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Aspirin in Biological News

Aspirin and atherosclerosis

... aspirin has become one of the most widely used ... and blood clotting. In animal studies, aspirin has also been shown to prevent atherosclerosis, ... Parthasarathy and colleagues observed that aspirin specifically its active byproduct salicylate can ...

Scientists suspect omega-3 fatty acids could slow acute wound healing

... similar study in which they are adding a low-dose aspirin to both the fish oil supplement and placebo groups. Some research has shown that aspirin can facilitate the anti-inflammatory properties of omega-3 fatty acids, and low-dose aspirin is commonly included in the medication regimen of ...

Ultra-low-dose aspirin might decrease bleeding severity in portal hypertension

... In rats with portal hypertension, ultraClow-dose aspirin has shown a normalizing effect of ... observed in this pathology. Ultra-low-dose aspirin has a prothrombotic effect that is the opposite ... attack. The antithrombotic properties of low-dose aspirin are achieved by the inhibition of COX 1 in ...

American Chemical Society's Weekly PressPac -- Jan. 7, 2009

... humans can make their own salicylic acid (SA) the material formed when aspirin breaks down in the body. SA, which is responsible for aspirin's renowned ... of its own." JS ARTICLE #4 FOR IMMEDIATE RELEASE "Salicylic Acid sans aspirin in Animals and Man: Persistence in Fasting and Biosynthesis from Benzoic ...

Mutation of the COX2 gene can double or treble a woman's risk of ovarian cancer

... be possible to use non-steroidal anti-inflammatory drugs (NSAIDs), such as aspirin and ibuprofen, which are used already for other conditions, to prevent ... enzyme and the therapeutic drugs that may inhibit its activity (such as aspirin and other NSAIDs). Former studies involving NSAIDs and risk for ovarian ...

Veterinarians developing model to help producers, vets make cattle more comfortable

... clinical sciences. They are developing a model that can evaluate pain management drugs for cattle. Although producers and veterinarians sometimes use aspirin and other anti-inflammatory drugs, there are no pharmaceuticals approved by the U.S. Food and Drug Administration specifically for pain management in ...

New evidence that people make aspirin's active principle -- salicylic acid

... 22, 2008 Scientists in the United Kingdom are reporting new evidence that humans can make their own salicylic acid (SA) the material formed when aspirin breaks down in the body. SA, which is responsible for aspirin's renowned effects in relieving pain and inflammation, may be the first in a new class ...

Novel bioreactor enhances interleukin-12 production in genetically modified tobacco plants

... we've collected the therapeutic proteins grown in the roots, all the remaining material is safely destroyed." Traditional pharmaceuticals, like aspirin or statins for lowering cholesterol, are made by synthesizing and combining chemicals in a factory-like production setting. Therapeutic proteins are ...

12-month ATLANTA trial data show sustained benefit of Catania Stent

... of 6.8 percent (five of 74 lesions analyzed at twelve months). Of note, all patients stopped dual anti-platelet therapy after 30 days, but continued aspirin (100 mg/d) throughout the 12-month period. The acute angiographic and procedural success rate in the ATLANTA Trial was 100 percent. Independent ...

Plants in forest emit aspirin chemical to deal with stress; discovery may help agriculture

... and it also has the potential to give farmers an early warning signal about crops that are failing. "Unlike humans, who are advised to take aspirin as a fever suppressant, plants have the ability to produce their own mix of aspirin-like chemicals, triggering the formation of proteins that boost ...

Broad Institute awarded grant to develop chemical probes for human biology and disease

... are readily transported through the body and include endogenous substances, such as hormones and neurotransmitters, as well as medicines like aspirin and penicillin. The six-year NIH grant designates the Broad Institute as one of four Comprehensive Screening Centers in the Molecular Libraries ...

Johns Hopkins scientists discover what drives the development of a fatal form of malaria

... infected separate sets of live mice with the malaria parasite: one set treated so that it lacked platelets altogether and two others treated with aspirin or Plavix, platelet inhibitors that prevent the release of PF4. The survival rate of mice without platelets as well as those treated with ...

New discoveries from Harvard and Baylor get to the heart of cardiovascular disease

... therapy," said Aksam Merched, PhD, Assistant Professor at Baylor College of Medicine and the first author of the study. "It's also noteworthy that aspirin stimulates the body to produce one class of these chemicals." "Even if we delay the process by exercise and rabbit food, sooner or later our blood ...

Why conservation efforts often fail

... "blueprint" that foolishly ignores local customs, economics and politics. "We now ridicule the doctors who long ago used to tell us, 'Take two aspirin and call me in the morning' as a treatment for every single illness," said Ostrom, a member of the National Academy of Sciences. "Resource management ...

Aspirin discovery may improve cancer treatments

... to prevent diseases such as cancer, but the way aspirin works is not yet fully understood. In a paper ... mouse cells, but not in cells deficient in PERK. aspirin was shown to activate PERK. Moreover, although aspirin inhibited protein synthesis in normal cells, this ...

