and it is possible that the chimpanzee is ...
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