Therapeutic prospects beyond Vioxx

... the impact of either COX-2 inhibitors or low-dose aspirin and compared them with treating healthy mice with ... also addressed the likely benefit of adding aspirin to diminish this effect of the inhibitors. ... some chatter to the contrary, this issue of an aspirin effect has not been addressed directly in any of ...

Aspirin reduces cardiovascular risks in men and women -- but differently

... aspirin can significantly reduce the risk of ... reduction differed between the sexes. For men, aspirin lowered the risk of a heart attack, while in women, aspirin reduced the risk of a stroke. The use of ...

UCSD researchers create roadmap to integrin activation

... chronic use. In sharp contrast, drugs such as clopidogrel (Plavix) and aspirin are two examples of antithrombotics that work well in chronic administration and are widely used for this purpose. "Drugs such as aspirin and clopidogrel work in large part by blocking the activation of ...

COX-2 inhibitors significantly reduce risk of cancer

... the same period was associated with a 64 percent reduction, while regular aspirin offered a 51 percent reduction in risk of the disease. On the other ... which has a negligible effect upon COX-2 activity, and low-dose aspirin provided no significant change in the risk of breast cancer. "The ...

Inflammation and drugs to control this activity studied in a variety of tumors sites

... who regularly take non-steroidal anti-inflammatory drugs (NSAIDs), such as aspirin and ibuprofen to treat conditions like arthritis, have lower rates of ... by precancerous tissues. "The combined results of 20 human studies of aspirin and ibuprofen reflect an approximate 30 percent reduction in the risk for ...

Function of new cancer genes discovered

... route in cylindromatosis patients could be an adequate form of treatment. aspirin is a well-known inhibitor of this route and a clinical study into the effectiveness of aspirin ointment in the treatment of cylindromatosis is currently being carried ...

Old memory traces in brain may trigger chronic pain

... have actually healed" The definitive answer -- and an effective treatment -- has long eluded scientists. Traditional analgesic drugs, such as aspirin and morphine derivatives, haven’t worked very well. A Northwestern University researcher has found a key source of chronic pain appears to be ...

New research shows that flu is a trigger of heart attacks

... among the priority groups to receive the vaccine or antiviral drugs. Meticulous use of plaque-stabilising agents such as statins, beta-blockers, aspirin and angiotensin-converting enzyme inhibitors should offer additional protection during an influenza outbreak," he said. Prof Madjid said that a ...

Worms produce surprise insight into human fever

... humans and whether drugs currently used to reduce fever in infected patients may make matters worse by preventing activation of the HSF-1 pathway. aspirin and similar anti-inflammatory drugs, which reduce fever but also activate HSF-1 signaling, could offer the best of both worlds, says Aballay. He ...

Mayo Clinic collaboration mining of ancient herbal text leads to potential new anti-bacterial drug

... to investigate as drugs for new and better therapies. "Natural products are invaluable sources of healing agents -- consider, for example, that aspirin derived originally from willow bark, and the molecular basis of the anti-cancer chemotherapeutic agent Taxol TM was derived from the bark of the ...

UCLA study finds same genes act differently in males and females

... different rates. "Our findings in the liver may explain why men and women respond differently to the same drug," noted Lusis. "Studies show that aspirin is more effective at preventing heart attack in men than women. One gender may metabolize the drug faster, leaving too little of the medication in ...

One in 14 men having a heart attack drive themselves to hospital

... that it took 54 minutes longer for women to be admitted to coronary care units than men. Women also waited longer to be assessed and treated with aspirin and to receive reperfusion therapy, which restores blood flow to the heart. Approximately 120 nurses working across the six coronary care ...

Access to existing medical treatments could save more lives than spending to improve the treatments

... clot-busting drugs failed to reach the break-even point, thus saving fewer lives than if gaps in care had been rectified. For example, getting aspirin to all eligible patients would have prevented more strokes than were prevented by developing more potent and more expensive antiplatelet drugs, Woolf ...

Cyberkinetics, Case to develop system to help restore extremity function

... these brain signals into a computer-mediated output under the person's own control. The sensor is a tiny silicon chip about the size of a baby aspirin with one hundred electrodes, each thinner than a human hair, that can detect the electrical activity of neurons. The sensor is implanted on the ...

Drugs from the deep blue

... leads for the next generation of drugs, whether those are anti-fungals or treatments for cancer. Many pharmaceutical drugs on the market, from aspirin to cholesterol-lowering "statins," are derived from natural products such as plants or bacteria. Molinski says modern developments in analytical ...

While on trail of dioxin, scientists pinpoint cancer target of green tea

... Just as people with aches and pains no longer have to chew on willow bark to receive the benefits of the substance salicin ?they simply take an aspirin –the current research opens the door to extending the health benefits first discovered in green tea to people who never touch the beverage. Isolating ...

Defenseless plants arm themselves with metals

... and help the plant resist infection. A molecule called salicylic acid - a common plant compound and the active ingredient in pharmaceuticals like aspirin and acne medications - governs this pathway. When faced with a fungus or bacteria, most plants turn up their production of salicylic acid, which ...
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